Organ transplantation has become a powerful strategy for the treatment of malignant diseases.Nevertheless,graft rejection is one of the main factors affecting graft survival after organ transplantation.Under this circ...Organ transplantation has become a powerful strategy for the treatment of malignant diseases.Nevertheless,graft rejection is one of the main factors affecting graft survival after organ transplantation.Under this circumstance,the transplant-related mortality still keeps up.This invention includes the precise medication guidance of Tacrolimus(FK506)inapplicable population,against the side-effects of this drug.This invention,based on second-generation sequencing,has the advantages of relatively low cost and high sequencing throughput.During the design process,we collect the data of single nucleotide polymorphism(SNP)concerning the adverse drug reactions of Tacrolimus.Then we filter and summarize fifteen SNPs basing on importance degree(level>key enzyme>race).Thenceforth,after the process of analyzing the raw extract by operating BWA,Picardtools,GATK,and Perl,we annotate SNPs by Annovar.Through this innovation,people can obtain further feedback on drugs that targets different genes in order to achieve the purpose of precision medication and minimizing the risks of misusing Tacrolimus.展开更多
The vibration reduction characteristics of composite beams filled with magnetorheological elastomer core are studied experimentally.The fiber metal laminates with magnetorheological elastomers core is self-designed an...The vibration reduction characteristics of composite beams filled with magnetorheological elastomer core are studied experimentally.The fiber metal laminates with magnetorheological elastomers core is self-designed and prepared.Internal magnetic field is applied to the beam to explore its action of damping vibration performance under the magnetic field for the first time.The composite elements test system with controllable magnetic field intensity is designed and the function of each part is introduced.Then,a set of reasonable and standard vibration test flow of this type of composite beam under different magnetic field intensity is clarified,and the practical test is conducted.It has been found that the composite beam has excellent damping performance with the first 4 damping ratios being greater than 10%.Moreover,after the magnetic field is applied,its damping results can be further improved to meet the active control purpose.展开更多
文摘Organ transplantation has become a powerful strategy for the treatment of malignant diseases.Nevertheless,graft rejection is one of the main factors affecting graft survival after organ transplantation.Under this circumstance,the transplant-related mortality still keeps up.This invention includes the precise medication guidance of Tacrolimus(FK506)inapplicable population,against the side-effects of this drug.This invention,based on second-generation sequencing,has the advantages of relatively low cost and high sequencing throughput.During the design process,we collect the data of single nucleotide polymorphism(SNP)concerning the adverse drug reactions of Tacrolimus.Then we filter and summarize fifteen SNPs basing on importance degree(level>key enzyme>race).Thenceforth,after the process of analyzing the raw extract by operating BWA,Picardtools,GATK,and Perl,we annotate SNPs by Annovar.Through this innovation,people can obtain further feedback on drugs that targets different genes in order to achieve the purpose of precision medication and minimizing the risks of misusing Tacrolimus.
基金This study was supported by the National Natural Science Foundation of China(granted No.51505070)the Fundamental Research Funds for the Central Universities of China(granted No.N160313002,N160312001,N170302001,N180302004,N180703018,N180312012 and N180313006)the National Key Laboratory of Science and Technology on Advanced Composites in Special Environments,Harbin Institute of Technology(granted No.6142905192512).
文摘The vibration reduction characteristics of composite beams filled with magnetorheological elastomer core are studied experimentally.The fiber metal laminates with magnetorheological elastomers core is self-designed and prepared.Internal magnetic field is applied to the beam to explore its action of damping vibration performance under the magnetic field for the first time.The composite elements test system with controllable magnetic field intensity is designed and the function of each part is introduced.Then,a set of reasonable and standard vibration test flow of this type of composite beam under different magnetic field intensity is clarified,and the practical test is conducted.It has been found that the composite beam has excellent damping performance with the first 4 damping ratios being greater than 10%.Moreover,after the magnetic field is applied,its damping results can be further improved to meet the active control purpose.
