Interferon-gamma(IFN-γ)plays a dual role in cancer;it is both a pro-and an antitumorigenic cytokine,depending on the type of cancer.The deregulation of the IFN-γcanonic pathway is associated with several disorders,i...Interferon-gamma(IFN-γ)plays a dual role in cancer;it is both a pro-and an antitumorigenic cytokine,depending on the type of cancer.The deregulation of the IFN-γcanonic pathway is associated with several disorders,including vulner-ability to viral infections,inflammation,and cancer progression.In particular,the interplay between lung adenocarcinoma(LUAD)and viral infections appears to exist in association with the deregulation of IFN-γsignaling.In this mini-review,we investigated the status of the IFN-γsignaling pathway and the expression level of its components in LUAD.Interestingly,a reduction in IFNGR1 expression seems to be associated with LUAD progression,affecting defenses against viruses such as severe acute respiratory syndrome coronavirus 2.In addition,alterations in the expression of IFNGR1 may inhibit the antiproliferative action of IFN-γsignaling in LUAD.展开更多
Alzheimer disease(AD)is the primary form of dementia that occurs spontaneously in older adults.Interestingly,the epigenetic profile of the cells forming the central nervous system changes during aging and may contribu...Alzheimer disease(AD)is the primary form of dementia that occurs spontaneously in older adults.Interestingly,the epigenetic profile of the cells forming the central nervous system changes during aging and may contribute to the progression of some neurodegenerative diseases such as AD.In this review,we present general insights into relevant epigenetic mechanisms and their relationship with aging and AD.The data suggest that some epigenetic changes during aging could be utilized as biomarkers and target molecules for the prevention and control of AD.展开更多
Cytoskeletal remodeling affects the shape,adhesion,and motility of cells.Cytoskeletal dynamics are modulated by matrix proteins,integrins,and several cytokines in the tumor microenvironment.In this scenario,signaling ...Cytoskeletal remodeling affects the shape,adhesion,and motility of cells.Cytoskeletal dynamics are modulated by matrix proteins,integrins,and several cytokines in the tumor microenvironment.In this scenario,signaling is activated by integrins and interferons,which can induce ISG15 gene expression.This gene encodes a ubiquitin-like protein that functions as a protein modifier via the ISGylation system.Furthermore,non-conjugated ISG15 acts as a cytokine-like protein.In this viewpoint,the interplay between free ISG15,protein ISGylation,and cytoskeletal dynamics in the tumor microenvironment is discussed.展开更多
TRIM25 is emerging as a central factor in breast cancer due to its regulation and function.In particular,it has been shown that:(1)Estrogens modulate TRIM25 gene expression;(2)TRIM25 has activity as an E3-ligase enzym...TRIM25 is emerging as a central factor in breast cancer due to its regulation and function.In particular,it has been shown that:(1)Estrogens modulate TRIM25 gene expression;(2)TRIM25 has activity as an E3-ligase enzyme for ubiquitin;and(3)TRIM25 is also an E3 ligase for interferon-stimulated gene 15 protein in the ISGylation system.Consequently,the proteome of mammary tissue is affected by TRIM25-associated pathways,involved in tumor development and metastasis.Here,we discuss the findings on the mechanisms involved in regulating TRIM25 expression and its functional relevance in breast cancer progression.These studies suggest that TRIM25 may be a biomarker and a therapeutic target for breast cancer.展开更多
文摘Interferon-gamma(IFN-γ)plays a dual role in cancer;it is both a pro-and an antitumorigenic cytokine,depending on the type of cancer.The deregulation of the IFN-γcanonic pathway is associated with several disorders,including vulner-ability to viral infections,inflammation,and cancer progression.In particular,the interplay between lung adenocarcinoma(LUAD)and viral infections appears to exist in association with the deregulation of IFN-γsignaling.In this mini-review,we investigated the status of the IFN-γsignaling pathway and the expression level of its components in LUAD.Interestingly,a reduction in IFNGR1 expression seems to be associated with LUAD progression,affecting defenses against viruses such as severe acute respiratory syndrome coronavirus 2.In addition,alterations in the expression of IFNGR1 may inhibit the antiproliferative action of IFN-γsignaling in LUAD.
文摘Alzheimer disease(AD)is the primary form of dementia that occurs spontaneously in older adults.Interestingly,the epigenetic profile of the cells forming the central nervous system changes during aging and may contribute to the progression of some neurodegenerative diseases such as AD.In this review,we present general insights into relevant epigenetic mechanisms and their relationship with aging and AD.The data suggest that some epigenetic changes during aging could be utilized as biomarkers and target molecules for the prevention and control of AD.
基金This research was supported by the School of Science and Technology(CCyT-2021-5)from the Autonomous University of Mexico City(UACM).
文摘Cytoskeletal remodeling affects the shape,adhesion,and motility of cells.Cytoskeletal dynamics are modulated by matrix proteins,integrins,and several cytokines in the tumor microenvironment.In this scenario,signaling is activated by integrins and interferons,which can induce ISG15 gene expression.This gene encodes a ubiquitin-like protein that functions as a protein modifier via the ISGylation system.Furthermore,non-conjugated ISG15 acts as a cytokine-like protein.In this viewpoint,the interplay between free ISG15,protein ISGylation,and cytoskeletal dynamics in the tumor microenvironment is discussed.
文摘TRIM25 is emerging as a central factor in breast cancer due to its regulation and function.In particular,it has been shown that:(1)Estrogens modulate TRIM25 gene expression;(2)TRIM25 has activity as an E3-ligase enzyme for ubiquitin;and(3)TRIM25 is also an E3 ligase for interferon-stimulated gene 15 protein in the ISGylation system.Consequently,the proteome of mammary tissue is affected by TRIM25-associated pathways,involved in tumor development and metastasis.Here,we discuss the findings on the mechanisms involved in regulating TRIM25 expression and its functional relevance in breast cancer progression.These studies suggest that TRIM25 may be a biomarker and a therapeutic target for breast cancer.
