Hydrogels,characterised as highly hydrophilic three-dimensional polymer networks,have gained increasing attention due to their unique physicochemical properties,finding applications in various fields.Natural polymer h...Hydrogels,characterised as highly hydrophilic three-dimensional polymer networks,have gained increasing attention due to their unique physicochemical properties,finding applications in various fields.Natural polymer hydrogels exhibit higher biocompatibility and biodegradability compared to traditional synthetic polymer hydrogels.Proteins,being the principal materials of natural polymer hydrogels,bear numerous modifiable functional groups.The resultant hydrogel possesses responsiveness,adjustable degradability,and underway as an excellent biomaterial.Seven common raw materials used to construct protein hydrogels are introduced.In terms of comparing natural polymer hydrogels with traditional synthetic polymer hydrogels,the authors conduct a detailed analysis and comparison,highlighting the advantages of natural polymer hydrogels in terms of biocompatibility and biodegradability,and summarising their characteristics.The authors also address the limitations of various protein hydrogels and list existing strengthening cross-linking strategies,proposing new insights to overcome the application limits of protein hydrogels.Additionally,the applications of protein hydrogels in drug delivery,biosensing,bio-inks and tissue engineering are discussed.The authors conclude by summarising the current challenges faced by protein hydrogels and prospecting its future development.展开更多
基金China Postdoctoral Science Foundation,Grant/Award Number:2023M742897Guangdong Basic and Applied Basic Research Foundation,Grant/Award Number:2021B1515120019+5 种基金Postdoctoral Fellowship Program of CPSF,Grant/Award Number:GZC20232192Fundamental Research Funds for the Central Universities of Beijing University of Chemical Technology,Grant/Award Number:2682023ZTPY056Sichuan Science and Technology Program,Grant/Award Number:2023ZYD0114National Key Research and Development Program of China Stem Cell and Translational Research,Grant/Award Number:2023YFC2411300National Natural Science Foundation of China,Grant/Award Numbers:82072071,82072073New Interdisciplinary Cultivation Fund of SWJTU,Grant/Award Numbers:2682023JX005,2682022KJ041。
文摘Hydrogels,characterised as highly hydrophilic three-dimensional polymer networks,have gained increasing attention due to their unique physicochemical properties,finding applications in various fields.Natural polymer hydrogels exhibit higher biocompatibility and biodegradability compared to traditional synthetic polymer hydrogels.Proteins,being the principal materials of natural polymer hydrogels,bear numerous modifiable functional groups.The resultant hydrogel possesses responsiveness,adjustable degradability,and underway as an excellent biomaterial.Seven common raw materials used to construct protein hydrogels are introduced.In terms of comparing natural polymer hydrogels with traditional synthetic polymer hydrogels,the authors conduct a detailed analysis and comparison,highlighting the advantages of natural polymer hydrogels in terms of biocompatibility and biodegradability,and summarising their characteristics.The authors also address the limitations of various protein hydrogels and list existing strengthening cross-linking strategies,proposing new insights to overcome the application limits of protein hydrogels.Additionally,the applications of protein hydrogels in drug delivery,biosensing,bio-inks and tissue engineering are discussed.The authors conclude by summarising the current challenges faced by protein hydrogels and prospecting its future development.
