Efficient water quality monitoring and ensuring the safety of drinking water by government agencies in areas where the resource is constantly depleted due to anthropogenic or natural factors cannot be overemphasized. ...Efficient water quality monitoring and ensuring the safety of drinking water by government agencies in areas where the resource is constantly depleted due to anthropogenic or natural factors cannot be overemphasized. The above statement holds for West Texas, Midland, and Odessa Precisely. Two machine learning regression algorithms (Random Forest and XGBoost) were employed to develop models for the prediction of total dissolved solids (TDS) and sodium absorption ratio (SAR) for efficient water quality monitoring of two vital aquifers: Edward-Trinity (plateau), and Ogallala aquifers. These two aquifers have contributed immensely to providing water for different uses ranging from domestic, agricultural, industrial, etc. The data was obtained from the Texas Water Development Board (TWDB). The XGBoost and Random Forest models used in this study gave an accurate prediction of observed data (TDS and SAR) for both the Edward-Trinity (plateau) and Ogallala aquifers with the R<sup>2</sup> values consistently greater than 0.83. The Random Forest model gave a better prediction of TDS and SAR concentration with an average R, MAE, RMSE and MSE of 0.977, 0.015, 0.029 and 0.00, respectively. For the XGBoost, an average R, MAE, RMSE, and MSE of 0.953, 0.016, 0.037 and 0.00, respectively, were achieved. The overall performance of the models produced was impressive. From this study, we can clearly understand that Random Forest and XGBoost are appropriate for water quality prediction and monitoring in an area of high hydrocarbon activities like Midland and Odessa and West Texas at large.展开更多
In this paper we present a five-generation kindred with familial eosinophilia, associated with valvular heart disease in one of seven members of the second generation, four of sixteen members of the third generation, ...In this paper we present a five-generation kindred with familial eosinophilia, associated with valvular heart disease in one of seven members of the second generation, four of sixteen members of the third generation, four of thirty-one members of the fourth generation, and two of twenty members of the fifth generation;the clinical features of the two members of the first generation are unavailable. Of a total of 48 members, 26 had eosinophilia, with counts ranging from 1761 to 6045 cells/mm<sup>3</sup>, with apparent autosomal dominant propagation;this confirms the experience of the authors of previous studies on this condition. Genetic analysis on eight members, which we reported in an earlier paper [1], revealed a pericentric inversion of chromosome 10 in two members. The entity of Familial Eosinophilia has been generally considered benign. However, the clinical presentation of this kindred was unusual in that valvular and endocardial damage, was frequent findings, without apparent involvement of the other organs and tissues. Mitral valve damage leading to both stenosis and regurgitation and requiring mitral valve replacement was noted in the index patient. This unique presentation may suggest that in patients with mitral valve disease, if blood eosinophilia is noted, it could point to a non-rheumatic etiology, thus a possible opportunity for treatment to prevent further damage to the heart. This recommendation may be even more timely, as many effective treatments are now available to treat even high-grade hypereosinophilia.展开更多
New results of two computer experiments on modeling of superthermal neutron-nuclear combustion of natural uranium for two different flux densities of external neutron source and duration of half a year each are presen...New results of two computer experiments on modeling of superthermal neutron-nuclear combustion of natural uranium for two different flux densities of external neutron source and duration of half a year each are presented. The simulation results demonstrate the dependence of the autowave combustion modes on the parameters of the external source.展开更多
Mixed-type structures combining the advantages of pile constructions(low material consumption and possibility to erect on weak soils)and gravity walls(high bearing capacity and stability,good reliability and durabilit...Mixed-type structures combining the advantages of pile constructions(low material consumption and possibility to erect on weak soils)and gravity walls(high bearing capacity and stability,good reliability and durability)are considered and improved.The sphere of application,main peculiarities,and practical technological aspects of these structures’implementation are analyzed.展开更多
The polyphenoloxidase（PPO） is the key enzyme considered to be responsible for mushroom browning.By using homology cloning and rapid amplification of cDNA ends（RACE）,two new PPO genes and the corresponding cDNA wer...The polyphenoloxidase（PPO） is the key enzyme considered to be responsible for mushroom browning.By using homology cloning and rapid amplification of cDNA ends（RACE）,two new PPO genes and the corresponding cDNA were identified from the fruit bodies of Agaricus bisporus（AbPPO3 and AbPPO4,GenBank accession nos.GU936494 and GU936493,respectively）.The genomic DNA sequences of AbPPO3 and AbPPO4 are 2 080 and 2 189 bp in length,respectively,encoding putative polypeptides of approximately 66 and 68 kDa.The deduced amino acid sequences show characteristic features of two copper-binding domains conserved in the type III copper proteins including fungal polyphenol oxidases.Sequence comparisons indicate that AbPPO3 and AbPPO4 present 55.3% similarity to each other（48% identity）.We also obtained more than 1.5-kb long sequences upstream of the start codon of the AbPPO3 and AbPPO4 and recognized them as their respective putative promoters.Analyses of the two PPO promoter regions show that they contain abundant cis-acting elements which are probably responsible for anaerobic induction,light,wound,stress,and auxin response.Semi-quantitative RT-PCR results indicate that AbPPO3 and AbPPO4 were highly expressed in the mature fruit bodies and up-regulated after 2-d storage of mushroom.These results suggest that AbPPO3 and AbPPO4 may play roles in A.bisporus browning and pigmentation during development and postharvest storage and the elements in promoters may act as regulatory elements for the inducible expression of AbPPO3 and AbPPO4.The successful cloning and expression analysis of AbPPO3 and AbPPO4 warrant a further investigation on the structure and function of A.bisporus PPO which points to the possible targets for genetic manipulation.展开更多
RNA sequencing is the use of hight hroughput next generation sequencing technology to survey, characterize, and quantify the transcriptome of a genome. RNA sequencing has been used to analyze the pathogenesis of sever...RNA sequencing is the use of hight hroughput next generation sequencing technology to survey, characterize, and quantify the transcriptome of a genome. RNA sequencing has been used to analyze the pathogenesis of several malignancies such melanoma, lung cancer, and colorectal cancer. RNA sequencing can identify differential expression of genes(DEG's), mutated genes, fusion genes, and gene isoforms in disease states. RNA sequencing has been used in the investigation of several colorectal diseases such as colorectal cancer, inflammatory bowel disease(ulcerative colitis and Crohn's disease), and irritable bowel syndrome.展开更多
The authors try to decide a problem of ovarian cancer resistance to platinum drugs by the way of correlation finding between platinum-resistance of tumor and presence of gene mutations in the patient.It was shown a va...The authors try to decide a problem of ovarian cancer resistance to platinum drugs by the way of correlation finding between platinum-resistance of tumor and presence of gene mutations in the patient.It was shown a variety of options for BRCA gene mutations in patients with ovarian cancer:BRCA 1(185delAG)-64.2%,BRCA 1(5382 insC)-55.7%,and BRCA 2(6174delT)-53.8%.Authors discovered a significant positive correlation between carriage of mutations in the BRCA genes 1/2 and the sensitivity of malignant ovarian tumors to chemotherapy with platinum.Mutations in these genes occurred significantly more often in patients with platinum-sensitive ovarian cancer.展开更多
【Objective】To evaluate the roles of 80A→G polymorphism of RFC-1 gene encoding the reduced folate carrier protein and 677C→T polymorphism of 5,10-methylenetetrahydrofolate reductase gene(MTHFR)in neural tube defect...【Objective】To evaluate the roles of 80A→G polymorphism of RFC-1 gene encoding the reduced folate carrier protein and 677C→T polymorphism of 5,10-methylenetetrahydrofolate reductase gene(MTHFR)in neural tube defects(NTD)risk in Ukrainian population.【Methods】The folate status,homocysteine levels and genotypes were assessed in 42 mothers of fetuses with spina bifida,anencephaly and encephalocele with the age of 19-40 years.Serum folate and plasma homocysteine levels were estimated using chemiluminescence technology.DNA was isolated from peripheral leukocytes obtained from blood using standard procedures.The presence of the RFC-1 80A→G polymorphism was investigated using polymerase chain reaction(PCR).Real time PCR was used to detect the presence of the 677C→T mutation in the MTHFR gene.【Results】Genotype frequencies for RFC-1 80A→G in NTD group were:homozygous wild type in 9(21.4%),heterozygous type in16(38.1%)women;17(40.5%)women surveyed were found homozygous for the mutant allele genotype of RFC-1(GG).Homozygous for the indicated mutation was found in 57.1%of women with fetal anencephaly in the past history and 29.6%of women with spina bifida fetuses.Allelic frequency in this group of women for allele A was 40.5%(34),for allele G was 59.5%(50).Among women with 80A/A genotype of RFC-1 gene reduced levels of serum folic acid were noticed only in 6(35.5%),but hyperhomocysteinemia was found in 10(58.8%)women.【Conclusion】80G→A polymorphism of RFC-1 gene is a potential genetic factor in the formation of fetus NTD in women of South Ukraine.展开更多
【Objective】To evaluate the clinical efficiency of different treatments cancellation and infertility in women with PCOS and hyperprolactinemia.【Method】We performed retrospective analysis of 502consecutive case hist...【Objective】To evaluate the clinical efficiency of different treatments cancellation and infertility in women with PCOS and hyperprolactinemia.【Method】We performed retrospective analysis of 502consecutive case histories during 5 years of reproductive results of treatment of women is with anovulatory infertility,caused by different factors.Aim of the study was to determine the efficiency of conservative and surgical treatment.【Result】Differentiated application of conservative medical therapy allows to attain the effect of proceeding in a fertile function in 33,8%of patients.It is found that surgical induction of ovulation by ovarian laparoscopic partial degradation is an option in the management of female infertility associated with PCOS,especially as a second-line treatment after the failure of clomiphene citrate treatment,enhancing the efficiency of complex infertility treatment to 40%.【Conclusions】It is feasible to develop an algorithm differentiated use of infertility treatments in women with PCOS and hyperprolactinemia.展开更多
The plane elastic problem for a semi-strip with a transverse crack is inves- tigated. The initial problem is reduced to a one-dimensional continuous problem by use of an integral transformation method with a generaliz...The plane elastic problem for a semi-strip with a transverse crack is inves- tigated. The initial problem is reduced to a one-dimensional continuous problem by use of an integral transformation method with a generalized scheme. The one-dimensional problem is first formulated as a vector boundary problem, and then reduced to a system of three singular integral equations （SIEs）. The system is solved by use of an orthogonal polynomial method and a special generalized method. The contribution of this work is the consideration of kernel fixed singularities in solving the system. The crack length and its location relative to the semi-strip＇s lateral sides are investigated to simplify the problem＇s statement. This simplification reduces the initial problem to a system of two SIEs.展开更多
Manufacturing is the primary industry promoting economic and social development.For the past 30 years,the global trends of preciseness and device miniaturisation have promoted manufacturing to the micro(μ)and nano(η...Manufacturing is the primary industry promoting economic and social development.For the past 30 years,the global trends of preciseness and device miniaturisation have promoted manufacturing to the micro(μ)and nano(η)scale.Identification of themost promising micro-nano manufacturing technologies(MNMT)is of interest to industry,academia and private and national science investing foundations.Considering the exponential broadening of the research area and an enormous volume of literature,providing an overview of the state of the art is far beyond the scope of a technical review paper.This study performs bibliometric analysis of a stream of academic literature devoted toμ-andη-machining.Themain goals of the analysis are to assess the current core and trends in the field ofMNMT.Literature and citation statistics from 1988 were collected from theWeb of Science,Google Scholar,Scopus,Engineering Village,ScienceDirect and SpringerLink databases and were then analysed and illustrated with Microsoft Excel and VOSviewer software.The top keywords,articles,journals,authors,universities and countrieswere identified according to different parameters.The index of normalised influence was offered to evaluate the top element in each category.We observed that the most powerful keywords were present in well-known articles published in prominent journals by authoritative scientists at leading universities in the countries that are most actively engaged in MNMT.The implications of the research outcomes for investors and academicians are summarised in the conclusion.展开更多
【Objective】 To investigate the possibility of early prophylaxis of preeclampsia by mean of investigation of uteroplacental blood flow(UPB) and feto-placental complex FPC function in pregnant women with suspected dys...【Objective】 To investigate the possibility of early prophylaxis of preeclampsia by mean of investigation of uteroplacental blood flow(UPB) and feto-placental complex FPC function in pregnant women with suspected dysfunction of spiral arteries and clinical signs of preeclampsia.【Method】 90 pregnant women were included in a prospective cohort study in the term of gestation from 9 to 40 weeks.The main clinical group consisted of 70 women,divided into two groups: the first-pregnant with the risk of PE,the others-with the clinical manifestation of PE.Biochemical and radioimmunoassay studies(determination of estradiol and placental lactogen(PL) in the peripheral blood),ultrasound examination with Doppler flow in the arteries of the uterus and the measurement of qualitative characteristics of the analysis of blood flow-resistance index(RI) and pulsatility index(PI),the ratio of systolic pressure for diastolic(ABP) were used.Treatment in the group of risk was directed to the correction of vascular blood flow and intravascular component(antiplatelet agents,antispasmodics,sedatives drugs,vitamins) and was conducted in terms of 9-12 weeks duration during 12-14 days.In the subgroup with PE-similar treatment in terms of 28-30 weeks.【Result】 In pregnant women of the group of risk for PE abnormal spiral artery blood flow parameters(RI,PI,ABP) in the uterine arteries were registered,indicating increased peripheral vascular resistance in the placental pool in early pregnancy,just as marked reduction of the hormonal activity of forming placental complex which testifies early placental insufficiency.Treatment,conducted in early pregnancy could significantly improve,but not normalize blood flow.【Conclusion】 Conduction of a Doppler examination for blood flow of the placenta may provide early diagnose of infusion-perfusion failure of placenta,and the appointment of a pathogenic therapy,that will provide an opportunity to avoid the development of placenta failure and PE in an group of risk.展开更多
The aim of the work was confined to the investigation of the epileptic activity dynamics under conditions of extremely high frequency electromagnetic waves(EHF) radiation(7.1 mm,0.1 mW/cm2) upon focal epileptic activi...The aim of the work was confined to the investigation of the epileptic activity dynamics under conditions of extremely high frequency electromagnetic waves(EHF) radiation(7.1 mm,0.1 mW/cm2) upon focal epileptic activity,which was penicillin-induced(10 000 IU/ml) in frontal zone of the brain cortex in myorelaxed and artificially ventilated rats under acute experimental condition.It was established that preliminarily performed hypogeomagnetic period(3.0 h) with the inductivity of geomagnetic field reduction not less than by 100 times caused the intensification of antiepileptic effects of EHF(15.0 min of exposition).It was pronounced in the form of decrease of foci intensity and significant reduction of life-span of foci-up to 115.3±13.4 minutes,which was both significant when compared with separate effects of hypogeomagnetic influence(187.3±12.5 min) and EHF(15.0 minutes of exposition) effect(164.2±12.5 minutes)(P <0.05).展开更多
Alternating bending shear stresses lead to the formation of twin orientations in the texture of FCC materials with middle and low stacking fault energy (SFE). Only in the stainless steel with a low SFE during alternat...Alternating bending shear stresses lead to the formation of twin orientations in the texture of FCC materials with middle and low stacking fault energy (SFE). Only in the stainless steel with a low SFE during alternating bending with different number of cycles components of shear texture {111};{hkl};{001} were formed. Copper (middle SFE), along with orientations of twinning and cubic texture formed orientation of deformation {135}. During alternating bending of aluminum (high SFE), a dynamic recovery occurred. The share of initial cubic texture increases with the increase of number of cycles of alternating bending and reaches its maximum after three cycles. Share of component of texture Goss increased slightly. The most significant change of the microstructure and texture occurred during the first 3 - 5展开更多
Amyotrophic lateral syndrome(ALS)is a progressive degenerative disorder characterized by motor neuron death and axon degeneration.Mitochondrial dysfunction plays a key role in the pathogenesis of ALS,the mechanism of ...Amyotrophic lateral syndrome(ALS)is a progressive degenerative disorder characterized by motor neuron death and axon degeneration.Mitochondrial dysfunction plays a key role in the pathogenesis of ALS,the mechanism of which remains poorly understood.The B-cell lymphoma-2(Bcl-2)family of proteins that control and mediate mitochondrial function and apoptosis,including the pro-apoptotic members Bcl2-Associated X(Bax),are involved in ALS development.The death receptor 6(DR6)regulates motor neuron death in ALS,and DR6 antibodies can prevent axon degeneration and motor neuron damage by blocking DR6.Previous studies demonstrated that PSAP localized to mitochondria and was required for DR6-induced apoptosis.In this study,SOD1^(G93A) was transfected into the motor neuron cell line NSC-34 to serve as an ALS cell model in vitro.The data assessed the role of PSAP in SOD1^(G93A)induced apoptosis and demonstrated that the overexpression of SOD1^(G93A),but not wtSOD1,induced PARP cleavage,caspase-3 activation,cytochrome c release,and Bax translocation.PSAP,Bax,and Bak were necessary for SOD1^(G93A)induced apoptosis,as silencing PSAP inhibited SOD1^(G93A)-mediated cell death that was dependent on Bax-Bak interaction.展开更多
文摘Efficient water quality monitoring and ensuring the safety of drinking water by government agencies in areas where the resource is constantly depleted due to anthropogenic or natural factors cannot be overemphasized. The above statement holds for West Texas, Midland, and Odessa Precisely. Two machine learning regression algorithms (Random Forest and XGBoost) were employed to develop models for the prediction of total dissolved solids (TDS) and sodium absorption ratio (SAR) for efficient water quality monitoring of two vital aquifers: Edward-Trinity (plateau), and Ogallala aquifers. These two aquifers have contributed immensely to providing water for different uses ranging from domestic, agricultural, industrial, etc. The data was obtained from the Texas Water Development Board (TWDB). The XGBoost and Random Forest models used in this study gave an accurate prediction of observed data (TDS and SAR) for both the Edward-Trinity (plateau) and Ogallala aquifers with the R<sup>2</sup> values consistently greater than 0.83. The Random Forest model gave a better prediction of TDS and SAR concentration with an average R, MAE, RMSE and MSE of 0.977, 0.015, 0.029 and 0.00, respectively. For the XGBoost, an average R, MAE, RMSE, and MSE of 0.953, 0.016, 0.037 and 0.00, respectively, were achieved. The overall performance of the models produced was impressive. From this study, we can clearly understand that Random Forest and XGBoost are appropriate for water quality prediction and monitoring in an area of high hydrocarbon activities like Midland and Odessa and West Texas at large.
文摘In this paper we present a five-generation kindred with familial eosinophilia, associated with valvular heart disease in one of seven members of the second generation, four of sixteen members of the third generation, four of thirty-one members of the fourth generation, and two of twenty members of the fifth generation;the clinical features of the two members of the first generation are unavailable. Of a total of 48 members, 26 had eosinophilia, with counts ranging from 1761 to 6045 cells/mm<sup>3</sup>, with apparent autosomal dominant propagation;this confirms the experience of the authors of previous studies on this condition. Genetic analysis on eight members, which we reported in an earlier paper [1], revealed a pericentric inversion of chromosome 10 in two members. The entity of Familial Eosinophilia has been generally considered benign. However, the clinical presentation of this kindred was unusual in that valvular and endocardial damage, was frequent findings, without apparent involvement of the other organs and tissues. Mitral valve damage leading to both stenosis and regurgitation and requiring mitral valve replacement was noted in the index patient. This unique presentation may suggest that in patients with mitral valve disease, if blood eosinophilia is noted, it could point to a non-rheumatic etiology, thus a possible opportunity for treatment to prevent further damage to the heart. This recommendation may be even more timely, as many effective treatments are now available to treat even high-grade hypereosinophilia.
文摘New results of two computer experiments on modeling of superthermal neutron-nuclear combustion of natural uranium for two different flux densities of external neutron source and duration of half a year each are presented. The simulation results demonstrate the dependence of the autowave combustion modes on the parameters of the external source.
文摘Mixed-type structures combining the advantages of pile constructions(low material consumption and possibility to erect on weak soils)and gravity walls(high bearing capacity and stability,good reliability and durability)are considered and improved.The sphere of application,main peculiarities,and practical technological aspects of these structures’implementation are analyzed.
基金supported by Zhejiang Provincial Natural Science Foundation of China (Y306633 and Y3100579)Zhejiang Provincial Edible Fungi Industrial Innovation Team Project of China
文摘The polyphenoloxidase（PPO） is the key enzyme considered to be responsible for mushroom browning.By using homology cloning and rapid amplification of cDNA ends（RACE）,two new PPO genes and the corresponding cDNA were identified from the fruit bodies of Agaricus bisporus（AbPPO3 and AbPPO4,GenBank accession nos.GU936494 and GU936493,respectively）.The genomic DNA sequences of AbPPO3 and AbPPO4 are 2 080 and 2 189 bp in length,respectively,encoding putative polypeptides of approximately 66 and 68 kDa.The deduced amino acid sequences show characteristic features of two copper-binding domains conserved in the type III copper proteins including fungal polyphenol oxidases.Sequence comparisons indicate that AbPPO3 and AbPPO4 present 55.3% similarity to each other（48% identity）.We also obtained more than 1.5-kb long sequences upstream of the start codon of the AbPPO3 and AbPPO4 and recognized them as their respective putative promoters.Analyses of the two PPO promoter regions show that they contain abundant cis-acting elements which are probably responsible for anaerobic induction,light,wound,stress,and auxin response.Semi-quantitative RT-PCR results indicate that AbPPO3 and AbPPO4 were highly expressed in the mature fruit bodies and up-regulated after 2-d storage of mushroom.These results suggest that AbPPO3 and AbPPO4 may play roles in A.bisporus browning and pigmentation during development and postharvest storage and the elements in promoters may act as regulatory elements for the inducible expression of AbPPO3 and AbPPO4.The successful cloning and expression analysis of AbPPO3 and AbPPO4 warrant a further investigation on the structure and function of A.bisporus PPO which points to the possible targets for genetic manipulation.
文摘RNA sequencing is the use of hight hroughput next generation sequencing technology to survey, characterize, and quantify the transcriptome of a genome. RNA sequencing has been used to analyze the pathogenesis of several malignancies such melanoma, lung cancer, and colorectal cancer. RNA sequencing can identify differential expression of genes(DEG's), mutated genes, fusion genes, and gene isoforms in disease states. RNA sequencing has been used in the investigation of several colorectal diseases such as colorectal cancer, inflammatory bowel disease(ulcerative colitis and Crohn's disease), and irritable bowel syndrome.
文摘The authors try to decide a problem of ovarian cancer resistance to platinum drugs by the way of correlation finding between platinum-resistance of tumor and presence of gene mutations in the patient.It was shown a variety of options for BRCA gene mutations in patients with ovarian cancer:BRCA 1(185delAG)-64.2%,BRCA 1(5382 insC)-55.7%,and BRCA 2(6174delT)-53.8%.Authors discovered a significant positive correlation between carriage of mutations in the BRCA genes 1/2 and the sensitivity of malignant ovarian tumors to chemotherapy with platinum.Mutations in these genes occurred significantly more often in patients with platinum-sensitive ovarian cancer.
文摘【Objective】To evaluate the roles of 80A→G polymorphism of RFC-1 gene encoding the reduced folate carrier protein and 677C→T polymorphism of 5,10-methylenetetrahydrofolate reductase gene(MTHFR)in neural tube defects(NTD)risk in Ukrainian population.【Methods】The folate status,homocysteine levels and genotypes were assessed in 42 mothers of fetuses with spina bifida,anencephaly and encephalocele with the age of 19-40 years.Serum folate and plasma homocysteine levels were estimated using chemiluminescence technology.DNA was isolated from peripheral leukocytes obtained from blood using standard procedures.The presence of the RFC-1 80A→G polymorphism was investigated using polymerase chain reaction(PCR).Real time PCR was used to detect the presence of the 677C→T mutation in the MTHFR gene.【Results】Genotype frequencies for RFC-1 80A→G in NTD group were:homozygous wild type in 9(21.4%),heterozygous type in16(38.1%)women;17(40.5%)women surveyed were found homozygous for the mutant allele genotype of RFC-1(GG).Homozygous for the indicated mutation was found in 57.1%of women with fetal anencephaly in the past history and 29.6%of women with spina bifida fetuses.Allelic frequency in this group of women for allele A was 40.5%(34),for allele G was 59.5%(50).Among women with 80A/A genotype of RFC-1 gene reduced levels of serum folic acid were noticed only in 6(35.5%),but hyperhomocysteinemia was found in 10(58.8%)women.【Conclusion】80G→A polymorphism of RFC-1 gene is a potential genetic factor in the formation of fetus NTD in women of South Ukraine.
文摘【Objective】To evaluate the clinical efficiency of different treatments cancellation and infertility in women with PCOS and hyperprolactinemia.【Method】We performed retrospective analysis of 502consecutive case histories during 5 years of reproductive results of treatment of women is with anovulatory infertility,caused by different factors.Aim of the study was to determine the efficiency of conservative and surgical treatment.【Result】Differentiated application of conservative medical therapy allows to attain the effect of proceeding in a fertile function in 33,8%of patients.It is found that surgical induction of ovulation by ovarian laparoscopic partial degradation is an option in the management of female infertility associated with PCOS,especially as a second-line treatment after the failure of clomiphene citrate treatment,enhancing the efficiency of complex infertility treatment to 40%.【Conclusions】It is feasible to develop an algorithm differentiated use of infertility treatments in women with PCOS and hyperprolactinemia.
文摘The plane elastic problem for a semi-strip with a transverse crack is inves- tigated. The initial problem is reduced to a one-dimensional continuous problem by use of an integral transformation method with a generalized scheme. The one-dimensional problem is first formulated as a vector boundary problem, and then reduced to a system of three singular integral equations （SIEs）. The system is solved by use of an orthogonal polynomial method and a special generalized method. The contribution of this work is the consideration of kernel fixed singularities in solving the system. The crack length and its location relative to the semi-strip＇s lateral sides are investigated to simplify the problem＇s statement. This simplification reduces the initial problem to a system of two SIEs.
基金partially funded by the Science Foundation Ireland (No.15/RP/B3208)
文摘Manufacturing is the primary industry promoting economic and social development.For the past 30 years,the global trends of preciseness and device miniaturisation have promoted manufacturing to the micro(μ)and nano(η)scale.Identification of themost promising micro-nano manufacturing technologies(MNMT)is of interest to industry,academia and private and national science investing foundations.Considering the exponential broadening of the research area and an enormous volume of literature,providing an overview of the state of the art is far beyond the scope of a technical review paper.This study performs bibliometric analysis of a stream of academic literature devoted toμ-andη-machining.Themain goals of the analysis are to assess the current core and trends in the field ofMNMT.Literature and citation statistics from 1988 were collected from theWeb of Science,Google Scholar,Scopus,Engineering Village,ScienceDirect and SpringerLink databases and were then analysed and illustrated with Microsoft Excel and VOSviewer software.The top keywords,articles,journals,authors,universities and countrieswere identified according to different parameters.The index of normalised influence was offered to evaluate the top element in each category.We observed that the most powerful keywords were present in well-known articles published in prominent journals by authoritative scientists at leading universities in the countries that are most actively engaged in MNMT.The implications of the research outcomes for investors and academicians are summarised in the conclusion.
文摘【Objective】 To investigate the possibility of early prophylaxis of preeclampsia by mean of investigation of uteroplacental blood flow(UPB) and feto-placental complex FPC function in pregnant women with suspected dysfunction of spiral arteries and clinical signs of preeclampsia.【Method】 90 pregnant women were included in a prospective cohort study in the term of gestation from 9 to 40 weeks.The main clinical group consisted of 70 women,divided into two groups: the first-pregnant with the risk of PE,the others-with the clinical manifestation of PE.Biochemical and radioimmunoassay studies(determination of estradiol and placental lactogen(PL) in the peripheral blood),ultrasound examination with Doppler flow in the arteries of the uterus and the measurement of qualitative characteristics of the analysis of blood flow-resistance index(RI) and pulsatility index(PI),the ratio of systolic pressure for diastolic(ABP) were used.Treatment in the group of risk was directed to the correction of vascular blood flow and intravascular component(antiplatelet agents,antispasmodics,sedatives drugs,vitamins) and was conducted in terms of 9-12 weeks duration during 12-14 days.In the subgroup with PE-similar treatment in terms of 28-30 weeks.【Result】 In pregnant women of the group of risk for PE abnormal spiral artery blood flow parameters(RI,PI,ABP) in the uterine arteries were registered,indicating increased peripheral vascular resistance in the placental pool in early pregnancy,just as marked reduction of the hormonal activity of forming placental complex which testifies early placental insufficiency.Treatment,conducted in early pregnancy could significantly improve,but not normalize blood flow.【Conclusion】 Conduction of a Doppler examination for blood flow of the placenta may provide early diagnose of infusion-perfusion failure of placenta,and the appointment of a pathogenic therapy,that will provide an opportunity to avoid the development of placenta failure and PE in an group of risk.
文摘The aim of the work was confined to the investigation of the epileptic activity dynamics under conditions of extremely high frequency electromagnetic waves(EHF) radiation(7.1 mm,0.1 mW/cm2) upon focal epileptic activity,which was penicillin-induced(10 000 IU/ml) in frontal zone of the brain cortex in myorelaxed and artificially ventilated rats under acute experimental condition.It was established that preliminarily performed hypogeomagnetic period(3.0 h) with the inductivity of geomagnetic field reduction not less than by 100 times caused the intensification of antiepileptic effects of EHF(15.0 min of exposition).It was pronounced in the form of decrease of foci intensity and significant reduction of life-span of foci-up to 115.3±13.4 minutes,which was both significant when compared with separate effects of hypogeomagnetic influence(187.3±12.5 min) and EHF(15.0 minutes of exposition) effect(164.2±12.5 minutes)(P <0.05).
文摘Alternating bending shear stresses lead to the formation of twin orientations in the texture of FCC materials with middle and low stacking fault energy (SFE). Only in the stainless steel with a low SFE during alternating bending with different number of cycles components of shear texture {111};{hkl};{001} were formed. Copper (middle SFE), along with orientations of twinning and cubic texture formed orientation of deformation {135}. During alternating bending of aluminum (high SFE), a dynamic recovery occurred. The share of initial cubic texture increases with the increase of number of cycles of alternating bending and reaches its maximum after three cycles. Share of component of texture Goss increased slightly. The most significant change of the microstructure and texture occurred during the first 3 - 5
基金supported by grants from the National Natural Science Foundation of China[Grant No.81701076,Linlin Zeng]the Science and Technology Department of Jilin Province[Grant No.20190701037GH,Fuqiang Zhang+2 种基金Grant No.20190701036GH,Linlin Zengand Grant No.20200201386JC,Guodong Li]the Education Department of Jilin Province[Grant No.JJKH20200948KJ,Linlin Zeng]。
文摘Amyotrophic lateral syndrome(ALS)is a progressive degenerative disorder characterized by motor neuron death and axon degeneration.Mitochondrial dysfunction plays a key role in the pathogenesis of ALS,the mechanism of which remains poorly understood.The B-cell lymphoma-2(Bcl-2)family of proteins that control and mediate mitochondrial function and apoptosis,including the pro-apoptotic members Bcl2-Associated X(Bax),are involved in ALS development.The death receptor 6(DR6)regulates motor neuron death in ALS,and DR6 antibodies can prevent axon degeneration and motor neuron damage by blocking DR6.Previous studies demonstrated that PSAP localized to mitochondria and was required for DR6-induced apoptosis.In this study,SOD1^(G93A) was transfected into the motor neuron cell line NSC-34 to serve as an ALS cell model in vitro.The data assessed the role of PSAP in SOD1^(G93A)induced apoptosis and demonstrated that the overexpression of SOD1^(G93A),but not wtSOD1,induced PARP cleavage,caspase-3 activation,cytochrome c release,and Bax translocation.PSAP,Bax,and Bak were necessary for SOD1^(G93A)induced apoptosis,as silencing PSAP inhibited SOD1^(G93A)-mediated cell death that was dependent on Bax-Bak interaction.
