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Oral epithelial stem cells in tissue maintenance and disease: the first steps in a long journey 被引量:5
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作者 Kyle B Jones Ophir D Klein 《International Journal of Oral Science》 SCIE CAS CSCD 2013年第3期121-129,共9页
The identification and characterization of stem cells is a major focus of developmental biology and regenerative medicine.The advent of genetic inducible fate mapping techniques has made it possible to precisely label... The identification and characterization of stem cells is a major focus of developmental biology and regenerative medicine.The advent of genetic inducible fate mapping techniques has made it possible to precisely label specific cell populations and to follow their progeny over time.When combined with advanced mathematical and statistical methods,stem cell division dynamics can be studied in new and exciting ways.Despite advances in a number of tissues,relatively little attention has been paid to stem cells in the oral epithelium.This review will focus on current knowledge about adult oral epithelial stem cells,paradigms in other epithelial stem cell systems that could facilitate new discoveries in this area and the potential roles of epithelial stem cells in oral disease. 展开更多
关键词 cancer stem cell invariant asymmetry neutral drift oral epithelial stem cell population asymmetry
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Spontaneous emergence of overgrown molar teeth in a colony of Prairie voles(Microtus ochrogaster)
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作者 Andrew H Jheon Michaela Prochazkova +4 位作者 Michael Sherman Devanand S Manoli Nirao M Shah Lawrence Carbone Ophir Klein 《International Journal of Oral Science》 SCIE CAS CSCD 2015年第1期23-26,共4页
Continuously growing incisors are common to all rodents, which include the Microtus genus of voles. However, unlike many rodents, voles also possess continuously growing molars. Here, we report spontaneous molar defec... Continuously growing incisors are common to all rodents, which include the Microtus genus of voles. However, unlike many rodents, voles also possess continuously growing molars. Here, we report spontaneous molar defects in a population of Prairie voles (Microtus ochrogaster). We identified bilateral protuberances on the ventral surface of the mandible in several voles in our colony. In some cases, the protuberances broke through the cortical bone. The mandibular molars became exposed and infected, and the maxillary molars entered the cranial vault. Visualisation upon soft tissue removal and microcomputed tomography (microCT) analyses confirmed that the protuberances were caused by the overgrowth of the apical ends of the molar teeth. We speculate that the unrestricted growth of the molars was due to the misregulation of the molar dental stem cell niche. Further study of this molar phenotype may yield additional insight into stem cell regulation and the evolution and development of continuously growing teeth. 展开更多
关键词 continuously growing teeth molar phenotype mutation stem cell regulation VOLES
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