This study aimed to evaluate the efficacy of an individualized remote exercise program on the improvement of body composition and physical fitness of a heterogeneous group of patients who completed breast cancer treat...This study aimed to evaluate the efficacy of an individualized remote exercise program on the improvement of body composition and physical fitness of a heterogeneous group of patients who completed breast cancer treatment.This prospective study included 107 women aged 18 to 60,shortly after curative treatment for localized breast cancer,at the Erasto Gaertner Cancer Hospital(HEG)in Curitiba,PR,Brazil.Body composition,maximal oxygen consumption,and muscle resistance were evaluated after nine months of intervention while considering adherence to the program,level of physical activity,presence of binge eating disorder,tumor classification,and treatment type.Seventy-eight women(72.8%)adhered to the training program.Adherent participants showed significant changes in body mass([-4.3±3.6]kg;p<0.0001),body mass index([-1.6±1.5]kg·m^(−2);p<0.0001),body fat(−3.4%±3.1%;p<0.0001),maximal oxygen consumption([7.5±2.0]ml·kg^(−1)·min^(−1));p<0.0001),and abdominal resistance([11.2±2.8]reps;p<0.0001).In contrast,these variables did not change significantly in the non-adherent group.Among the adherent participants,those subclassified in the severe binge group showed a more noticeable reduction in body mass,body mass index,and body fat(p<0.05)than those in the non-binge group.Individualized remotely-guided physical exercise programs can improve the body composition and physical fitness of women undergoing post-breast cancer surveillance,regardless of pathological history or treatment.展开更多
Dear Editor,The incidence of rectal cancer has increased in patients younger than 50 years old during the last decade.It is well established that young age at cancer onset is a hallmark of hereditary cancer.The preval...Dear Editor,The incidence of rectal cancer has increased in patients younger than 50 years old during the last decade.It is well established that young age at cancer onset is a hallmark of hereditary cancer.The prevalence of germline variants among early-onset rectal cancer(EORC)patients is largely unexplored.Here,we aimed to determine the spectrum of germline variants and their clinical impact in EORC patients diagnosed at age 40 or younger.We investigated 71 EORC patients(Supplementary Table S1),one of the largest cohorts to date,using a customized panel with 93 genes(Supplementary Table S2).展开更多
文摘This study aimed to evaluate the efficacy of an individualized remote exercise program on the improvement of body composition and physical fitness of a heterogeneous group of patients who completed breast cancer treatment.This prospective study included 107 women aged 18 to 60,shortly after curative treatment for localized breast cancer,at the Erasto Gaertner Cancer Hospital(HEG)in Curitiba,PR,Brazil.Body composition,maximal oxygen consumption,and muscle resistance were evaluated after nine months of intervention while considering adherence to the program,level of physical activity,presence of binge eating disorder,tumor classification,and treatment type.Seventy-eight women(72.8%)adhered to the training program.Adherent participants showed significant changes in body mass([-4.3±3.6]kg;p<0.0001),body mass index([-1.6±1.5]kg·m^(−2);p<0.0001),body fat(−3.4%±3.1%;p<0.0001),maximal oxygen consumption([7.5±2.0]ml·kg^(−1)·min^(−1));p<0.0001),and abdominal resistance([11.2±2.8]reps;p<0.0001).In contrast,these variables did not change significantly in the non-adherent group.Among the adherent participants,those subclassified in the severe binge group showed a more noticeable reduction in body mass,body mass index,and body fat(p<0.05)than those in the non-binge group.Individualized remotely-guided physical exercise programs can improve the body composition and physical fitness of women undergoing post-breast cancer surveillance,regardless of pathological history or treatment.
基金This study was supported by grants from the Region of Southern Denmark Research Fund,Denmark,and the National Institute of Science and Technology in Oncogenomics(INCITO,FAPESP#2008/57887-9 and CNPq#573589/08-9)Brazil.Caroline Moraes Beltrami received a fellowship from the National Council for Scientific and Technological Development(CNPq#371497/2013-2)Luisa Matos do Canto received a fellowship from the Sao Paulo Research Foundation(FAPESP#2014/06323-9 and#2015/25803-4).
文摘Dear Editor,The incidence of rectal cancer has increased in patients younger than 50 years old during the last decade.It is well established that young age at cancer onset is a hallmark of hereditary cancer.The prevalence of germline variants among early-onset rectal cancer(EORC)patients is largely unexplored.Here,we aimed to determine the spectrum of germline variants and their clinical impact in EORC patients diagnosed at age 40 or younger.We investigated 71 EORC patients(Supplementary Table S1),one of the largest cohorts to date,using a customized panel with 93 genes(Supplementary Table S2).
