Background:The development of the kidneys and other organs of the urinary tract also follow the natural rule of gene-environment-lifestyle interaction.Both intrinsic and extrinsic factors may be associated with the et...Background:The development of the kidneys and other organs of the urinary tract also follow the natural rule of gene-environment-lifestyle interaction.Both intrinsic and extrinsic factors may be associated with the etiology of various kinds of urinary malformations.The environmental factors belong to extrinsic factors,which have attracted increasing attention from researchers.Methods:Publications about urinary malformations were searched from databases such as PubMed,Elsevier,Chemical Abstract,Excerpta Medica,Chinese Hospital Knowledge Database and Wanfang Database.Results:Urinary malformation is associated with low birth weight,maternal diseases,placental insufficiency,maternal drug exposure,and maternal exposure to environmental pesticides.Living environment and socioeconomic factors may also influence the incidence of urinary malformation.Conclusion:It is important to understand the association of environmental factors with the development of the renal system and urinary malformation in order to decrease the incidence of urinary malformations.展开更多
基金supported by a grant from the 125 Talented Young Generation Program of the Third Xiangya Hospital of Central South University(xy3yy2013-125-02)
文摘Background:The development of the kidneys and other organs of the urinary tract also follow the natural rule of gene-environment-lifestyle interaction.Both intrinsic and extrinsic factors may be associated with the etiology of various kinds of urinary malformations.The environmental factors belong to extrinsic factors,which have attracted increasing attention from researchers.Methods:Publications about urinary malformations were searched from databases such as PubMed,Elsevier,Chemical Abstract,Excerpta Medica,Chinese Hospital Knowledge Database and Wanfang Database.Results:Urinary malformation is associated with low birth weight,maternal diseases,placental insufficiency,maternal drug exposure,and maternal exposure to environmental pesticides.Living environment and socioeconomic factors may also influence the incidence of urinary malformation.Conclusion:It is important to understand the association of environmental factors with the development of the renal system and urinary malformation in order to decrease the incidence of urinary malformations.
