The 33rd International Geological Congress, Oslo 2008

The 33rd International Geological Congress is being organised jointly by the Nordic countries and to be held in Oslo, Norway, August 6-14th, 2008. This ＂Geoscience World Congress 2008＂ will run up to 40 parallel science sessions, poster sessions, an extensive exhibition, short-courses, workshops, and business meet- ings; about 50 exciting preand post-Congress excursions are planned. The excursions include all the Nordic countries, as well as Greenland, Svalbard, the Faeroes, Russia and Ukraine. All major geoscientific themes are being covered by the Congress which has been divided into two parts, Sunday lOth August being without Symposia and dedicated to workshops, short courses, business meetings and excursions. Through a series of ＂Themes of the Day＂, seven themes with major societal impact will be covered in plenary sessions with invited lecturers, including a key-note ＂StatoiIHydro lecture＂ given each day during the lunch interval. The venue is set up to offer a compact Congress with easy access to all sessions and other events. An extensive social and cultural programme is also being arranged.

1956—2022年鄱阳湖枯水情势演变及驱动机制分析

鄱阳湖枯水情势变化将极大影响区域水资源、水环境和水生态安全状态。复杂条件下鄱阳湖水文极端事件成因分析与灾害预警是当前亟待突破的难点。本文基于湖区年补水-退水水文过程分析,运用“江湖关系”分期分析等方法,探究了湖区枯水情势演变规律和驱动机制。结果显示:(1)后三峡时期,湖区枯水情势显著加剧,星子站年最低水位平均下降5.7%,低水烈度、低水天数平均增加36.9%、26.6%;(2)单因素分析中,湖区低水天数受长江水流条件的影响大于湖区最低水位、低水烈度;多因素分析中,6个解释因子综合解释了上述3个湖区枯水特征量的演变,相应回归模型的R 2依次为0.83、0.83、0.70;(3)贡献分析表明,近20年的枯水整体加剧趋势主要源于长江水流条件改变的综合影响,以湖区年最低水位减小为例,江湖水位流量关系变异贡献138.0%,三峡水库蓄水期汉口径流减小贡献8.4%,三峡水库补水期汉口径流增加(缓解)贡献-34.2%。本研究将为鄱阳湖的枯水情势驱动机制解耦、干旱预警研究提供参考。

Dose-response associations,physical activity intensity and mortality risk:A narrative review

Physical activity is consistently associated with reduced mortality,decreased risk for non-communicable diseases,and improved mental health in observational studies.Randomized controlled trials and observational Mendelian randomization studies support causal links between physical activity and health outcomes.However,the scarcity of evidence from randomized controlled trials,along with their inherent challenges like exposure contrasts,healthy volunteer biases,loss to follow-up,and limited real-world dose-response data,warrants a comprehensive approach.This review advocates synthesizing insights from diverse study designs to better understand the causal relationship between physical activity,mortality risk,and other health outcomes.Additionally,it summarizes recent research since the publication of current physical activity recommendations.Novel observational studies utilizing device-measured physical activity underscore the importance of every minute of activity and suggest that all intensity levels confer health benefits,with vigorous-intensity potentially requiring lower volumes for substantial benefits.Future guidelines,informed by device-measured physical activity studies,may offer refined age-specific recommendations,emphasize vigorous-intensity physical activity,and include daily step counts as a simple,easily assessable metric using commercial wearables.

支持死后医疗数据捐赠:呼吁对个人健康数据的伦理利用

死后医疗数据捐赠对于科学研究的意义重大。但目前不存在有针对性的准则用于指导捐赠过程。如果死后医疗数据的使用缺乏监管可能会引发多种风险,一是给他人利益造成损害;二是造成数据的不规范使用。因此,应当类比现有捐献制度,允许并鼓励捐献死后医疗数据用于科学研究,并起草专门的捐赠准则。该准则的制定应当建立在遵循五大基本原则的前提下,主张以自愿参与的方式使用个人医疗数据,反对未经书面同意将数据用于以病例档案为基础的医学研究。

人类世人类学的可持续性

早期社会与文化人类学所研究的社会都被默认为我们现在所称的可持续性社会,因为它们被认为能够无限地复制自己,并且只会逐渐地,几乎难以被察觉地发生改变。变化也被认为是由外生因素引起的,如殖民主义。这与当代人类学实践和理论的对比显著:人类世人类学将全球化当作一种事实,认为社会是相互联系的,文化是无界的,对可持续性的威胁主要是从生态破坏和气候变化的角度来概念化的。可持续发展的概念于1987年被提出,之后在联合国可持续发展目标中得到了详细阐述,其与当代人类学的全球视野一致,但以经济增长为前提,并将文化多样性纳入其中。对于这一论述及其相关实践,人类学正在做出重大贡献,它从一个世纪前取得的方法论进步中获益,将民族志置于全球人类世的背景中,用学科工具来批判轻率的普遍主义,与地方世界进行对话并呈现了许多替代性选择。虽然为研究表面不变的乡村社会而设计的方法论对研究全球危机仍具意义,但新人类学必然是跨学科的。

Chronic hepatitis B virus infection in Eastern Ethiopia:Clinical characteristics and determinants of cirrhosis

BACKGROUND Chronic hepatitis B(CHB)virus infection is a major cause of liver-associated morbidity and mortality,particularly in low-income countries.A better understanding of the epidemiological,clinical,and virological characteristics of CHB will guide appropriate treatment strategies and improve the control and management of CHB in Ethiopia.AIM To investigate the characteristics of CHB in Eastern Ethiopia and assess the efficacy and safety of antiviral treatment.METHODS This cohort study included 193 adults who were human immunodeficiency virus-negative with CHB between June 2016 and December 2019.Baseline assessments included chemistry,serologic,and viral markers.χ^(2) tests,Mann-Whitney U tests,and logistic regression analyses were used to identify the determinants of cirrhosis.Tenofovir disoproxil fumarate(TDF)was initiated using treatment criteria from the Ethiopian CHB pilot program.RESULTS A total of 132 patients(68.4%)were men,with a median age of 30 years[interquartile range(IQR):24-38].At enrollment,60(31.1%)patients had cirrhosis,of whom 35(58.3%)had decompensated cirrhosis.Khat use,hepatitis B envelope antigen positivity,and a high viral load were independently associated with cirrhosis.Additionally,66 patients(33.4%)fulfilled the treatment criteria and 59(30.6%)started TDF.Among 29 patients who completed 24 months of treatment,the median aspartate aminotransferase to platelet ratio index declined from 1.54(IQR:0.66-2.91)to 1.10(IQR:0.75-2.53)(P=0.002),and viral suppression was achieved in 80.9%and 100%of patients after 12 months and 24 months of treatment,respectively.Among the treated patients,12(20.3%)died within the first 6 months of treatment,of whom 8 had decompensated cirrhosis.CONCLUSION This study highlights the high prevalence of cirrhosis,initial mortality,and the efficacy of TDF treatment.Scaling up measures to prevent and control CHB infections in Ethiopia is crucial.

Spatiotemporal deformation characteristics of Outang landslide and identification of triggering factors using data mining

Since the impoundment of Three Gorges Reservoir(TGR)in 2003,numerous slopes have experienced noticeable movement or destabilization owing to reservoir level changes and seasonal rainfall.One case is the Outang landslide,a large-scale and active landslide,on the south bank of the Yangtze River.The latest monitoring data and site investigations available are analyzed to establish spatial and temporal landslide deformation characteristics.Data mining technology,including the two-step clustering and Apriori algorithm,is then used to identify the dominant triggers of landslide movement.In the data mining process,the two-step clustering method clusters the candidate triggers and displacement rate into several groups,and the Apriori algorithm generates correlation criteria for the cause-and-effect.The analysis considers multiple locations of the landslide and incorporates two types of time scales:longterm deformation on a monthly basis and short-term deformation on a daily basis.This analysis shows that the deformations of the Outang landslide are driven by both rainfall and reservoir water while its deformation varies spatiotemporally mainly due to the difference in local responses to hydrological factors.The data mining results reveal different dominant triggering factors depending on the monitoring frequency:the monthly and bi-monthly cumulative rainfall control the monthly deformation,and the 10-d cumulative rainfall and the 5-d cumulative drop of water level in the reservoir dominate the daily deformation of the landslide.It is concluded that the spatiotemporal deformation pattern and data mining rules associated with precipitation and reservoir water level have the potential to be broadly implemented for improving landslide prevention and control in the dam reservoirs and other landslideprone areas.

Data-augmented landslide displacement prediction using generative adversarial network

Landslides are destructive natural disasters that cause catastrophic damage and loss of life worldwide.Accurately predicting landslide displacement enables effective early warning and risk management.However,the limited availability of on-site measurement data has been a substantial obstacle in developing data-driven models,such as state-of-the-art machine learning(ML)models.To address these challenges,this study proposes a data augmentation framework that uses generative adversarial networks(GANs),a recent advance in generative artificial intelligence(AI),to improve the accuracy of landslide displacement prediction.The framework provides effective data augmentation to enhance limited datasets.A recurrent GAN model,RGAN-LS,is proposed,specifically designed to generate realistic synthetic multivariate time series that mimics the characteristics of real landslide on-site measurement data.A customized moment-matching loss is incorporated in addition to the adversarial loss in GAN during the training of RGAN-LS to capture the temporal dynamics and correlations in real time series data.Then,the synthetic data generated by RGAN-LS is used to enhance the training of long short-term memory(LSTM)networks and particle swarm optimization-support vector machine(PSO-SVM)models for landslide displacement prediction tasks.Results on two landslides in the Three Gorges Reservoir(TGR)region show a significant improvement in LSTM model prediction performance when trained on augmented data.For instance,in the case of the Baishuihe landslide,the average root mean square error(RMSE)increases by 16.11%,and the mean absolute error(MAE)by 17.59%.More importantly,the model’s responsiveness during mutational stages is enhanced for early warning purposes.However,the results have shown that the static PSO-SVM model only sees marginal gains compared to recurrent models such as LSTM.Further analysis indicates that an optimal synthetic-to-real data ratio(50%on the illustration cases)maximizes the improvements.This also demonstrates the robustness and effectiveness of supplementing training data for dynamic models to obtain better results.By using the powerful generative AI approach,RGAN-LS can generate high-fidelity synthetic landslide data.This is critical for improving the performance of advanced ML models in predicting landslide displacement,particularly when there are limited training data.Additionally,this approach has the potential to expand the use of generative AI in geohazard risk management and other research areas.

Seabed structures and foundations related to deep-sea resource development:A review based on design and research

The deep‐sea ground contains a huge amount of energy and mineral resources,for example,oil,gas,and minerals.Various infrastructures such as floating structures,seabed structures,and foundations have been developed to exploit these resources.The seabed structures and foundations can be mainly classified into three types:subsea production structures,offshore pipelines,and anchors.This study reviewed the development,installation,and operation of these infrastructures,including their structures,design,installation,marine environment loads,and applications.On this basis,the research gaps and further research directions were explored through this literature review.First,different floating structures were briefly analyzed and reviewed to introduce the design requirements of the seabed structures and foundations.Second,the subsea production structures,including subsea manifolds and their foundations,were reviewed and discussed.Third,the basic characteristics and design methods of deep‐sea pipelines,including subsea pipelines and risers,were analyzed and reviewed.Finally,the installation and bearing capacity of deep‐sea subsea anchors and seabed trench influence on the anchor were reviewed.Through the review,it was found that marine environment conditions are the key inputs for any offshore structure design.The fabrication,installation,and operation of infrastructures should carefully consider the marine loads and geological conditions.Different structures have their own mechanical problems.The fatigue and stability of pipelines mainly depend on the soil‐structure interaction.Anchor selection should consider soil types and possible trench formation.These focuses and research gaps can provide a helpful guide on further research,installation,and operation of deep‐sea structures and foundations.

A novel saliva-based miRNA profile to diagnose and predict oral cancer

Oral cancer (OC) is the most common form of head and neck cancer. Despite the high incidence and unfavourable patient outcomes, currently, there are no biomarkers for the early detection of OC. This study aims to discover, develop, and validate a novel saliva-based microRNA signature for early diagnosis and prediction of OC risk in oral potentially malignant disorders (OPMD).The Cancer Genome Atlas (TCGA) miRNA sequencing data and small RNA sequencing data of saliva samples were used to discover differentially expressed miRNAs. Identified miRNAs were validated in saliva samples of OC (n=50), OPMD (n=52), and controls(n=60) using quantitative real-time PCR. Eight differentially expressed miRNAs (miR-7-5p, miR-10b-5p, miR-182-5p, miR-215-5p,miR-431-5p, miR-486-3p, miR-3614-5p, and miR-4707-3p) were identified in the discovery phase and were validated. The efficiency of our eight-miRNA signature to discriminate OC and controls was:area under curve (AUC):0.954, sensitivity:86%, specificity:90%,positive predictive value (PPV):87.8%and negative predictive value (NPV):88.5%whereas between OC and OPMD was:AUC:0.911,sensitivity:90%, specificity:82.7%, PPV:74.2%and NPV:89.6%. We have developed a risk probability score to predict the presence or risk of OC in OPMD patients. We established a salivary miRNA signature that can aid in diagnosing and predicting OC,revolutionising the management of patients with OPMD. Together, our results shed new light on the management of OC by salivary miRNAs to the clinical utility of using miRNAs derived from saliva samples.

Speed and surface steepness affect internal tibial loading during running

Background:Internal tibial loading is influenced by modifiable factors with implications for the risk of stress injury.Runners encounter varied surface steepness(gradients)when running outdoors and may adapt their speed according to the gradient.This study aimed to quantify tibial bending moments and stress at the anterior and posterior peripheries when running at different speeds on surfaces of different gradients.Methods:Twenty recreational runners ran on a treadmill at 3 different speeds(2.5 m/s,3.0 m/s,and 3.5 m/s)and gradients(level:0%;uphill:+5%,+10%,and+15%;downhill:-5%,-10%,and-15%).Force and marker data were collected synchronously throughout.Bending moments were estimated at the distal third centroid of the tibia about the medial-lateral axis by ensuring static equilibrium at each 1%of stance.Stress was derived from bending moments at the anterior and posterior peripheries by modeling the tibia as a hollow ellipse.Two-way repeated-measures analysis of variance were conducted using both functional and discrete statistical analyses.Results:There were significant main effects for running speed and gradient on peak bending moments and peak anterior and posterior stress.Higher running speeds resulted in greater tibial loading.Running uphill at+10%and+15%resulted in greater tibial loading than level running.Running downhill at-10%and-15%resulted in reduced tibial loading compared to level running.There was no difference between+5%or-5%and level running.Conclusion:Running at faster speeds and uphill on gradients≥+10%increased internal tibial loading,whereas slower running and downhill running on gradients≥-10%reduced internal loading.Adapting running speed according to the gradient could be a protective mechanism,providing runners with a strategy to minimize the risk of tibial stress injuries.

挪威水电发展历程综述与思考

挪威水电高度发达,长期的发展过程中积累的丰富水电开发利用技术和先进管理经验对我国的水电开发具有一定的借鉴和参考意义。本文介绍了挪威水电资源情况及开发利用现状,回顾了其水电开发历史进程,总结了持之以恒发展水电、逐步完善法律法规、持续革新技术理念、妥善做好环境保护、广泛公众参与机制、弘扬发展水电文化等先进经验,并结合我国水电的建设和发展提出了相关建议,以期助力我国实现可持续的能源发展道路。

Optimal transcorneal electrical stimulation parameters for preserving photoreceptors in a mouse model of retinitis pigmentosa

Retinitis pigmentosa is a hereditary retinal disease that affects rod and cone photoreceptors,leading to progressive photoreceptor loss.Previous research supports the beneficial effect of electrical stimulation on photoreceptor survival.This study aims to identify the most effective electrical stimulation parameters and functional advantages of transcorneal electrical stimulation(tcES)in mice affected by inherited retinal degeneration.Additionally,the study seeked to analyze the electric field that reaches the retina in both eyes in mice and post-mortem humans.In this study,we recorded waveforms and voltages directed to the retina during transcorneal electrical stimulation in C57BL/6J mice using an intraocular needle probe with rectangular,sine,and ramp waveforms.To investigate the functional effects of electrical stimulation on photoreceptors,we used human retinal explant cultures and rhodopsin knockout(Rho^(-/-))mice,demonstrating progressive photoreceptor degeneration with age.Human retinal explants isolated from the donors’eyes were then subjected to electrical stimulation and cultured for 48 hours to simulate the neurodegenerative environment in vitro.Photoreceptor density was evaluated by rhodopsin immunolabeling.In vivo Rho^(-/-)mice were subjected to two 5-day series of daily transcorneal electrical stimulation using rectangular and ramp waveforms.Retinal function and visual perception of mice were evaluated by electroretinography and optomotor response(OMR),respectively.Immunolabeling was used to assess the morphological and biochemical changes of the photoreceptor and bipolar cells in mouse retinas.Oscilloscope recordings indicated effective delivery of rectangular,sine,and ramp waveforms to the retina by transcorneal electrical stimulation,of which the ramp waveform required the lowest voltage.Evaluation of the total conductive resistance of the post-mortem human compared to the mouse eyes indicated higher cornea-to-retina resistance in human eyes.The temperature recordings during and after electrical stimulation indicated no significant temperature change in vivo and only a subtle temperature increase in vitro(~0.5-1.5°C).Electrical stimulation increased photoreceptor survival in human retinal explant cultures,particularly at the ramp waveform.Transcorneal electrical stimulation(rectangular+ramp)waveforms significantly improved the survival and function of S and M-cones and enhanced visual acuity based on the optomotor response results.Histology and immunolabeling demonstrated increased photoreceptor survival,improved outer nuclear layer thickness,and increased bipolar cell sprouting in Rho^(-/-)mice.These results indicate that transcorneal electrical stimulation effectively delivers the electrical field to the retina,improves photoreceptor survival in both human and mouse retinas,and increases visual function in Rho^(-/-)mice.Combined rectangular and ramp waveform stimulation can promote photoreceptor survival in a minimally invasive fashion.

Leisure-time physical activity and all-cause mortality and cardiovascular disease in adults with type 2 diabetes:Cross-country comparison of cohort studies

Purpose:This study aimed to quantify the dose-response association and the minimal effective dose of leisure-time physical activity(PA)to prevent mortality and cardiovascular disease in adults with type 2 diabetes.Methods:Cross-country comparison of 2 prospective cohort studies including 14,913 and 17,457 population-based adults with type 2 diabetes from the UK and China.Baseline leisure-time PA was self-reported and categorized by metabolic equivalent hours per week(MET-h/week)according to World Health Organization recommendations:none,below recommendation(>0-7.49 MET-h/week);at recommended level(7.5-14.9 MET-h/week);above recommendation(>15 MET-h/week).Mortality and cardiovascular disease data were obtained from national registries.Results:During a median follow-up of 12.4 and 9.7 years,in the UK and China cohorts,repectively,higher levels of leisure-time PA were inversely associated with all-cause(1571 and 2351 events)and cardiovascular mortality(392 and 1060 events),mostly consistent with a linear dose-response relationship.PA below,at,and above recommendations,compared with no activity,yielded all-cause mortality hazard ratios of0.94(95%confidence interval(95%CI):0.79-1.12),0.90(95%CI:0.74-1.10),and 0.85(95%CI:0.70-1.02)in British adults and 0.87(95%CI:0.68-1.10),0.88(95%CI:0.74-1.03),and 0.77(95%CI:0.70-0.85)in Chinese adults.Associations with cardiovascular mortality were more pronounced in British adults(0.80(95%CI:0.58-1.11),0.75(95%CI:0.52-1.09),and 0.69(95%CI:0.48-0.97))but less pronounced in Chinese adults(1.06(95%CI:0.76-1.47),1.01(95%CI:0.80-1.28),and 0.79(95%CI:0.69-0.92)).PA at recommended levels was not associated with lower rates of major adverse cardiovascular events(2345 and 4458 events).Conclusion:Leisure-time PA at the recommended levels was not convincingly associated with lower mortality and had no association with risk of major adverse cardiovascular events in British or Chinese adults with type 2 diabetes.Leisure-time PA above current recommendations may be needed to prevent cardiovascular disease and premature mortality in adults with type 2 diabetes.

Interstitial Doping of SnO_(2) Film with Li for Indium-Free Transparent Conductor

SnO_(2)films exhibit significant potential as cost-effective and high electron mobility substitutes for In_(2)O_(3)films.In this study,Li is incorporated into the interstitial site of the SnO_(2)lattice resulting in an exceptionally low resistivity of 2.028×10^(-3)Ω·cm along with a high carrier concentration of 1.398×10^(20)cm^(-3)and carrier mobility of 22.02 cm^(2)/V·s.

Bayesian partial pooling to reduce uncertainty in overcoring rock stress estimation

The state of in situ stress is a crucial parameter in subsurface engineering,especially for critical projects like nuclear waste repository.As one of the two ISRM suggested methods,the overcoring(OC)method is widely used to estimate the full stress tensors in rocks by independent regression analysis of the data from each OC test.However,such customary independent analysis of individual OC tests,known as no pooling,is liable to yield unreliable test-specific stress estimates due to various uncertainty sources involved in the OC method.To address this problem,a practical and no-cost solution is considered by incorporating into OC data analysis additional information implied within adjacent OC tests,which are usually available in OC measurement campaigns.Hence,this paper presents a Bayesian partial pooling(hierarchical)model for combined analysis of adjacent OC tests.We performed five case studies using OC test data made at a nuclear waste repository research site of Sweden.The results demonstrate that partial pooling of adjacent OC tests indeed allows borrowing of information across adjacent tests,and yields improved stress tensor estimates with reduced uncertainties simultaneously for all individual tests than they are independently analysed as no pooling,particularly for those unreliable no pooling stress estimates.A further model comparison shows that the partial pooling model also gives better predictive performance,and thus confirms that the information borrowed across adjacent OC tests is relevant and effective.

Inflow and outflow permeability tests in a very soft clay under low stresses

In situ inflow and outflow permeability tests with the BAT probe at SarapuíII soft clay test site are presented.A description of the BAT permeability test is provided,discussing its advantages and shortcomings,especially in the case of very soft clays under low stresses.Pore pressures were monitored during probe installation and were found to be slightly lower than piezocone u2 pore pressures,consistent with the position of the filter.The role of filter tip saturation was investigated after the usual saturation procedure provided an unsatisfactory pore pressure response during probe installation.Results show that the vacuum saturation procedure provides adequate response during installation and increases the reliability of the coefficient of permeability determination in early measurements.Both inflow and outflow tests yielded similar results,indicating that careful execution of the test can lead to good test repeatability regardless of the loading condition.Various sequences of alternated inflow and outflow tests have yielded similar results,indicating that soil reconsolidation and filter clogging were negligible in the tests performed.Data are presented concerning the relationship between index parameters and the in situ coefficient of permeability for SarapuíII clay,which plot outside the range of existing databases.

The big data challenge-and how polypharmacology supports the translation from pre-clinical research into clinical use against neurodegenerative diseases and beyond

Introductory comments:The identification and validation of disease-modifying proteins are fundamental aspects in drug development.However,the m ultifactority of n eurodegen era tive diseases poses a real challenge for targeted therapies.Furthermore,the behavior of individually(over-)expressed to rget proteins in vitro is likely to differ from their actual functional behavior when embedded in cascades and pathways in vivo.

From London buses to activity trackers:A reflection of 70 years of physical activity research

In 1953,Morris et al.^(1)published their ground-breaking findings among London bus drivers and conductors,linking physical activity to a major chronic disease for the first time.This seminal paper marked the birth of a new field—physical activity epidemiology.^(1)Since then,the field has flourished,evidenced by mounting scientific publications.^(2)Our knowledge about the role of physical activity in disease prevention has expanded from coronary heart disease in Morris et al.’s^(1)initial study to dozens of additional diseases and conditions,such as diabetes,cancers,and dementia.^(3)More than 7 decades and thousands of publications later,we critically reflect on several aspects of the progress in physical activity epidemiology.

海上风电大直径单桩基础循环重固结效应离心机试验研究

我国东南沿海台风频发,海上风机在其服役期内往往经历多次循环重固结阶段。然而当前绝大多数研究仅局限于未经历重固结的单桩循环响应,鲜有研究考虑循环重固结效应对后续单桩响应的影响。为此,针对软黏土中两种桩径的大直径单桩基础开展了一系列不同幅值下的循环重固结离心机试验,旨在揭示并量化循环重固结效应对大直径单桩循环累积位移、桩头刚度等关键设计指标的影响。试验结果表明:同等循环荷载幅值下,经历2轮循环重固结后,单桩基础桩头刚度相比初始刚度最大提高了1.5倍,这使得单桩累积位移显著减小,最大减幅达63%。因此,若设计过程中不考虑循环重固结效应对单桩后续循环响应的影响,而直接将每场极端台风下单桩的累积位移进行累加,则会严重高估桩头累积位移,使单桩基础设计偏于保守。