In March of 2002,a Harvard Academy research team received a grant for the project“Religion in Global Politics”.The aim of the research was to provide a systematic,broad,and comparative analysis of the impact on glob...In March of 2002,a Harvard Academy research team received a grant for the project“Religion in Global Politics”.The aim of the research was to provide a systematic,broad,and comparative analysis of the impact on global politics of religious beliefs and organizations.The project was led by the veteran Harvard scholar Samuel P.Huntington.The result of his research into the link between religion and national identity and the question how they influence international relations was never finished or published.From the available unfinished manuscripts and various draft papers from the Harvard University Archives Samuel P.Huntington Personal Archive,the article tries to establish the content of Huntington’s probably last article while also providing the missing references for the first time and attempts to put the writing in its context within the author’s oeuvre.展开更多
Brain is one of the most temperature sensitive organs.Besides the fundamental role of temperature in cellular metabolism,thermal response of neuronal populations is also significant during the evolution of various neu...Brain is one of the most temperature sensitive organs.Besides the fundamental role of temperature in cellular metabolism,thermal response of neuronal populations is also significant during the evolution of various neurodegenerative diseases.For such critical environmental factor,thorough mapping of cellular response to variations in temperature is desired in the living brain.So far,limited efforts have been made to create complex devices that are able to modulate temperature,and concurrently record multiple features of the stimulated region.In our work,the in vivo application of a multimodal photonic neural probe is demonstrated.Optical,thermal,and electrophysiological functions are monolithically integrated in a single device.The system facilitates spatial and temporal control of temperature distribution at high precision in the deep brain tissue through an embedded infrared waveguide,while it provides recording of the artefact-free electrical response of individual cells at multiple locations along the probe shaft.Spatial distribution of the optically induced temperature changes is evaluated through in vitro measurements and a validated multi-physical model.The operation of the multimodal microdevice is demonstrated in the rat neocortex and in the hippocampus to increase or suppress firing rate of stimulated neurons in a reversible manner using continuous wave infrared light(λ=1550 nm).Our approach is envisioned to be a promising candidate as an advanced experimental toolset to reveal thermally evoked responses in the deep neural tissue.展开更多
文摘In March of 2002,a Harvard Academy research team received a grant for the project“Religion in Global Politics”.The aim of the research was to provide a systematic,broad,and comparative analysis of the impact on global politics of religious beliefs and organizations.The project was led by the veteran Harvard scholar Samuel P.Huntington.The result of his research into the link between religion and national identity and the question how they influence international relations was never finished or published.From the available unfinished manuscripts and various draft papers from the Harvard University Archives Samuel P.Huntington Personal Archive,the article tries to establish the content of Huntington’s probably last article while also providing the missing references for the first time and attempts to put the writing in its context within the author’s oeuvre.
基金We are thankful to theNational Brain Research Program(grant:2017_1.2.1-NKP-2017-00002)the National Research,Development and Innovation Office(grants:NKFIH K 120143,NKFIH PD121307)+2 种基金New National Excellence Program of the Ministry for Innovation and Technology(UNKP-19-4-PPKE-9,UNKP-19-3-I-OE-36)the BME-Nanonotechnology FIKP grant of EMMI(BME FIKP-NAT)The support of the European Union through the grant EFOP-3.6.3-VEKOP-16-2017-00002 co-financed by the European Social Fund is also acknowledged.
文摘Brain is one of the most temperature sensitive organs.Besides the fundamental role of temperature in cellular metabolism,thermal response of neuronal populations is also significant during the evolution of various neurodegenerative diseases.For such critical environmental factor,thorough mapping of cellular response to variations in temperature is desired in the living brain.So far,limited efforts have been made to create complex devices that are able to modulate temperature,and concurrently record multiple features of the stimulated region.In our work,the in vivo application of a multimodal photonic neural probe is demonstrated.Optical,thermal,and electrophysiological functions are monolithically integrated in a single device.The system facilitates spatial and temporal control of temperature distribution at high precision in the deep brain tissue through an embedded infrared waveguide,while it provides recording of the artefact-free electrical response of individual cells at multiple locations along the probe shaft.Spatial distribution of the optically induced temperature changes is evaluated through in vitro measurements and a validated multi-physical model.The operation of the multimodal microdevice is demonstrated in the rat neocortex and in the hippocampus to increase or suppress firing rate of stimulated neurons in a reversible manner using continuous wave infrared light(λ=1550 nm).Our approach is envisioned to be a promising candidate as an advanced experimental toolset to reveal thermally evoked responses in the deep neural tissue.
