This paper examined the relationship between cultural consumption and the floating population’s integration into host cities based on data from China’s Seventh National Population Census and the 2018 China Migrants ...This paper examined the relationship between cultural consumption and the floating population’s integration into host cities based on data from China’s Seventh National Population Census and the 2018 China Migrants Dynamic Survey(CMDS).The findings indicate that improving the floating population’s consumption level and quality,especially the quality of development-oriented cultural consumption,can significantly improve the level of their integration.Moreover,development-oriented cultural consumption has a positive effect on the floating population’s integration and social participation,while entertainment-oriented cultural consumption facilitates their integration mainly by improving their sense of well-being.These findings could guide policymakers in developing targeted cultural consumption policies,implementing specific regional industry adjustments,and expanding domestic consumption demand.展开更多
Sm2Fe17-xNbx (x = 0-4) powder was synthesized by HDDR treatment and nitrogenation. The effects of partial Nb substitution for Fe on the structural and magnetic properties of Sm2Fe17-xNbx alloys and their nitlides we...Sm2Fe17-xNbx (x = 0-4) powder was synthesized by HDDR treatment and nitrogenation. The effects of partial Nb substitution for Fe on the structural and magnetic properties of Sm2Fe17-xNbx alloys and their nitlides were investigated. It was seen that Sm2(Fe,Nb)17 phase exists in both annealed and HDDR-treated Sm2Fe17-xNbx alloys. However, its content is decreased with the increase in Nb substitution. In annealed alloys, Sm2(Fe,Nb)17 phase becomes unstable and will dissociate into SmFe2 and Fe-rich phases when x 〉 1.5. With HDDR-treatment, the Nb concentration in recombined Sm2(Fe,Nb)17 phase is decreased, and the content of Fe-rich phases is increased. Sm2Fe17-xNbx powder exhibits dendritic cracks and fine particles with a size of less than 300 nm. In nitrogenated alloys, N atoms mainly enter 2:17-type phase to form Sm2(Fe,Nb)17Ny. Partial Nb atoms in Sm2(Fe,Nb)17Ny phase will be released or excluded by nitrogen atoms. Fe-rich phases increase, and are followed by the amorphous Sm2(Fe,Nb)17Ny phase. Nb substitution for Fe with x = 0.5 and 1.0 in Sm2Fe17-xNbxNy powders increases the coercivity and remanence. But when x is greater than 2.0, Nb substitution will deteriorate the magnetic properties.展开更多
There are numerous studies comparing different kinds of environmental taxes and standards.However,forms of environmental standards focused by former researchers are usually quantitybased limits/standards(e.g.pounds pe...There are numerous studies comparing different kinds of environmental taxes and standards.However,forms of environmental standards focused by former researchers are usually quantitybased limits/standards(e.g.pounds per day or pounds per unit of output).Concentration-based emission standard(e.g.milligrams per liter of wastewater) as one important form of environmental standard has not been given much attention.In this article,comparable estimates of their probable effect on enterprise pollution reduction will be developed for concentrationbased effluent standards,effluent taxes,and a combination of both.A linear simulation model is used to clearly and obviously compare the effects of effluent taxes and concentration-based standards within the same figure.With one detailed application to the paper industry,some enlightenment and conclusions-as well as the general applicability of these principles-are then provided:Under the same effluent tax rate,enterprises,groups,and industries that are cleaner will reduce more pollutants than those that have higher pollutant abatement costs.It is recommended that effluent taxes are set by avoiding cutting it even at one stroke and considering the feasibility of pollution-reducing technology in various industries.It is necessary to reduce MAC of enterprises to better stimulate enterprises' or industries' emission reduction by preferential measures,such as high tax rate coordinated by speeding up the depreciation of environmental protection equipment.展开更多
Sucrose non-fermenting 1-related protein kinase 2(Sn RK2) is a plant-specific serine/threonine kinase involved in response to adverse environmental stimuli. Previous studies showed that Ta Sn RK2.4 was involved in res...Sucrose non-fermenting 1-related protein kinase 2(Sn RK2) is a plant-specific serine/threonine kinase involved in response to adverse environmental stimuli. Previous studies showed that Ta Sn RK2.4 was involved in response to abiotic stresses and conferred enhanced tolerance to multiple stresses in Arabidopsis. Further experiments were performed to decipher the underlying mechanisms and discover new functions. The genomic sequences of Ta Sn RK2.4 s locating on chromosome 3 A, 3 B and 3 D were obtained. Sequencing identified one and 13 variations of Ta Sn RK2.4-3 A and Ta Sn RK2.4-3 B, respectively, but no variation was detected in Ta Sn RK2.4-3 D. The markers 2.4 AM1, 2.4 BM1 and 2.4 BM2 were developed based on three variations. Association analysis showed that both Ta Sn RK2.4-3 A and Ta Sn RK2.4-3 B were significantly associated with thousand-kernel weight(TKW), and that SNP3 A-T and SNP3 B-C were favorable alleles for higher TKW. Yeast two-hybrid and split luciferase assays showed that Ta Sn RK2.4 physically interacted with abiotic stress responsive protein Ta LTP3, suggesting that Ta Sn RK2.4 enhanced abiotic stress tolerance by activating Ta LTP3. Our studies suggested that Ta Sn RK2.4 have potential in improving TKW and response to abiotic stress.展开更多
Directed capillary ingrowth has long been considered synonymous with tumor vascularization.However,the vasculature of primary tumors and metastases is not necessarily formed by endothelial cell sprouting;instead,malig...Directed capillary ingrowth has long been considered synonymous with tumor vascularization.However,the vasculature of primary tumors and metastases is not necessarily formed by endothelial cell sprouting;instead,malignant tumors can acquire blood vessels via alternative vascularization mechanisms,such as intussusceptive microvascular growth,vessel co-option,and glomeruloid angiogenesis.Importantly,in response to anti-angiogenic therapies,malignant tumors can switch from one vascularization mechanism to another.In this article,we briefly review the biological features of these mechanisms and discuss on their significance in medical oncology.展开更多
We obtain the boundedness on Fp^α,q(R^n)for the Poisson summation and Gauss summation. Their maximal operators are proved to be bounded from Fp^α,q(R^n)to L∞(R^n)For the maximal operator of the Bochner-Riesz ...We obtain the boundedness on Fp^α,q(R^n)for the Poisson summation and Gauss summation. Their maximal operators are proved to be bounded from Fp^α,q(R^n)to L∞(R^n)For the maximal operator of the Bochner-Riesz summation, we prove that it is bounded from Fp^α,q(R^n)to L n-pα/pn,(0〈p≤ 1)∞(R^n).展开更多
Tank-mix adjuvant has the potential to improve the weed control efficacy of post-emergence herbicides. In order to study the synergistic effect of adjuvant, the effects of different rates of fomesafen alone or applied...Tank-mix adjuvant has the potential to improve the weed control efficacy of post-emergence herbicides. In order to study the synergistic effect of adjuvant, the effects of different rates of fomesafen alone or applied methylated soybean oil adjuvant(MSO) were sprayed on redroot pigweed, abutilon and black nightshade under greenhouse condition. The results showed that fomesafen had different performance on the three weeds, and MSO adjuvant could effectively increase the control. The nightshade control was lower than other two weeds with all the fomesafen doses from 131.25 to 506.25 ga.i. · hm-2 with or without adjuvant. The control of abutilon was between the black nightshade and the redroot pigweed, and had better control at 375 ga.i. · hm-2 with adjuvant or 506.25 ga.i. · hm-2 alone or with adjuvant respectively. The results indicated that mixing adjuvant with fomesafen improved the control on weeds, especially at the low rate. Black nightshade was more difficult to control. The redroot pigweed had the most susceptibility to fomesafen alone or with adjuvant.展开更多
We investigate the effect of strategy-homogeneity on the prisoner’s dilemma game in a square lattice. Strategy-homogeneity means that the population contains at least one connected group in which individuals maintain...We investigate the effect of strategy-homogeneity on the prisoner’s dilemma game in a square lattice. Strategy-homogeneity means that the population contains at least one connected group in which individuals maintain the same strategy at each iteration and may update according to updating rule at next iteration. The simulation results show that the introduction of strategy-homogeneity increases the cooperation in the evolutionary stable state. For any value of temptation to defect, the density of cooperators in equilibrium state increases firstly and then decreases as the level of strategy-homogeneity increases constantly, and there exists an appropriate level of strategy-homogeneity, maximizing the density of cooperators. The results may be favorable for comprehending cooperative behaviors in societies composed of connected groups with coherent strategy.展开更多
Diffusion models, a family of generative models based on deep learning, have become increasinglyprominent in cutting-edge machine learning research. With distinguished performance in generating samples thatresemble th...Diffusion models, a family of generative models based on deep learning, have become increasinglyprominent in cutting-edge machine learning research. With distinguished performance in generating samples thatresemble the observed data, diffusion models are widely used in image, video, and text synthesis nowadays. Inrecent years, the concept of diffusion has been extended to time-series applications, and many powerful models havebeen developed. Considering the deficiency of a methodical summary and discourse on these models, we providethis survey as an elementary resource for new researchers in this area and to provide inspiration to motivate futureresearch. For better understanding, we include an introduction about the basics of diffusion models. Except forthis, we primarily focus on diffusion-based methods for time-series forecasting, imputation, and generation, andpresent them, separately, in three individual sections. We also compare different methods for the same applicationand highlight their connections if applicable. Finally, we conclude with the common limitation of diffusion-basedmethods and highlight potential future research directions.展开更多
Parkinson's disease(PD)is the second most prevalent neurodegenerative disorder globally,significantly affecting the quality of life of affected individuals.Systemic drug delivery to the brain is inefficient becaus...Parkinson's disease(PD)is the second most prevalent neurodegenerative disorder globally,significantly affecting the quality of life of affected individuals.Systemic drug delivery to the brain is inefficient because of first-pass metabolism,the blood-brain barrier(BBB),and the blood-cerebrospinal fluid barrier.This inefficiency necessitates increased dosage as the disease progresses,leading to severe side effects that compromise the efficacy of the medication.Nose-to-brain(N2B)administration bypasses the BBB,allowing delivery of both small molecules and large protein substances to the central nervous system.Compared with systemic administration,this method enhances brain bioavailability,reduces enzymatic degradation,and minimizes systemic adverse reactions.However,the N2B delivery system is associated with several critical challenges,including mucociliary clearance,enzymatic degradation,and drug translocation via efflux mechanisms.This paper provides a comprehensive overview of the current research progress in intranasal treatment of PD,considering both preclinical and clinical studies,and discusses the physiological aspects and limitations of its delivery system.展开更多
Several derivatives have been synthesized from chrysin, diosmetin, apigenin, and luteolin, which were isolated from diverse natural plants. The α-glucosidase inhibitory activity of these compounds was evaluated. The ...Several derivatives have been synthesized from chrysin, diosmetin, apigenin, and luteolin, which were isolated from diverse natural plants. The α-glucosidase inhibitory activity of these compounds was evaluated. The glucosidase inhibitory activity of all derivatives (IC50 〈 24.396 μmol]L) was higher compared with that of the reference drug, acarbose (IC50=563.601 ±40.492μmol/L), and 1- deoxynojirimycin (IC50 = 226.912± 12.573 μmol/L). O3',O7-Hexyl diosmetin (IC50 = 2.406 ± 0.101μmol/L) was the most potent inhibitor identified. These compounds showed a higher inhibitory ability compared with their precursors except the luteolin derivatives. In general, the inhibitory activity of the synthetic derivatives was enhanced with long alkyl chains at positions 3', 4' and 7 of the flavonoid.展开更多
This article presents the results of a numerical simulation on the vortex induced vibration of various fumed cylinders at low Reynolds number. The non-dimensional, incompressible Navier-Stokes equations and continuity...This article presents the results of a numerical simulation on the vortex induced vibration of various fumed cylinders at low Reynolds number. The non-dimensional, incompressible Navier-Stokes equations and continuity equation were adopted to simulate the fluid around the cylinder. The cylinder (with or without fins) in fluid flow was approximated as a mass-spring system. The fluid-body interaction of the cylinder with fins and uniform flow was numerically simulated by applying the displacement and stress iterative computation on the fluid-body interfaces. Both vortex structures and response amplitudes of cylinders with various arrangements of fins were analyzed and discussed. The remarkable decrease of response amplitude for the additions of Triangle60 fins and Quadrangle45 fins was found to be comparable with that of bare cylinder. However, the additions of Triangle00 fins and Quadrangle00 fins enhance the response amplitude greatly. Despite the assumption of two-dimensional laminar flow, the present study can give a good insight into the phenomena of cylinders with various arrangements of fins.展开更多
Water regime and nitrogen(N) fertilizer are two important factors impacting greenhouse gases(GHG) emission from paddy field, whereas their effects have not been well studied in cold region. In this study, we condu...Water regime and nitrogen(N) fertilizer are two important factors impacting greenhouse gases(GHG) emission from paddy field, whereas their effects have not been well studied in cold region. In this study, we conducted a two-year field experiment to study the impacts of water regime and N fertilizer on rice yields and GHG emissions in Harbin, China, a cold region located in high latitudes. Our results showed that intermittent irrigation significantly decreased methane(CH4) emission compared with continuous flooding, however,the decrement was far lower than the global average level. The N2O emissions were very small when flooded but peaked at the beginning of the disappearance of floodwater. The N fertilizer treatments increased CH4 emissions at low level(75 kg N/ha). But both CH4 and N2O emissions were uninfluenced at the levels of 150 kg N/ha and 225 kg N/ha. Rice yields increased under intermittent irrigation and were highest at the level of 150 kg N/ha. From our results, we recommended that the intermittent irrigation and 150 kg N/ha as the ideal water regime-nitrogen fertilizer incorporation for this area to achieve low GHG emissions without impacting rice yields.展开更多
This paper aims to investigate the geodesic motion in the spacetime of a non-linear magnetic charged black hole surrounded by quintessence. By varying the Lagrangian corresponding to the metric, the orbital motion equ...This paper aims to investigate the geodesic motion in the spacetime of a non-linear magnetic charged black hole surrounded by quintessence. By varying the Lagrangian corresponding to the metric, the orbital motion equation has been obtained. The effects of the magnetic charge Q, positive normalization factor C, angular momentum b, and energy E on time-like and null geodesic motion are discussed from three aspects: orbital stability, orbital types, and circular orbits. By comparing the effects of the above parameters C, b on the effective potential, it is found that quintessence has an impact on the types and stability of orbits. In addition, for time-like orbital motion, when 3.443113 ≤ b ≤ 6.392 578(for fixed C = 0.0002, M = 1, Q = 0.7), there are bound orbits, and within this range, the stable circular orbits exist,and the radii of the innermost and outermost stable circular orbit are r = 5.912 654 and r = 56.745 933, respectively. For null orbital motion, the orbital types have only unstable circular orbit which occur at r = 2.951 072(E2= E22= 0.4),absorb orbits and escape orbits, but no stable circular orbits, and bound orbits.展开更多
Objective To investigate the structures of compounds in the rhizome of Cynanchum otophyllum(Asclepiadaceae), and to find new C21 steroidal glycosides. Methods The ethyl acetate extract from the rhizome was subjected...Objective To investigate the structures of compounds in the rhizome of Cynanchum otophyllum(Asclepiadaceae), and to find new C21 steroidal glycosides. Methods The ethyl acetate extract from the rhizome was subjected to acidic hydrolysis and isolated by column chromatography; The structures of the purified compounds were determined by spectral methods. Literature search confirmed whether those compounds were of new structures. Results Three compounds were isolated and their structures were deacetylmetaplexigenin 3-O-β-D-oleandropyranosyl-(1→4)-α-D-oleandropyranosyl-(1→4)-α-D-oleandropyranoside(1), deacetylmetaplexigenin 3-O-α-D-oleandropyranosyl-(1→4)-β-D-thevetopyranosyl-(1→4)-α-D-oleandropyranoside(2), and deacetylmeta-plexigenin 3-O-β-D-cymaropyranosyl-(1→4)-α-D-oleandropyranoside(3), respectively. Conclusion Compounds 1-3 are new compounds.展开更多
The dispute settlement mechanism(DSM) has long been the focus of attention because of its significant role in the institutional construction of China's free trade agreements(FTAs). Thus, this paper is to make an a...The dispute settlement mechanism(DSM) has long been the focus of attention because of its significant role in the institutional construction of China's free trade agreements(FTAs). Thus, this paper is to make an analysis of the DSMs of China's established FTAs from a legal perspective of international regime study, which leads to the finding of a co-existence mode of formal and informal DSMs in China's FTAs. This paper also discusses the motivation and significance of such a choice.展开更多
基金Study on Green Development in Agriculture and Rural Areas to Enable the Building of a Low-Carbon Society (LD23YB02)funded by the 2023 Chengdu Green and Low-Carbon Development Research Base Project.
文摘This paper examined the relationship between cultural consumption and the floating population’s integration into host cities based on data from China’s Seventh National Population Census and the 2018 China Migrants Dynamic Survey(CMDS).The findings indicate that improving the floating population’s consumption level and quality,especially the quality of development-oriented cultural consumption,can significantly improve the level of their integration.Moreover,development-oriented cultural consumption has a positive effect on the floating population’s integration and social participation,while entertainment-oriented cultural consumption facilitates their integration mainly by improving their sense of well-being.These findings could guide policymakers in developing targeted cultural consumption policies,implementing specific regional industry adjustments,and expanding domestic consumption demand.
基金This work was financially supported by the National Natural Sciences Foundation of China (No. 50271024) and the Natu-ral Science Foundation of Hebei Province, China (No.501013).
文摘Sm2Fe17-xNbx (x = 0-4) powder was synthesized by HDDR treatment and nitrogenation. The effects of partial Nb substitution for Fe on the structural and magnetic properties of Sm2Fe17-xNbx alloys and their nitlides were investigated. It was seen that Sm2(Fe,Nb)17 phase exists in both annealed and HDDR-treated Sm2Fe17-xNbx alloys. However, its content is decreased with the increase in Nb substitution. In annealed alloys, Sm2(Fe,Nb)17 phase becomes unstable and will dissociate into SmFe2 and Fe-rich phases when x 〉 1.5. With HDDR-treatment, the Nb concentration in recombined Sm2(Fe,Nb)17 phase is decreased, and the content of Fe-rich phases is increased. Sm2Fe17-xNbx powder exhibits dendritic cracks and fine particles with a size of less than 300 nm. In nitrogenated alloys, N atoms mainly enter 2:17-type phase to form Sm2(Fe,Nb)17Ny. Partial Nb atoms in Sm2(Fe,Nb)17Ny phase will be released or excluded by nitrogen atoms. Fe-rich phases increase, and are followed by the amorphous Sm2(Fe,Nb)17Ny phase. Nb substitution for Fe with x = 0.5 and 1.0 in Sm2Fe17-xNbxNy powders increases the coercivity and remanence. But when x is greater than 2.0, Nb substitution will deteriorate the magnetic properties.
基金supported by Beijing Natural Science Foundation(9154036)"Water Pollution Control Strategy and Decision Support Platform"[grant No.2009ZX07631-02-03]"Water Pollution Accident Damage Assessment Technology Research[grant No.201309060]"
文摘There are numerous studies comparing different kinds of environmental taxes and standards.However,forms of environmental standards focused by former researchers are usually quantitybased limits/standards(e.g.pounds per day or pounds per unit of output).Concentration-based emission standard(e.g.milligrams per liter of wastewater) as one important form of environmental standard has not been given much attention.In this article,comparable estimates of their probable effect on enterprise pollution reduction will be developed for concentrationbased effluent standards,effluent taxes,and a combination of both.A linear simulation model is used to clearly and obviously compare the effects of effluent taxes and concentration-based standards within the same figure.With one detailed application to the paper industry,some enlightenment and conclusions-as well as the general applicability of these principles-are then provided:Under the same effluent tax rate,enterprises,groups,and industries that are cleaner will reduce more pollutants than those that have higher pollutant abatement costs.It is recommended that effluent taxes are set by avoiding cutting it even at one stroke and considering the feasibility of pollution-reducing technology in various industries.It is necessary to reduce MAC of enterprises to better stimulate enterprises' or industries' emission reduction by preferential measures,such as high tax rate coordinated by speeding up the depreciation of environmental protection equipment.
基金supported by the National Key Research and Development Program of China (2017YFD0300202)the National Natural Science Foundation of China (31571660)+1 种基金the Heilongjiang Postdoctoral Financial Assistance, China (LBH-Z17200)the Research Project of Heilongjiang Academy of Agricultural Sciences, China (2018YYYF018)。
文摘Sucrose non-fermenting 1-related protein kinase 2(Sn RK2) is a plant-specific serine/threonine kinase involved in response to adverse environmental stimuli. Previous studies showed that Ta Sn RK2.4 was involved in response to abiotic stresses and conferred enhanced tolerance to multiple stresses in Arabidopsis. Further experiments were performed to decipher the underlying mechanisms and discover new functions. The genomic sequences of Ta Sn RK2.4 s locating on chromosome 3 A, 3 B and 3 D were obtained. Sequencing identified one and 13 variations of Ta Sn RK2.4-3 A and Ta Sn RK2.4-3 B, respectively, but no variation was detected in Ta Sn RK2.4-3 D. The markers 2.4 AM1, 2.4 BM1 and 2.4 BM2 were developed based on three variations. Association analysis showed that both Ta Sn RK2.4-3 A and Ta Sn RK2.4-3 B were significantly associated with thousand-kernel weight(TKW), and that SNP3 A-T and SNP3 B-C were favorable alleles for higher TKW. Yeast two-hybrid and split luciferase assays showed that Ta Sn RK2.4 physically interacted with abiotic stress responsive protein Ta LTP3, suggesting that Ta Sn RK2.4 enhanced abiotic stress tolerance by activating Ta LTP3. Our studies suggested that Ta Sn RK2.4 have potential in improving TKW and response to abiotic stress.
基金supported by the Grants from KTIA AIK 12-1-2013-0041Semmelweis University Start-Up Grant 40148-11658+3 种基金OTKA K109626,OTKA SNN1 14490,OTKA K100931,OTKA PD109201,EUREKA_HU_12-1-2012-0057TAMOP 4.2.4.A/1-11-1-2012-0001ONB Jubilaumsfondsprojekt Nr.14043 and Nr.14574the Vienna Fund for Innovative Interdisciplinary Cancer Research
文摘Directed capillary ingrowth has long been considered synonymous with tumor vascularization.However,the vasculature of primary tumors and metastases is not necessarily formed by endothelial cell sprouting;instead,malignant tumors can acquire blood vessels via alternative vascularization mechanisms,such as intussusceptive microvascular growth,vessel co-option,and glomeruloid angiogenesis.Importantly,in response to anti-angiogenic therapies,malignant tumors can switch from one vascularization mechanism to another.In this article,we briefly review the biological features of these mechanisms and discuss on their significance in medical oncology.
基金Supported by the Zhejiang Postdoctoral Science Foundation of China(BSH1302046)the National Natural Science Foundation of China(11271330)the Zhejiang Natural Science Foundation of China(Y604563)
文摘We obtain the boundedness on Fp^α,q(R^n)for the Poisson summation and Gauss summation. Their maximal operators are proved to be bounded from Fp^α,q(R^n)to L∞(R^n)For the maximal operator of the Bochner-Riesz summation, we prove that it is bounded from Fp^α,q(R^n)to L n-pα/pn,(0〈p≤ 1)∞(R^n).
基金Supported by the Postdoctoral Grant of Heilongjiang Academy of Agricultural Sciences(LRB10-2446)the Doctoral Foundation of Northeast Agricultural University(2010RCB16)the Science and Technology Project of Heilongjiang Education Committee(12521034)
文摘Tank-mix adjuvant has the potential to improve the weed control efficacy of post-emergence herbicides. In order to study the synergistic effect of adjuvant, the effects of different rates of fomesafen alone or applied methylated soybean oil adjuvant(MSO) were sprayed on redroot pigweed, abutilon and black nightshade under greenhouse condition. The results showed that fomesafen had different performance on the three weeds, and MSO adjuvant could effectively increase the control. The nightshade control was lower than other two weeds with all the fomesafen doses from 131.25 to 506.25 ga.i. · hm-2 with or without adjuvant. The control of abutilon was between the black nightshade and the redroot pigweed, and had better control at 375 ga.i. · hm-2 with adjuvant or 506.25 ga.i. · hm-2 alone or with adjuvant respectively. The results indicated that mixing adjuvant with fomesafen improved the control on weeds, especially at the low rate. Black nightshade was more difficult to control. The redroot pigweed had the most susceptibility to fomesafen alone or with adjuvant.
文摘We investigate the effect of strategy-homogeneity on the prisoner’s dilemma game in a square lattice. Strategy-homogeneity means that the population contains at least one connected group in which individuals maintain the same strategy at each iteration and may update according to updating rule at next iteration. The simulation results show that the introduction of strategy-homogeneity increases the cooperation in the evolutionary stable state. For any value of temptation to defect, the density of cooperators in equilibrium state increases firstly and then decreases as the level of strategy-homogeneity increases constantly, and there exists an appropriate level of strategy-homogeneity, maximizing the density of cooperators. The results may be favorable for comprehending cooperative behaviors in societies composed of connected groups with coherent strategy.
文摘Diffusion models, a family of generative models based on deep learning, have become increasinglyprominent in cutting-edge machine learning research. With distinguished performance in generating samples thatresemble the observed data, diffusion models are widely used in image, video, and text synthesis nowadays. Inrecent years, the concept of diffusion has been extended to time-series applications, and many powerful models havebeen developed. Considering the deficiency of a methodical summary and discourse on these models, we providethis survey as an elementary resource for new researchers in this area and to provide inspiration to motivate futureresearch. For better understanding, we include an introduction about the basics of diffusion models. Except forthis, we primarily focus on diffusion-based methods for time-series forecasting, imputation, and generation, andpresent them, separately, in three individual sections. We also compare different methods for the same applicationand highlight their connections if applicable. Finally, we conclude with the common limitation of diffusion-basedmethods and highlight potential future research directions.
基金National Natural Science Foundation of China,Grant/AwardNumber:82371119。
文摘Parkinson's disease(PD)is the second most prevalent neurodegenerative disorder globally,significantly affecting the quality of life of affected individuals.Systemic drug delivery to the brain is inefficient because of first-pass metabolism,the blood-brain barrier(BBB),and the blood-cerebrospinal fluid barrier.This inefficiency necessitates increased dosage as the disease progresses,leading to severe side effects that compromise the efficacy of the medication.Nose-to-brain(N2B)administration bypasses the BBB,allowing delivery of both small molecules and large protein substances to the central nervous system.Compared with systemic administration,this method enhances brain bioavailability,reduces enzymatic degradation,and minimizes systemic adverse reactions.However,the N2B delivery system is associated with several critical challenges,including mucociliary clearance,enzymatic degradation,and drug translocation via efflux mechanisms.This paper provides a comprehensive overview of the current research progress in intranasal treatment of PD,considering both preclinical and clinical studies,and discusses the physiological aspects and limitations of its delivery system.
基金supported by the National Natural Science Foundation of China(22108196 and 21978201)the National College Student Innovation and Entrepreneurship Training Program(202110056036)。
基金supported by the Research Fund for the Doctoral Program of Higher Education of China(No.20114301120004)Hunan Provincial Natural Science Foundation of China(No.12JJ6081)+1 种基金Dr.’s Start-up Foundation of Xiangtan University(No.06KZjKZ08035)Natural Science Foundation of Xiangtan University(No.2011XZX09)
文摘Several derivatives have been synthesized from chrysin, diosmetin, apigenin, and luteolin, which were isolated from diverse natural plants. The α-glucosidase inhibitory activity of these compounds was evaluated. The glucosidase inhibitory activity of all derivatives (IC50 〈 24.396 μmol]L) was higher compared with that of the reference drug, acarbose (IC50=563.601 ±40.492μmol/L), and 1- deoxynojirimycin (IC50 = 226.912± 12.573 μmol/L). O3',O7-Hexyl diosmetin (IC50 = 2.406 ± 0.101μmol/L) was the most potent inhibitor identified. These compounds showed a higher inhibitory ability compared with their precursors except the luteolin derivatives. In general, the inhibitory activity of the synthetic derivatives was enhanced with long alkyl chains at positions 3', 4' and 7 of the flavonoid.
基金supported by the key program of the National Natural Science foundation of China (Grant No. 50439010)the Main Program of the Ministry of Education of China (Grant No. 305003)
文摘This article presents the results of a numerical simulation on the vortex induced vibration of various fumed cylinders at low Reynolds number. The non-dimensional, incompressible Navier-Stokes equations and continuity equation were adopted to simulate the fluid around the cylinder. The cylinder (with or without fins) in fluid flow was approximated as a mass-spring system. The fluid-body interaction of the cylinder with fins and uniform flow was numerically simulated by applying the displacement and stress iterative computation on the fluid-body interfaces. Both vortex structures and response amplitudes of cylinders with various arrangements of fins were analyzed and discussed. The remarkable decrease of response amplitude for the additions of Triangle60 fins and Quadrangle45 fins was found to be comparable with that of bare cylinder. However, the additions of Triangle00 fins and Quadrangle00 fins enhance the response amplitude greatly. Despite the assumption of two-dimensional laminar flow, the present study can give a good insight into the phenomena of cylinders with various arrangements of fins.
基金supported by the China Postdoctoral Science Foundation(No.2012M511005)National Key Technology Support Program of China(No.2015BAC02B02)+6 种基金the Agro-scientific Research Programs in Public Interest(No.201303102)National Natural Science Foundation of China(No.31501263)the Postdoctoral Financial Assistance of Heilongjiang Province(No.LBH-Z12232)the Scientific Research Initiation Fund for Introduction of Ph.D Talent of Heilongjiang Academy of Agricultural Sciences(No.201507-14)the State Key Program of China(No.2016YFD0300900)the Major Project of Research and Development of Applied Technology of Heilongjiang Province(No.GA15B101)the Provincial Matching Funds to the National Foundation of Applied Technology Research and Development Program in Heilongjiang Province(No.GX16B002)
文摘Water regime and nitrogen(N) fertilizer are two important factors impacting greenhouse gases(GHG) emission from paddy field, whereas their effects have not been well studied in cold region. In this study, we conducted a two-year field experiment to study the impacts of water regime and N fertilizer on rice yields and GHG emissions in Harbin, China, a cold region located in high latitudes. Our results showed that intermittent irrigation significantly decreased methane(CH4) emission compared with continuous flooding, however,the decrement was far lower than the global average level. The N2O emissions were very small when flooded but peaked at the beginning of the disappearance of floodwater. The N fertilizer treatments increased CH4 emissions at low level(75 kg N/ha). But both CH4 and N2O emissions were uninfluenced at the levels of 150 kg N/ha and 225 kg N/ha. Rice yields increased under intermittent irrigation and were highest at the level of 150 kg N/ha. From our results, we recommended that the intermittent irrigation and 150 kg N/ha as the ideal water regime-nitrogen fertilizer incorporation for this area to achieve low GHG emissions without impacting rice yields.
基金Supported partly by the National Natural Science Foundation of China under Grant No.11565016the Special Training Program for Distinguished Young Teachers of the Higher Education Institutions of Yunnan Province under Grant No.1096837802the Applied Basic Research Programs of Yunnan Provincial Science and Technology Department under Grant No.2016FB008
文摘This paper aims to investigate the geodesic motion in the spacetime of a non-linear magnetic charged black hole surrounded by quintessence. By varying the Lagrangian corresponding to the metric, the orbital motion equation has been obtained. The effects of the magnetic charge Q, positive normalization factor C, angular momentum b, and energy E on time-like and null geodesic motion are discussed from three aspects: orbital stability, orbital types, and circular orbits. By comparing the effects of the above parameters C, b on the effective potential, it is found that quintessence has an impact on the types and stability of orbits. In addition, for time-like orbital motion, when 3.443113 ≤ b ≤ 6.392 578(for fixed C = 0.0002, M = 1, Q = 0.7), there are bound orbits, and within this range, the stable circular orbits exist,and the radii of the innermost and outermost stable circular orbit are r = 5.912 654 and r = 56.745 933, respectively. For null orbital motion, the orbital types have only unstable circular orbit which occur at r = 2.951 072(E2= E22= 0.4),absorb orbits and escape orbits, but no stable circular orbits, and bound orbits.
基金National Natural Science Foundation of China (30572322)Natural Science Foundation of Yunnan Province (2005C0036Q)
文摘Objective To investigate the structures of compounds in the rhizome of Cynanchum otophyllum(Asclepiadaceae), and to find new C21 steroidal glycosides. Methods The ethyl acetate extract from the rhizome was subjected to acidic hydrolysis and isolated by column chromatography; The structures of the purified compounds were determined by spectral methods. Literature search confirmed whether those compounds were of new structures. Results Three compounds were isolated and their structures were deacetylmetaplexigenin 3-O-β-D-oleandropyranosyl-(1→4)-α-D-oleandropyranosyl-(1→4)-α-D-oleandropyranoside(1), deacetylmetaplexigenin 3-O-α-D-oleandropyranosyl-(1→4)-β-D-thevetopyranosyl-(1→4)-α-D-oleandropyranoside(2), and deacetylmeta-plexigenin 3-O-β-D-cymaropyranosyl-(1→4)-α-D-oleandropyranoside(3), respectively. Conclusion Compounds 1-3 are new compounds.
基金the Chinese Education Ministry Key Research Program(No.14JJD810017)the China Postdoctoral Science Foundation(No.2015M581553)
文摘The dispute settlement mechanism(DSM) has long been the focus of attention because of its significant role in the institutional construction of China's free trade agreements(FTAs). Thus, this paper is to make an analysis of the DSMs of China's established FTAs from a legal perspective of international regime study, which leads to the finding of a co-existence mode of formal and informal DSMs in China's FTAs. This paper also discusses the motivation and significance of such a choice.