Objective To investigate the structures of compounds in the rhizome of Cynanchum otophyllum（Asclepiadaceae）, and to find new C21 steroidal glycosides. Methods The ethyl acetate extract from the rhizome was subjected...Objective To investigate the structures of compounds in the rhizome of Cynanchum otophyllum（Asclepiadaceae）, and to find new C21 steroidal glycosides. Methods The ethyl acetate extract from the rhizome was subjected to acidic hydrolysis and isolated by column chromatography; The structures of the purified compounds were determined by spectral methods. Literature search confirmed whether those compounds were of new structures. Results Three compounds were isolated and their structures were deacetylmetaplexigenin 3-O-β-D-oleandropyranosyl-（1→4）-α-D-oleandropyranosyl-（1→4）-α-D-oleandropyranoside（1）, deacetylmetaplexigenin 3-O-α-D-oleandropyranosyl-（1→4）-β-D-thevetopyranosyl-（1→4）-α-D-oleandropyranoside（2）, and deacetylmeta-plexigenin 3-O-β-D-cymaropyranosyl-（1→4）-α-D-oleandropyranoside（3）, respectively. Conclusion Compounds 1-3 are new compounds.展开更多
基金National Natural Science Foundation of China (30572322)Natural Science Foundation of Yunnan Province (2005C0036Q)
文摘Objective To investigate the structures of compounds in the rhizome of Cynanchum otophyllum（Asclepiadaceae）, and to find new C21 steroidal glycosides. Methods The ethyl acetate extract from the rhizome was subjected to acidic hydrolysis and isolated by column chromatography; The structures of the purified compounds were determined by spectral methods. Literature search confirmed whether those compounds were of new structures. Results Three compounds were isolated and their structures were deacetylmetaplexigenin 3-O-β-D-oleandropyranosyl-（1→4）-α-D-oleandropyranosyl-（1→4）-α-D-oleandropyranoside（1）, deacetylmetaplexigenin 3-O-α-D-oleandropyranosyl-（1→4）-β-D-thevetopyranosyl-（1→4）-α-D-oleandropyranoside（2）, and deacetylmeta-plexigenin 3-O-β-D-cymaropyranosyl-（1→4）-α-D-oleandropyranoside（3）, respectively. Conclusion Compounds 1-3 are new compounds.
