The traceability system can effectively reduce the food safety risks, however, it is confronted with various problems during its implementation. In this context, the paper carries out a case study of consumers in Weif...The traceability system can effectively reduce the food safety risks, however, it is confronted with various problems during its implementation. In this context, the paper carries out a case study of consumers in Weifang, Shandong Province, and studies their willingness to pay the traceable pork with different quality information. The results indicate that, the consumers show high expectations towards the introduction of traceability system, and they tend to buy the traceable pork only with breeding and slaughter information; their behaviors of purchase are greatly influenced by the following factors: the consumers education, age, income, attention on food safety and whether there are pregnant family members, etc..展开更多
Long-term kinematic research of slowmoving debris slide is rare despite of the widespread global distribution of this kind. This paper presents a study of the kinematics and mechanism of the Jinpingzi debris slide loc...Long-term kinematic research of slowmoving debris slide is rare despite of the widespread global distribution of this kind. This paper presents a study of the kinematics and mechanism of the Jinpingzi debris slide located on the Jinsha river bank in southwest China. This debris slide is known to have a volume of 27×106 m3 in active state for at least one century. Field survey and geotechnical investigation were carried out to define the structure of the landslide. The physical and mechanical properties of the landslide materials were obtained by in-situ and laboratory tests. Additionally, surface and subsurface displacements, as well as groundwater level fluctuations, were monitored since 2005. Movement features, especially the response of the landslide movement to rainfall, were analysed. Relationships between resisting forces and driving forces were analysed by using the limit equilibrium method assuming rigid-plastic frictional slip. The results confirmed a viscous component in the long-termcontinuous movement resulting in the quasioverconsolidated state of the slip zone with higher strength parameters than some other types of slowmoving landslides. Both surface and subsurface displacements showed an advancing pattern by the straight outwardly inclined(rather than gently or reversely inclined) slip zone, which resulted in low resistance to the entire sliding mass. The average surface displacement rate from 2005 to 2016 was estimated to be 0.19~0.87 mm/d. Basal sliding on the silty clay seam accounted for most of the deformation with different degrees of internal deformation in different parts. Rainfall was the predominant factor affecting the kinematics of Jinpingzi landslide while the role of groundwater level, though positive, was not significant. The response of the groundwater level to rainfall infiltration was not apparent. Unlike some shallow slow-moving earth flows or mudslides, whose behaviors are directly related to the phreatic groundwater level, the mechanism for Jinpingzi landslide kinematics is more likely related to the changing weight of the sliding mass and thedownslope seepage pressure in the shallow soil mass resulting from rainfall events.展开更多
The loading on U-steel yieldable support cannot be organically combined withthe law of strata behaviors from the surrounding rocks of roadway. In order to effectivelysolve the problem, U-steel yieldable support with b...The loading on U-steel yieldable support cannot be organically combined withthe law of strata behaviors from the surrounding rocks of roadway. In order to effectivelysolve the problem, U-steel yieldable support with backfill material and the performancerequirements of backfill material were analyzed on the basis of structural mechanics. Themechanical properties of backfill material selected were tested in the laboratory, and thetest results show that the ratio of the backfill material complies with the requirements ofbackfill technology; it can effectively optimize the relationship between the support and thesurrounding rock, and the filling layer can avoid the partial stress concentration and fullyimprove the support performance. Compared with U-steel yieldable support with ganguefilling, the filed application shows that the supporting result of U-steel yieldable supportwith backfill technology is satisfactory, the stress on U-steel yieldable support with backfilltechnology decreases greatly and distributes uniformly, convergence of the surroundingrock of roadway is decreased by more than 50%, and the surrounding rocks of roadwayare controlled effectively.展开更多
As the agricultural heritage,Hani terrace is not only culturally authentic and non- renew able,but has its ow n characteristics. Firstly,it is a kind of economic and social mode of production. Secondly,it reflects the...As the agricultural heritage,Hani terrace is not only culturally authentic and non- renew able,but has its ow n characteristics. Firstly,it is a kind of economic and social mode of production. Secondly,it reflects the idea of harmonious and sustainable development betw een human beings and nature. T hirdly,the participation of human beings — or farmers is important. As a result,to exploit and protect the agricultural heritage,it is crucial to balance systematic protection and sustainable development in order to realize dynamic protection. In addition,the agricultural heritage shall be treated as the driving agent to coordinate the social and economic development. T hrough analyzing the characteristics of the agricultural heritage and the concept of protecting the agricultural heritage,this paper proposes to promote the protection of agricultural authenticity by alternative tourism development in order to balance the development and realize the sustainability of the agricultural dynamic system.展开更多
Objective:Using network pharmacology to explore the target and mechanism of Chuanxiong Rhizoma and Acori Tatarinowii Rhizoma in the treatment of vascular dementia(VaD),so as to provide a reference for treating VaD thr...Objective:Using network pharmacology to explore the target and mechanism of Chuanxiong Rhizoma and Acori Tatarinowii Rhizoma in the treatment of vascular dementia(VaD),so as to provide a reference for treating VaD through them.Methods:Traditional Chinese medicine systems pharmacology database and analysis platform were used to screen the main active ingredients and targets of Chuanxiong Rhizoma and Acori Tatarinowii Rhizoma.By means of Gene Cards and Online Mendelian Inheritance in Man(OMIM),targets of VaD were collected.The intersecting targets were obtained by using the Venn map.The String online database was used to build a protein-protein interactions Network and the Metascape database was used to perform GO function enrichment analysis and KEGG pathway enrichment analysis.A“drug-ingredient-target-pathway”network was constructed by Cytoscape software.Autodock vina software was used to conduct molecular docking between targets.Results:A total of 7 active ingredients in Chuanxiong Rhizoma and 4 active ingredients in Acori Tatarinowii Rhizoma were screened.There were 42 active targets of Chuanxiong Rhizoma and 70 active targets of Acori Tatarinowii Rhizoma and 1152 disease targets.After deleting the repeat value,51 drugs targets were obtained.After the intersection,with a total of 25 targets.According to GO and KEGG enrichment analysis,the main biological processes involved include cellular response to lipid,negative regulation of apoptotic signaling pathway,blood circulation,response to a steroid hormone,etc.The main pathways include pathways in cancer,PI3K-Akt signaling pathway,and AGE-RAGE signaling pathway in diabetic complications,etc.Molecular docking showed that the most active docking combinations were AKT1 and Perlolyrine,RELA and FA,MAPK14 and FA,respectively.Conclusion:Chuanxiong Rhizoma and Acori Tatarinowii Rhizoma play an important role in the treatment of VaD mainly by anti-inflammatory and anti-apoptosis.展开更多
The diagnosis of COVID-19 requires chest computed tomography(CT).High-resolution CT images can provide more diagnostic information to help doctors better diagnose the disease,so it is of clinical importance to study s...The diagnosis of COVID-19 requires chest computed tomography(CT).High-resolution CT images can provide more diagnostic information to help doctors better diagnose the disease,so it is of clinical importance to study super-resolution(SR)algorithms applied to CT images to improve the reso-lution of CT images.However,most of the existing SR algorithms are studied based on natural images,which are not suitable for medical images;and most of these algorithms improve the reconstruction quality by increasing the network depth,which is not suitable for machines with limited resources.To alleviate these issues,we propose a residual feature attentional fusion network for lightweight chest CT image super-resolution(RFAFN).Specifically,we design a contextual feature extraction block(CFEB)that can extract CT image features more efficiently and accurately than ordinary residual blocks.In addition,we propose a feature-weighted cascading strategy(FWCS)based on attentional feature fusion blocks(AFFB)to utilize the high-frequency detail information extracted by CFEB as much as possible via selectively fusing adjacent level feature information.Finally,we suggest a global hierarchical feature fusion strategy(GHFFS),which can utilize the hierarchical features more effectively than dense concatenation by progressively aggregating the feature information at various levels.Numerous experiments show that our method performs better than most of the state-of-the-art(SOTA)methods on the COVID-19 chest CT dataset.In detail,the peak signal-to-noise ratio(PSNR)is 0.11 dB and 0.47 dB higher on CTtest1 and CTtest2 at×3 SR compared to the suboptimal method,but the number of parameters and multi-adds are reduced by 22K and 0.43G,respectively.Our method can better recover chest CT image quality with fewer computational resources and effectively assist in COVID-19.展开更多
Our previous study found that large-leaf yellow tea(LYT)had interesting hypoglycemic activity in high-fat diet-induced obese mice and highly safety in healthy mice. To study the anti-diabetic potential of LYT, the pre...Our previous study found that large-leaf yellow tea(LYT)had interesting hypoglycemic activity in high-fat diet-induced obese mice and highly safety in healthy mice. To study the anti-diabetic potential of LYT, the present study further investigated the preventive effects and mechanisms of action of LYT administration on diabetes and diabetic nephropathy in high-fat diet plus streptozotocin-induced diabetic mice. Results showed that LYT infusions(1/100 and 1/50, m/V)as drinking fluid for 4 weeks reduced diabetic polydipsia and polyuria, enhanced glucose tolerance and insulin sensitivity, and lowered fasting blood glucose level. The underlying mechanisms involve downregulation of gluconeogenesis(lower protein levels of TXNIP and FBP and enzyme activity of FBP), upregulation of lipid catabolism(higher protein levels of CPT-1α and PPARα), downregulation of lipogenesis(lower protein level of SREBP-1), and modification of the structure and abundance of gut microbiota to modulate metabolic homeostasis. Moreover, LYT administration prevented diabetic nephropathy, possibly due to reduced glucose-caused osmotic diuresis and lowered levels of renal PKC-β2, NLRP3 as well as membrane PKC-α, AQP2 and glycosylated AQP2 proteins. Taken together, LYT exhibits the activities in alleviating diabetic symptoms, ameliorating glucose and lipid dysmetabolism and fatty liver, and preventing diabetic nephropathy in diabetic mice. These activities may be explored for the prevention and treatment of diabetes in humans.展开更多
Background:Chinese medicine is widely applied in Asian and Western countries for its outstanding therapeutic effect,but there are still unsolved problems such as unclear active ingredients and pharmacological effects....Background:Chinese medicine is widely applied in Asian and Western countries for its outstanding therapeutic effect,but there are still unsolved problems such as unclear active ingredients and pharmacological effects.The application of nano/microparticle technology in Chinese medicine may become a promising strategy to solve this problem in the near future(provided that more efforts are made to in-depth exploration).In this work,a comprehensive analysis of the field was carried out from a bibliometrics perspective,and further the publishing trends and research hotspots were figured out.Methods:The articles or reviews from 2000 to 2020 were retrieved in the database of Web of Science Core Collection.The documents were processed by Clarivate Analytic,Visualization of Similarities viewer,Statistical Analysis Toolkit for Informetrics and bibliometric online platform,and the data were visualized.Finally,a bibliometric summary,citation analysis results and research trends were described.Results:A bibliometric analysis of 773 articles of interest showed that research in this field had continued to grow in recent years,with a high degree of interdisciplinary integration.Secondly,this field attached great importance to the quantitative analysis of Chinese medicine combined with nano/micro particle technology.Chinese medicine,nanoparticles and liposomes were the most accessed keywords.China was the main contributing country,and the top-10 contributing organizations were all located in China.Co-authorship was a common phenomenon in this field.Conclusion:The published literature on the application of nano/micro particle technology in Chinese medicine was summarized.The results suggested that bibliometric analysis could predict possible directions for future research in this field.展开更多
Objective The activation state of microglia is known to occupy a central position in the pathophysiological process of cerebral inflammation.Autophagy is a catabolic process responsible for maintaining cellular homeos...Objective The activation state of microglia is known to occupy a central position in the pathophysiological process of cerebral inflammation.Autophagy is a catabolic process responsible for maintaining cellular homeostasis.In recent years,autophagy has been demonstrated to play an important role in neuroinflammation.Resolvin D1(RvD1)is a promising therapeutic mediator that has been shown to exert substantial anti-inflammatory and proresolving activities.However,whether RvD1-mediated resolution of inflammation in microglia is related to autophagy regulation needs further investigation.The present study aimed to explore the effect of RvD1 on microglial autophagy and its corresponding pathways.Methods Mouse microglial cells(BV-2)were cultured,treated with RvD1,and examined by Western blotting,confocal immunofluorescence microscopy,transmission electron microscopy,and flow cytometry.Results RvD1 promoted autophagy in both BV-2 cells and mouse primary microglia by favoring the maturation of autophagosomes and their fusion with lysosomes.Importantly,RvD1 had no significant effect on the activation of mammalian target of rapamycin(mTOR)signaling.Furthermore,RvD1-induced mTOR-independent autophagy was confirmed by observing reduced cytoplasmic calcium levels and suppressed calcium/calmodulin-dependent protein kinase II(CaMK II)activation.Moreover,by downregulating ATG5,the increased phagocytic activity induced by RvD1 was demonstrated to be tightly controlled by ATG5-dependent autophagy.Conclusion The present work identified a previously unreported mechanism responsible for the role of RvD1 in microglial autophagy,highlighting its therapeutic potential against neuroinflammation.展开更多
“The Fundamental Rights and obligations of Citizens”, the title of Chapter II of the current Constitution of PRC, and the stipulation that citizens must fulfill certain obligations while enjoying rights have trigger...“The Fundamental Rights and obligations of Citizens”, the title of Chapter II of the current Constitution of PRC, and the stipulation that citizens must fulfill certain obligations while enjoying rights have triggered many debates. Considering the historical origin, constitutional philosophy, and the text and structure of the Constitution, the special provisions of the current Constitution are influenced by the principle of consistency of rights and obligations. The principle of consistency of rights and obligations in the Constitution is of complex connotation. Therefore, although the principle of consistency of rights and obligations effectively connects the public and private spheres, it ignores the diversity and differences of the interests and elements contained in the Constitution, the asymmetry of the normative status of fundamental rights and fundamental obligations,and the right of citizens to self-determination of personal interests.The principle of consistency of rights and obligations should be purposefully narrowed and concretized: In the context of public-private integration and risk society prevention, the principle of consistency of rights and obligations can be used as a supplement to the functional system of the Constitution;in the field of fundamental political obligations, the principle of consistency of rights and obligations should be in line with the requirements of the state to respect and protect human rights;in the field of fundamental social obligations, the exercise of fundamental rights by individuals is protected by the Constitution as long as they comply with the law and do not infringe upon the interests of the social community. The principle of the consistency of rights and obligations is only used as the negative constituents of the determination of rights and the basis for the effect against a third party of fundamental rights.展开更多
The physical and mechanical change processes of coal and rock are closely related to energy transformation,and the destruction and failure of coal and rock is an instability phenomena driven by energy change.However,t...The physical and mechanical change processes of coal and rock are closely related to energy transformation,and the destruction and failure of coal and rock is an instability phenomena driven by energy change.However,the energy change of large-scale coal rock in the mine site is hardly calculated accurately,making it difficult to monitor coal-rock systematic failure and collapse from the perspective of energy.By the energy dissipation EMR monitoring system,we studied the damage and failure of coal and rock with bursting liability from the energy dissipation point using the geophysical method-EMR,and explored the energy dissipation characteristics during uniaxial compression and their main influencing factors.The results show that under displacement-control loading mode,there are 2 types of energy dissipation trends for both coal and rock with bursting liability.The type Ⅰ trend is a steady increase one during the whole process,therein,the energy dissipation of rock samples is accelerated at the peak load.The type Ⅱ trend energy is a W-shaped fluctuating one containing 6 stages.Under load-control loading mode,there is one energy dissipation trend of shock downward-steady rise.Besides that,rock samples also present a trend of 4 stages.The energy dissipation characteristics of coal and rockduring loading failure process can be used as effective criteria to assess whether they are in a stable or destructive stage.The factors influencing energy dissipation in the loading failure process of coal and rock mainly include strength,homogeneity,and energy input efficiency.展开更多
Background: Evidence indicates that early weaning predisposes piglets to intestinal oxidative stress and increases the risk of intestinal dysfunction;however, there are minimal satisfactory treatment strategies for th...Background: Evidence indicates that early weaning predisposes piglets to intestinal oxidative stress and increases the risk of intestinal dysfunction;however, there are minimal satisfactory treatment strategies for these conditions.This study investigated the potential of resveratrol and its analog, pterostilbene, as antioxidant protectants for regulating intestinal morphology, barrier function, and redox status among weanling piglets.Methods: A total of 144 piglets were selected at 21 days of age and randomly allocated into one of four treatment groups, each of which included six replicates. Piglets in a sow-reared control group were suckling normally between ages 21 and 28 days, while those in weaned groups were fed a basal diet, supplemented with either 300 mg/kg of resveratrol or with 300 mg/kg of pterostilbene. Parameters associated with intestinal injury and redox status were analyzed at the end of the feeding trial.Results: Early weaning disrupted the intestinal function of young piglets, with evidence of increased diamine oxidase activity and D-lactate content in the plasma, shorter villi, an imbalance between cell proliferation and apoptosis, an impaired antioxidant defense system, and severe oxidative damage in the jejunum relative to suckling piglets. Feeding piglets with a resveratrol-supplemented diet partially increased villus height(P = 0.056) and tended to diminish apoptotic cell numbers(P = 0.084) in the jejunum compared with those fed a basal diet. Similarly, these beneficial effects were observed in the pterostilbene-fed piglets. Pterostilbene improved the feed efficiency of weanling piglets between the ages of 21 and 28 days;it also resulted in diminished plasma diamine oxidase activity and D-lactate content relative to untreated weaned piglets(P < 0.05). Notably, pterostilbene restored jejunal antioxidant capacity, an effect that was nearly absent in the resveratrol-fed piglets. Pterostilbene reduced the malondialdehyde and 8-hydroxy-2′-deoxyguanosine contents of jejunal mucosa possibly through its regulatory role in facilitating the nuclear translocation of nuclear factor erythroid-2-related factor 2 and the expression levels of NAD(P)H quinone dehydrogenase 1 and superoxide dismutase 2(P < 0.05).Conclusions: The results indicate that pterostilbene may be more effective than its parent compound in alleviating early weaning-induced intestinal damage and redox imbalance among young piglets.展开更多
Torsional impact drilling is a new technology which has the advantages of high rock-breaking efficiency and a high rate of penetration(ROP).So far,there is no in-depth understanding of the rock-breaking mechanism for ...Torsional impact drilling is a new technology which has the advantages of high rock-breaking efficiency and a high rate of penetration(ROP).So far,there is no in-depth understanding of the rock-breaking mechanism for the ROP increase from torsional impact tools.Therefore,it has practical engineering significance to study the rock-breaking mechanism of torsional impact.In this paper,discrete element method(DEM)software(PFC2 D)is used to compare granite breaking under the steady and torsional impacting conditions.Meanwhile,the energy consumption to break rock,microscopic crushing process and chip characteristics as well as the relationship among these three factors for granite under different impacting frequencies and amplitudes are discussed.It is found that the average cutting force is smaller in the case of torsional impact cutting(TIC)than that in the case of steady loading.The mechanical specific energy(MSE)and the ratio of brittle energy consumption to total energy are negatively correlated;rock-breaking efficiency is related to the mode of action between the cutting tooth and rock.Furthermore,the ROP increase mechanism of torsional impact drilling technology is that the ratio of brittle energy consumption under the TIC condition is larger than that under a steady load;the degree of repeated fragmentation of rock chips under the TIC condition is lower than that under the steady load,and the TIC load promotes the formation of a transverse cracking network near the free surface and inhibits the formation of a deep longitudinal cracking network.展开更多
The over-load protective relay is widely used for motor protection. The reliability of the over-load protective relay directly affects the safe running of a motor. The reliability testing and reliability analysis of t...The over-load protective relay is widely used for motor protection. The reliability of the over-load protective relay directly affects the safe running of a motor. The reliability testing and reliability analysis of the over-load protective relay is an important way to improve the reliability of products. In this paper, the reliability test method of the over-load protective relay is studied, and the reliability tests of the typical products are carried out on a reliability tester developed by authors. In terms of the testing results, the reliability analysis is finished. The failure reasons are found and the measures are put forward to improve the reliability of the products.展开更多
From the viewpoints of both fuzzy system and fuzzy reasoning, a new fuzzy reasoning method which contains the α- triple I restriction method as its particular case is proposed. The previous α-triple I restriction pr...From the viewpoints of both fuzzy system and fuzzy reasoning, a new fuzzy reasoning method which contains the α- triple I restriction method as its particular case is proposed. The previous α-triple I restriction principles are improved, and then the optimal restriction solutions of this new method are achieved, especially for seven familiar implications. As its special case, the corresponding results of α-triple I restriction method are obtained and improved. Lastly, it is found by examples that this new method is more reasonable than the α-triple I restriction method.展开更多
基金Supported by the Youth Project for Humanities and Social Sciences of Ministry of Education in 2012(12YJC630326 and 12XJJC790003)
文摘The traceability system can effectively reduce the food safety risks, however, it is confronted with various problems during its implementation. In this context, the paper carries out a case study of consumers in Weifang, Shandong Province, and studies their willingness to pay the traceable pork with different quality information. The results indicate that, the consumers show high expectations towards the introduction of traceability system, and they tend to buy the traceable pork only with breeding and slaughter information; their behaviors of purchase are greatly influenced by the following factors: the consumers education, age, income, attention on food safety and whether there are pregnant family members, etc..
文摘Long-term kinematic research of slowmoving debris slide is rare despite of the widespread global distribution of this kind. This paper presents a study of the kinematics and mechanism of the Jinpingzi debris slide located on the Jinsha river bank in southwest China. This debris slide is known to have a volume of 27×106 m3 in active state for at least one century. Field survey and geotechnical investigation were carried out to define the structure of the landslide. The physical and mechanical properties of the landslide materials were obtained by in-situ and laboratory tests. Additionally, surface and subsurface displacements, as well as groundwater level fluctuations, were monitored since 2005. Movement features, especially the response of the landslide movement to rainfall, were analysed. Relationships between resisting forces and driving forces were analysed by using the limit equilibrium method assuming rigid-plastic frictional slip. The results confirmed a viscous component in the long-termcontinuous movement resulting in the quasioverconsolidated state of the slip zone with higher strength parameters than some other types of slowmoving landslides. Both surface and subsurface displacements showed an advancing pattern by the straight outwardly inclined(rather than gently or reversely inclined) slip zone, which resulted in low resistance to the entire sliding mass. The average surface displacement rate from 2005 to 2016 was estimated to be 0.19~0.87 mm/d. Basal sliding on the silty clay seam accounted for most of the deformation with different degrees of internal deformation in different parts. Rainfall was the predominant factor affecting the kinematics of Jinpingzi landslide while the role of groundwater level, though positive, was not significant. The response of the groundwater level to rainfall infiltration was not apparent. Unlike some shallow slow-moving earth flows or mudslides, whose behaviors are directly related to the phreatic groundwater level, the mechanism for Jinpingzi landslide kinematics is more likely related to the changing weight of the sliding mass and thedownslope seepage pressure in the shallow soil mass resulting from rainfall events.
文摘The loading on U-steel yieldable support cannot be organically combined withthe law of strata behaviors from the surrounding rocks of roadway. In order to effectivelysolve the problem, U-steel yieldable support with backfill material and the performancerequirements of backfill material were analyzed on the basis of structural mechanics. Themechanical properties of backfill material selected were tested in the laboratory, and thetest results show that the ratio of the backfill material complies with the requirements ofbackfill technology; it can effectively optimize the relationship between the support and thesurrounding rock, and the filling layer can avoid the partial stress concentration and fullyimprove the support performance. Compared with U-steel yieldable support with ganguefilling, the filed application shows that the supporting result of U-steel yieldable supportwith backfill technology is satisfactory, the stress on U-steel yieldable support with backfilltechnology decreases greatly and distributes uniformly, convergence of the surroundingrock of roadway is decreased by more than 50%, and the surrounding rocks of roadwayare controlled effectively.
基金This paper is the phased achievement of the key program of the social science fund of the Education Department of Yunnan Province-R esearch on the Bridgehead Strategy of the Yunnan Frontier culture(N o.:2012Z059)
文摘As the agricultural heritage,Hani terrace is not only culturally authentic and non- renew able,but has its ow n characteristics. Firstly,it is a kind of economic and social mode of production. Secondly,it reflects the idea of harmonious and sustainable development betw een human beings and nature. T hirdly,the participation of human beings — or farmers is important. As a result,to exploit and protect the agricultural heritage,it is crucial to balance systematic protection and sustainable development in order to realize dynamic protection. In addition,the agricultural heritage shall be treated as the driving agent to coordinate the social and economic development. T hrough analyzing the characteristics of the agricultural heritage and the concept of protecting the agricultural heritage,this paper proposes to promote the protection of agricultural authenticity by alternative tourism development in order to balance the development and realize the sustainability of the agricultural dynamic system.
基金supported by National Key R&D Program of(China2019YFC1708502).
文摘Objective:Using network pharmacology to explore the target and mechanism of Chuanxiong Rhizoma and Acori Tatarinowii Rhizoma in the treatment of vascular dementia(VaD),so as to provide a reference for treating VaD through them.Methods:Traditional Chinese medicine systems pharmacology database and analysis platform were used to screen the main active ingredients and targets of Chuanxiong Rhizoma and Acori Tatarinowii Rhizoma.By means of Gene Cards and Online Mendelian Inheritance in Man(OMIM),targets of VaD were collected.The intersecting targets were obtained by using the Venn map.The String online database was used to build a protein-protein interactions Network and the Metascape database was used to perform GO function enrichment analysis and KEGG pathway enrichment analysis.A“drug-ingredient-target-pathway”network was constructed by Cytoscape software.Autodock vina software was used to conduct molecular docking between targets.Results:A total of 7 active ingredients in Chuanxiong Rhizoma and 4 active ingredients in Acori Tatarinowii Rhizoma were screened.There were 42 active targets of Chuanxiong Rhizoma and 70 active targets of Acori Tatarinowii Rhizoma and 1152 disease targets.After deleting the repeat value,51 drugs targets were obtained.After the intersection,with a total of 25 targets.According to GO and KEGG enrichment analysis,the main biological processes involved include cellular response to lipid,negative regulation of apoptotic signaling pathway,blood circulation,response to a steroid hormone,etc.The main pathways include pathways in cancer,PI3K-Akt signaling pathway,and AGE-RAGE signaling pathway in diabetic complications,etc.Molecular docking showed that the most active docking combinations were AKT1 and Perlolyrine,RELA and FA,MAPK14 and FA,respectively.Conclusion:Chuanxiong Rhizoma and Acori Tatarinowii Rhizoma play an important role in the treatment of VaD mainly by anti-inflammatory and anti-apoptosis.
基金supported by the General Project of Natural Science Foundation of Hebei Province of China(H2019201378)the Foundation of the President of Hebei University(XZJJ201917)the Special Project for Cultivating Scientific and Technological Innovation Ability of University and Middle School Students of Hebei Province(2021H060306).
文摘The diagnosis of COVID-19 requires chest computed tomography(CT).High-resolution CT images can provide more diagnostic information to help doctors better diagnose the disease,so it is of clinical importance to study super-resolution(SR)algorithms applied to CT images to improve the reso-lution of CT images.However,most of the existing SR algorithms are studied based on natural images,which are not suitable for medical images;and most of these algorithms improve the reconstruction quality by increasing the network depth,which is not suitable for machines with limited resources.To alleviate these issues,we propose a residual feature attentional fusion network for lightweight chest CT image super-resolution(RFAFN).Specifically,we design a contextual feature extraction block(CFEB)that can extract CT image features more efficiently and accurately than ordinary residual blocks.In addition,we propose a feature-weighted cascading strategy(FWCS)based on attentional feature fusion blocks(AFFB)to utilize the high-frequency detail information extracted by CFEB as much as possible via selectively fusing adjacent level feature information.Finally,we suggest a global hierarchical feature fusion strategy(GHFFS),which can utilize the hierarchical features more effectively than dense concatenation by progressively aggregating the feature information at various levels.Numerous experiments show that our method performs better than most of the state-of-the-art(SOTA)methods on the COVID-19 chest CT dataset.In detail,the peak signal-to-noise ratio(PSNR)is 0.11 dB and 0.47 dB higher on CTtest1 and CTtest2 at×3 SR compared to the suboptimal method,but the number of parameters and multi-adds are reduced by 22K and 0.43G,respectively.Our method can better recover chest CT image quality with fewer computational resources and effectively assist in COVID-19.
基金supported by the Open Fund of State Key Laboratory of Tea Plant Biology and Utilization (SKLTOF20200127 and SKLT0F20200108)the Open Fund of Key Laboratory of Tea Plant Resources Comprehensive Development in South Henan Province (HNKLTOF2020005)the Zhejiang Provincial Basic Public Welfare Research Program Project (LGF20H280007)。
文摘Our previous study found that large-leaf yellow tea(LYT)had interesting hypoglycemic activity in high-fat diet-induced obese mice and highly safety in healthy mice. To study the anti-diabetic potential of LYT, the present study further investigated the preventive effects and mechanisms of action of LYT administration on diabetes and diabetic nephropathy in high-fat diet plus streptozotocin-induced diabetic mice. Results showed that LYT infusions(1/100 and 1/50, m/V)as drinking fluid for 4 weeks reduced diabetic polydipsia and polyuria, enhanced glucose tolerance and insulin sensitivity, and lowered fasting blood glucose level. The underlying mechanisms involve downregulation of gluconeogenesis(lower protein levels of TXNIP and FBP and enzyme activity of FBP), upregulation of lipid catabolism(higher protein levels of CPT-1α and PPARα), downregulation of lipogenesis(lower protein level of SREBP-1), and modification of the structure and abundance of gut microbiota to modulate metabolic homeostasis. Moreover, LYT administration prevented diabetic nephropathy, possibly due to reduced glucose-caused osmotic diuresis and lowered levels of renal PKC-β2, NLRP3 as well as membrane PKC-α, AQP2 and glycosylated AQP2 proteins. Taken together, LYT exhibits the activities in alleviating diabetic symptoms, ameliorating glucose and lipid dysmetabolism and fatty liver, and preventing diabetic nephropathy in diabetic mice. These activities may be explored for the prevention and treatment of diabetes in humans.
基金the financial supports from the Fundamental Research Funds for the Central Universities(No.21621012)the National Natural Science Foundation of China(No.82104070).
文摘Background:Chinese medicine is widely applied in Asian and Western countries for its outstanding therapeutic effect,but there are still unsolved problems such as unclear active ingredients and pharmacological effects.The application of nano/microparticle technology in Chinese medicine may become a promising strategy to solve this problem in the near future(provided that more efforts are made to in-depth exploration).In this work,a comprehensive analysis of the field was carried out from a bibliometrics perspective,and further the publishing trends and research hotspots were figured out.Methods:The articles or reviews from 2000 to 2020 were retrieved in the database of Web of Science Core Collection.The documents were processed by Clarivate Analytic,Visualization of Similarities viewer,Statistical Analysis Toolkit for Informetrics and bibliometric online platform,and the data were visualized.Finally,a bibliometric summary,citation analysis results and research trends were described.Results:A bibliometric analysis of 773 articles of interest showed that research in this field had continued to grow in recent years,with a high degree of interdisciplinary integration.Secondly,this field attached great importance to the quantitative analysis of Chinese medicine combined with nano/micro particle technology.Chinese medicine,nanoparticles and liposomes were the most accessed keywords.China was the main contributing country,and the top-10 contributing organizations were all located in China.Co-authorship was a common phenomenon in this field.Conclusion:The published literature on the application of nano/micro particle technology in Chinese medicine was summarized.The results suggested that bibliometric analysis could predict possible directions for future research in this field.
基金the National Natural Science Foundation of China(No.81902016).
文摘Objective The activation state of microglia is known to occupy a central position in the pathophysiological process of cerebral inflammation.Autophagy is a catabolic process responsible for maintaining cellular homeostasis.In recent years,autophagy has been demonstrated to play an important role in neuroinflammation.Resolvin D1(RvD1)is a promising therapeutic mediator that has been shown to exert substantial anti-inflammatory and proresolving activities.However,whether RvD1-mediated resolution of inflammation in microglia is related to autophagy regulation needs further investigation.The present study aimed to explore the effect of RvD1 on microglial autophagy and its corresponding pathways.Methods Mouse microglial cells(BV-2)were cultured,treated with RvD1,and examined by Western blotting,confocal immunofluorescence microscopy,transmission electron microscopy,and flow cytometry.Results RvD1 promoted autophagy in both BV-2 cells and mouse primary microglia by favoring the maturation of autophagosomes and their fusion with lysosomes.Importantly,RvD1 had no significant effect on the activation of mammalian target of rapamycin(mTOR)signaling.Furthermore,RvD1-induced mTOR-independent autophagy was confirmed by observing reduced cytoplasmic calcium levels and suppressed calcium/calmodulin-dependent protein kinase II(CaMK II)activation.Moreover,by downregulating ATG5,the increased phagocytic activity induced by RvD1 was demonstrated to be tightly controlled by ATG5-dependent autophagy.Conclusion The present work identified a previously unreported mechanism responsible for the role of RvD1 in microglial autophagy,highlighting its therapeutic potential against neuroinflammation.
文摘“The Fundamental Rights and obligations of Citizens”, the title of Chapter II of the current Constitution of PRC, and the stipulation that citizens must fulfill certain obligations while enjoying rights have triggered many debates. Considering the historical origin, constitutional philosophy, and the text and structure of the Constitution, the special provisions of the current Constitution are influenced by the principle of consistency of rights and obligations. The principle of consistency of rights and obligations in the Constitution is of complex connotation. Therefore, although the principle of consistency of rights and obligations effectively connects the public and private spheres, it ignores the diversity and differences of the interests and elements contained in the Constitution, the asymmetry of the normative status of fundamental rights and fundamental obligations,and the right of citizens to self-determination of personal interests.The principle of consistency of rights and obligations should be purposefully narrowed and concretized: In the context of public-private integration and risk society prevention, the principle of consistency of rights and obligations can be used as a supplement to the functional system of the Constitution;in the field of fundamental political obligations, the principle of consistency of rights and obligations should be in line with the requirements of the state to respect and protect human rights;in the field of fundamental social obligations, the exercise of fundamental rights by individuals is protected by the Constitution as long as they comply with the law and do not infringe upon the interests of the social community. The principle of the consistency of rights and obligations is only used as the negative constituents of the determination of rights and the basis for the effect against a third party of fundamental rights.
基金supported by Youth Science Foundation of the National Natural Science Foundation of China(No.51104156)the Fundamental Research Funds for the Central Universities of China(No.2013QNB02)the 12th Five Year National Science and Technology Support Key Project of China(Nos. 2012BAK04B07-2 and 2012BAK09B01-04)
文摘The physical and mechanical change processes of coal and rock are closely related to energy transformation,and the destruction and failure of coal and rock is an instability phenomena driven by energy change.However,the energy change of large-scale coal rock in the mine site is hardly calculated accurately,making it difficult to monitor coal-rock systematic failure and collapse from the perspective of energy.By the energy dissipation EMR monitoring system,we studied the damage and failure of coal and rock with bursting liability from the energy dissipation point using the geophysical method-EMR,and explored the energy dissipation characteristics during uniaxial compression and their main influencing factors.The results show that under displacement-control loading mode,there are 2 types of energy dissipation trends for both coal and rock with bursting liability.The type Ⅰ trend is a steady increase one during the whole process,therein,the energy dissipation of rock samples is accelerated at the peak load.The type Ⅱ trend energy is a W-shaped fluctuating one containing 6 stages.Under load-control loading mode,there is one energy dissipation trend of shock downward-steady rise.Besides that,rock samples also present a trend of 4 stages.The energy dissipation characteristics of coal and rockduring loading failure process can be used as effective criteria to assess whether they are in a stable or destructive stage.The factors influencing energy dissipation in the loading failure process of coal and rock mainly include strength,homogeneity,and energy input efficiency.
基金Supported by the National Natural Science Foundation of China, No. 30400591 the Heilongjiang Province Natural Science Foundation, No. D2004-13, D200505 Harbin City Young Scientist Foundation, No. 2004AFQXJ035
基金offered by from the National Natural Science Foundation of China (No. 31802094)the Fundamental Research Funds for the Central Universities (No. KJQN201934)+2 种基金the Natural Science Foundation of Jiangsu Province (No. BK20180531)the Postdoctoral Research Foundation of China (No. 2018 M632320 and 2019 T120436)the Open Project of Shanghai Key Laboratory of Veterinary Biotechnology (No.klab201710)。
文摘Background: Evidence indicates that early weaning predisposes piglets to intestinal oxidative stress and increases the risk of intestinal dysfunction;however, there are minimal satisfactory treatment strategies for these conditions.This study investigated the potential of resveratrol and its analog, pterostilbene, as antioxidant protectants for regulating intestinal morphology, barrier function, and redox status among weanling piglets.Methods: A total of 144 piglets were selected at 21 days of age and randomly allocated into one of four treatment groups, each of which included six replicates. Piglets in a sow-reared control group were suckling normally between ages 21 and 28 days, while those in weaned groups were fed a basal diet, supplemented with either 300 mg/kg of resveratrol or with 300 mg/kg of pterostilbene. Parameters associated with intestinal injury and redox status were analyzed at the end of the feeding trial.Results: Early weaning disrupted the intestinal function of young piglets, with evidence of increased diamine oxidase activity and D-lactate content in the plasma, shorter villi, an imbalance between cell proliferation and apoptosis, an impaired antioxidant defense system, and severe oxidative damage in the jejunum relative to suckling piglets. Feeding piglets with a resveratrol-supplemented diet partially increased villus height(P = 0.056) and tended to diminish apoptotic cell numbers(P = 0.084) in the jejunum compared with those fed a basal diet. Similarly, these beneficial effects were observed in the pterostilbene-fed piglets. Pterostilbene improved the feed efficiency of weanling piglets between the ages of 21 and 28 days;it also resulted in diminished plasma diamine oxidase activity and D-lactate content relative to untreated weaned piglets(P < 0.05). Notably, pterostilbene restored jejunal antioxidant capacity, an effect that was nearly absent in the resveratrol-fed piglets. Pterostilbene reduced the malondialdehyde and 8-hydroxy-2′-deoxyguanosine contents of jejunal mucosa possibly through its regulatory role in facilitating the nuclear translocation of nuclear factor erythroid-2-related factor 2 and the expression levels of NAD(P)H quinone dehydrogenase 1 and superoxide dismutase 2(P < 0.05).Conclusions: The results indicate that pterostilbene may be more effective than its parent compound in alleviating early weaning-induced intestinal damage and redox imbalance among young piglets.
基金supported by the National Natural Science Foundation of China(Grant No.51674214)International Cooperation Project of Sichuan Science and Technology Plan(2016HH0008)+1 种基金Youth Science and Technology Innovation Research Team of Sichuan Province(2017TD0014)Applied Basic Research of Sichuan Province(Free Exploration-2019YJ0520)
文摘Torsional impact drilling is a new technology which has the advantages of high rock-breaking efficiency and a high rate of penetration(ROP).So far,there is no in-depth understanding of the rock-breaking mechanism for the ROP increase from torsional impact tools.Therefore,it has practical engineering significance to study the rock-breaking mechanism of torsional impact.In this paper,discrete element method(DEM)software(PFC2 D)is used to compare granite breaking under the steady and torsional impacting conditions.Meanwhile,the energy consumption to break rock,microscopic crushing process and chip characteristics as well as the relationship among these three factors for granite under different impacting frequencies and amplitudes are discussed.It is found that the average cutting force is smaller in the case of torsional impact cutting(TIC)than that in the case of steady loading.The mechanical specific energy(MSE)and the ratio of brittle energy consumption to total energy are negatively correlated;rock-breaking efficiency is related to the mode of action between the cutting tooth and rock.Furthermore,the ROP increase mechanism of torsional impact drilling technology is that the ratio of brittle energy consumption under the TIC condition is larger than that under a steady load;the degree of repeated fragmentation of rock chips under the TIC condition is lower than that under the steady load,and the TIC load promotes the formation of a transverse cracking network near the free surface and inhibits the formation of a deep longitudinal cracking network.
基金Manuscript received March 5, 2010 accepted March 2, 2011 Supported by National Natural Science Foundation of China (61004103), National Research Foundation for the Doctoral Program of Higher Education of China (20100111110005), China Postdoctoral Science Foundation (20090460742), and Natural Science Foundation of Anhui Province of China (090412058, 11040606Q44)
基金Project (No. E2005000039) supported by the Natural Science Foun-dation of Hebei Province, China
文摘The over-load protective relay is widely used for motor protection. The reliability of the over-load protective relay directly affects the safe running of a motor. The reliability testing and reliability analysis of the over-load protective relay is an important way to improve the reliability of products. In this paper, the reliability test method of the over-load protective relay is studied, and the reliability tests of the typical products are carried out on a reliability tester developed by authors. In terms of the testing results, the reliability analysis is finished. The failure reasons are found and the measures are put forward to improve the reliability of the products.
基金supported by the National Natural Science Foundation of China (61105076 61070124)+2 种基金the National High Technology Research and Development Program of China (863 Program) (2012AA011103)the Open Project of State Key Laboratory of Virtual Reality Technology and Systems of China (BUAA-VR-10KF-5)the Fundamental Research Funds for the Central Universities (2011HGZY0004)
文摘From the viewpoints of both fuzzy system and fuzzy reasoning, a new fuzzy reasoning method which contains the α- triple I restriction method as its particular case is proposed. The previous α-triple I restriction principles are improved, and then the optimal restriction solutions of this new method are achieved, especially for seven familiar implications. As its special case, the corresponding results of α-triple I restriction method are obtained and improved. Lastly, it is found by examples that this new method is more reasonable than the α-triple I restriction method.