Morphological abnormalities in <i>Drosophila</i>with overexpression of human APP gene

Alzheimer’s disease (AD) is the leading and one of the most severe forms of dementia. Molecular mechanisms underlying AD pathogenesis despite much work on this subject still remain unclear. Cleavage of amyloid precursor protein (APP) to amyloid beta peptide (A-beta) and following formation of amyloid plaques are the key events of Alzheimer’s pathology. Thus changes in APP expression and metabolism can lead to pathology development. Here we show that overexpression of human APP in Drosophila neural cells manifests in different morphological abnormalities of Drosophila imago that can be observed immediately after fly eclosion. This observation can help to further understand APP molecular functions and its participation in different molecular pathways.

In situ formation of LDH-based nanocontainers on the surface of AZ91 magnesium alloy and detailed investigation of their crystal structure

In the presented work, the possibility of direct synthesis of LDH(layered double hydroxide) on the AZ91 surface in the presence of a chelating agent(diethylenetriaminepentaacetic acid-DTPA) is reported. Conversion layer of LDH nanocontainers were formed under ambient pressure conditions without carbonate addition in the electrolyte. The obtained LDH was characterized using experimental(SEM,XRD, TGA, XPS, Raman, etc.) and computational methods(thermodynamic calculation, modeling of possible LDH crystal structures). A comparison of three possible LDHs(LDH-OH,-NO_(3) and-CO_(3)) was performed. Based on the experimental results and crystal simulation approach, it was confirmed, that the mixed LDH-OH/CO_(3) is grown on the surface in the presence of DTPA pentasodium salt.

Evaluation of Natural Radioactivity Levels for Structural Material Used in the Construction of the Neutrino Detector

In this work, the evaluation of natural radioactivity and spontaneous fission rates was performed for 8 nuclides from the natural radioactive 238U, 235U and 232Th decay chains. For this purpose, three samples of structural materials of the neutrino detector, i.e. aluminum, titanium and glass were analyzed by gamma spectroscopy and by neutron activation analysis to quantify a specific radioactivity of the samples. According to the results of this investigation, glass and aluminum samples have maximum values of the mean uranium concentrations 7.3(7) × 10-4% and 3.1(6) × 10-5%, respectively, while the lowest value for mean concentration of the uranium was found in titanium samples to be 4.7(3) × 10-6%. Aluminum sample had maximum values of the mean thorium concentrations, 2.5(8) × 10-3%, while the lowest value for mean concentration of the thorium was found in titanium samples to be 6.2(3) × 10-7%.

Absolute Neutron Activation Analysis Technique of a Large Crude Oil Sample

This manuscript presents an application of calculation methods in neutron activation analysis (NAA) of a large crude oil sample. Monte-Carlo computer code was developed. The computer code calculates neutron cross sections and neutron flux density distribution in the interior large sample. ENDF/B-VII.0 data files and ENSDF BNL-NCS-51655-01/02-Rev data files were used as nuclear databases in our computer code. HPGe planar detector efficiency registration technique and the software were developed for the absolute NAA technique of the large sample. The concentrations of Na, K, Ca, Sc, Cr, Fe, Co, Ni, Cu, Zn, Ga, As, Br, Sr, Zr, Mo, Ag, Sb, Cs, Ba, Ce, Nd, Sm, Eu, Tb, Dy, Ho, Tm, Yb, Lu, Hf, Ta, W, Pt, Au, Hg, Th and U in the crude oil samples of Eastern Siberia oilfield were determined using calculation and relative techniques in the concentration range from 10-9 to 0.5%.

Determination of Major, Minor and Trace Element Compositions of the Gd₂O₂S:Pr,Ce Scintillation Ceramics with Neutron Activation Analysis

Neutron activation analysis technique of the Gd2O2S:М scintillation ceramics was developed. The concentrations of 15 trace, minor and major elements (As, Ce, Co, Cr, Cs, Eu, Fe, La, Sc, Tb, Zn, Zr, Pr, Gd, Na) have been measured with the instrumental neutron activation analysis of the Gd2O2S:Pr sample. The concentrations range of the determined elements is from 3 × 10-8 to 2.0% in mass. The determination limit of the elements was calculated to be (0.6 - 1.3 × 10-8% in mass).

Search for "Missing" α-decay Branch in ^(239)Cm

As a continuous search for the 'missing'α-decay of 239Cm, several irradiation experiments were done in July, 2005. The whole experimental procedure was similar as last year. To increase the yield of expected isotopes with intensive 12C beam, all of the irradiation have been done at night, and typical beam intensities varied between 0. 4-0.6 particleμA. Each irradiation lasted 4-6 h. The procedure of preparing

Search for "missing" α-decay Branch in ^(239)Cm

It is of special interest to search for those unknown α-emitters in the transuranium region which (i) are located along the path of α-decay chains that start in the superheavy element region, and (ii) establish a link to nuclides with known masses. The knowledge of all Qαvalues in an α-decay chain allows obtaining

Microwave diagnostics of pulsed atmospheric discharge with electrolytic electrode and long-lived luminous formation in its afterglow

The Gatchina discharge phenomenon holds significant promise as a laboratory model for simulating ball lightning.However,crucial aspects concerning the plasma components of the resulting afterglow remain unresolved.Notably,the measurement of the electron density,a critical parameter,has not been fully achieved thus far.In this study,microwave diagnostics and video recording were employed during a pulsed Gatchina discharge,along with synchronous measurement of discharge current and voltage.Distinct antennas were positioned at different heights to enable separate diagnosis of the discharge and the ensuing long-lived afterglow.The findings revealed that during the active phase of the Gatchina discharge,the plasma density was substantial enough to cause reflection of an electromagnetic wave with a frequency of 20 GHz from this highly conductive object.In the afterglow,the signal experienced only a moderate weakening of 10–20 percent,facilitating the determination of the time dependence of average electron density during the afterglow's passage between the two antennas.These measurements verified the unusually slow plasma decay in the afterglow of the Gatchina discharge,suggesting the potential significance of chemi-ionisation processes involving long-lived(metastable)particles.

Autoimmunity in acute ischemic stroke and the role of bloodbrain barrier: the dark side or the light one?

This article presents a synopsis of the current data on the mechanisms of blood-brain barrier (BBB) alteration and autoimmune response in acute ischemic stroke. Most researchers confirm the relationship between the severity of immunobiochemical changes and clinical outcome of acute ischemic stroke. Ischemic stroke is accompanied by aseptic inflammation, which alters the brain tissue and exposes the co-stimulatory molecules of the immune system and the neuronal antigens. To date, BBB is not considered the border between the immune system and central nervous system, and the local immune subsystems are found within and behind the BBB. BBB disruption contributes to the leakage of brain autoantigens and induction of secondary autoimmune response to neuronal antigens and long-term inflammation. Glymphatic system function is altered and jeopardized both in hemorrhagic and ischemic stroke types. The receptors of innate immunity (toll-like receptor-2 and toll-like receptor-4) are also involved in acute ischemia-reperfusion injury. Immune response is related to the key processes of blood clotting and fibrinolysis. At the same time, the stroke-induced immune activation may promote reparation phenomena in the brain. Subsequent research on the reduction of the acute ischemic brain injury through the target regulation of the immune response is promising.

Scaling behavior of the thermopower of the archetypal heavy-fermion metal YbRh2Si2

We reveal and explain the scaling behavior of the thermopower S/T exhibited by the archetypal heavy-fermion （HF） metal YbRh2Si2 under the application of magnetic field B at temperature T. We show that the same scaling is demonstrated by different HF compounds such as/3-YbA1B4 and the strongly correlated layered cobalt oxide [BiBa0.66K0.3602]CoO2. Using YbRh2Si2 as an example, we demonstrate that the scaling behavior of SIT is violated at the antiferromagnetic phase transition, while both the residual resistivity Po and the density of states, N, experience jumps at the phase transition, causing the thermopower to make two jumps and change its sign. Our elucidation is based on flattening of the single-particle spectrum that profoundly affects Po and N. To depict the main features of the SIT behavior, we construct a T-B schematic phase diagram of YbRh2Si2. Our calculated SIT for the HF compounds are in good agreement with experimental facts and support our observations.

Exotic pentaquarks as Gamov-Teller resonances

If the number of colors N c is taken large,baryons and their excitations can be considered in a mean-field approach.We argue that the mean field in baryons breaks spontaneously the spherical and SU（3） flavor symmetries,but retains the SU（2） symmetry of simultaneous rotations in space and isospace.The one-quark and quark-hole excitations in the mean field,together with the SU（3） rotational bands about them determine the spectrum of baryon resonances,which turns out to be in good accordance with reality when one puts N c =3.A by-product of this scheme is a confirmation of the light pentaquark Θ ＋ baryon uudds as a typical Gamov–Teller resonance long known in nuclear physics.An extension of the same large-N c logic to charmed baryons leads to a prediction of a anti-decapenta （15）-plet of charmed pentaquarks,two of which,B ＋＋ c = cuuds and B ＋ c = cudds,may be light and stable with respect to strong decays.

多电荷离子双电子复合中的宇称不守恒效应(英文)

A parity nonconserving (PNC) asymmetry in the cross section for dielectronic recombination of polarized electrons on multiply charged ions with Z≥40 is discussed. This effect is strongly enhanced for close doubly-excited states of opposite parity in the intermediate compound ion. Such states are known for He-like ions.However, these levels have large energy and large radiative widths which hampers observation of the PNC asymmetry. We argue that accidentally degenerate states of more complex ions may be more suitable for the corresponding experiment.

Strongly correlated new state Fermi systems as a of matter

The aim of this review paper is to expose a new state of matter exhibited by strongly correlated Fermi systems represented by various heavy-fermion （HF） metals, two-dimensional liquids like 3He, compounds with quantum spin liquids, quasicrystals, and systems with one-dimensional quantum spin liquid. We name these various systems HF compounds, since they exhibit the behavior typical of HF metals. In HF compounds at zero temperature the unique phase transition, dubbed throughout as the fermion condensation quantum phase transition （FCQPT） can occur; this FCQPT creates flat bands which in turn lead to the specific state, known as the fermion condensate. Unlimited increase of the effective mass of quasiparticles signifies FCQPT; these quasiparticles determine the thermodynamic, transport and relaxation properties of HF compounds. Our discussion of numerous salient experimen- tal data within the framework of FCQPT resolves the mystery of the new state of matter. Thus, FCQPT and the fermion condensation can be considered as the universal reason for the non-Fermi liquid behavior observed in various HF compounds. We show analytically and using arguments based completely on the experimental grounds that these systems exhibit universal scaling behavior of their thermodynamic, transport and relaxation properties. Therefore, the quantum physics of different HF compounds is universal, and emerges regardless of the microscopic structure of the compounds. This uniform behavior allows us to view it as the main characteristic of a new state of matter exhibited by HF compounds.

Bonn-Gatchina partial wave analysis

The present status of the Bonn-Gatchina partial wave analysis of the photoproduction and pion induced data is presented. An observation of signals which can be associated with new baryon resonances and possible interpretations of the baryon spectrum is discussed.

Luminosity determination for the dd→αK^+K^- experiment at ANKE/COSY

High resolution studies of ao/fo（980） decays into channels involving open strangeness are currently being performed at COSY-Julich. As a ＂filter＂ for isospin-zero intermediate states, i.e. to selectively produce the f0（980） resonance, the dd →αK^＋K^-reaction was measured with the magnetic ANKE spectrometer. In order to determine the luminosity of this experiment, the elastically and quasi-elastically scattered deuterons were recorded simultaneously with the αK^＋K^- events. Here we report about the luminosity determination via investigating the （quasi-） elastic deuterons at ANKE.

Coherent spin transport through helical edge states of topological insulator

We study coherent spin transport through helical edge states of topological insulator tunnel-coupled to metallic leads.We demonstrate that unpolarized incoming electron beam acquires finite polarization after transmission through such a setup provided that edges contain at least one magnetic impurity.The finite polarization appears even in the fully classical regime and is therefore robust to dephasing.There is also a quantum magnetic field-tunable contribution to the polarization,which shows sharp identical Aharonov-Bohm resonances as a function of magnetic flux—with the period hc/2e—and survives at relatively high temperature.We demonstrate that this tunneling interferometer can be described in terms of ensemble of flux-tunable qubits giving equal contributions to conductance and spin polarization.The number of active qubits participating in the charge and spin transport is given by the ratio of the temperature and the level spacing.The interferometer can effectively operate at high temperature and can be used for quantum calculations.In particular,the ensemble of qubits can be described by a single Hadamard operator.The obtained results open wide avenue for applications in the area of quantum computing.

Study of the production of Λ_b^0 band ~0 hadrons in pp collisions and first measurement of the Λ_b^0→J/ψpK^- branching fraction

The product of the ∧0/b （-B/0） differential production cross-section and the branching fraction of the decay ∧0/b→ J/ψ pK-（-B/0→ J/ψ-K＊（892）0）is measured as a function of the beauty hadron transverse momentum, PT, and rapidity, y. The kinematic region of the measurements is pT〈20 GeV/c and 2.0 〈g〈4.5.The measurements use a data sample corresponding to an integrated luminosity of 3fb-1 collected by the LHCb detector in pp collisions at centre-of-mass energies √s=7 TeV in 2011 and √s=8 TeV in 2012. Based on previous LHCb results of the fragmentation fraction ratio,f∧0/b/fd,the branching fraction of the decay ∧0/b→ J/ψ pK-is measured to be B（∧0/b→ J/ψ pK-）=（3.17±0.04±0.07±0.34＋0.45/-0.28）×10-4,where the first uncertainty is statistical, the second is systematic, the third is due to the uncertainty on the branching fraction of the decay -B/0 →J/ψ-K＊（892）0,and the fourth is due to the knowledge of f∧0/b/fd.The sum of the asymmetries in the production and decay between ∧0/b and ∧0/bis also measured as a function of PT and y.The previously published branching fraction of ∧0/b→ J/ψ pπ-,relative to that of ∧0/b→ J/ψ pK-,is updated. The branching fractions of ∧0/b→P＋c（→ J/ψp）K-are determined.

Search for the doubly charmed baryon ■

A search for the doubly charmed baryon ■^+cc is performed through its decay to theΛ^+c K^-π^+ final state,using proton-proton collision data collected with the LHCb detector at centre-of-mass energies of 7,8 and 13 TeV.The data correspond to a total integrated luminosity of 9 fb^-1.No significant signal is observed in the mass range from 3.4 to 3.8 GeV/c^2.Upper limits are set at 95%credibility level on the ratio of the ■^+cc production cross-section times the branching fraction to that ofΛ^+c and ■^++cc baryons.The limits are determined as functions of the ■^+cc mass for different lifetime hypotheses,in the rapidity range from 2.0 to 4.5 and the transverse momentum range from 4 to 15 GeV/c.

Measurement of Ξcc++ production in pp collisions at s1/2=13 TeV

The production of ■baryons in proton-proton collisions at a centre-of-mass energy of √s = 13 TeV is measured in the transverse-momentum range 4<pT<15GeV/c and the rapidity range2.0<y<4.5.The data used in this measurement correspond to an integrated luminosity of 1.7fb^-1,recorded by the LHCb experiment during 2016.The ratio of the ■ production cross-section times the branching fraction of the■→∧^+cK^-π^+ π^+decay relative to the prompt ∧^+c production cross-section is found to be(2.22±0.27±0.29)×10^-4,assuming the central value of the measured lifetime,where the first uncertainty is statistical and the second systematic.