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人卵巢癌顺铂耐药细胞裸鼠腹腔转移模型的建立(英文)
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作者 黄守国 孔北华 +1 位作者 杨瑞芳 江森 《中国现代医学杂志》 CAS CSCD 2003年第23期11-14,共4页
目的 探讨建立人卵巢癌顺铂耐药细胞裸鼠腹腔转移模型的方法。方法 人卵巢癌细胞株 3AO和顺铂耐药细胞株 3AO/cDDP细胞体外培养。 4× 10 6个 3AO、3AO/cDDP分别接种于裸鼠腹腔 96h后 ,各随机分为 2组 ,分别腹腔内注射生理盐水和... 目的 探讨建立人卵巢癌顺铂耐药细胞裸鼠腹腔转移模型的方法。方法 人卵巢癌细胞株 3AO和顺铂耐药细胞株 3AO/cDDP细胞体外培养。 4× 10 6个 3AO、3AO/cDDP分别接种于裸鼠腹腔 96h后 ,各随机分为 2组 ,分别腹腔内注射生理盐水和顺铂 (cDDP) ,观察各组裸鼠的致瘤率、生存期和生存延长率。采用流式细胞技术观察转移瘤LRP、MRP基因的表达情况。转移瘤瘤体行病理学检查。结果  3AO、3AO/cDDP细胞的裸鼠致瘤率差异无显著性 ,P >0 .0 5 ;cDDP能提高 3AO荷瘤鼠的生存期及生存延长率 ,与 3AO/cDDP荷鼠相比 ,差异有显著性 ,P <0 .0 5 ;3AO/cDDP转移瘤的LRP、MRP基因的表达水平显著高于 3AO转移瘤 ,P <0 .0 5 ;病理学检查提示裸鼠腹腔转移瘤细胞具人恶性特征。结论 该方法建立裸鼠卵巢癌腹腔转移模型具有成瘤率高的特点 ,并能保持顺铂耐药特征。 展开更多
关键词 卵巢肿瘤 顺铂 肿瘤转移 抗药性 裸鼠
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Adaptive Antenna-Activation Based Beamforming for Large-Scale MIMO Communication Systems of High Speed Railway 被引量:3
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作者 Meng Cheng Shaoshi Yang Xuming Fang 《China Communications》 SCIE CSCD 2016年第9期12-23,共12页
Large-scale array aided beamforming improves the spectral efficiency(SE) as a benefit of high angular resolution.When dual-beam downlink beamforming is applied to the train moving towards cell edge,the inter-beam ambi... Large-scale array aided beamforming improves the spectral efficiency(SE) as a benefit of high angular resolution.When dual-beam downlink beamforming is applied to the train moving towards cell edge,the inter-beam ambiguity(IBA) increases as the directional difference between beams becomes smaller.An adaptive antenna activation based beamforming scheme was proposed to mitigate IBA.In the district near the base station(BS),all antenna elements(AEs) were activated to generate two beams.As the distance from the train to the BS increased,only the minimum number of AEs satisfying the resolution criterion would be activated.At the cell edge,one beam was switched off due to intolerable IBA.The proposed scheme can achieve SE gain to the non-adaptive scheme and show more robustness against the direction-of-arrival(DOA) estimation error. 展开更多
关键词 wireless communications adap- tive antenna activation large-scale antenna array downlink beamforming high speed railway
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Research Progress on the Large-scale Culture Technology of Mammalian Cells
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作者 LI Chunyan XIAO Jing JIANG Yonghou 《Journal of Northeast Agricultural University(English Edition)》 CAS 2009年第2期72-76,共5页
The culture of mammalian cells is closely related to the development of biotechnology, which has been used extensively in the research and application fields of biology and medical science. In this article, various fa... The culture of mammalian cells is closely related to the development of biotechnology, which has been used extensively in the research and application fields of biology and medical science. In this article, various factors affecting cell cultivation and the application of microcarrier and bioreactor on large-scale culture of mammalian ceils were reviewed. 展开更多
关键词 mammalian cell CULTURE MICROCARRIER BIOREACTOR
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Kinetic Monte Carlo simulation of film morphologies at the initial stages 被引量:1
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作者 ZHENG XiaoPing ZHANG PeiFeng +1 位作者 HE DeYan LI Lian 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS 2008年第1期56-63,共8页
The morphologies at the initial stages of thin film growth were studied by using Kinetic Monte Carlo techniques.A more efficient model was used to calculate the activity energy.The model involves incident atom attachm... The morphologies at the initial stages of thin film growth were studied by using Kinetic Monte Carlo techniques.A more efficient model was used to calculate the activity energy.The model involves incident atom attachment,diffusion,detachment from the surface,detached atom returning,and dimer diffusion.We edited a set of software of the model and simulated the surface morphologies by the principle of computer graphics.It is shown that the nucleuses formed at the initial stages and the surface morphologies at high temperatures are very different from those at low temperatures.The later surface growth depends on the nucleuses at the initial stages.The mechanism results from the atom thermal movement,the temperature determines the diffusion ability,and the deposition rate determines the diffusion time. 展开更多
关键词 FILM INITIAL stage MORPHOLOGIES simulation KINETIC MONTE Carlo(KMC)
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