Dear Editor,In development,after cells make a commitment to their fates,they undergo a continuous and adaptive maturation process to eventually reach their terminal states.Cell maturity often decays during aging and p...Dear Editor,In development,after cells make a commitment to their fates,they undergo a continuous and adaptive maturation process to eventually reach their terminal states.Cell maturity often decays during aging and pathogenesis.The immature phenotypes of stem cell-differentiated cells deposit a major bottleneck in regenerative medicine.展开更多
Tanshinone ⅡA（TSⅡA） is the major bioactive constituent of Salvia miltiorrhiza Bunge,a Chinese herbal medicine,which has protective effects on myocardial ischemia/reperfusion（MIR） injury.However,the cardioprotect...Tanshinone ⅡA（TSⅡA） is the major bioactive constituent of Salvia miltiorrhiza Bunge,a Chinese herbal medicine,which has protective effects on myocardial ischemia/reperfusion（MIR） injury.However,the cardioprotective effects of TSⅡA as well as its clinical use were limited due to its poor water solubility.The objective of this study was to evaluate whether Tanshinone ⅡA derivative（TD）,a new water soluble compound synthesized by TSⅡA and N-Methyl-D-Glucamine,had protective effects on MIR injury and what the related mechanism was.The cardioprotective effects of TD were evaluated and compared with TSⅡA in a rat MIR model.The results show that pretreatment with TD significantly alleviated inflammatory infiltration and exhibited antioxidant effect in MIR injury by reducing the activity of lactate dehydrogenase（LDH） and malondialdehyde（MDA）,decreasing expression of nuclear factor-κ-gene binding（NF-κB） and upregulating expression of heme oxygenase（HO-1）,but having no effect on the content of total superoxide dismutase（T-SOD） and m RNA expression of superoxide dismutase（SOD-1）.Thus,our study reveals that TD exerted significant protective effects on MIR injury through attenuating oxidative stress and inflammatory responses.展开更多
基金supported by the National Key Research and Development Program of China (2022YFA1104800)the National Natural Science Foundation of China (82222006,32100660,82170367)+5 种基金Beijing Nova Program (Z211100002121003,20220484205)Beijing Natural Science Foundation (7232094)supported by National Institute of Health (R01HL146634 and UM1HL098166)supported by the Natural Science Foundation of China (82070235 and 92168113)the CAMS Innovation Fund for Medical Sciences (2021-I2M-5003)Haihe Laboratory of Cell Ecosystem Innovation Fund (HH22KYZX0047)。
文摘Dear Editor,In development,after cells make a commitment to their fates,they undergo a continuous and adaptive maturation process to eventually reach their terminal states.Cell maturity often decays during aging and pathogenesis.The immature phenotypes of stem cell-differentiated cells deposit a major bottleneck in regenerative medicine.
基金The National Natural Science Foundation of China(Grant No.81360054)
文摘Tanshinone ⅡA（TSⅡA） is the major bioactive constituent of Salvia miltiorrhiza Bunge,a Chinese herbal medicine,which has protective effects on myocardial ischemia/reperfusion（MIR） injury.However,the cardioprotective effects of TSⅡA as well as its clinical use were limited due to its poor water solubility.The objective of this study was to evaluate whether Tanshinone ⅡA derivative（TD）,a new water soluble compound synthesized by TSⅡA and N-Methyl-D-Glucamine,had protective effects on MIR injury and what the related mechanism was.The cardioprotective effects of TD were evaluated and compared with TSⅡA in a rat MIR model.The results show that pretreatment with TD significantly alleviated inflammatory infiltration and exhibited antioxidant effect in MIR injury by reducing the activity of lactate dehydrogenase（LDH） and malondialdehyde（MDA）,decreasing expression of nuclear factor-κ-gene binding（NF-κB） and upregulating expression of heme oxygenase（HO-1）,but having no effect on the content of total superoxide dismutase（T-SOD） and m RNA expression of superoxide dismutase（SOD-1）.Thus,our study reveals that TD exerted significant protective effects on MIR injury through attenuating oxidative stress and inflammatory responses.
