AIM To compare the outcomes of retrograde intrarenal surgery(RIRS) and miniaturized percutaneous nephrolithotomy(mini-PCNL) in treating lower pole(LP) renal stones with a diameter of 1.5-2.5 cm.METHODS A total of 216 ...AIM To compare the outcomes of retrograde intrarenal surgery(RIRS) and miniaturized percutaneous nephrolithotomy(mini-PCNL) in treating lower pole(LP) renal stones with a diameter of 1.5-2.5 cm.METHODS A total of 216 patients who underwent mini-PCNL(n = 103) or RIRS n = 113) for LP stones with a diameter of 1.5-2.5 cm were enrolled between December 2015 and April 2017 at the Urology Department of Ningbo Urology and Nephrology Hospital.RESULTS Significant differences were found in the hospital stay(9.39 ± 4.01 vs 14.08 ± 5.26, P < 0.0001) and hospitalization costs(2624.5 ± 513.36 vs 3255.2 ± 976.5, P < 0.0001) between the RIRS and mini-PCNL groups. The mean operation time was not significantly different between the RIRS group(56.48 ± 24.77) and the mini-PCNL group(60.04 ± 30.38, P = 0.345). The stone-free rates at the first postoperative day(RIRS vs mini-PCNL: 90.2% vs 93.2%, P = 0.822) and the second month postoperatively(RIRS vs mini-PCNL: 93.8% vs 95.1%, P = 0.986) were not significantly different.CONCLUSION RIRS and mini-PCNL are both safe and effective methods for treating LP stones with a diameter of 1.5-2.5 cm. RIRS can be considered as an alternative to PCNL for the treatment for LP stones of 1.5-2.5 cm.展开更多
To the Editor:Chronic kidney disease(CKD)is a global burden of the public health.The global prevalence of CKD exceeded 10%while the awareness was around 10%.[1]In the era of big data,improving the identification of CK...To the Editor:Chronic kidney disease(CKD)is a global burden of the public health.The global prevalence of CKD exceeded 10%while the awareness was around 10%.[1]In the era of big data,improving the identification of CKD using informatic tools is important.Computable phenotype is proven as an efficient tool to facilitate the process of patient identification using electronic health record(EHR)data.展开更多
Introduction The last 30 years have witnessed the development of evidencebased medicine.It helps to achieve best practice by incorporating best available evidence into everyday practice.Conventionally,best evidence is...Introduction The last 30 years have witnessed the development of evidencebased medicine.It helps to achieve best practice by incorporating best available evidence into everyday practice.Conventionally,best evidence is generated through clinical studies such as randomized clinical trials(RCTs)and synthesized by systematic review and meta-analysis.Compared to evidence generation,fewer activities are taken to promote evidence uptake in practice.There is a long time lag between evidence and practice,and it may take up to 17 years[1].To close the gap,the concept of learning health system(LHS)was proposed in a roundtable on evidence-based medicine by the Institute of Medicine(IOM)in 2006,which provides a way to leverage data to learn knowledge and to feed it back to the frontline practice in real time[2].展开更多
基金Supported by the Ningbo Medical Science and Technology Project,No.2014A33
文摘AIM To compare the outcomes of retrograde intrarenal surgery(RIRS) and miniaturized percutaneous nephrolithotomy(mini-PCNL) in treating lower pole(LP) renal stones with a diameter of 1.5-2.5 cm.METHODS A total of 216 patients who underwent mini-PCNL(n = 103) or RIRS n = 113) for LP stones with a diameter of 1.5-2.5 cm were enrolled between December 2015 and April 2017 at the Urology Department of Ningbo Urology and Nephrology Hospital.RESULTS Significant differences were found in the hospital stay(9.39 ± 4.01 vs 14.08 ± 5.26, P < 0.0001) and hospitalization costs(2624.5 ± 513.36 vs 3255.2 ± 976.5, P < 0.0001) between the RIRS and mini-PCNL groups. The mean operation time was not significantly different between the RIRS group(56.48 ± 24.77) and the mini-PCNL group(60.04 ± 30.38, P = 0.345). The stone-free rates at the first postoperative day(RIRS vs mini-PCNL: 90.2% vs 93.2%, P = 0.822) and the second month postoperatively(RIRS vs mini-PCNL: 93.8% vs 95.1%, P = 0.986) were not significantly different.CONCLUSION RIRS and mini-PCNL are both safe and effective methods for treating LP stones with a diameter of 1.5-2.5 cm. RIRS can be considered as an alternative to PCNL for the treatment for LP stones of 1.5-2.5 cm.
基金National Natural Science Foundation of China(Nos.82100741,82003529,91846101,81771938,81900665,82090021)Beijing Municipal Science and Technology Commission(Grant No.7212201)+5 种基金the University of Michigan Health System-Peking University Health Science Center Joint Institute for Translational and Clinical Research(Nos.BMU2020JI011,BMU2019JI005,BMU2018JI012)Beijing Nova Programme Interdisciplinary Cooperation Project(No.Z191100001119008)National Key R&D Program of the Ministry of Science and Technology of China(No.2019YFC2005000)the National Key Research and Development Program of China(No.2018AAA0102100)PKU-Baidu Fund(Nos.2020BD005,2019BD017)CAMS Innovation Fund for Medical Sciences(No.2019-I2M-5-046)
文摘To the Editor:Chronic kidney disease(CKD)is a global burden of the public health.The global prevalence of CKD exceeded 10%while the awareness was around 10%.[1]In the era of big data,improving the identification of CKD using informatic tools is important.Computable phenotype is proven as an efficient tool to facilitate the process of patient identification using electronic health record(EHR)data.
基金Beijing Natural Science Foundation(7212201)The National Science Fund for Distinguished Young Scholars of China(72125009)+1 种基金Humanities and Social Science Project of Ministry of Education of China(22YJA630036)The Joint Project of Institute for Translational and Clinical Research,Michigan Medicine and Peking University Health Science Center(BMU2020JI011).
文摘Introduction The last 30 years have witnessed the development of evidencebased medicine.It helps to achieve best practice by incorporating best available evidence into everyday practice.Conventionally,best evidence is generated through clinical studies such as randomized clinical trials(RCTs)and synthesized by systematic review and meta-analysis.Compared to evidence generation,fewer activities are taken to promote evidence uptake in practice.There is a long time lag between evidence and practice,and it may take up to 17 years[1].To close the gap,the concept of learning health system(LHS)was proposed in a roundtable on evidence-based medicine by the Institute of Medicine(IOM)in 2006,which provides a way to leverage data to learn knowledge and to feed it back to the frontline practice in real time[2].