[Objectives]The aim of this paper was to reveal the changes of large livestock industry and their influence on animal husbandry economy in Guyuan City of Ningxia.[Methods]The linear trend method was employed to quanti...[Objectives]The aim of this paper was to reveal the changes of large livestock industry and their influence on animal husbandry economy in Guyuan City of Ningxia.[Methods]The linear trend method was employed to quantify the change trends of the indicators for large livestock industry,and the ridge regression model was conducted to analyze their impacts on the gross output value of animal husbandry(GOVAH).[Results]The numbers of sold and slaughtered cattle and sheep in Guyuan presented a significant upward trend,while the number for hog had a significant downward trend,during 2000-2019.The GOVAH in Guyuan and its 5 counties had increased by 2-3 times in recent 20 years,which was mainly driven by large-scale livestock breeding.The cattle and sheep breeding sectors had positive effects on GOVAH,while the hog breeding sector had negative effect.[Conclusions]This study provides a reference for the structural adjustment and large-scale development of animal husbandry.展开更多
Skin cancer,a prevalent malignancy worldwide,poses significant health concerns owing to its increasing incidence.Autophagy,a natural cellular process,is a pivotal event in skin cancer and has advantageous and detrimen...Skin cancer,a prevalent malignancy worldwide,poses significant health concerns owing to its increasing incidence.Autophagy,a natural cellular process,is a pivotal event in skin cancer and has advantageous and detrimental effects.This duality has prompted extensive investigations into medical interventions targeting autophagy modulation for their substantial therapeutic potential.This systematic review aimed to investigate the relationship between skin cancer and autophagy and the contribution and mechanism of autophagy modulators in skin cancer.We outlined the effectiveness and safety of targeting autophagy as a promising therapeutic strategy for the treatment of skin cancer.This comprehensive review identified a diverse array of autophagy modulators with promising potential for the treatment of skin cancer.Each of these compounds demonstrates efficacy through distinct physiological mechanisms that have been elucidated in detail.Interestingly,findings from a literature search indicated that none of the natural,synthetic,or semisynthetic compounds exhibited notable adverse effects in either human or animal models.Consequently,this review offers novel mechanistic and therapeutic perspectives on the targeted modulation of autophagy in skin cancer.展开更多
基金Ningxia Key Research and Development Program(Special Talents)(2020BEB04028)(2019BEB04040).
文摘[Objectives]The aim of this paper was to reveal the changes of large livestock industry and their influence on animal husbandry economy in Guyuan City of Ningxia.[Methods]The linear trend method was employed to quantify the change trends of the indicators for large livestock industry,and the ridge regression model was conducted to analyze their impacts on the gross output value of animal husbandry(GOVAH).[Results]The numbers of sold and slaughtered cattle and sheep in Guyuan presented a significant upward trend,while the number for hog had a significant downward trend,during 2000-2019.The GOVAH in Guyuan and its 5 counties had increased by 2-3 times in recent 20 years,which was mainly driven by large-scale livestock breeding.The cattle and sheep breeding sectors had positive effects on GOVAH,while the hog breeding sector had negative effect.[Conclusions]This study provides a reference for the structural adjustment and large-scale development of animal husbandry.
文摘Skin cancer,a prevalent malignancy worldwide,poses significant health concerns owing to its increasing incidence.Autophagy,a natural cellular process,is a pivotal event in skin cancer and has advantageous and detrimental effects.This duality has prompted extensive investigations into medical interventions targeting autophagy modulation for their substantial therapeutic potential.This systematic review aimed to investigate the relationship between skin cancer and autophagy and the contribution and mechanism of autophagy modulators in skin cancer.We outlined the effectiveness and safety of targeting autophagy as a promising therapeutic strategy for the treatment of skin cancer.This comprehensive review identified a diverse array of autophagy modulators with promising potential for the treatment of skin cancer.Each of these compounds demonstrates efficacy through distinct physiological mechanisms that have been elucidated in detail.Interestingly,findings from a literature search indicated that none of the natural,synthetic,or semisynthetic compounds exhibited notable adverse effects in either human or animal models.Consequently,this review offers novel mechanistic and therapeutic perspectives on the targeted modulation of autophagy in skin cancer.
