In May 2022,the world witnessed the re-emergence of the zoonotic disease monkeypox.While this was not the first epidemic of this disease,what differentiated the outbreak was the rapid global spread and increase of cas...In May 2022,the world witnessed the re-emergence of the zoonotic disease monkeypox.While this was not the first epidemic of this disease,what differentiated the outbreak was the rapid global spread and increase of cases,which led the WHO to declare monkeypox a global health emergency.Although the disease spreads mainly through inadequately cooked meat of various rodent species,this virus also shows droplet,respiratory,sexual,and even vertical transmission.Monkeypox further multiplies in lymphoproliferative organs and presents with a classical smallpox-like rash,fever,headache,and muscle aches.Diagnosis is confirmed with a polymerase-chain-reaction test and is managed largely supportively with possible usage of some antivirals and immunoglobulins.Moreover,some pre-exposure and postexposure prophylactic vaccines have been developed.This paper aims to conduct an in-depth review of the historical epidemics,transmission,pathophysiology,clinical presentation,and management of the monkeypox disease.展开更多
The relationship between the severity of dengue infection and allergy is still obscure. We conducted an electronic search across 12 databases for relevant articles reporting allergic symptoms, dengue infection, and de...The relationship between the severity of dengue infection and allergy is still obscure. We conducted an electronic search across 12 databases for relevant articles reporting allergic symptoms, dengue infection, and dengue classification. These studies were categorized according to dengue severity and allergy symptoms, and a meta-analysis was performed by pooling the studies in each category. Among the included 57 articles, pruritus was the most common allergic sign followed by non-specified allergy and asthma(28.6%, 13%, and 6.5%, respectively). Despite the reported significant association of dengue with pruritus and total Ig E level(P \ 0.05), in comparison with non-dengue cases and healthy controls, there was no association between the different severe dengue group with pruritus, skin allergy, food allergy or asthma. However,removing the largest study revealed a significant association between asthma with dengue hemorrhagic fever(DHF) rather than dengue fever(DF). In comparison with DF, DHF was associated with Ig E positivity. Furthermore, specific-Ig E level was higher in secondary DF rather than primary DF. There was a possible association between allergy symptoms and dengue severity progression. Further studies are needed to clarify this association.展开更多
文摘In May 2022,the world witnessed the re-emergence of the zoonotic disease monkeypox.While this was not the first epidemic of this disease,what differentiated the outbreak was the rapid global spread and increase of cases,which led the WHO to declare monkeypox a global health emergency.Although the disease spreads mainly through inadequately cooked meat of various rodent species,this virus also shows droplet,respiratory,sexual,and even vertical transmission.Monkeypox further multiplies in lymphoproliferative organs and presents with a classical smallpox-like rash,fever,headache,and muscle aches.Diagnosis is confirmed with a polymerase-chain-reaction test and is managed largely supportively with possible usage of some antivirals and immunoglobulins.Moreover,some pre-exposure and postexposure prophylactic vaccines have been developed.This paper aims to conduct an in-depth review of the historical epidemics,transmission,pathophysiology,clinical presentation,and management of the monkeypox disease.
文摘The relationship between the severity of dengue infection and allergy is still obscure. We conducted an electronic search across 12 databases for relevant articles reporting allergic symptoms, dengue infection, and dengue classification. These studies were categorized according to dengue severity and allergy symptoms, and a meta-analysis was performed by pooling the studies in each category. Among the included 57 articles, pruritus was the most common allergic sign followed by non-specified allergy and asthma(28.6%, 13%, and 6.5%, respectively). Despite the reported significant association of dengue with pruritus and total Ig E level(P \ 0.05), in comparison with non-dengue cases and healthy controls, there was no association between the different severe dengue group with pruritus, skin allergy, food allergy or asthma. However,removing the largest study revealed a significant association between asthma with dengue hemorrhagic fever(DHF) rather than dengue fever(DF). In comparison with DF, DHF was associated with Ig E positivity. Furthermore, specific-Ig E level was higher in secondary DF rather than primary DF. There was a possible association between allergy symptoms and dengue severity progression. Further studies are needed to clarify this association.
