Although previous RNA sequencing methods have been widely used in orthopedic research and have provided ideas for therapeutic strategies,the specific mechanisms of some orthopedic disorders,including osteoarthritis,lu...Although previous RNA sequencing methods have been widely used in orthopedic research and have provided ideas for therapeutic strategies,the specific mechanisms of some orthopedic disorders,including osteoarthritis,lumbar disc herniation,rheumatoid arthritis,fractures,tendon injuries,spinal cord injury,heterotopic ossification,and osteosarcoma,require further elucidation.The emergence of the single-cell RNA sequencing(sc RNA-seq)technique has introduced a new era of research on these topics,as this method provides information regarding cellular heterogeneity,new cell subtypes,functions of novel subclusters,potential molecular mechanisms,cell-fate transitions,and cell-cell interactions that are involved in the development of orthopedic diseases.Here,we summarize the cell subpopulations,genes,and underlying mechanisms involved in the development of orthopedic diseases identified by sc RNA-seq,improving our understanding of the pathology of these diseases and providing new insights into therapeutic approaches.展开更多
To the Editor:Core decompression(CD),the predominant hip-preserving procedure for pre-collapse osteonecrosis of the femoral head(ONFH),is renowned for its improved short-term outcomes and relatively low postoperative ...To the Editor:Core decompression(CD),the predominant hip-preserving procedure for pre-collapse osteonecrosis of the femoral head(ONFH),is renowned for its improved short-term outcomes and relatively low postoperative complication rates;however,the reported medium-tolong-term survival rates in the literature vary and are a subject of controversy.Consequently,we conducted a large,prospective cohort study to assess the frequency and timing of conversion from CD to total hip arthroplasty(THA)and the factors associated with it.展开更多
文摘Although previous RNA sequencing methods have been widely used in orthopedic research and have provided ideas for therapeutic strategies,the specific mechanisms of some orthopedic disorders,including osteoarthritis,lumbar disc herniation,rheumatoid arthritis,fractures,tendon injuries,spinal cord injury,heterotopic ossification,and osteosarcoma,require further elucidation.The emergence of the single-cell RNA sequencing(sc RNA-seq)technique has introduced a new era of research on these topics,as this method provides information regarding cellular heterogeneity,new cell subtypes,functions of novel subclusters,potential molecular mechanisms,cell-fate transitions,and cell-cell interactions that are involved in the development of orthopedic diseases.Here,we summarize the cell subpopulations,genes,and underlying mechanisms involved in the development of orthopedic diseases identified by sc RNA-seq,improving our understanding of the pathology of these diseases and providing new insights into therapeutic approaches.
基金supported by the Central Guided Local Science and Technology Development Funds Project(Science and Technology Innovation Base Project)(No.236Z7754G)Excellent Talents of Hebei Provincial Department of Finance and Health Commission(No.2023).
文摘To the Editor:Core decompression(CD),the predominant hip-preserving procedure for pre-collapse osteonecrosis of the femoral head(ONFH),is renowned for its improved short-term outcomes and relatively low postoperative complication rates;however,the reported medium-tolong-term survival rates in the literature vary and are a subject of controversy.Consequently,we conducted a large,prospective cohort study to assess the frequency and timing of conversion from CD to total hip arthroplasty(THA)and the factors associated with it.
