A new Dy-based coordination polymer, namely {[Dy(cptpy)_2(H_2O)_2](TPT)(Cl)}_n(1, Hcptpy = 4-(4-carboxyphenyl)-4,2?:6?,4??-terpyridine, TPT = 2,4,6-tri(4-pyridyl)-1,3,5-triazine, DMA = N,N-dimethylac...A new Dy-based coordination polymer, namely {[Dy(cptpy)_2(H_2O)_2](TPT)(Cl)}_n(1, Hcptpy = 4-(4-carboxyphenyl)-4,2?:6?,4??-terpyridine, TPT = 2,4,6-tri(4-pyridyl)-1,3,5-triazine, DMA = N,N-dimethylacetamide) has been solvothermally synthesized by the reactions of DyCl_3, Hcptpy and TPT in a mixture solvent of DMA and H_2O. Single-crystal X-ray structural analysis reveals that 1 is a 1D linear chain coordination polymer with quadrangle channels which are occupied by the TPT ligands. The compound has been characterized by singe-crystal analyses, thermogravimetry analyses and powder X-ray diffraction measurements. The antitumor activity of compound 1 and its corresponding organic ligands Hcptpy and TPT were then investigated against four human lung cancer cell lines(NCI-H460, Calu-3, A549 and NCI-H292) by MTT assay. It was found that compared with Hcptpy and TPT, compound 1 exerted rather potent activity against all of these cell lines.展开更多
基金supported by the grants from the Health and Family Planning Commission of Guizhou Province(gzwjkj2015-1-023)the Guizhou Province Science&Cooperative Project of 2015(No.7126)the Guiyang Science and Technology Project of 20141001(No.61)
文摘A new Dy-based coordination polymer, namely {[Dy(cptpy)_2(H_2O)_2](TPT)(Cl)}_n(1, Hcptpy = 4-(4-carboxyphenyl)-4,2?:6?,4??-terpyridine, TPT = 2,4,6-tri(4-pyridyl)-1,3,5-triazine, DMA = N,N-dimethylacetamide) has been solvothermally synthesized by the reactions of DyCl_3, Hcptpy and TPT in a mixture solvent of DMA and H_2O. Single-crystal X-ray structural analysis reveals that 1 is a 1D linear chain coordination polymer with quadrangle channels which are occupied by the TPT ligands. The compound has been characterized by singe-crystal analyses, thermogravimetry analyses and powder X-ray diffraction measurements. The antitumor activity of compound 1 and its corresponding organic ligands Hcptpy and TPT were then investigated against four human lung cancer cell lines(NCI-H460, Calu-3, A549 and NCI-H292) by MTT assay. It was found that compared with Hcptpy and TPT, compound 1 exerted rather potent activity against all of these cell lines.