This perspective provides an overview of the techniques that have been developed for the conjugation of DNA to colloidal quantum dots （QDs）, or semiconductor nanocrystals. Methods described include： ligand exchange...This perspective provides an overview of the techniques that have been developed for the conjugation of DNA to colloidal quantum dots （QDs）, or semiconductor nanocrystals. Methods described include： ligand exchange at the QD surface, covalent conjugation of DNA to the QD surface ligands, and one-step DNA functionalization on core QDs or during core/shell QD synthesis in aqueous solution, with an emphasis on tile most recent progress in our lab. We will also discuss emerging trends in DNA-functionalized QDs for potential applications.展开更多
基金The authors acknowledge the grant support from the Office of Naval Research （ONR） to YL and ZD, and the National Science Foundation （NSF） to HY and YL We also thank Dr. Jeanette Nangreave for assistance in proofreading the manuscript.
文摘This perspective provides an overview of the techniques that have been developed for the conjugation of DNA to colloidal quantum dots （QDs）, or semiconductor nanocrystals. Methods described include： ligand exchange at the QD surface, covalent conjugation of DNA to the QD surface ligands, and one-step DNA functionalization on core QDs or during core/shell QD synthesis in aqueous solution, with an emphasis on tile most recent progress in our lab. We will also discuss emerging trends in DNA-functionalized QDs for potential applications.
