The field data of shale fracturing demonstrate that the flowback performance of fracturing fluid is different from that of conventional reservoirs,where the flowback rate of shale fracturing fluid is lower than that o...The field data of shale fracturing demonstrate that the flowback performance of fracturing fluid is different from that of conventional reservoirs,where the flowback rate of shale fracturing fluid is lower than that of conventional reservoirs.At the early stage of flowback,there is no single-phase flow of the liquid phase in shale,but rather a gas-water two-phase flow,such that the single-phase flow model for tight oil and gas reservoirs is not applicable.In this study,pores and microfractures are extracted based on the experimental results of computed tomography(CT)scanning,and a spatial model of microfractures is established.Then,the influence of rough microfracture surfaces on the flow is corrected using the modified cubic law,which was modified by introducing the average deviation of the microfracture height as a roughness factor to consider the influence of microfracture surface roughness.The flow in the fracture network is simulated using the modified cubic law and the lattice Boltzmann method(LBM).The results obtained demonstrate that most of the fracturing fluid is retained in the shale microfractures,which explains the low fracturing fluid flowback rate in shale hydraulic fracturing.展开更多
This study conducted temporary plugging and diversion fracturing(TPDF)experiments using a true triaxial fracturing simulation system within a laboratory setting that replicated a lab-based horizontal well completion w...This study conducted temporary plugging and diversion fracturing(TPDF)experiments using a true triaxial fracturing simulation system within a laboratory setting that replicated a lab-based horizontal well completion with multi-cluster sand jetting perforation.The effects of temporary plugging agent(TPA)particle size,TPA concentration,single-cluster perforation number and cluster number on plugging pressure,multi-fracture diversion pattern and distribution of TPAs were investigated.A combination of TPAs with small particle sizes within the fracture and large particle sizes within the segment is conducive to increasing the plugging pressure and promoting the diversion of multi-fractures.The addition of fibers can quickly achieve ultra-high pressure,but it may lead to longitudinal fractures extending along the wellbore.The temporary plugging peak pressure increases with an increase in the concentration of the TPA,reaching a peak at a certain concentration,and further increases do not significantly improve the temporary plugging peak pressure.The breaking pressure and temporary plugging peak pressure show a decreasing trend with an increase in single-cluster perforation number.A lower number of single-cluster perforations is beneficial for increasing the breaking pressure and temporary plugging peak pressure,and it has a more significant control on the propagation of multi-cluster fractures.A lower number of clusters is not conducive to increasing the total number and complexity of artificial fractures,while a higher number of clusters makes it difficult to achieve effective plugging.The TPAs within the fracture is mainly concentrated in the complex fracture areas,especially at the intersections of fractures.Meanwhile,the TPAs within the segment are primarily distributed near the perforation cluster apertures which initiated complex fractures.展开更多
Two allyldimethylalkyl quaternary ammonium salt(AQAS)monomers,N,N-dimethylallylphenylpropylammonium bromide(AQAS1)and N,N-dimethylallylnonylammonium bromide(AQAS2),were synthesized and used to prepare modified polyacr...Two allyldimethylalkyl quaternary ammonium salt(AQAS)monomers,N,N-dimethylallylphenylpropylammonium bromide(AQAS1)and N,N-dimethylallylnonylammonium bromide(AQAS2),were synthesized and used to prepare modified polyacrylamide materials.Two new drag reducers were synthesized from acrylamide(AM),sodium acrylate(Na AA)and a cationic modified monomer(AQAS1 or AQAS2)via aqueous solution polymerization,and the copolymers were named P(AM/Na AA/AQAS1)and P(AM/Na AA/AQAS2),respectively.The structures of the drag reduction agents were confirmed by IR and1H NMR spectroscopies.The molecular weight(Mw)of P(AM/Na AA/AQAS1)was 1.79×10^(6)g/mol.When the copolymer concentration was 1000 mg/L and the flow rate was 45 L/min,in fresh water the highest drag reduction rate was 75.8%,in 10,000 mg/L Na Cl solution the drag reduction rate decreased to 72.9%.The molecular weight of P(AM/Na AA/AQAS2)was 3.17×10^(6)g/mol.When the copolymer concentration was500 mg/L and the flow rate was 45 L/min,the drag reduction rate reached 75.2%,and in 10,000 mg/L Na Cl solution the drag reduction rate was 73.3%,decreased by approximately 1.9%.The drag reduction rate for partially hydrolyzed polyacrylamide(HPAM)was also investigated,and the results showed that the drag reduction rates for 500 and 1000 mg/L HPAM solutions were merely 43.2%and 49.0%in brine,respectively.Compared with HPAM,both of the above copolymers presented better drag reduction capacities.展开更多
Almost all sandstone reservoirs contain interlayers. The identification and characterization of these interlayers iscritical for minimizing the uncertainty associated with oilfield development and improving oil and ga...Almost all sandstone reservoirs contain interlayers. The identification and characterization of these interlayers iscritical for minimizing the uncertainty associated with oilfield development and improving oil and gas recovery.Identifying interlayers outside wells using identification methods based on logging data and machine learning isdifficult and seismic-based identification techniques are expensive. Herein, a numerical model based on seepageand well-testing theories is introduced to identify interlayers using transient pressure data. The proposed modelrelies on the open-source MATLAB Reservoir Simulation Toolbox. The effects of the interlayer thickness, position,and width on the pressure response are thoroughly investigated. A procedure for inverting interlayer parametersin the reservoir using the bottom-hole pressure is also proposed. This method uses only transient pressuredata during well testing and can effectively identify the interlayer distribution near the wellbore at an extremelylow cost. The reliability of the model is verified using effective oilfield examples.展开更多
The paleoenvironment of shales can be reconstructed to some extent using the combinations or concentrations of elements that correlate strongly with environmental conditions.In this study,we analyzed rare earth elemen...The paleoenvironment of shales can be reconstructed to some extent using the combinations or concentrations of elements that correlate strongly with environmental conditions.In this study,we analyzed rare earth elements(REEs),major elements,and trace elements in the marine-continental transitional shales(transitional shales for short)of the Shan 2^(3)submember of the Shanxi Formation in the southeastern Ordos Basin.The purpose is to deduce the paleoenvironmental conditions of the shales,encompassing paleoredox,paleoclimate,paleoproductivity,and paleo-provenance.The Shan 2^(3)submember comprises four sections,namely Shan 2^(3)-1,Shan 2^(3)-2,Shan 2^(3)-3,and Shan 2^(3)-4.The Ba/Al,P/Al,and Cu/Al ratios,along with biogenic barium(Babio),indicate that the paleoproductivity of the submember peaked during the Shan 2^(3)-1 deposition and exhibited a downtrend upward in other sections.Trends in the Uau and the Ni/Co,V/Cr,U/Th,and V/Sc ratios suggest that suboxic conditions prevailed during the Shan 2^(3)-1 deposition,with the oxidation level gradually increasing from Shan 2^(3)-1 to Shan 2^(3)-4.C-value and the Sr/Cu vs.Ga/Rb cross-plot indicate a warm and arid paleoclimate during the Shan 2^(3)-1 deposition,which transitioned to cooler,drier conditions during the deposition of other sections.Indicators sensitive to paleoclimate,such as the K/Rb and Th/U ratios,along with the ICV,PIA,and Chemical Index of Alteration(CIA),highlight elevated weathering from Shan 2^(3)-2 to Shan 2^(3)-4,with Shan 2^(3)-1 exhibiting the weakest weathering during its deposition.As suggested by the REE data,the Zr/Sc vs.Th/Sr cross-plot,provenance discriminant functions,and the cross-plots of Hf vs.La/Th,Th vs.Hf-Co,and∑REE vs.La/Yb,the sedimentary provenance for the transitional shales of the Shan 2^(3)submember is of multiple origins,with significant contributions from the Upper Continental Crust(UCC).Discriminant diagrams,including those of Th-Co-Zr/10,Th-Sc-Zr/10,La-Th-Sc,and K_(2)O/Na_(2)O vs.SiO_(2),suggest that the transitional shales of the Shan 2^(3)submember were primarily deposited under tectonic settings such as continental island arcs(CIAs)and passive continental margins(PCMs).展开更多
Incomplete fault signal characteristics and ease of noise contamination are issues with the current rolling bearing early fault diagnostic methods,making it challenging to ensure the fault diagnosis accuracy and relia...Incomplete fault signal characteristics and ease of noise contamination are issues with the current rolling bearing early fault diagnostic methods,making it challenging to ensure the fault diagnosis accuracy and reliability.A novel approach integrating enhanced Symplectic geometry mode decomposition with cosine difference limitation and calculus operator(ESGMD-CC)and artificial fish swarm algorithm(AFSA)optimized extreme learning machine(ELM)is proposed in this paper to enhance the extraction capability of fault features and thus improve the accuracy of fault diagnosis.Firstly,SGMD decomposes the raw vibration signal into multiple Symplectic geometry components(SGCs).Secondly,the iterations are reset by the cosine difference limitation to effectively separate the redundant components from the representative components.Additionally,the calculus operator is performed to strengthen weak fault features and make them easier to extract,and the singular value decomposition(SVD)weighted by power spectrum entropy(PSE)can be utilized as the sample feature representation.Finally,AFSA iteratively optimized ELM is adopted as the optimized classifier for fault identification.The superior performance of the proposed method has been validated by various experiments.展开更多
In recent years, some governments have been working on solutions to transform public administrations and provide high-quality services to users. The United Nations has recommended integrating digital technology into v...In recent years, some governments have been working on solutions to transform public administrations and provide high-quality services to users. The United Nations has recommended integrating digital technology into various aspects of life, including public services. The objective is to offer real-time, high-quality digital services, improve the delivery of public services, enhance their effectiveness and efficiency, while achieving objectives such as transparency, interoperability and citizen satisfaction. However, most governments in developing countries are unable to keep up with this trend. As a result, they often create digital public services that fall short of users’ expectations. This study aims to identify the fundamental factors influencing the quality of service in relation to user satisfaction and to explore the relevance of digital technology in implementing this quality within Cameroon public administrations. To achieve this, we used a qualimetric research method, which included non-directive interviews, questionnaires, and structured observations. The results showed that the public services offered in our study environment did not meet users’ expectations. However, the study identified the fundamental aspects to be considered in providing quality public services connected to user satisfaction, as well as the strengths of digitization in achieving this quality.展开更多
A stable surface to move manpower and equipment is a key for the construction operations. To create a stable road surface, the road construction techniques are time-consuming and expensive for a traditional constructi...A stable surface to move manpower and equipment is a key for the construction operations. To create a stable road surface, the road construction techniques are time-consuming and expensive for a traditional construction which requires compaction of soil, aggregate base, sub-base and asphaltic layers. A Geosynthetic Access Mat (GAM) system can serve as an alternative to other traditional construction techniques to accommodate temporary construction. Due to its rigidity, the mat system can provide substantial vertical resistance to the applied load under a large deflection subject to soil conditions. This paper provides details of GAM specifications, soil conditions, applications, installation procedure, comparison with other soil stabilization methods and Aramco experience for deployments of these mats.展开更多
At 09:15 local time on May 13,2018 in the Republic of Mozambique,Li Zhanshu,a member of the Standing Committee of the Political Bureau of the CPC Central Committee and Chairman of the Standing Committee of the Nationa...At 09:15 local time on May 13,2018 in the Republic of Mozambique,Li Zhanshu,a member of the Standing Committee of the Political Bureau of the CPC Central Committee and Chairman of the Standing Committee of the National People's Congress (NPC),and Veronica Macamo,Speaker of the Republic of Mozambique,attended the founding ceremony of the Chinese aid project for the Confucius Institute and Media Arts Institute in Mozambique.展开更多
Thermoelectric generators(TEGs)are considered promising devices for waste heat recovery from various systems.The Seebeck effect can be utilized to generate power using the residual heat emitted by the filter dryer rec...Thermoelectric generators(TEGs)are considered promising devices for waste heat recovery from various systems.The Seebeck effect can be utilized to generate power using the residual heat emitted by the filter dryer receiver(FDR)of an air conditioning(A/C)system,which would otherwise go to waste.The study aims to build a set of thermoelectric generators(TEG)to collect the waste heat of the FDR and generate low-power electricity.A novel electrical circuit with two transformers is designed and fabricated to produce a more stable voltage for operation and charging.The thermoelectric generator(TEGs)was installed on the FDR of the A/C unit.The test showed that climate conditions have a significant impact on the output power generated from the system.The results showed that the peak voltage recorded in the current study is 5.2 V per day(wet,cold,and wind weather)with an output power of 0.2 W.These values are acceptable for powering the load and charging a single battery with 3.5 V as the voltage increases battery 0.1 V/20 min charge.A case study of operating the emergency signs in a building was considered.The current heat recovery system is deemed to be easily installed and can be connected to a network of TEGs to produce more power.展开更多
Schwann cells are glial cells in the peripheral nervous system that provide trophic support for the growth and maintenance of sensory,motor,and autonomic neurons and ensheath their axons in either a myelinating or an ...Schwann cells are glial cells in the peripheral nervous system that provide trophic support for the growth and maintenance of sensory,motor,and autonomic neurons and ensheath their axons in either a myelinating or an unmyelinating form.Myelinating Schwann cells wrap around largedia meter axons to form m ultilayered myelin structures essential for the rapid action potential propagation from one node of Ranvier to the next node(saltatory conduction).展开更多
Figuring out rock strength plays essential roles in the sub ground mining activities,such as oil and gas well drilling and hydraulic fracturing,coal mining,tunneling,and other civil engineering scenarios.To help under...Figuring out rock strength plays essential roles in the sub ground mining activities,such as oil and gas well drilling and hydraulic fracturing,coal mining,tunneling,and other civil engineering scenarios.To help understand the effects of the mineralogical composition on evaluating the rock strength,this research tries to establish indirect prediction models of rock strength by specific input mineral contents for common sedimentary rocks.Using rock samples collected from the outcrops in the Sichuan Basin,uniaxial compression tests have been conducted to sandstone,carbonate,and shale cores.Combining with statistical analysis,the experimental data prove it true that the mineralogical composition can be utilized to predict the rock strength under specific conditions but the effects of mineralogical composition on the rock strength highly depend on the rock lithologies.According to the statistical analysis results,the predicted values of rock strengths by the mineral contents can get high accuracies in sandstone and carbonate rocks while no evidences can be found in shale rocks.The best indicator for predicting rock strength should be the quartz content for the sandstone rocks and the dolomite content for the carbonate rocks.Especially,to improve the evaluation accuracy,the rock strengths of sandstones can be obtained by substituting the mineral contents of quartz and clays,and those of carbonates can be calculated by the mineral contents of dolomite and calcite.Noticeably,the research data point out a significant contrast of quartz content in evaluating the rock strength of the sandstone rocks and the carbonate rocks.Increasing quartz content helps increase the sandstone strength but decrease the carbonate strength.As for shale rocks,no relationship exists between the rock strength and the mineralogical composition(e.g.,the clay fractions).To provide more evidences,detailed discussion also provides the readers more glances into the framework of the rock matrix,which can be further studied in the future.These findings can help understand the effects of mineralogical composition on the rock strengths,explain the contrasts in the rock strength of the responses to the same mineral content(e.g.,the quartz content),and provide another indirect method for evaluating the rock strength of common sedimentary rocks.展开更多
Assessment of water quality by firefly algorithm based on BP neural network model(FA-BP model)is built.In this model,the evaluation index function is constructed by BP Artificial Neural Network Algorithm(BP model),and...Assessment of water quality by firefly algorithm based on BP neural network model(FA-BP model)is built.In this model,the evaluation index function is constructed by BP Artificial Neural Network Algorithm(BP model),and Firefly Algorithm(FA model)is introduced to optimize weight values and thresholds to find the optimal solution.Fuzzy Comprehensive Evaluation method,Grey Incidence Analysis Algorithm and FA-BP model will be applied to evaluate the water quality of the five main rivers in Lianyungang City including Longwei,Yudai,Dapu,Paidan,and Dongyan River.The results show that the Fuzzy Comprehensive Evaluation method is difficult to use for slight pollution rivers with several slightly over standard indexes.It will be easy to ignore the impact of extreme indexes by Grey Incidence Analysis Algorithm.FA-BP model solves the shortcomings of the two methods.The evaluation results provide an important reference for the formulation of reasonable measures.It is a relatively comprehensive evaluation method and has a good application prospect in water quality evaluation.展开更多
The relationship between paleogeographic pattern and sedimentary differentiation of evaporite-carbonate symbiotic system is examined based on logging,core and thin section data,by taking the sixth sub-member of fifth ...The relationship between paleogeographic pattern and sedimentary differentiation of evaporite-carbonate symbiotic system is examined based on logging,core and thin section data,by taking the sixth sub-member of fifth member of Ordovician Majiagou Formation(M56)in the central-eastern Ordos Basin as an example.(1)Seven sub-geomorphic units(Taolimiao west low,Taolimiao underwater high,Taolimiao east low,Hengshan high,East salt low,North slope and Southwest slope)developed in the study area.(2)The“three lows”from west to east developed dolomitic restricted lagoon,evaporite evaporative lagoon and salt evaporative lagoon sedimentary facies respectively,the"two highs"developed high-energy grain beach and microbial mound,and the north and south slopes developed dolomitic flats around land.(3)The paleogeographic pattern caused natural differentiation of replenishment seawater from the northwest Qilian sea,leading to the eccentric sedimentary differentiation of dolomite,evaporite and salt rock symbiotic system from west to east,which is different from the classic“bull's eye”and“tear drop”distribution patterns.(4)As the Middle Qilian block subducted and collided into the North China Plate,the far-end compression stress transferred,giving rise to the alternate highland and lowland in near north to south direction during the sedimentary period of M56 sub-member.(5)Taolimiao underwater high and Hengshan high developed favorable zones of microbial mounds and grain shoals in south to north strike in M56 sub-member,making them favorable exploration areas with great exploration potential in the future.展开更多
To study the casing deformation(CD)in shale gas well fracturing caused by natural fracture slip,a fracture face stress model is built based on stress analysis,and a CD prediction model is established based on complex ...To study the casing deformation(CD)in shale gas well fracturing caused by natural fracture slip,a fracture face stress model is built based on stress analysis,and a CD prediction model is established based on complex function to analyze factors affecting wellbore shear stress and CD.(1)The fracture and wellbore approach angles have significant impacts on the wellbore shear stress.In Weiyuan shale gas field,Sichuan Basin,under the common wellbore approach angle of nearly 90°,the wellbore is subjected to large shear stress and high risk of CD at the fracture approach angle range of 20° to 55° or its supplementary angle range.(2)When the fracture is partially opened,the wellbore shear stress is positively correlated with the fluid pressure,and negatively correlated with the fracture friction coefficient;when the fracture is fully opened,the wellbore shear stress is positively correlated with the natural fracture area.(3)The lower the elastic modulus and the longer the fracture length,the more serious the CD will be,and the Poisson’s ratio has a weak influence on the CD.The deformation first increases and then decreases with the increase of fracture approach angle,and reaches the maximum when the fracture approach angle is 45°.(4)At a given fracture approach angle,appropriately adjusting the wellbore approach angle can avoid high shear stress acting on wellbore,and reasonable control of the fluid pressure in the fracture can reduce the CD risk.The shear stress acting on casing is usually much greater than the shear strength of casing,so increasing casing strength or cementing quality have limited effect on reducing the risk of CD.Caliper logging data has verified that the CD prediction model is reliable,so the model can be used to establish risk analysis chart and calculate deformation value,to provide a reference for quick CD risk prediction in fracturing design.展开更多
According to the blasting construction of the diaphragm wall of Puxi approaching section of East Fuxing Road river-crossing tunnel, the monitoring project of the vibration of the existing tun-nel induced by the blasti...According to the blasting construction of the diaphragm wall of Puxi approaching section of East Fuxing Road river-crossing tunnel, the monitoring project of the vibration of the existing tun-nel induced by the blasting construction is put forward, which includes the sensors’ location, moni-tor method and the vibration monitoring system. Based on the monitoring data of the explosion vibration, the vibration wave forms, velocities, acceleration responses, main frequencies and fields of measure points are analyzed under the conditions of three locations and different charge quanti-ties. According to the safety-judging standard of explosion vibration, the conclusion that the exist- ing tunnel is safe under the explosion vibration is then drawn. Furthermore, the spectrum character-istics of three explosion vibrations and the spectrum changing properties of explosion vi-bration wave transmitting in different directions are concluded, which can provide reference to similar projects.展开更多
Long-term kinematic research of slow- moving debris slide is rare despite of the widespread global distribution of this kind. This paper presents a study of the kinematics and mechanism of the Jinpingzi debris slide l...Long-term kinematic research of slow- moving debris slide is rare despite of the widespread global distribution of this kind. This paper presents a study of the kinematics and mechanism of the Jinpingzi debris slide located on the Jinsha river bank in southwest China. This debris slide is known to have a volume of 27×106 ms in active state for at least one century. Field survey and geotechnical investigation were carried out to define the structure of the landslide. The physical and mechanical properties of the landslide materials were obtained by in-situ and laboratory tests. Additionally, surface and subsurface displacements, as well as groundwater level fluctuations, were monitored since 2005. Movement features, especially the response of the landslide movement to rainfall, were analysed. Relationships between resisting forces and driving forces were analysed by using the limit equilibrium method assuming rigid-plastic frictional slip. The results confirmed a viscous comoonent in the long-term continuous movement resulting in the quasioverconsolidated state of the slip zone with higher strength parameters than some other types of slowmoving landslides. Both surface and subsurface displacements showed an advancing pattern by the straight outwardly inclined (rather than gently or reversely inclined) slip zone, which resulted in low resistance to the entire sliding mass. The average surface displacement rate from 2005 to 2016 was estimated to be 0.19-0.87 mm/d. Basal sliding on the silty clay seam accounted for most of the deformation with different degrees of internal deformation in different parts. Rainfall was the predominant factor affecting the kinematics of Jinpingzi landslide while the role of groundwater level, though positive, was not significant. The response of the groundwater level to rainfall infiltration was not apparent. Unlike some shallow slow-moving earth flows or mudslides, whose behaviors are directly related to the phreatic groundwater level, the mechanism for Jinpingzi landslide kinematics is more likely related to the changing weight of the sliding mass and the downslope seepage pressure in the shallow soil mass resulting from rainfall events.展开更多
BACKGROUND Catheter ablation for atrial fibrillation(AF)is commonly performed worldwide.However,the clinical charac-teristics of hospitalized patients with AF and national trends in catheter ablation at tertiary hospi...BACKGROUND Catheter ablation for atrial fibrillation(AF)is commonly performed worldwide.However,the clinical charac-teristics of hospitalized patients with AF and national trends in catheter ablation at tertiary hospitals in China remain unreported.METHODS This study used the Chinese national database(Hospital Quality Monitoring System)from 2013 to 2016,which is a mandatory database that collects the front page of patients’medical records for hospital accreditation,to describe the clinical cha-racteristics of patients with AF as an overall cohort and as subgroups divided by catheter ablation and sex.RESULTS Of 597,919 AF patients first admitted,57,983 patients underwent catheter ablation[56,384 cases(97.2%)of radiofre-quency ablation and 1599 cases(2.8%)of cryoablation]at 746 tertiary hospitals.Nearly 10%of patients hospitalized with AF at ter-tiary hospitals in China underwent catheter ablation,and the percentage of patients undergoing catheter ablation was on the rise bet-ween 2013 and 2016,and the number of cases increased by 2.5 times.Compared with AF patients who did not undergo catheter ablation,those who did were younger,more frequently male,and had fewer baseline comorbidities.Although the overall CHA_(2)DS_(2)-VASc score revealed over half of the patients were high-risk,patients who underwent catheter ablation were mostly low-risk(71.2%of males and 59.1%of females).Considering in-hospital adverse events,the overall pericardial tamponade and all-cause death incidences were 0.2%(0.6%in the ablation group)and 1.2%(0.1%in the ablation group),respectively;both of which were higher in females than males.CONCLUSIONS In this study,AF patients who underwent catheter ablation were relatively young,had a low thrombosis risk,and had few comorbidities and adverse events.Females were older and experienced more complications than males.展开更多
Based on the elastoplastic model of cement sheath considering the influence of three-dimensional principal stress and the stress field model of interface crack,a mechanical performance design method of cement sheath i...Based on the elastoplastic model of cement sheath considering the influence of three-dimensional principal stress and the stress field model of interface crack,a mechanical performance design method of cement sheath is established to meet the wellbore sealing requirements during fracturing.This method takes the failure types of the cement sheath,such as tensile failure,plastic yield,interface crack propagation along interface and zigzag propagation into account.Meanwhile,the elasticity modulus and Poisson's ratio quantitative design charts of cement sheath are constructed based on this method,and the safety and risk areas of wellbores are defined,which quantify the yield strength and tensile strength indexes of cement sheath.The results show that decreasing elasticity modulus,increasing yield strength and Poisson's ratio of cement sheath can avoid plastic deformation of cement sheath;increasing the tensile strength of cement sheath can prevent its tensile failure;increasing elasticity modulus and Poisson's ratio of cement sheath is good for shortening the length of the interface crack,but will increase the risk of interface cracks zigzagging into cement sheath.The model calculation and case verification has proved that the method in this paper can give accurate calculation results and is convenient for field application.展开更多
Glucagon-like peptide 1(GLP-1)is secreted from enteroendocrine L cells in response to nutrient ingestion and exhibits insulinotropic properties by stimulating specific G protein-linked receptors(GLP-1Rs)on pancrea...Glucagon-like peptide 1(GLP-1)is secreted from enteroendocrine L cells in response to nutrient ingestion and exhibits insulinotropic properties by stimulating specific G protein-linked receptors(GLP-1Rs)on pancreaticβcells.Several GLP-1 mimetics,such as exenatide(exendin-4(Ex-4)),liraglutide,and lixisenatide,have been developed and approved as treatments for patients with type 2 diabetes.These peptides show bioactiv-ities almost identical to those of GLP- 1 and have a substantially longer plasma half-life than GLP-1 because of their resistance to dipeptidyl peptidase-4, a GLP-1 degrading enzyme.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.52022087).
文摘The field data of shale fracturing demonstrate that the flowback performance of fracturing fluid is different from that of conventional reservoirs,where the flowback rate of shale fracturing fluid is lower than that of conventional reservoirs.At the early stage of flowback,there is no single-phase flow of the liquid phase in shale,but rather a gas-water two-phase flow,such that the single-phase flow model for tight oil and gas reservoirs is not applicable.In this study,pores and microfractures are extracted based on the experimental results of computed tomography(CT)scanning,and a spatial model of microfractures is established.Then,the influence of rough microfracture surfaces on the flow is corrected using the modified cubic law,which was modified by introducing the average deviation of the microfracture height as a roughness factor to consider the influence of microfracture surface roughness.The flow in the fracture network is simulated using the modified cubic law and the lattice Boltzmann method(LBM).The results obtained demonstrate that most of the fracturing fluid is retained in the shale microfractures,which explains the low fracturing fluid flowback rate in shale hydraulic fracturing.
基金Supported by the National Natural Science Foundation of China(51974332).
文摘This study conducted temporary plugging and diversion fracturing(TPDF)experiments using a true triaxial fracturing simulation system within a laboratory setting that replicated a lab-based horizontal well completion with multi-cluster sand jetting perforation.The effects of temporary plugging agent(TPA)particle size,TPA concentration,single-cluster perforation number and cluster number on plugging pressure,multi-fracture diversion pattern and distribution of TPAs were investigated.A combination of TPAs with small particle sizes within the fracture and large particle sizes within the segment is conducive to increasing the plugging pressure and promoting the diversion of multi-fractures.The addition of fibers can quickly achieve ultra-high pressure,but it may lead to longitudinal fractures extending along the wellbore.The temporary plugging peak pressure increases with an increase in the concentration of the TPA,reaching a peak at a certain concentration,and further increases do not significantly improve the temporary plugging peak pressure.The breaking pressure and temporary plugging peak pressure show a decreasing trend with an increase in single-cluster perforation number.A lower number of single-cluster perforations is beneficial for increasing the breaking pressure and temporary plugging peak pressure,and it has a more significant control on the propagation of multi-cluster fractures.A lower number of clusters is not conducive to increasing the total number and complexity of artificial fractures,while a higher number of clusters makes it difficult to achieve effective plugging.The TPAs within the fracture is mainly concentrated in the complex fracture areas,especially at the intersections of fractures.Meanwhile,the TPAs within the segment are primarily distributed near the perforation cluster apertures which initiated complex fractures.
基金supported by the National Natural Science Foundation of China(Project Nos.51774062 and 52274032)Scientific and Technological Key Research Program of Chongqing Municipal Education Commission(KJZD-K201901502)+1 种基金General Project of Chongqing Natural Science Foundation(CSTB2022NSCQMSX0349)Science and Technology Research Program of Chongqing Municipal Education Commission(KJQN202313101)。
文摘Two allyldimethylalkyl quaternary ammonium salt(AQAS)monomers,N,N-dimethylallylphenylpropylammonium bromide(AQAS1)and N,N-dimethylallylnonylammonium bromide(AQAS2),were synthesized and used to prepare modified polyacrylamide materials.Two new drag reducers were synthesized from acrylamide(AM),sodium acrylate(Na AA)and a cationic modified monomer(AQAS1 or AQAS2)via aqueous solution polymerization,and the copolymers were named P(AM/Na AA/AQAS1)and P(AM/Na AA/AQAS2),respectively.The structures of the drag reduction agents were confirmed by IR and1H NMR spectroscopies.The molecular weight(Mw)of P(AM/Na AA/AQAS1)was 1.79×10^(6)g/mol.When the copolymer concentration was 1000 mg/L and the flow rate was 45 L/min,in fresh water the highest drag reduction rate was 75.8%,in 10,000 mg/L Na Cl solution the drag reduction rate decreased to 72.9%.The molecular weight of P(AM/Na AA/AQAS2)was 3.17×10^(6)g/mol.When the copolymer concentration was500 mg/L and the flow rate was 45 L/min,the drag reduction rate reached 75.2%,and in 10,000 mg/L Na Cl solution the drag reduction rate was 73.3%,decreased by approximately 1.9%.The drag reduction rate for partially hydrolyzed polyacrylamide(HPAM)was also investigated,and the results showed that the drag reduction rates for 500 and 1000 mg/L HPAM solutions were merely 43.2%and 49.0%in brine,respectively.Compared with HPAM,both of the above copolymers presented better drag reduction capacities.
文摘Almost all sandstone reservoirs contain interlayers. The identification and characterization of these interlayers iscritical for minimizing the uncertainty associated with oilfield development and improving oil and gas recovery.Identifying interlayers outside wells using identification methods based on logging data and machine learning isdifficult and seismic-based identification techniques are expensive. Herein, a numerical model based on seepageand well-testing theories is introduced to identify interlayers using transient pressure data. The proposed modelrelies on the open-source MATLAB Reservoir Simulation Toolbox. The effects of the interlayer thickness, position,and width on the pressure response are thoroughly investigated. A procedure for inverting interlayer parametersin the reservoir using the bottom-hole pressure is also proposed. This method uses only transient pressuredata during well testing and can effectively identify the interlayer distribution near the wellbore at an extremelylow cost. The reliability of the model is verified using effective oilfield examples.
基金funded by the Science and Technology Cooper-ation Project of the CNPC-SWPU Innovation Alliance(Grant No.2020CX030101)the National Natural Science Foundation of China(Grant No.51674044).
文摘The paleoenvironment of shales can be reconstructed to some extent using the combinations or concentrations of elements that correlate strongly with environmental conditions.In this study,we analyzed rare earth elements(REEs),major elements,and trace elements in the marine-continental transitional shales(transitional shales for short)of the Shan 2^(3)submember of the Shanxi Formation in the southeastern Ordos Basin.The purpose is to deduce the paleoenvironmental conditions of the shales,encompassing paleoredox,paleoclimate,paleoproductivity,and paleo-provenance.The Shan 2^(3)submember comprises four sections,namely Shan 2^(3)-1,Shan 2^(3)-2,Shan 2^(3)-3,and Shan 2^(3)-4.The Ba/Al,P/Al,and Cu/Al ratios,along with biogenic barium(Babio),indicate that the paleoproductivity of the submember peaked during the Shan 2^(3)-1 deposition and exhibited a downtrend upward in other sections.Trends in the Uau and the Ni/Co,V/Cr,U/Th,and V/Sc ratios suggest that suboxic conditions prevailed during the Shan 2^(3)-1 deposition,with the oxidation level gradually increasing from Shan 2^(3)-1 to Shan 2^(3)-4.C-value and the Sr/Cu vs.Ga/Rb cross-plot indicate a warm and arid paleoclimate during the Shan 2^(3)-1 deposition,which transitioned to cooler,drier conditions during the deposition of other sections.Indicators sensitive to paleoclimate,such as the K/Rb and Th/U ratios,along with the ICV,PIA,and Chemical Index of Alteration(CIA),highlight elevated weathering from Shan 2^(3)-2 to Shan 2^(3)-4,with Shan 2^(3)-1 exhibiting the weakest weathering during its deposition.As suggested by the REE data,the Zr/Sc vs.Th/Sr cross-plot,provenance discriminant functions,and the cross-plots of Hf vs.La/Th,Th vs.Hf-Co,and∑REE vs.La/Yb,the sedimentary provenance for the transitional shales of the Shan 2^(3)submember is of multiple origins,with significant contributions from the Upper Continental Crust(UCC).Discriminant diagrams,including those of Th-Co-Zr/10,Th-Sc-Zr/10,La-Th-Sc,and K_(2)O/Na_(2)O vs.SiO_(2),suggest that the transitional shales of the Shan 2^(3)submember were primarily deposited under tectonic settings such as continental island arcs(CIAs)and passive continental margins(PCMs).
基金supported by National Key Research and Development Project (2020YFE0204900)National Natural Science Foundation of China (Grant Numbers 62073193,61873333)Key Research and Development Plan of Shandong Province (Grant Numbers 2019TSLH0301,2021CXGC010204).
文摘Incomplete fault signal characteristics and ease of noise contamination are issues with the current rolling bearing early fault diagnostic methods,making it challenging to ensure the fault diagnosis accuracy and reliability.A novel approach integrating enhanced Symplectic geometry mode decomposition with cosine difference limitation and calculus operator(ESGMD-CC)and artificial fish swarm algorithm(AFSA)optimized extreme learning machine(ELM)is proposed in this paper to enhance the extraction capability of fault features and thus improve the accuracy of fault diagnosis.Firstly,SGMD decomposes the raw vibration signal into multiple Symplectic geometry components(SGCs).Secondly,the iterations are reset by the cosine difference limitation to effectively separate the redundant components from the representative components.Additionally,the calculus operator is performed to strengthen weak fault features and make them easier to extract,and the singular value decomposition(SVD)weighted by power spectrum entropy(PSE)can be utilized as the sample feature representation.Finally,AFSA iteratively optimized ELM is adopted as the optimized classifier for fault identification.The superior performance of the proposed method has been validated by various experiments.
文摘In recent years, some governments have been working on solutions to transform public administrations and provide high-quality services to users. The United Nations has recommended integrating digital technology into various aspects of life, including public services. The objective is to offer real-time, high-quality digital services, improve the delivery of public services, enhance their effectiveness and efficiency, while achieving objectives such as transparency, interoperability and citizen satisfaction. However, most governments in developing countries are unable to keep up with this trend. As a result, they often create digital public services that fall short of users’ expectations. This study aims to identify the fundamental factors influencing the quality of service in relation to user satisfaction and to explore the relevance of digital technology in implementing this quality within Cameroon public administrations. To achieve this, we used a qualimetric research method, which included non-directive interviews, questionnaires, and structured observations. The results showed that the public services offered in our study environment did not meet users’ expectations. However, the study identified the fundamental aspects to be considered in providing quality public services connected to user satisfaction, as well as the strengths of digitization in achieving this quality.
文摘A stable surface to move manpower and equipment is a key for the construction operations. To create a stable road surface, the road construction techniques are time-consuming and expensive for a traditional construction which requires compaction of soil, aggregate base, sub-base and asphaltic layers. A Geosynthetic Access Mat (GAM) system can serve as an alternative to other traditional construction techniques to accommodate temporary construction. Due to its rigidity, the mat system can provide substantial vertical resistance to the applied load under a large deflection subject to soil conditions. This paper provides details of GAM specifications, soil conditions, applications, installation procedure, comparison with other soil stabilization methods and Aramco experience for deployments of these mats.
文摘At 09:15 local time on May 13,2018 in the Republic of Mozambique,Li Zhanshu,a member of the Standing Committee of the Political Bureau of the CPC Central Committee and Chairman of the Standing Committee of the National People's Congress (NPC),and Veronica Macamo,Speaker of the Republic of Mozambique,attended the founding ceremony of the Chinese aid project for the Confucius Institute and Media Arts Institute in Mozambique.
文摘Thermoelectric generators(TEGs)are considered promising devices for waste heat recovery from various systems.The Seebeck effect can be utilized to generate power using the residual heat emitted by the filter dryer receiver(FDR)of an air conditioning(A/C)system,which would otherwise go to waste.The study aims to build a set of thermoelectric generators(TEG)to collect the waste heat of the FDR and generate low-power electricity.A novel electrical circuit with two transformers is designed and fabricated to produce a more stable voltage for operation and charging.The thermoelectric generator(TEGs)was installed on the FDR of the A/C unit.The test showed that climate conditions have a significant impact on the output power generated from the system.The results showed that the peak voltage recorded in the current study is 5.2 V per day(wet,cold,and wind weather)with an output power of 0.2 W.These values are acceptable for powering the load and charging a single battery with 3.5 V as the voltage increases battery 0.1 V/20 min charge.A case study of operating the emergency signs in a building was considered.The current heat recovery system is deemed to be easily installed and can be connected to a network of TEGs to produce more power.
文摘Schwann cells are glial cells in the peripheral nervous system that provide trophic support for the growth and maintenance of sensory,motor,and autonomic neurons and ensheath their axons in either a myelinating or an unmyelinating form.Myelinating Schwann cells wrap around largedia meter axons to form m ultilayered myelin structures essential for the rapid action potential propagation from one node of Ranvier to the next node(saltatory conduction).
基金supported by National Key Research and Development Program of China(2019YFA0708302)National Natural Science Foundation of China(Grant No.52004296,and Grant No.52274016)+1 种基金the Foundation of State Key Laboratory of Petroleum Resources and Prospecting(PRP/DX-2206)Science Foundation of China University of Petroleum-Beijing(No.2462022YXZZ007,No.2462022BJRC012).
文摘Figuring out rock strength plays essential roles in the sub ground mining activities,such as oil and gas well drilling and hydraulic fracturing,coal mining,tunneling,and other civil engineering scenarios.To help understand the effects of the mineralogical composition on evaluating the rock strength,this research tries to establish indirect prediction models of rock strength by specific input mineral contents for common sedimentary rocks.Using rock samples collected from the outcrops in the Sichuan Basin,uniaxial compression tests have been conducted to sandstone,carbonate,and shale cores.Combining with statistical analysis,the experimental data prove it true that the mineralogical composition can be utilized to predict the rock strength under specific conditions but the effects of mineralogical composition on the rock strength highly depend on the rock lithologies.According to the statistical analysis results,the predicted values of rock strengths by the mineral contents can get high accuracies in sandstone and carbonate rocks while no evidences can be found in shale rocks.The best indicator for predicting rock strength should be the quartz content for the sandstone rocks and the dolomite content for the carbonate rocks.Especially,to improve the evaluation accuracy,the rock strengths of sandstones can be obtained by substituting the mineral contents of quartz and clays,and those of carbonates can be calculated by the mineral contents of dolomite and calcite.Noticeably,the research data point out a significant contrast of quartz content in evaluating the rock strength of the sandstone rocks and the carbonate rocks.Increasing quartz content helps increase the sandstone strength but decrease the carbonate strength.As for shale rocks,no relationship exists between the rock strength and the mineralogical composition(e.g.,the clay fractions).To provide more evidences,detailed discussion also provides the readers more glances into the framework of the rock matrix,which can be further studied in the future.These findings can help understand the effects of mineralogical composition on the rock strengths,explain the contrasts in the rock strength of the responses to the same mineral content(e.g.,the quartz content),and provide another indirect method for evaluating the rock strength of common sedimentary rocks.
基金Research Project of Lianyungang Association for Science and Technology(Lkxyb1907)Research Project of"333 Project"of Jiangsu Province(BRA2019245)Research Project of"521"Project of Lianyungang City(LYG52105-2018090)。
文摘Assessment of water quality by firefly algorithm based on BP neural network model(FA-BP model)is built.In this model,the evaluation index function is constructed by BP Artificial Neural Network Algorithm(BP model),and Firefly Algorithm(FA model)is introduced to optimize weight values and thresholds to find the optimal solution.Fuzzy Comprehensive Evaluation method,Grey Incidence Analysis Algorithm and FA-BP model will be applied to evaluate the water quality of the five main rivers in Lianyungang City including Longwei,Yudai,Dapu,Paidan,and Dongyan River.The results show that the Fuzzy Comprehensive Evaluation method is difficult to use for slight pollution rivers with several slightly over standard indexes.It will be easy to ignore the impact of extreme indexes by Grey Incidence Analysis Algorithm.FA-BP model solves the shortcomings of the two methods.The evaluation results provide an important reference for the formulation of reasonable measures.It is a relatively comprehensive evaluation method and has a good application prospect in water quality evaluation.
基金Supported by the Fundamental Project of China National Petroleum Corporation(2021DJ0501).
文摘The relationship between paleogeographic pattern and sedimentary differentiation of evaporite-carbonate symbiotic system is examined based on logging,core and thin section data,by taking the sixth sub-member of fifth member of Ordovician Majiagou Formation(M56)in the central-eastern Ordos Basin as an example.(1)Seven sub-geomorphic units(Taolimiao west low,Taolimiao underwater high,Taolimiao east low,Hengshan high,East salt low,North slope and Southwest slope)developed in the study area.(2)The“three lows”from west to east developed dolomitic restricted lagoon,evaporite evaporative lagoon and salt evaporative lagoon sedimentary facies respectively,the"two highs"developed high-energy grain beach and microbial mound,and the north and south slopes developed dolomitic flats around land.(3)The paleogeographic pattern caused natural differentiation of replenishment seawater from the northwest Qilian sea,leading to the eccentric sedimentary differentiation of dolomite,evaporite and salt rock symbiotic system from west to east,which is different from the classic“bull's eye”and“tear drop”distribution patterns.(4)As the Middle Qilian block subducted and collided into the North China Plate,the far-end compression stress transferred,giving rise to the alternate highland and lowland in near north to south direction during the sedimentary period of M56 sub-member.(5)Taolimiao underwater high and Hengshan high developed favorable zones of microbial mounds and grain shoals in south to north strike in M56 sub-member,making them favorable exploration areas with great exploration potential in the future.
基金Supported by National Natural Science Foundation of China(51904258,51874250)Project of Science and Technology of Shale Gas Exploration&Development of CCDC(2019-JS-941)National Major Project of Science and Technology(2016ZX05048-004-006)。
文摘To study the casing deformation(CD)in shale gas well fracturing caused by natural fracture slip,a fracture face stress model is built based on stress analysis,and a CD prediction model is established based on complex function to analyze factors affecting wellbore shear stress and CD.(1)The fracture and wellbore approach angles have significant impacts on the wellbore shear stress.In Weiyuan shale gas field,Sichuan Basin,under the common wellbore approach angle of nearly 90°,the wellbore is subjected to large shear stress and high risk of CD at the fracture approach angle range of 20° to 55° or its supplementary angle range.(2)When the fracture is partially opened,the wellbore shear stress is positively correlated with the fluid pressure,and negatively correlated with the fracture friction coefficient;when the fracture is fully opened,the wellbore shear stress is positively correlated with the natural fracture area.(3)The lower the elastic modulus and the longer the fracture length,the more serious the CD will be,and the Poisson’s ratio has a weak influence on the CD.The deformation first increases and then decreases with the increase of fracture approach angle,and reaches the maximum when the fracture approach angle is 45°.(4)At a given fracture approach angle,appropriately adjusting the wellbore approach angle can avoid high shear stress acting on wellbore,and reasonable control of the fluid pressure in the fracture can reduce the CD risk.The shear stress acting on casing is usually much greater than the shear strength of casing,so increasing casing strength or cementing quality have limited effect on reducing the risk of CD.Caliper logging data has verified that the CD prediction model is reliable,so the model can be used to establish risk analysis chart and calculate deformation value,to provide a reference for quick CD risk prediction in fracturing design.
文摘According to the blasting construction of the diaphragm wall of Puxi approaching section of East Fuxing Road river-crossing tunnel, the monitoring project of the vibration of the existing tun-nel induced by the blasting construction is put forward, which includes the sensors’ location, moni-tor method and the vibration monitoring system. Based on the monitoring data of the explosion vibration, the vibration wave forms, velocities, acceleration responses, main frequencies and fields of measure points are analyzed under the conditions of three locations and different charge quanti-ties. According to the safety-judging standard of explosion vibration, the conclusion that the exist- ing tunnel is safe under the explosion vibration is then drawn. Furthermore, the spectrum character-istics of three explosion vibrations and the spectrum changing properties of explosion vi-bration wave transmitting in different directions are concluded, which can provide reference to similar projects.
文摘Long-term kinematic research of slow- moving debris slide is rare despite of the widespread global distribution of this kind. This paper presents a study of the kinematics and mechanism of the Jinpingzi debris slide located on the Jinsha river bank in southwest China. This debris slide is known to have a volume of 27×106 ms in active state for at least one century. Field survey and geotechnical investigation were carried out to define the structure of the landslide. The physical and mechanical properties of the landslide materials were obtained by in-situ and laboratory tests. Additionally, surface and subsurface displacements, as well as groundwater level fluctuations, were monitored since 2005. Movement features, especially the response of the landslide movement to rainfall, were analysed. Relationships between resisting forces and driving forces were analysed by using the limit equilibrium method assuming rigid-plastic frictional slip. The results confirmed a viscous comoonent in the long-term continuous movement resulting in the quasioverconsolidated state of the slip zone with higher strength parameters than some other types of slowmoving landslides. Both surface and subsurface displacements showed an advancing pattern by the straight outwardly inclined (rather than gently or reversely inclined) slip zone, which resulted in low resistance to the entire sliding mass. The average surface displacement rate from 2005 to 2016 was estimated to be 0.19-0.87 mm/d. Basal sliding on the silty clay seam accounted for most of the deformation with different degrees of internal deformation in different parts. Rainfall was the predominant factor affecting the kinematics of Jinpingzi landslide while the role of groundwater level, though positive, was not significant. The response of the groundwater level to rainfall infiltration was not apparent. Unlike some shallow slow-moving earth flows or mudslides, whose behaviors are directly related to the phreatic groundwater level, the mechanism for Jinpingzi landslide kinematics is more likely related to the changing weight of the sliding mass and the downslope seepage pressure in the shallow soil mass resulting from rainfall events.
基金supported by the China-WHO Biennial Collaborative Projects 2016–2017(No.2016/648722–0).
文摘BACKGROUND Catheter ablation for atrial fibrillation(AF)is commonly performed worldwide.However,the clinical charac-teristics of hospitalized patients with AF and national trends in catheter ablation at tertiary hospitals in China remain unreported.METHODS This study used the Chinese national database(Hospital Quality Monitoring System)from 2013 to 2016,which is a mandatory database that collects the front page of patients’medical records for hospital accreditation,to describe the clinical cha-racteristics of patients with AF as an overall cohort and as subgroups divided by catheter ablation and sex.RESULTS Of 597,919 AF patients first admitted,57,983 patients underwent catheter ablation[56,384 cases(97.2%)of radiofre-quency ablation and 1599 cases(2.8%)of cryoablation]at 746 tertiary hospitals.Nearly 10%of patients hospitalized with AF at ter-tiary hospitals in China underwent catheter ablation,and the percentage of patients undergoing catheter ablation was on the rise bet-ween 2013 and 2016,and the number of cases increased by 2.5 times.Compared with AF patients who did not undergo catheter ablation,those who did were younger,more frequently male,and had fewer baseline comorbidities.Although the overall CHA_(2)DS_(2)-VASc score revealed over half of the patients were high-risk,patients who underwent catheter ablation were mostly low-risk(71.2%of males and 59.1%of females).Considering in-hospital adverse events,the overall pericardial tamponade and all-cause death incidences were 0.2%(0.6%in the ablation group)and 1.2%(0.1%in the ablation group),respectively;both of which were higher in females than males.CONCLUSIONS In this study,AF patients who underwent catheter ablation were relatively young,had a low thrombosis risk,and had few comorbidities and adverse events.Females were older and experienced more complications than males.
基金Supported by Science and Technology Cooperation Project of the CNPC-SWPU Innovation Alliance(2020CX040000)Sichuan Science and Technology Program(2020JDTD0019)+1 种基金National Natural Science Foundation of China(52004231)Research Project of Dagang Oilfield(NO.DGYT-2018-JS-244).
文摘Based on the elastoplastic model of cement sheath considering the influence of three-dimensional principal stress and the stress field model of interface crack,a mechanical performance design method of cement sheath is established to meet the wellbore sealing requirements during fracturing.This method takes the failure types of the cement sheath,such as tensile failure,plastic yield,interface crack propagation along interface and zigzag propagation into account.Meanwhile,the elasticity modulus and Poisson's ratio quantitative design charts of cement sheath are constructed based on this method,and the safety and risk areas of wellbores are defined,which quantify the yield strength and tensile strength indexes of cement sheath.The results show that decreasing elasticity modulus,increasing yield strength and Poisson's ratio of cement sheath can avoid plastic deformation of cement sheath;increasing the tensile strength of cement sheath can prevent its tensile failure;increasing elasticity modulus and Poisson's ratio of cement sheath is good for shortening the length of the interface crack,but will increase the risk of interface cracks zigzagging into cement sheath.The model calculation and case verification has proved that the method in this paper can give accurate calculation results and is convenient for field application.
基金supported by a Grant-in-aid for Scientific Research from the Ministry of EducationScience+3 种基金Sports and Culture of Japan(grant number:25430056)the fund from Nukada Institute for Medical and Biological ResearchChibaJapan
文摘Glucagon-like peptide 1(GLP-1)is secreted from enteroendocrine L cells in response to nutrient ingestion and exhibits insulinotropic properties by stimulating specific G protein-linked receptors(GLP-1Rs)on pancreaticβcells.Several GLP-1 mimetics,such as exenatide(exendin-4(Ex-4)),liraglutide,and lixisenatide,have been developed and approved as treatments for patients with type 2 diabetes.These peptides show bioactiv-ities almost identical to those of GLP- 1 and have a substantially longer plasma half-life than GLP-1 because of their resistance to dipeptidyl peptidase-4, a GLP-1 degrading enzyme.