Feature Fusion Based Deep Transfer Learning Based Human Gait Classification Model

Gait is a biological typical that defines the method by that people walk.Walking is the most significant performance which keeps our day-to-day life and physical condition.Surface electromyography(sEMG)is a weak bioelectric signal that portrays the functional state between the human muscles and nervous system to any extent.Gait classifiers dependent upon sEMG signals are extremely utilized in analysing muscle diseases and as a guide path for recovery treatment.Several approaches are established in the works for gait recognition utilizing conventional and deep learning(DL)approaches.This study designs an Enhanced Artificial Algae Algorithm with Hybrid Deep Learning based Human Gait Classification(EAAA-HDLGR)technique on sEMG signals.The EAAA-HDLGR technique extracts the time domain(TD)and frequency domain(FD)features from the sEMG signals and is fused.In addition,the EAAA-HDLGR technique exploits the hybrid deep learning(HDL)model for gait recognition.At last,an EAAA-based hyperparameter optimizer is applied for the HDL model,which is mainly derived from the quasi-oppositional based learning(QOBL)concept,showing the novelty of the work.A brief classifier outcome of the EAAA-HDLGR technique is examined under diverse aspects,and the results indicate improving the EAAA-HDLGR technique.The results imply that the EAAA-HDLGR technique accomplishes improved results with the inclusion of EAAA on gait recognition.

Arterial hypertension and electrocardiographic diagnosis of left ventricular hypertension in the group of geriatric patients with coronary heart disease living in the far north

As a result of research, high prevalence of arterial hypertension has been identified in the group of patients with coronary heart disease aged 60 and older. Most often, occurring form of arterial hypertension among geriatric patients is isolated systolic arterial hypertension (ISAH). The comparison of two ethnic groups of the population has showed higher levels of systolic and diastolic blood pressure (SBP and DBP) in the group of patients of non-indigenous nationality, rather than Yakut patients. Correlation was recorded in the group of non-indigenous patients as they age. Significant increase in the level of SBP was identified in the group of senile and long-livers than in the elderly. Detection of ECG signs of LVH showed the lowest specificity of Cornell voltage criterion comparing to Sokolow-Lyon criterion with its more often occurrence. ECG-signs of left ventricle hypertrophy are significantly more often established by Sokolow-Lyon criterion for men, Cornell voltage—for women. Correlation has been found between the presence of LVH and combination of Cornell voltage criterion with both Gubner-Ungerleider and Sokolow-Lyon criteria.

Influence of frost weathering on the recession of surfaces of technogenic landforms in Yakutia

The article assesses the influence of permafrost weathering on the rate of destruction of technogenic land forms,as exhibit ed on as illustrated by the railway embankment of the Amur Yakut mainline in the Sakha Republic(Yakutia).Studies were carried out on a railway section more than 375 km long.The subsidence rate of the embankment slopes and structur al excavations was determined using laboratory methods that simulate various mechanisms of temperature(with a transi tion through 0℃)impact on rocks.For the first time,a quantitative assessment of the influence of cryogenic weathering on the stability of the railway in the region belonging to the northern building climatic zone is given.For the territory un der consideration,embankment rocks were experimentally determined to undergo more than 100 freezing and thawing cy cles during a year.Under the existing climatic conditions,cryogenic weathering actively affects the embankment of the railway to a depth of 30 cm.Most of the embankment deformations detected during field observations are due to defects in the integrity of this particular layer.The size of the disintegrating layer of particular types of rock comprising the rail way embankment has been established as reaching 10 cm per year.In 5 years following the formation of embankments comprising the upper structure of the railroad tracks,the physical and mechanical properties of rocks,which initially had a tensile strength for uniaxial compression in the range of 40 70 MPa,were reduced by more than 50%.According to the authors,the establishment of regional cryohypergenesis features is universal in nature and can be applied to solving a wide range of tasks related to the assessment and prediction of the degree of cryogenic transformation of rocks having different structural properties.

The angiotension converting enzyme (ACE) gene I/D polymorphism in different ethnic groups of geriatric age living in the Far North

The study of ACE gene I/D polymorphism has been carried out in elderly, senile and long-liver patients with coronary heart disease (CHD) taking into account their nationality, age and sex. It has been recorded that with the increase of age there is a decrease in the frequency of the genotype ACE*I/*I and a tendency of increase in the frequency of the genotype ACE*D/*D. A comparative analysis of genotypes АСЕ*D/*D and АСЕ*D/*I has showed sex differences in the frequency of homozygous genotype detection. Left ventricular hypertrophy can be observed significantly more often among carriers of genotype ACE*I/*I established by Sokolow-Lyon ECG signs. Association analysis of ACE gene I/D polymorphism has registered significant differences in BMI and blood lipid parameters.

A Seismotectonic Zonation Map of Eastern Siberia: New Principles and Methods of Mapping

The paper reviews goals and objectives, stages and components of a seismotectonic study conducted in Eastern Siberia, Russia. Based on a comprehensive analysis of geological and geophysical data, our study establishes whether the local earthquakes are of tectonic origin and reveals relationships among earthquakes with recent geodynamic processes in the area under study. Seismic hazard assessment and evaluation of tectonic processes are the two major closely interrelated aspects of seismotectonic studies. A seismotectonic study is generally combined with a seismic study and conducted prior to the stage of detailed seismic zonation (DSZ) which is followed by seismic micro-zonation (SMZ). In three stages of the seismotectonic study, we analyze specific geological structures, reveal the regional dynamics of seismotectonic processes, clarify details of potential seismic hazard locations and identify sites of the potential instantaneous deformation of the crust which may take place due to active faulting. Based on results of our longterm studies, a seismotectonic zonation map of Eastern Siberia is compiled. The paper briefly reviews the methods of mapping and refers to data on active faults and neotectonic structures revealed in the area under study, which are closely related to regional earthquake sources.

Microbiota of Fossil Animals Preserved in Yakut Permafrost

Microbiological investigation of the fossil animals preserved in permafrost represents obvious interest for science. Lack of data in this sphere gives even greater importance to any findings giving us opportunity to learn more about remote past of microorganisms. In this respect, preserved remains of fossil are considered as unique biological materials for scientific investigations. Bacillus bacteria strains isolated from the paleomicrobiota of mammoth fauna are not only have high durability （20-30 thousand of years） in permafrost, but are still able to produce biologically active substances. Strains of bacteria of the genus Bacillus, isolated from the tissues of the representatives of the mammoth fauna have strong antagonistic properties to hemolytic streptococci--Streptococcus equi, pathogenic for animals--Salmonella abortus equi, also toxigenic micromycetes genera Aspergillus, Alternuria, Penicillum and fungal pathogens of plant diseases--Botrytis cimeria and Fuzarium oxysporium. The strains of bacteria of the genus Bacillus are not pathogenic to plants and animals, but initially resistant to wide range of antibiotics. Dominance strains of Bacillus bacteria, producing strong bacteriocins in the soft tissues of fossil animals, contributing to their long cryo bio conservation. In addition, bacterial strains of Bacillus subtilis, isolated from paleo microbiota have strong oxidizing properties. Microbiota of fossils preserved in permafrost of Yakutia is of particular interest for microbiology and modem biotechnology.

Diagnostics of Sensory Ataxia in Patients with Sensory Predominant Chronic Inflammatory Demyelinating Polyneuropathy from Republic of Sakha (Yakutia) and Krasnoyarsk Region

Materials and Methods: A group of healthy volunteers (24 people) and patients with SP-CIDP from Republic of Sakha (Yakutia) (42 people) and Krasnoyarsk region (87 people). Diagnostics Methods: Clinical neurologic, neurophysiological. Results: The results of stabilometry research of patients with SP-CIDP have revealed area expansion of pressure centre in phase EO and EC with deflection PC forward by anteropulsion type among patients with SP-CIDP from Republic of Sakha (Yakutia). Also in the Yakut group has been noted to have severer clinical course in comparison with inhabitants of Krasnoyarsk region. Conclusion: The method of computer stabilometry allows estimating objectively presence and degree of manifestation of sensitive ataxia in patients with SP-CIDP.

一类变系数非齐次电报方程的数值解法

利用特解方法数值求解一类变系数非齐次电报方程.首先用有限差分方法对时间方向进行离散,进而转化为在空间方向上利用特解方法进行近似,最终利用待定系数法逐步求出在不同时刻的方程的数值解.利用Matlab程序对给定的方程进行数值求解并进行误差估计.通过数值算例,可见所采用的数值方法具有较高的近似精度.

Modeling historical budget for β-Hexachlorocyclohexane(HCH)in the Arctic Ocean:A contrast to α-HCH

The historical annual loading to,removal from,and cumulative burden in the Arctic Ocean for β-hexachlorocyclohexane(β-HCH),an isomer comprising 5e12%of technical HCH,is investigated using a mass balance box model from 1945 to 2020.Over the 76 years,loading occurred predominantly through ocean currents and river inflow(83%)and only a small portion via atmospheric transport(16%).β-HCH started to accumulate in the Arctic Ocean in the late 1940s,reached a peak of 810 t in 1986,and decreased to 87 t in 2020,when its concentrations in the Arctic water and air were~30 ng m^(-3)and~0.02 pg m^(-3),respectively.Even though β-HCH and α-HCH(60e70%of technical HCH)are both the isomers of HCHs with almost identical temporal and spatial emission patterns,these two chemicals have shown different major pathways entering the Arctic.Different from α-HCH with the long-range atmospheric transport(LRAT)as its major transport pathway,β-HCH reached the Arctic mainly through long-range oceanic transport(LROT).The much higher tendency of β-HCH to partition into the water,mainly due to its much lower Henry's Law Constant than α-HCH,produced an exceptionally strong pathway divergence with β-HCH favoring slow transport in water and α-HCH favoring rapid transport in air.The concentration and burden of β-HCH in the Arctic Ocean are also predicted for the year 2050 when only 4.4-5.3 t will remain in the Arctic Ocean under the influence of climate change.

Artemisia kruhsiana leaf extract induces autophagic cell death in human prostate cancer cells

Some species of Artemisia have been reported to induce apoptosis and autophagy,but little is known of the apoptotic and autophagic effects of the stems and leaves of Artemisia kruhsiana Bess.(AkB).This study was conducted to investigate the antioxidant and anti-autophagic effects of the methanol extracts of the stems(EAkBs)and leaves(EAkBl)of AkB on human prostate cancer PC-3 cells.The antioxidant effects of EAkBs and EAkBl were measured using in vitro total flavonoid and total phenolic assays and a free radical scavenging assay.The effects of EAkBl on cell viability,apoptosis,autophagy,intracellular reactive oxygen species(ROS)generation and protein expression levels were also investigated.EAkBl was found to induce apoptosis,autophagy,and intracellular ROS generation in PC-3 cells.In terms of protein levels,EAkBl reduced phospho(p)-protein kinase B(AKT)/AKT,p-mammalian target of rapamycin(mTOR)/mTOR,B-cell lymphoma 2(Bcl-2)/Bcl-2-associated X protein(Bax)ratios,and the activations of beclin 1/β-actin and microtubule-associated protein 1A/1B-light chain 3(LC3)Ⅱ/LC3Ⅰratios in PC-3 cells.The results of this study indicate EAkBl has antioxidant and anticancer effects on prostate cancer cells,and that these effects are associated with suppressions of p-AKT,p-mTOR,Bcl-2,and Bax,and the activations of beclin 1 and LC3.Our results indicate EAkBl has potential as a treatment for prostate cancer.

Dracocephalum palmatum Stephan extract induces apoptosis in human prostate cancer cells via the caspase-8-mediated extrinsic pathway

Dracocephalum palmatum Stephan is a medicinal plant traditionally used by nomadic people in Eastern Russia;however,research on this plant is currently limited.Recently,although studies have been conducted on the constituents of this plant and their antioxidant effects,data on its various pharmacological activities are still lacking.Thus,this study examined the anticancer potential of the dried leaves of D.palmatum S.(DpL)using human prostate cancer PC-3 cells.The antioxidant potential of DpL was evaluated by estimating the total flavonoid and total phenolic content(TFC and TPC,respectively).Additionally,we investigated the effects of the DpL ethyl acetate fraction(DpLE)on cell proliferation,intracellular reactive oxygen species(ROS)generation,apoptosis,and cell cycle arrest in this cell line.The expression levels of superoxide dismutase(SOD)-1,SOD-2,B-cell lymphoma 2(Bcl-2)and Bcl-2 associated X(Bax)ratio,phospho-protein kinase B(p-AKT),cleaved caspase-8,poly adenosine diphosphate(ADP)ribose polymerase(PARP),and cleaved-PARP were evaluated by western blotting.The results indicated that DpLE causes apoptosis and exerts intracellular ROS-independent anticancer effects on prostate cancer cells,associated with increased SOD-2,cleaved caspase-8,and cleaved-PARP expression and inhibited p-AKT signaling.Thus,DpLE may be a potential resource for the development of promising chemotherapeutic agents for prostate cancer.

A new insight into the nature of seasonal variations in coordinate time series of GPS sites located near active faults

This study provides new insights into the nature of seasonal variations in coordinate time series of GPS sites located near active faults and methods of their modeling. Monthly averaged coordinate time series were analyzed for several pairs of collocated GPS sites situated near the active fault intersection area, in close proximity to the central part of the northern boundary of the Amurian plate and the vicinity of the San Andreas Fault zone. It is concluded that the observed seasonal variations are best described by a breather function which is one of the solutions of the well-known sine-Gordon equation. The obtained results suggest that, in this case, the source of seasonal variations may be caused by the appearance of solitary strain waves in the fault intersection system, which may be qualitatively treated as standing waves of compression-extension of the geological medium. Based on statistical testing, the limits of applicability of the suggested model have been established.

Time-Lapse 3-D Seismic Wave Simulation via the Generalized Multiscale Finite Element Method

Numerical solution of time-lapse seismic monitoring problems can be challenging due to the presence of finely layered reservoirs.Repetitive wave modeling using fine layered meshes also adds more computational cost.Conventional approaches such as finite difference and finite element methods may be prohibitively expensive if the whole domain is discretized with the cells corresponding to the grid in the reservoir subdomain.A common approach in this case is to use homogenization techniques to upscale properties of subsurface media and assign the background properties to coarser grid;however,inappropriate application of upscaling might result in a distortion of the model,which hinders accurate monitoring of the fluid change in subsurface.In this work,we instead investigate capabilities of a multiscale method that can deal with fine scale heterogeneities of the reservoir layer and more coarsely meshed rock properties in the surrounding domains in the same fashion.To address the 3-D wave problems,we also demonstrate how the multiscale wave modeling technique can detect the changes caused by fluid movement while the hydrocarbon production activity proceeds.

Timoshenko inclusions in elastic bodies crossing an external boundary at zero angle

The paper concerns an analysis of equilibrium problems for 2D elastic bodies with a thin Timoshenko inclusion crossing an external boundary at zero angle. The inclusion is assumed to be delaminated, thus forming a crack between the inclusion and the body. We consider elastic inclusions as well as rigid inclusions. To prevent a mutual penetration between the crack faces, inequality type boundary conditions are imposed at the crack faces. Theorems of existence and uniqueness are established. Passages to limits are investigated as a rigidity parameter of the elastic inclusion going to infinity.