保证内回路稳定的鲁棒可靠控制器设计

鲁棒可靠控制器的设计是容错飞行控制系统研究的重要内容,设计思想就是建立系统的正常情况下的模型和故障情况下的模型,根据Lyapunov稳定性定理求得反馈增益K,使得其能保证正常情况和故障情况下都能满足一定水平的指标要求。基于参数依赖Lyapunov方程和迭代线性矩阵不等式在直升机不确定性、H∞/LQ性能指标约束下提出直升机鲁棒可靠控制器设计方法,保证跟踪增广系统中内环系统的稳定性,通过仿真验证了该算法的有效性。

Research on Ultrasonic Vibration Grinding of the Hard and Brittle Materials

It is well known that grinding techniques are main methods to machine hard and brittle materials such as engineering ceramics. But the conventional grinding has many shortcomings such as poorer surface finish, quicker wear and tear of grinding tools, lower efficiency and so on. Ultrasonic vibration grinding （UVG） which combines ultrasonic machining and grinding emerged as a developing and promising technique in recent years. In this paper, experimental studies on UVG were conducted on several kinds of hard and brittle material by altering processing parameters such as vibration frequency and its amplitude, diamond abrasive grit size, cutting depth, feeding speed and rotary speed of tools. The experimental results show that alteration in any of above mentioned parameters will bring effects on the processed surface finish of these materials. Of them, the diamond abrasive grit size has the greatest. Moreover, conventional grinding experiments were also carried out on these materials. By comparison, it was found that the UVG is superior to the conventional method in terms of the ground surface quality, the working efficiency and the wear rate of tools.

Hepatitis C virus protease inhibitor-resistance mutations: Our experience and review

Direct-acting antiviral agents(DAAs)for hepatitis C virus(HCV)infection are one of the major advances in its medical treatment.The HCV protease inhibitors boceprevir and telaprevir were the first approved DAAs in the United States,Europe,and Japan.When combined with peginterferon plus ribavirin,these agents increase sustained virologic response rates to70%-80%in treatment-na?ve patients and previoustreatment relapsers with chronic HCV genotype 1 infection.Without peginterferon plus ribavirin,DAA monotherapies increased DAA-resistance mutations.Several new DAAs for HCV are now in clinical development and are likely to be approved in the near future.However,it has been reported that the use of these drugs also led to the emergence of DAA-resistance mutations in certain cases.Furthermore,these mutations exhibit cross-resistance to multiple drugs.The prevalence of DAA-resistance mutations in HCV-infected patients who were not treated with DAAs is unknown,and it is as yet uncertain whether such variants are sensitive to DAAs.We performed a population sequence analysis to assess the frequency of such variants in the sera of HCV genotype 1-infected patients not treated with HCV protease inhibitors.Here,we reviewed the literature on resistance variants of HCV protease inhibitors in treatment na?ve patients with chronic HCV genotype 1,as well as our experience.

Effect of Cambering on the Aerodynamic Performance of Heaving Airfoils

In the present work,a parametric numerical study is conducted in order to assess the effect of airfoil cambering on the aerodynamic performance of rigid heaving airfoils.The incompressible Navier-Stokes equations are solved in their velocity-pressure formulation using a second-order accurate in space and time finite-difference scheme.To tackle the problem of moving boundaries,the governing equations are solved on overlapping structured grids.The numerical simulations are performed at a Reynolds number of Re=1100 and at different values of Strouhal number and reduced frequency.The results obtained show that the airfoil cambering geometric parameter has a strong influence on the average lift coefficient,while it has a smaller impact on the average thrust coefficient and propulsive efficiency of heaving airfoils.

Influence on the hydrodynamic performance of a variable vector propeller of different rules of pitch angle change

To design a more effective blade pitch adjustment mechanism,research was done on changes to the hydrodynamic characteristics of VVPs(Variable Vector Propeller) caused by different rules for changing pitch angle. A mathematical method for predicting the hydrodynamic characteristics of a VVP under unsteady conditions is presented based on the panel method. Mathematical models for evaluation based on potential flow theory and the Green theorem are also presented. The hydrodynamic characteristics are numerically predicted. To avoid gaps between panels,hyperboloidal quadrilateral panels were used. The pressure Kutta condition on the trailing edge of the VVP blade was satisfied by the Newton-Raphson iterative procedure. The influence coefficients of the panels were calculated by Morino's analytical formulations to improve numerical calculation speed,and the method developed by Yanagizawa was used to eliminate the point singularity on derivation calculus while determining the velocities on propeller surfaces. The calculation results show that it's best for the hydrodynamic characteristics of the VVP that pitch angle changes follow the sine rule.

Higher-mode effect on the seismic responses of buildings with viscoelastic dampers

In conventional modal analysis procedures,usually only a few dominant modes are required to describe the dynamic behavior of multi-degrees-of-freedom buildings.The number of modes needed in the dynamic analysis depends on the higher-mode contribution to the structural response,which is called the higher-mode effect.The modal analysis approach, however,may not be directly applied to the dynamic analysis of viscoelastically damped buildings.This is because the dynamic properties of the viscoelastic dampers depend on their vibration frequency.Therefore,the structural stiffness and damping contributed from those dampers would be different for each mode.In this study,the higher-mode effect is referred to as the response difference induced by the frequency-dependent property of viscoelastic dampers at higher modes.Modal analysis procedures for buildings with viscoelastic dampers distributed proportionally and non-proportionally to the stiffness of the buildings are developed to consider the higher-mode effect.Numerical studies on shear-type viscoelastically damped building models are conducted to examine the accuracy of the proposed procedures and to investigate the significance of the higher-mode effect on their seismic response.Two damper models are used to estimate the peak damper forces in the proposed procedures. Study results reveal that the higher-mode effect is significant for long-period viscoelastically damped buildings.The higher-mode effect on base shear is less significant than on story acceleration response.Maximum difference of the seismic response usually occurs at the top story.Also,the higher-mode effect may not be reduced by decreasing the damping ratio provided by the viscoelastic dampers.For practical application,it is realized that the linear viscous damping model without considering the higher-mode effect may predict larger damper forces and hence,is on the conservative side.

硫喷妥钠引起的淋巴细胞凋亡不依赖CD95的激活

背景:当脑外伤病人颅内压升高对其他治疗措施反应不佳时,常常应用巴比妥酸盐.然而,巴比妥酸盐介导的神经保护作用可能会导致淋巴细胞减少,使发生感染的危险性增加.巴比妥酸盐引起淋巴细胞减少的机制还不清楚.

Mechanical Properties of Two Kinds of New Cold-Formed Flange-Closed Welding Section Members

The hollow flange beam(HFB) is a unique cold-formed steel section developed in Australia for use as a flexural member.It′s a particular cross section with two torsion rigid closed triangular flanges and a comparatively flexible web,and it is a type of high efficient cross section.This paper presents two kinds of new cold-formed flange-closed welding sections named HF1 and HF2 according to different section component and parameters of HFB.Nonlinear finite element method has been adopted to investigate the mechanical properties such as buckling mode,deformation process,rigidity,ductility and correlation curve of two kinds of new section members which being subjected to axial compression,flexure,combined compression and bending.Systematical comparisons of the consumed steel quantities of per unit load carrying capacity between new section members and the same section dimensions of cold-formed C-section members have been carried out.Some conclusions can be drawn from above work that the new sections have some superior properties including higher load carrying capacity and section modulus,sufficient section stiffness,and difficult occurrence for the sub element local buckling.The new sections are suitable for bearing flexure,compression,combined compression and bending.The new sections′ consumed steel quantities of per unit load carrying capacity are almost half as those of the same dimension C-section members′.The experimental investigation is carried out further on the new cold-formed flange-closed welding section members and can be used in the practical engineering.

Synthesis mechanism of Pr doped BaTi_4O_9 powder by sol-gel process

Pr Doped BaTi4O9 gel was prepared by sol-gel method using Ti(OC4H9)4, Ba(CH3COO)2, CH3COOH and CH3OCH2CH2OH as raw materials. Through analyzing dry gel thermal treated at different temperatures, the possible synthesis mechanism of Pr doped BaTi4O9 powder was discussed. At first, Ti(OC4H9)4 hydrolyzes and three dimensional networks form, in which Ba2+ and CH3COO- are mostly in the form of ions; organic solvent is gradually volatilized through calefaction at 700 ℃, then the offspring is turned into BaTi5O11. With the temperature increasing to 850 ℃, BaTi5O11 begins resolving partly and forming BaTi4O9, and at 1000℃ Ba4Ti13O22 forms partly, but BaTi4O9 is the main crystal phase. BaTi5O11 and Ba4Ti13O30 decomposes completely at 1200℃ and forms single-phase BaTi4O9. The infrared (IR) analysis also shows that the absorbing peak of Ti-O bond is not in the characteristic absorption range of Ti-O-Ti (700-900 cm-1), but slightly shifted to the higher end (908 cm-1). It is probably because that doping Pr enters into the crystal lattice and causes the abnormal absorption of Ti-O bond.

Quantity and Quality Equally Important in Utilizing Foreign Investment

A new round of FDI flow and new wave of international industry transfer has offered new opportunities for China to participate in international economic competition and cooperation. Utilization of foreign investment has crucial implications for enhancing China's position in the international division of labor,cultivating new competitive advantages and strengthening overall competitiveness. China should grasp the opportunity and improve the investment environment in terms of legislation,system,policy,administration and service and ensure that foreign investment plays an important role in China's economic development and promotion of independent innovation and industry upgrade.

Stroke Due to Hypercoagulable State Can Mimic Multiple Sclerosis: A Case Report

Introduction: Stroke is the second major cause of mortality worldwide and in several cases, and it may lead to disability. Factor V Leiden is a common genetic thrombophilia, which causes activated protein C (APC) resistance. Hyperhomocysteinemia and factor V Leiden deficiency, two independent coagulopathy factors, can lead to venous and arterial infarctions in multiple small and large arteries and veins anywhere in the body. Case Report: Here, we report a unique case in which both hyperhomocysteinemia and factor V Leiden deficiency are documented together with MTHFR (C677T) (Methylene Tetra Hydro Folate Reductase) gene polymorphism and activated protein C resistance respectively. Conclusion: More interestingly, the mode of presentation in this case highly resembled that of progressive multiple sclerosis;all signs and symptoms slowly progressed without any systemic signs at first few years. Further studies needed to assess current outcomes.

对难以转染的细胞进行成功的电穿孔

对原代人体嗜中性粒细胞的转染是很重要的,因为它实现了对人体发炎响应中通道的研究,而这在以前是很难实现的,原因在于培养嗜中性粒细胞很困难。通过这项研究,从细胞存活率及siRNA传递角度,研究者确立了最佳的嗜中性粒细胞转染的电穿孔条件。使用这些条件,可以进一步将该技术应用到包括干细胞在内的其他难以转染的原代细胞中。可以预见,这一领域将会在不久的将来蓬勃发展起来。

四唑类化合物的合成及应用研究新进展

四唑是一种重要的五元芳杂环,具有多氮富电子的平面结构特征.这种特殊的结构使得四唑类化合物作为药物、炸药、功能材料等在医学、农学、材料科学等众多领域具有广泛的应用前景.相关研究十分活跃,已取得了许多重要进展.结合作者唑类方面的研究,参考国内外近五年文献,系统地综述了四唑类化合物的合成及其在医药、农药、材料等领域的应用研究新近况.

Velocity Profiles between Two Baffles in a Shell and Tube Heat Exchanger

Heat exchangers are extensively utilized for waste heat recovery,oil refining,chemical processing,and steam generation.In this study,velocity profiles are measured using a 3D particle image velocimetry(PIV)system between two baffles in a shell and tube heat exchanger for parallel and counter flows.The PIV and computational fluid dynamics results show the occurrence of some strong vectors near the bottom.These vectors are assumed due to the clearance between the inner tubes and the front baffle.Therefore,the major parts of the vectors are moved out through the bottom opening of the rear baffle,and other vectors produce a large circle between the two baffles.Numerical simulations are conducted to investigate the effects of the baffle on the heat exchanger using the Fluent software.The k-εturbulence model is employed to calculate the flows along the heat exchanger.

ANALYTICAL SOLUTIONS FOR THE LAYERED GEO-MATERIALS SUBJECTED TO AN ARBITRARY POINT LOAD IN THE CARTESIAN COORDINATE

This paper presents analytical solutions for the stress and displacement field in elastic layered geo-materials induced by an arbitrary point load in the Cartesian coordinate system. The point load solutions can be obtained by referring to the integral transform and the transfer matrix technique. However, former solutions usually exist in the cylindrical coordinate system subjected, to axisymmetric loading. Based on the proposed solutions in the Cartesian coordinate, it is very easy to solve asymmetric problems and consider the condition with internal loads in multi-layered geo-materials. Moreover, point load solutions can be used to construct solutions for analytical examination of elastic problems and incorporated into numerical schemes such as boundary element methods. The results discussed in this paper indicate that there is no problem in the evaluation of the point load solutions with high accuracy and efficiency, and that the material non-homogeneity has a significant effect on the elastic field due to adjacent loading.

Velocity Profiles between Two Baffles in a Horizontal Circular Tube

The shell and tube heat exchanger is an essential part of a power plant for recovering heat transfer between the feed water of a boiler and the wasted heat.The baffles are also an important element inside the heat exchanger.Internal materials influence the flow pattern in the bed.The influence of baffles in the velocity profiles was observed using a three-dimensional particle image velocimetry around baffles in a horizontal circular tube.The velocity of the particles was measured before the baffle and between them in the test tube.Results show that the flows near the front baffle flow were parallel to the vertical wall,and then concentrate on the upper opening of the front baffle.The flows circulate in the front and rear baffles.These flow profiles are related to the Reynolds number(Re) or the flow intensity.The velocity profiles at lower Re number showed a complicated mixing,concentrating on the lower opening of the rear baffle as front wall.Swirling flow was employed in this study,which was produced using tangential velocities at the inlet.At the entrance of the front baffle,the velocity vector profiles with swirl were much different from that without swirl.However,velocities between two baffles are not much different from those without swirl.