Analysis of periodic pulsating nanofluid flow and heat transfer through a parallel-plate channel in the presence of magnetic field

In this paper,we focus on the two-dimensional pulsating nanofluid flow through a parallel-plate channel in the presence of a magnetic field.The pulsating flow is produced by an applied pressure gradient that fluctuates with a small amplitude.A kind of proper transformation is used so that the governing equations describing the momentum and thermal energy are reduced to a set of non-dimensional equations.The analytical expressions of the pulsating velocity,temperature,and Nusselt number of nanofluids are obtained by the perturbation technique.In the present study,the effects of the Cu-H2O and Al_(2)O_(3)-H2O nanofluids on the flow and heat transfer in pulsating flow are compared and analyzed.The results show that the convective heat transfer effect of Cu-H2O nanofluids is better than that of Al_(2)O_(3)-H2O nanofluids.Also,the effects of the Hartmann number and pulsation amplitude on the velocity,temperature,and Nusselt number are examined and discussed in detail.The present work indicates that increasing the Hartmann number and pulsation amplitude can enhance the heat transfer of the pulsating flow.In addition,selecting an optimal pulsation frequency can maximize the convective heat transfer of the pulsating flow.Therefore,improved understanding of these fundamental mechanisms is conducive to the optimal design of thermal systems.

Harnessing macrophages in thermal and non-thermal ablative therapies for urologic cancers-Potential for immunotherapy

Prostate and bladder cancers are one of the cancers occurring worldwide.In addition to radical surgery,the past decade has also focused on targeted therapy of overexpressed cancer proteins that are lethal and critical for cancer cell survival.However,targeted therapy cannot adapt for changing of cancer molecular characteristics and,ultimately,a clone that bypasses the targeted therapy emerges.This can be overcome by immunotherapy.New studies on ablative therapy of cancers show presence of immunomodulatory effect in these modalities.Tumor ablation prime the immune system for further destruction of persistent primary tumor in addition to destruction of concurrent metastatic disease and also reduce recurrence.Ablative therapies can achieve a state of increased antigenicity.Its combination with a novel macrophage targeted therapy may enhance immune priming,trafficking,and/or effector phases;thereby improving clinical outcomes.Tumor associated macrophages or M2 phenotype are now known to mediate this immunosuppressive pro-tumorigenic effect.Alteration of macrophage differentiation may enhance tumor destruction of ablative therapy.This breakthrough in immunotherapy opens up arenas for further robust clinical trials on combinatorial therapies.In the present review,we aim to elucidate the major aspects of immune stimulatory minimal invasive approaches by combining with macrophage directed pathways.

Parametric Geometric Model and Shape Optimization of Airfoils of a Biomimetic Manta Ray Underwater Vehicle

As a new kind of autonomous underwater vehicle,bionic submersible has many merits such as high efficiency and low costs.In order to obtain such advantages,it is a good way to simulate the shapes of marine animals and apply them to the design of artificial underwater vehicle.In this paper,an optimization system of airfoils is proposed by the improved class-shape-transformation(CST)parameterization method and genetic algorithm(GA).The appearance of a manta-ray-inspired underwater vehicle is rebuilt using the optimal sectional airfoils obtained by the proposed optimization system.Computational simulations are carried out to investigate the hydrodynamic performance of the submersible using the commercial computational fluid dynamics(CFD)code Fluent.The results demonstrate that the maximum thickness of the vehicle increases by 9%,which means the loading capacity is increased.Moreover,the underwater vehicle shows better hydrodynamic performance,and the lift-drag ratio of initial design is increased by more than 10%using the presented optimization system of airfoils.

A simpliied fatigue assessment method for transverse illet welded joints

Under the as-welded condition the fatigue crack initiation period was considered nonexistent and Linear Elastic Fracture Mechanics（LEFM） was used to calculate fatigue strength for a range of weld geometries. Fracture mechanics assessment of welded joints requires accurate solutions for stress intensity factor（SIF）. However, the solutions for the SIF of complex welded joints are dificult to determine due to the complicated correction factors. Three methods for SIF prediction are discussed on illet welded specimens containing continuous or semi-elliptical surface cracks, including the traditional correction method Mk, the approximate correction method Kt, and the suggested additional crack size method（ac＋ae）.The new additional crack parameter ae is used to replace the stress concentration effect of weld proile Mk, which simpliies the calculation process. Experimental results are collected to support fatigue strength assessment of the additional crack size method.

功能至上

时尚的舞台上不再有绝对的权威,任何曾经汹涌的潮流在各领风骚数年之后都逐渐消退,没有哪一种风格可以长久地统领全局,但唯有功能主义贯穿始终。因为无论是何种繁复的设计,终究不能舍弃满足人们功能需求的第一准则。用最简单的线条表现雅致生活,用最简单的设计实现最多的功能,功能主义就是功能至上。设计师们在对生活进行细致观察后。