Integrated adsorption and photocatalytic removal of methylene blue dye from aqueous solution by hierarchical Nb_(2)O_(5)@PAN/PVDF/ANO composite nanofibers

This work presents the development of hierarchical niobium pentoxide(Nb_(2)O_(5))-based composite nanofiber membranes for integrated adsorption and photocatalytic degradation of methylene blue(MB)pollutants from aqueous solutions.The Nb_(2)O_(5) nanorods were vertically grown using a hydrothermal process on a base electrospun nanofibrous membrane made of polyacrylonitrile/polyvinylidene fluoride/ammonium niobate(V)oxalate hydrate(Nb_(2)O_(5)@PAN/PVDF/ANO).They were characterized using field-emission scanning electron microscopy(FE-SEM),X-ray diffraction(XRD)analysis,and Fourier transform infrared(FTIR)spectroscopy.These composite nanofibers possessed a narrow optical bandgap energy of 3.31 eV and demonstrated an MB degradation efficiency of 96%after 480 min contact time.The pseudo-first-order kinetic study was also conducted,in which Nb_(2)O_(5)@PAN/PVDF/ANO nanofibers have kinetic constant values of 1.29×10^(-2) min^(-1) and 0.30×10^(-2) min^(-1) for adsorption and photocatalytic degradation of MB aqueous solutions,respectively.These values are 17.7 and 7.8 times greater than those of PAN/PVDF/ANO nanofibers without Nb_(2)O_(5) nanostructures.Besides their outstanding photocatalytic performance,the developed membrane materials exhibit advantageous characteristics in recycling,which subsequently widen their practical use in environmental remediation applications.

Metaheuristic Optimization Algorithm for Signals Classification of Electroencephalography Channels

Digital signal processing of electroencephalography(EEG)data is now widely utilized in various applications,including motor imagery classification,seizure detection and prediction,emotion classification,mental task classification,drug impact identification and sleep state classification.With the increasing number of recorded EEG channels,it has become clear that effective channel selection algorithms are required for various applications.Guided Whale Optimization Method(Guided WOA),a suggested feature selection algorithm based on Stochastic Fractal Search(SFS)technique,evaluates the chosen subset of channels.This may be used to select the optimum EEG channels for use in Brain-Computer Interfaces(BCIs),the method for identifying essential and irrelevant characteristics in a dataset,and the complexity to be eliminated.This enables(SFS-Guided WOA)algorithm to choose the most appropriate EEG channels while assisting machine learning classification in its tasks and training the classifier with the dataset.The(SFSGuided WOA)algorithm is superior in performance metrics,and statistical tests such as ANOVA and Wilcoxon rank-sum are used to demonstrate this.

Apoptotic and cytostatic actions of maslinic acid in colorectal cancer cells through possible IKK-β inhibition

Objective:To explore the anti-cancer activity of maslinic acid against colorectal cancer(CRC)cell lines and its possible mechanism.Methods:The inhibitory effect of maslinic acid was screened against five CRC cell lines(HT-29,HCT 116,SW480,SW48,and LS 174 T)via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.Apoptosis and cell cycle analyses were carried out using annexinⅤ-FITC/propidium iodide staining and propidium iodide staining,respectively and subjected to fluorescence-activated cell sorting analysis.Protein expression studies of inhibitor ofκB kinase-β(IKK-β),checkpoint kinase 1(Chk1)and cyclin D1 were conducted using the JESS system.Results:Maslinic acid exhibited growth inhibitory effect in a doseand time-dependent manner in HT-29 and HCT 116 cell lines.A more prominent apoptosis induced by maslinic acid was observed in HCT 116 cell line.However,in HT-29 cell line,maslinic acid induced cell cycle arrest by inhibiting the G1-S transition,which was accompanied by the downregulation of cyclin D1.The expression of unphosphorylated IKK-βprotein was increased in both(HT-29 and HCT 116)cell lines after maslinic acid treatment.Conclusions:Maslinic acid inhibits the growth of HT-29 and HCT 116 cells in a different manner,induces cell cycle arrest in HT-29 cells and causes apoptosis in HCT 116 cells partially via NF-κB pathway inhibition.

Apoptosis,antimicrobial and antioxidant activities of phytochemicals from Garcinia malaccensis Hk.f

Objective:To study the chemical constituents of stembark of Garcinia malaccenm（G.malaccenm） together with apoptotic.antimicrobial and antioxidant activities.Methods:Purification and structure elucidation were carried out by chromatographic and spectroscopic techniques, respectively.MTT and trypan blue exclusion methods were performed to study the cytotoxic activity.Antibacterial activity was conducted by dise diffusion and microdilulion methods, whereas antioxidant activities were done by ferric thiocyanate method and DPPH radical scavenging.Results:The phylochemical study led lo the isolation ofα,β-mangostin and cycloarl-24-en-3β-ol.α-Mangostin exhibited cytotoxic activity against HSC-3 cells with an IC50 of 0.33μM.β- andα-mangostin showed activity against K562 cells with IC50 of 0.40μM and 0.48μM,respectively,α-Mangostin was active against Gram-positive bacteria, Staphylococcus aureus（S.aureus） and Bacilus anthracis（B.anthmcis） with inhibition zone and MIC value of（19 mm;0.02S mg/mL） and（20 mm;0.013 mg/mL）,respectively.In antioxidant assay,α-mangostin exhibited activity as an inhibitor of lipid peroxidation.Conclusions:G.malaccenm presenceα- andβ-mangostin and cycloart-24-en-3β-ol.β-Mangostin was found very active against H.SC-3 cells and KS62.The results suggest that mangoslins derivatives have the potential to inhibit the growth of cancer cells by inducing apoptosis.In addition,α-andβ-mangostin was found inhibit the growth of Cram-positive pathogenic bacteria and also showed the activity as an inhibitor of lipid peroxidation.

Environmental Friendly Lightweight Material from Natural Fibers of Oil Palm Empty Fruit Bunch

Indonesia is the most producer of crude palm oil (CPO) worldwide with production more that 25 million tons in 2013. Through increasing production of CPO the wastes generated are growing up as well. The empty fruit bunch of oil palm (EFB) is one of the solid waste (biomass) which is generated at the palm oil mill. Its amount is equivalent to the CPO production, but only about 50% of its weight are good fibers for further usage as industrial raw material. The EFB fiber consists an interesting honey comb/lightweight structure. By mixing the EFB natural fiber with bio binding agent based on potato the environmental friendly materials (biocomposites) can be produced which are 100% biodegadrable. The biocomposites with 2 mm thickness have strengthness about 7 GPa according to the 3 points bending test standard of DIN 53 457. After coating process the environmental friendly lightweight materials with density less than 0.4 g/cm3 will be ready to be implemented for different technical applications.

A Position-Aware Transformer for Image Captioning

Image captioning aims to generate a corresponding description of an image.In recent years,neural encoder-decodermodels have been the dominant approaches,in which the Convolutional Neural Network(CNN)and Long Short TermMemory(LSTM)are used to translate an image into a natural language description.Among these approaches,the visual attention mechanisms are widely used to enable deeper image understanding through fine-grained analysis and even multiple steps of reasoning.However,most conventional visual attention mechanisms are based on high-level image features,ignoring the effects of other image features,and giving insufficient consideration to the relative positions between image features.In this work,we propose a Position-Aware Transformer model with image-feature attention and position-aware attention mechanisms for the above problems.The image-feature attention firstly extracts multi-level features by using Feature Pyramid Network(FPN),then utilizes the scaled-dot-product to fuse these features,which enables our model to detect objects of different scales in the image more effectivelywithout increasing parameters.In the position-aware attentionmechanism,the relative positions between image features are obtained at first,afterwards the relative positions are incorporated into the original image features to generate captions more accurately.Experiments are carried out on the MSCOCO dataset and our approach achieves competitive BLEU-4,METEOR,ROUGE-L,CIDEr scores compared with some state-of-the-art approaches,demonstrating the effectiveness of our approach.

金钗石斛对MPTP诱导PD小鼠的神经保护作用及机制研究

目的探究金钗石斛提取物(Dendrobium nobile Lindl,DNL)在1-甲基v-4-苯基-1,2,3,6-四氢吡啶(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,MPTP)诱导的小鼠帕金森病(Parkinson’s disease,PD)模型中的神经保护作用。方法将小鼠随机分为对照组、模型组,美多芭组(阳性药组)、DNL(100、200、300 mg/kg)组,通过腹腔注射(i.p)MPTP(30 mg/(kg·d),7 d)建立亚急性小鼠PD模型,进行步态分析实验、爬杆实验、悬挂实验等评估DNL对PD小鼠运动异常的影响;酶联免疫吸附测定法(ELISA)检测各组小鼠纹状体区和皮层区肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-6(interleukin-6,IL-6)和白细胞介素-1β(interleukin-1β,IL-1β)表达的变化;蛋白质印迹法(Western blot)检测各组小鼠纹状体caspase-3和caspase-9的表达情况。结果模型组与对照组相比,推进指数、支撑时相的步态指标有显著变化(P<0.05);与模型组相比,美多芭组、DNL(100、200、300 mg/kg)组在左后、右前、右后推进指数,左后、右前、右后支撑时相均有明显改善(P<0.05);与对照组相比,模型组在爬杆上半段和总时间增加(P<0.01、P<0.001),调头时间和下半段时间无明显变化(P>0.05);与模型组相比,DNL(300 mg/kg)组可以改善上半段时间(P<0.05),美多芭和DNL(100、200 mg/kg)组无明显改善(P>0.05);与对照组相比,模型组的悬挂评分降低(P<0.05),与模型组相比,DNL(300 mg/kg)可以增加悬挂评分(P<0.05),美多芭和DNL(100、200 mg/kg)无明显改善(P>0.05);与对照组相比,模型组小鼠纹状体中TNF-α、IL-1β、IL-6含量增加(P<0.05),caspase-3和caspase-9蛋白表达水平显著增高(P<0.001);与模型组相比,美多芭、DNL(300 mg/kg)组炎症因子指标均降低(P<0.05),皮层中各组含量无差异(P>0.05);caspase-3和caspase-9蛋白表达水平均降低(P<0.05)。结论DNL能够改善MPTP诱导的PD小鼠行为变化,减轻脑组织中的炎症反应,抑制神经细胞凋亡,在治疗PD药物及功能食品研发方面具有较好的潜力。

Apoptosis commitment- translating survival signals into decisions on mitochondria

最有缺点、讨厌的房间由 apoptosis 死，为没有损坏包围织物，移开如此的房间的一个精致地控制的基因计划。一旦一个房间承诺了 apoptosis，这个过程是显著地有效的，并且在开始的一些分钟以内被完成。为一个 apoptotic 房间的没有回来的这个点通常被坚持是外部 mitochondrial 膜是 permeabilised 的在点，一个过程由蛋白质的 Bcl-2 家庭调整了。这些蛋白质怎么调整这个决定点，对象 apoptotic 控制被失去的癌症那样的疾病中央。在这评论，我们将讨论 apoptotic 发信号并且一个房间怎么做不可逆的决定死。我们将集中于幸存信号，对细胞外的矩阵(ECM ) 的房间粘附导出的那些，和使用的一个集合这些加亮 apoptotic 发信号的复杂性。特别地，我们将说明多重发信号小径怎么收敛决定批评房间命运决定。

PillCam COLON 2~ in Crohn's disease:A new concept of pan-enteric mucosal healing assessment

AIM: To evaluate mucosal healing in patients with small bowel plus colonic Crohn's disease(CD) with a single non-invasive examination, by using PillCam COLON 2.(PCC2).METHODS: Patients with non-stricturing nonpenetrating small bowel plus colonic CD in sustained corticosteroid-free remission were included. At diagnosis,patients had undergone ileocolonoscopy to identify active CD lesions, such as ulcers and erosions, and small bowel capsule endoscopy to assess the Lewis Score(LS). After ≥ 1 year of follow-up, patients underwent entire gastrointestinal tract evaluation with PCC2. The primary endpoint was assessment of CD mucosal healing, defined as no active colonic CD lesions and LS < 135.RESULTS: Twelve patients were included(7 male;mean age: 32 years), and mean follow-up was 38 mo.The majority of patients(83.3%) received immunosuppressive therapy. Three patients(25%) achieved mucosal healing in both the small bowel and the colon,while disease activity was limited to either the small bowel or the colon in 5 patients(42%). It was possible to observe the entire gastrointestinal tract in 10 of the12 patients(83%) who underwent PCC2.CONCLUSION: Only three patients in sustainedcorticosteroid-free clinical remission achieved mucosal healing in both the small bowel and the colon, highlighting the limitations of clinical assessment when stratifying disease activity, and the need for pan-enteric endoscopy to guide therapeutic modification.

DYNAMICAL BEHAVIOR OF AN INNOVATION DIFFUSION MODEL WITH INTRA-SPECIFIC COMPETITION BETWEEN COMPETING ADOPTERS

In this paper,we proposed an innovation diffusion model with three compartments to investigate the diffusion of an innovation(product)in a particular region.The model exhibits two equilibria,namely,the adopter-free and an interior equilibrium.The existence and local stability of the adopter-free and interior equilibria are explored in terms of the effective Basic Influence Number(BIN)R_(A).It is investigated that the adopter free steady-state is stable if R_(A)<1.By consideringτ(the adoption experience of the adopters)as the bifurcation parameter,we have been able to obtain the critical value ofτresponsible for the periodic solutions due to Hopf bifurcation.The direction and stability analysis of bifurcating periodic solutions has been performed by using the arguments of normal form theory and the center manifold theorem.Exhaustive numerical simulations in the support of analytical results have been presented.

Caving performance through the integration of microseismic activity and numerical modeling at DOZ-PT Freeport,Indonesia

This article describes an undergoing research at PT Freeport, Indonesia, in which the main goal is to use the microseismic information recorded as a result of mining to analyze cave propagation and stress performance on the actual production and fixed infrastructure. At the moment, several numerical experiments have been conducted to correlate the mining activity with the microseismic events using the data collected during year 2005 and 2006. As a result of the preliminary analysis a micro- and a macrocracking envelop were proposed on the basis of computation of stress behavior at the location of the events. Stresses have been computed using standard elastic continuous boundary element models. The correlation between the average source radius and the stress performance has provided a method to propose a macrocracking criterion. Several techniques have been tested to nucleate the microseismic activity around different geological features. This last attempt was aimed to look at potential overstresses induced over the undercut and extraction level drifts. A method was devised to integrate the microseismicity into a 3-dimensional ride distribution model. This model has shown to be very effective to quantify the overstress induced as a result of computing volumetric microseismicity density. The volumetric microseismic model showed to induce overstress up to 10 MPa over a period of two months. The future work will concentrate on the calibration of the integrated model with actual damage observations made at the current mining infrastructure.

Increased susceptibility to Trichuris muris infection and exacerbation of colitis in Mdr1a-/-mice

AIM:To investigate the influence of Trichuris muris(T.muris)infection in a mouse model of genetic susceptibility to inflammatory bowel disease,Mdr1a-/-.METHODS:Mdr1a-/-mice were housed under specific pathogen free conditions to slow the development of colitis and compared to congenic FVB controls.Mice were infected with approximately 200 embryonated ova from T.muris and assessed for worm burden and histological and functional markers of gut inflammation on day 19 post infection.RESULTS:Mdr1a-/-mice exhibited a marked increase in susceptibility to T.muris infection with a 10-fold increase in colonic worm count by day 19 pi compared to FVB controls.Prior to infection,Mdr1a-/-exhibitedlow-level mucosal inflammation with evidence of an enhanced Th1 environment.T.muris infection accelerated the progression of colitis in Mdr1a-/-as evidenced by marked increases in several indicators including histological damage score,mucosal CD4+T-cell and DC infiltration and dramatically increased production of proinflammatory cytokines.CONCLUSION:These data provide further evidence of the complex interaction between T.muris and an inflammatory bowel disease(IBD)-susceptible host which may have relevance to the application of helminth therapy in the treatment of human IBD.

Modelling of Photovoltaic Modules Optical Losses Due to Saharan Dust Deposition in Dakar, Senegal, West Africa

This study aims to evaluate the optical losses of photovoltaic modules due to Saharan dust deposition in Dakar, Senegal, West Africa. For this purpose, an air-dust-glass system is modeled to simulate optical losses in transmittance and reflectance. To do this, we have collected dust samples from Photo-Voltaic (PV) surface in Dakar area (14°42'N latitude, 17°28'W longitude), Senegal. X-ray fluorescence reveals that silicon (Si), iron (Fe), calcium (Ca) and potassium (K) mainly composed these dust samples. Then, dust refractive indices obtained from an ellipsometer were used as an input to be used in the model. Simulations show that for radiation (at normal incidence) arriving on a dust layer of 30 μm-thick (corresponding to a dust deposit of 1.63 g/m2), 79% of the visible spectrum is transmitted; 19% is reflected and 2% is absorbed. Overall, the transmittance decreases by more than 50% as of dust layer of 70 μm-thick corresponding to a dust deposit of 3.3 g/m2.

Efficacy of Chinese herbal compound GAPT for the treatment of Alzheimer’s disease during mouse/rat studies:A systematic review and meta-analysis

Objective:To evaluate the efficacy of the Chinese herbal compound GAPT for the treatment of Alzheimer’s disease(AD)and to provide current evidence for potential treatment mechanisms.Methods:A comprehensive search of PubMed,Embase,Web of Science,SinoMed,China Network Knowledge Infrastructure,Wanfang Data,and Chinese Scientific Journals Database was performed to identify GAPT mouse/rat studies published from inception to July 2019.The outcomes extracted were Morris water maze results and molecular biological quantifications.Results:A total of 19 studies were included in this analysis.The analysis indicated that GAPT was able to significantly improve learning and memory abilities compared with model mice/rats,as assessed by Morris water maze,and showed similar efficacy as donepezil.Subgroup analyses showed that low,medium,and high doses resulted in no obvious dose-dependent effects.Additionally,the GAPT group had significantly reduced expression levels of amyloid-beta peptide,presenilin 1,phosphorylated tau,acetylcholinesterase,and glycogen synthase kinase-3b,but increased expression levels of Shank1,and protein phosphatase-2A,and improved synapses structures compared with the model group,and subgroup analyses showed the medium dose of GAPT was superior to the low and high doses.Conclusions:Based on the pooled analysis,GAPT improved the learning and memory abilities and regulated the expression levels of related proteins during the progression of AD in mouse/rat studies.Notably,the medium dose of GAPT exhibited better performance than the other two doses,providing experimental evidence for further applications of GAPT during clinical practice.

Comparative efficacy and optimal duration of first-line antibiotic regimens for acute otitis media in children and adolescents:a systematic review and network meta-analysis of 89 randomized clinicaltrials

Introduction Antibiotic use for acute otitis media(AOM)is one of the major sources of antimicrobial resistance.However,the effective minimal antibiotic duration for AOM remains unclear.Moreover,guidelines often recommend broad ranges(5-10 days)of antibiotic use,yet the clinical impact of such a wide window has not been assessed.Methods We systematically searched PubMed/MEDLINE,Embase,Scopus,Web of Science,and Cochrane Library from database inception to 6 October 2021.Network meta-analysis was conducted on randomized controlled trials that assessed antibiotic treatment for AOM in children(PROSPERO CRD42020196107).Results For amoxicillin and amoxicillin-clavulanate,7-day regimens were noninferior to 10-day regimens in clinical responses[amoxicillin:risk ratio(RR)0.919(95%CI 0.820-1.031),amoxicillin-clavulanate:RR 1.108(0.957-1.282)],except for≤2 years.For the third-generation cephalosporins,7-day and 10-day regimens had similar clinical responses compared to placebo[7-day:RR 1.420(1.190-1.694),10-day:RR 1.238(1.125-1.362)compared to placebo].However,5-day regimens of amoxicillin-clavulanate and third-generation cephalosporins were inferior to 10-day regimens.Compared to amoxicillin,a shorter treatment duration was tolerable with amoxicillin-clavulanate.Conclusions Our findings indicated that 1O days of antibiotic use may be unnecessarily long,while the treatment duration should be longer than 5 days.Otherwise,5-day regimens would be sufficient for a modest treatment goal.Our findings revealed that the current wide range of recommended antibiotic durations may have influenced the clinical outcome of AOM,and a narrower antibiotic duration window should be re-established.

考虑制造误差和油膜作用力的齿轮敲击动力学分析

为准确评估变速器空套齿轮受角加速度激励的敲击表现,采用集中参数法建立了模拟变速器敲击台架试验的10自由度扭转动力学模型;在包含时变啮合刚度、间隙非线性和拖曳力矩的基础上,进一步考虑齿轮制造误差和润滑油膜作用力。敲击台架试验结果表明包含楔入和挤压效应的润滑油膜作用力模型能正确反映变速器的敲击响应;数值分析结果表明润滑油膜可以减少制造误差位移激励和时变啮合刚度参数激励产生的齿面敲击,敲击强度随制造误差幅值的增加呈凹函数变化,当制造误差的幅值增加到某一数值时,齿轮副在无角加速度激励时亦产生敲击现象。润滑油温度对敲击的影响与角加速度激励有关:无角加速度激励时,低温时较低幅值的齿轮低频圆周误差通过改变油膜作用力方向产生敲击;油膜作用力产生的敲击响应频率比齿面接触的敲击响应频率更低;当存在角加速度激励时,敲击强度随温度的升高呈凸函数增加。

足下垂刺激器联合牵伸训练对脑卒中后足下垂患者足底压力、步态特征变化的影响

目的探讨足下垂刺激器联合牵伸训练对脑卒中后足下垂患者足底压力、步态特征变化的影响。方法选择2021年11月至2022年6月中国康复研究中心北京博爱医院接收的105例脑卒中后足下垂患者,在组间主要基线特征可比的基础上,采用随机数字表法分为对照组(n=52)与观察组(n=53)。对照组实施牵伸训练干预,观察组实施足下垂刺激器联合牵伸训练干预。比较两组患者干预前后足底压力、步态特征、胫骨前肌与腓肠肌表面肌电信号变化、平衡功能,统计两组患者干预期间跌倒发生率。结果两组患者干预后脚趾区、第一、第二跖骨区、足后跟区足底压力均较干预前升高,且观察组高于对照组,两组第三至第五跖骨区、足底中部区较干预前降低,且观察组低于对照组,组间差异均有统计学意义(P<0.05)。两组患者干预后步速、步频、步幅均较干预前提高,且观察组高于对照组,两组步行周期参数较干预前降低,且观察组低于对照组,组间差异均有统计学意义(P<0.05)。两组患者的干预后胫骨前肌与腓肠肌表面肌电信号值均较干预前提高,且观察组高于对照组,组间差异均有统计学意义(P<0.05)。两组患者干预后Berg平衡量表评分均较干预前升高,且观察组高于对照组,组间差异均有统计学意义(P<0.05)。两组干预期间跌倒发生率比较,差异无统计学意义(P>0.05)。结论脑卒中后足下垂患者应用足下垂刺激器联合牵伸训练,可改善足底压力和平衡功能,纠正步态特征,增强肌群活动能力,降低跌倒风险。

将具有低粉尘高堆积密度性能的颗粒状型月桂酸硫酸钠(SLS)用于牙膏发泡剂用途的新方案

月桂酸硫酸钠(Sodium Lauryl Sulfate,通称SLS)是阴离子型表面活性剂,作为发泡剂被广泛用于牙膏产品。过去常用的粉末型SLS在作业过程中容易产生粉尘,本研究的颗粒状型SLS因其粒径特点,能够很好地控制产生粉尘的程度(单位空间的粉尘量降低到大约1/37以下)。颗粒状型与粉末型相比还有很多其他特点。例如,堆积密度较高,可实现高效保管和运输,选择合适条件后易溶于水等。

深圳朗峻广场项目复杂高层结构设计

朗峻广场项目是多个整体建筑体块错落叠合而成的复杂建筑,其造型独特,具有45m跨度刚性连接连体、斜撑转换、竖向构件收进和大悬挑等特征,结构采用框架-多筒体剪力墙体系。阐述了刚性连体构成、转换结构的设计选型与思路,重点介绍了筒体剪力墙墙肢的关键设计要点。此外,根据项目特点确定结构的性能目标,提出了小震设计参数结果的合理提取方法和中震的设计原则,复核结构在大震下的抗震性能并根据结果采取适宜的抗震措施。结果表明本工程结构具有较好的抗震性能,采用的设计方法可行。

高大空间自承重砌体墙稳定性计算方法

以弹性力学薄板屈曲理论为基础,采用能量法并选取满足边界条件的挠曲试函数,借助Python软件自编计算程序,推导了对边简支对边自由板、三边简支一边自由板及四边简支板在轴向均布荷载作用下的屈曲临界承载力计算公式,采用有限元模型分析对结果进行验证,并给出屈曲特征系数ξ与高宽比r的简化关系式。基于面外抗弯刚度和面内轴向刚度相等原则,将带构造柱和圈梁的砌体墙由非均匀各向异性材料等效成各向同性材料,并验证等效模型用于墙体屈曲分析的可靠性。提出可用于不同平面布置形式自承重砌体墙的稳定性设计验算方法,并给出其在两个实际工程中的应用。该文方法操作简便,可考虑砌体墙不同边界条件、构造柱和圈梁布置、自承重墙三角形轴力分布特点等影响,相关结论可供类似工程设计参考。