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Cancers of the lung, head and neck on the rise: perspectives on the genotoxicity of air pollution 被引量:6
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作者 Ian Chi Kei Wong Yuen-Keng Ng Vivian Wai Yan Lui 《Chinese Journal of Cancer》 SCIE CAS CSCD 2014年第10期476-480,共5页
Outdoor air pollution has been recently classified as a class I human carcinogen by the World Health Organization(WHO). Cumulative evidence from across the globe shows that polluted air is associated with increased ri... Outdoor air pollution has been recently classified as a class I human carcinogen by the World Health Organization(WHO). Cumulative evidence from across the globe shows that polluted air is associated with increased risk of lung, head and neck, and nasopharyngeal cancers—all of which affect the upper aerodigestive tract. Importantly, these cancers have been previously linked to smoking. In this article, we review epidemiologic and experimental evidence of the genotoxic and mutagenic effects of air pollution on DNA, purportedly a key mechanism for cancer development. The alarming increase in cancers of the upper aerodigestive tract in Asia suggests a need to focus government efforts and research on reducing air pollution, promoting clean energy, and investigating the carcinogenic effects of air pollution on humans. 展开更多
关键词 空气污染 头颈部 癌症 遗传毒性 肺癌 世界卫生组织 上升 实验证据
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