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Computerized cognitive remediation therapy on cognitive impairment and social function in patients with chronic schizophrenia
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作者 Jian-Jun Hu Xi-Rong Sun +1 位作者 Shuang-Ming Ni Yan Kong 《World Journal of Psychiatry》 SCIE 2024年第6期884-893,共10页
BACKGROUND Patients with schizophrenia may have various disease manifestations,most of which gradually tend toward incurable chronic decline,leading to mental disability.The basic symptoms of the disease can impair so... BACKGROUND Patients with schizophrenia may have various disease manifestations,most of which gradually tend toward incurable chronic decline,leading to mental disability.The basic symptoms of the disease can impair social function,whereas long-term hospitalization produces hospitalization syndrome,causing serious damage to social function.AIM To investigate the effects of Computerized Cognitive Remediation Therapy(CCRT)on cognitive and social functioning in patients with chronic schizophrenia.METHODS A retrospective analysis of 120 patients with chronic schizophrenia in Shanghai Pudong New Area Mental Health Center was performed.They were divided into an intervention group(60 cases treated with CCRT combined with conventional medication)and a control group(60 cases treated with conventional medication).After treatment,effects on cognitive function and social roles were observed in both groups.The Positive and Negative Syndrome Scale(PANSS)was used to assess the patients'psychiatric symptoms.The Wisconsin Card Sorting Test(WCST)was used to assess the patients'cognitive functioning,and the Social Functioning Scale for Psychiatric Inpatients(SSPI)was used to assess the social functioning of the inpatient psychiatric patients.RESULTS No significant differences were observed in the PANSS,WCST,and SSPI intergroup scores before treatment(P>0.05).After 2,4,and 6 wk of therapy,general psychopathological factors,positive symptoms,negative symptoms,and total PANSS scores of PANSS in the intervention group were lower than in the control group(P<0.05).After 2,4,and 6 wk of treatment,the number of false responses,number of persistent bugs,and total responses in the WCST were significantly lower in the intervention group than in the control group(P<0.05),and the amount of completed classification was significantly higher than in the control group(P<0.05).After 2,4,and 6 wk of therapy,the SSPI scores were significantly greater than those of the controls(P<0.05).After 6 wk of treatment,the efficacy rates of the control and intervention groups were 81.67%and 91.67%,respectively.The curative effect in the intervention group was significantly higher than that in the control group(P<0.05).CONCLUSION CCRT can significantly improve cognitive function and social abilities in patients with chronic schizophrenia. 展开更多
关键词 Computerized cognitive correction therapy SCHIZOPHRENIA Cognitive function Social function Psychopathological factors
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Research on Ideological and Political Education Psychological Counseling and Its Efficiency Improvement under the Network Background 被引量:1
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作者 Wang Ying Yu Qinming 《学术界》 CSSCI 北大核心 2016年第5期281-285,共5页
Ideological and political education psychological counseling is facing problems.Therefore,it is necessary to help the party workers to learn and master the knowledge a—bout psychological service,improve the ability o... Ideological and political education psychological counseling is facing problems.Therefore,it is necessary to help the party workers to learn and master the knowledge a—bout psychological service,improve the ability of party workers to participate in psychological counseling,strengthen the cultivation of the good political attitude of netizens and enhance the psychological service mechanism for the ideological and political works in order to further improve the efficiency of the psychological counseling of China's current ideological and political education. 展开更多
关键词 思想政治教育 心理疏导 网络 思想政治工作 心理咨询 服务机制 工作者 学习
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The Relationship between Psychological Suzhi and Mental Health among Chinese College Students 被引量:4
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作者 Xinqiang Wang Xueqi Zhang Dajun Zhang 《Journal of Biosciences and Medicines》 2016年第5期21-29,共9页
Object: To explore the relationship between psychological suzhi and mental health among Chinese college students, and to gain psychological suzhi factors that are predictors for mental health. Method: By using stratif... Object: To explore the relationship between psychological suzhi and mental health among Chinese college students, and to gain psychological suzhi factors that are predictors for mental health. Method: By using stratified sampling method, an investigation was conducted among 734 subjects. They were assessed with the College Student Psychological Suzhi Scale (CSPS, including 3 subscales, 28 factors) and General Health Questionnaire-20 item (GHQ-20, including 3 subscales). Results: 1) Psychological suzhi score for Chinese college students had negative correlation with the score of GHQ-20, GHQ-depression and GHQ-anxiety (p < 0.001), and positive correlation with the score of GHQ-self-affirmation (p < 0.001);2) Psychological suzhi score for Chinese college students was predictor of the score for GHQ-20 and its subscales namely GHQ-self-affirmation, GHQ-depression, and GHQ-anxiety (β = ?0.448, 0.439, ?0.262, ?0.259, p < 0.001);the variance explained by the score of GHQ-20 and its subscales were 19.9%, 19.1%, 6.7%, 6.5%;3) There were 12 psychological suzhi factors that were predictors for GHQ-self-affirmation which was known as the positive indicator of mental health (p < 0.05);11 psychological suzhi factors were predictors for GHQ-depression and GHQ-anxiety which was known as the negative indicator of mental health (p < 0.05). Conclusion: There exists a correlation between psychological suzhi and mental health, particularly in positive mental health. Indeed, the psychological suzhi factors are able to enhance the pertinence of mental health education. 展开更多
关键词 Chinese College Students Mental Health Psychological Suzhi Dual-Factor Model of Mental Health
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The Diagnosis for the Psychological and Behavioral Characteristics of the University Students' Suicide 被引量:1
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作者 YAO Yuehong 《美国中华健康卫生杂志》 2005年第4期83-86,共4页
关键词 大学生 自杀 心理特征 行为特征 诊断
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Neglected Trauma Suffered by the Brave—— Intervention in Psychological Crisis of Tianjin Firemen
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作者 Hai Ci Zhang Xinghai Sun Yijiang 《China Population Today》 2015年第6期20-31,共12页
Late at night on 12 August2015 at Tianjin Port,there was an explosion of chemicals equivalent to more than 20 tons of TNT explosives.Even people living200 km away were jarred awake.Wide attention was given to the peop... Late at night on 12 August2015 at Tianjin Port,there was an explosion of chemicals equivalent to more than 20 tons of TNT explosives.Even people living200 km away were jarred awake.Wide attention was given to the people that suffered,including victims,relatives of the martyrs,residents in the disaster area,the injured,and people who may be contaminated by the chemical explosion. 展开更多
关键词 下线 服务 迁移
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The Influence of Family Factors on the Mental Health of College Students was Analyzed Combined with Literature and Cases
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作者 Hongtao Xu Xuan Shen Ting Wang 《Journal of Psychological Research》 2023年第2期4-11,共8页
Through the combing of relevant literature and the analysis of relevant psychological students’cases,the composition of family factors affecting college students’mental health is analyzed,the specific manifestations... Through the combing of relevant literature and the analysis of relevant psychological students’cases,the composition of family factors affecting college students’mental health is analyzed,the specific manifestations of college students’psychological problems are summarized,and the influence of family factors on college students’mental health status is analyzed in detail.The article finally puts forward suggestions and recommendations for strengthening college students’family education and tries to explore how to promote college students’mental health through improving family education. 展开更多
关键词 Mental health Family factors Case analysis College students
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Effects of Different Feedback Conditions on Sensorimotor Adaptation Revealed in a Mirror Reversal Paradigm
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作者 Jingyue Xu Chen Yang +6 位作者 Mengzhan Liufu Shuai Chang Jinpeng Chen Feng Lu Alkis M. Hadjiosif Adrian M. Haith Xueqian Deng 《Journal of Behavioral and Brain Science》 2023年第7期127-141,共15页
Humans are able to overcome sensory perturbations imposed on their movements through motor learning. One of the key mechanisms to accomplish this is sensorimotor adaptation, an implicit, error-driven learning mechanis... Humans are able to overcome sensory perturbations imposed on their movements through motor learning. One of the key mechanisms to accomplish this is sensorimotor adaptation, an implicit, error-driven learning mechanism. Past work on sensorimotor adaptation focused mainly on adaptation to rotated visual feedback—A paradigm known as visuomotor rotation. Recent studies have shown that sensorimotor adaptation can also occur under mirror-reversed visual feedback. In visuomotor rotation, sensorimotor adaptation can be driven by both endpoint and online feedback [1] [2]. However, it’s not been clear whether both kinds of feedback can similarly drive adaptation under a mirror reversed perturbation. We performed a study to establish what kinds of feedback can drive adaptation under mirror reversal. In the first two conditions, the participants were asked to ignore visual feedback. In the first condition, we provided mirror reversed online feedback and endpoint feedback. We reproduced previous findings showing that online feedback elicited adaptation under mirror reversal. In a second condition, we provided mirror reversed endpoint feedback. However, in the second condition, we found that endpoint feedback alone failed to elicit adaptation. In a third condition, we provided both types of feedback at the same time, but in a conflicting way: endpoint feedback was non-reversed while online feedback was mirror reversed. The participants were asked to ignore online visual feedback and try to hit the target with help from veridical endpoint feedback. In the third condition, in which veridical endpoint feedback and mirror reversed online feedback were provided, adaptation still occurred. Our results showed that endpoint feedback did not elicit adaptation under mirror reversal but online feedback did. This dissociation between effects of endpoint feedback and online feedback on adaptation under mirror reversal suggests that adaptation under these different kinds of feedback might in fact operate via distinct mechanisms. 展开更多
关键词 Endpoint Feedback Online Feedback Motor Learning Implicit Adaptation Mirror Reversal
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Look into my eyes:What can eye-based measures tell us about the relationship between physical activity and cognitive performance?
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作者 Liye Zou Fabian Herold +11 位作者 Sebastian Ludyga Keita Kamijo Notger G.Muller Matthew B.Pontifex Matthew Heath Ryuta Kuwamizu Hideaki Soya Charles H.Hillman Soichi Ando Brandon L.Alderman Boris Cheval Arthur F.Kramer 《Journal of Sport and Health Science》 SCIE CAS CSCD 2023年第5期568-591,共24页
Background:There is a growing interest to understand the neurobiological mechanisms that drive the positive associations of physical activity and fitness with measures of cognitive performance.To better understand tho... Background:There is a growing interest to understand the neurobiological mechanisms that drive the positive associations of physical activity and fitness with measures of cognitive performance.To better understand those mechanisms,several studies have employed eye-based measures(e.g., eye movement measures such as saccades,pupillary measures such as pupil dilation,and vascular measures such as retinal vessel diameter)deemed to be proxies for specific neurobiological mechanisms.However,there is currently no systematic review providing a comprehensive overview of these studies in the field of exercise-cognition science.Thus,this review aimed to address that gap in the literature.Methods:To identify eligible studies,we searched 5 electronic databases on October 23,2022.Two researchers independently extracted data and assessed the risk of bias using a modified version of the Tool for the assEssment of Study qualiTy and reporting in EXercise(TESTEX scale,for interventional studies) and the critical appraisal tool from the Joanna Briggs Institute(for cross-sectional studies).Results:Our systematic review(n=35 studies) offers the following main findings:(a) there is insufficient evidence available to draw solid conclusions concerning gaze-fixation-based measures;(b) the evidence that pupillometric measures,which are a proxy for the noradrenergic system,can explain the positive effect of acute exercise and cardiorespiratory fitness on cognitive performance is mixed;(c) physical training-or fitness-related changes of the cerebrovascular system(operationalized via changes in retinal vasculature) are,in general,positively associated with cognitive performance improvements;(d) acute and chronic physical exercises show a positive effect based on an oculomotor-based measure function(operationalized via antisaccade tasks);and(e) the positive association between cardiorespiratory fitness and cognitive performance is partly mediated by the dopaminergic system(operationalized via spontaneous eye-blink rate).Conclusion:This systematic review offers confirmation that eye-based measures can provide valuable insigt into the neurobiological mechanisms that may drive positive associations between physical activity and fitness and measures of cognitive performance.However,due to the limited number of studies utilizing specific methods for obtaining eye-based measures(e.g.,pupillometry,retinal vessel analysis,spontaneous eye blink rate) or investigating a possible dose-response relationship,further research is necessary before more nuanced conclusions can be drawn.Given that eye-based measures are economical and non-invasive,we hope this review will foster the future application of eye-based measures in the field of exercise-cognition science. 展开更多
关键词 COGNITION EXERCISE FITNESS Pupil size RetinaTagedAPTARAEnd
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心理韧性研究诸进路 被引量:143
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作者 席居哲 左志宏 WU Wei 《心理科学进展》 CSSCI CSCD 北大核心 2012年第9期1426-1447,共22页
心理韧性研究自发轫至今出现了若干可供遵循的进路,主要有:以人为中心模型、以变量为中心模型、时间路径模型和因素-过程模型等。以人为中心进路围绕"人"开展研究,将甄别出的心理韧性者与非韧性者及未经历严重压力/逆境者进... 心理韧性研究自发轫至今出现了若干可供遵循的进路,主要有:以人为中心模型、以变量为中心模型、时间路径模型和因素-过程模型等。以人为中心进路围绕"人"开展研究,将甄别出的心理韧性者与非韧性者及未经历严重压力/逆境者进行比较,尝试理解心理韧性的由来。以变量为中心进路则聚焦于压力/危险逆境指标、心理韧性相关因子及心理社会发展功能指标,经由分析这些变量的关系以探寻和推测心理韧性发展的机制。时间路径进路专注于时间进程,追踪研究对象在严重压力/逆境开始前后到相当长一段时期心理社会功能变化过程特点,以解读人类压力/逆境适应系统的运作特征及其功能差异,推断心理韧性发展的过程及机制。因素-过程整合进路则以生态系统理论为指导,兼顾因素与过程,尝试提供一个更具研究指导性的心理韧性整合模型和一套机制解释策略基准框架。诸心理韧性研究进路各有侧重,互有长短,研究者对之了然于胸将有助于选择适切的研究设计与分析策略,取长避短,从而提高研究揭示效力。 展开更多
关键词 心理韧性 研究进路 以人为中心模型 以变量为中心模型 时间路径模型 因素-过程整合模型
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心理弹性儿童的心理理论 被引量:30
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作者 桑标 席居哲 +1 位作者 左志宏 Wu Wei 《心理科学》 CSSCI CSCD 北大核心 2011年第3期581-587,共7页
本研究探讨了心理弹性儿童与缺乏心理弹性儿童心理理论的差异及其心理弹性发展意蕴。对523名从小学三年级至初中二年级中小学生利用多信源汇聚操作甄别法,通过逆境/压力综合评定与心理社会发展功能综合评定,甄别出心理弹性儿童99人和缺... 本研究探讨了心理弹性儿童与缺乏心理弹性儿童心理理论的差异及其心理弹性发展意蕴。对523名从小学三年级至初中二年级中小学生利用多信源汇聚操作甄别法,通过逆境/压力综合评定与心理社会发展功能综合评定,甄别出心理弹性儿童99人和缺乏心理弹性儿童176人。对全部被试施测12类心理理论任务。在控制了阅读能力、性别和年龄所进行的多元协方差分析(MANCOVA)结果发现:心理弹性儿童在心理理论得分总体上显著高于缺乏心理弹性儿童;对12类任务分别进行协方差分析(ANCOVA)表明,两组儿童心理理论得分显著性差异主要体现在诸如假装、讽刺、说服、双重欺骗、误解等5类任务上,白谎任务上组间差异临界显著,其余任务组间差异未达统计学意义显著性水平。以年龄和性别为控制变量所进行的偏相关分析结果提示,心理理论与心理社会发展功能之间存在显著的正向关联。最后较详细讨论了心理理论对心理弹性发展的意义。 展开更多
关键词 心理弹性 儿童 逆境/压力 心理理论 奇异故事测验
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不同心理韧性高中生的日常情绪状态与情绪自我调节方式 被引量:28
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作者 席居哲 左志宏 WU Wei 《中国心理卫生杂志》 CSSCI CSCD 北大核心 2013年第9期709-714,共6页
目的:比较高、中、低心理韧性水平高中生的日常情绪状态及情绪自我调节方式。方法:选取202名高中生,施测青少年心理韧性量表(RSCA)、正负情绪情感量表(PANAS)和情绪调节方式问卷(ERQ)。依据RSCA得分分为高(n=87)、中(n=61)、低心理韧性... 目的:比较高、中、低心理韧性水平高中生的日常情绪状态及情绪自我调节方式。方法:选取202名高中生,施测青少年心理韧性量表(RSCA)、正负情绪情感量表(PANAS)和情绪调节方式问卷(ERQ)。依据RSCA得分分为高(n=87)、中(n=61)、低心理韧性组(n=54),比较不同心理韧性组日常情绪状态及积极、消极情绪的调节方式差异。结果:高心理韧性组PANAS积极情绪情感得分高于中、低心理韧性组[(33.3±6.2)vs.(30.8±5.2),(29.4±6.9);P<0.001],低心理韧性组PANAS消极情绪情感得分高于高、中心理韧性组[(27.5±7.7)vs.(22.3±6.0),(24.0±7.3);P<0.001]。在积极情绪调节方式上,高心理韧性组ERQ重视得分高于低心理韧性组[(3.4±0.6)vs.(3.0±0.8);P<0.05],宣泄得分高于中、低心理韧性组[(3.2±0.7)vs.(3.0±0.6),(2.8±0.9);P<0.01],而抑制得分低于中、低心理韧性组[(1.4±0.5)vs.(1.6±0.5),(1.8±0.8);P<0.01];在消极情绪调节方式上,高心理韧性组抑制得分低于中、低心理韧性组[(2.2±0.7)vs.(2.5±0.6),(2.6±0.8);P<0.05],而低心理韧性组重视得分高于高、中心理韧性组[(2.1±0.7)vs.(1.8±0.5),(1.9±0.5);P<0.001)]。结论:不同心理韧性高中生日常情绪状态存在差异,高心理韧性高中生倾向于对积极情绪采用更多的重视、宣泄和更少的减弱调节,对消极情绪则采用更少的重视和抑制调节。 展开更多
关键词 心理韧性 高中生 日常情绪状态 情绪自我调节方式 横断面研究
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图画书指导阅读对幼儿挑战行为的改善 被引量:9
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作者 左志宏 席居哲 石静 《学前教育研究》 CSSCI 北大核心 2012年第6期29-35,41,共8页
幼儿挑战行为指幼儿不适宜的、烦扰或有害的行为,具体体现为行为过多或不足、不合时宜、漫不经心、无事生非或节外生枝。具有挑战行为的幼儿在同龄群体中占有较高比例且有增加之势,寻求有效干预幼儿挑战行为的途径是当前学前教育工作者... 幼儿挑战行为指幼儿不适宜的、烦扰或有害的行为,具体体现为行为过多或不足、不合时宜、漫不经心、无事生非或节外生枝。具有挑战行为的幼儿在同龄群体中占有较高比例且有增加之势,寻求有效干预幼儿挑战行为的途径是当前学前教育工作者须着力解决的重要课题之一。已有的干预方案因条件的可控性限制了其使用范围,探索与幼儿教育生态紧密结合的干预方法将更具应用前景。本研究利用自编幼儿社会行为观察表筛选出36名具有挑战行为的幼儿,并将其分成对照组(18名)和干预组(18名)。对照组不进行任何特别的教育处置,对干预组则进行为期2周每天20分钟的图画书指导阅读;采用5个时间点采集两组儿童社会行为得分。结果发现:干预组幼儿与对照组幼儿在基线期挑战行为得分没有显著性差异,至第1周周三即出现了显著性差异,干预组幼儿挑战行为得分显著低于对照组幼儿;随着时间的推移,干预组幼儿的挑战行为得到明显的改善。重复测量的方差分析表明,干预组幼儿社会行为随时间推进表现出极其显著的改善。这一研究结果证明幼儿的挑战行为具有较大的可塑性,选择适宜的图画书进行指导性阅读,是改善幼儿挑战行为的有效途径之一。 展开更多
关键词 挑战行为幼儿 图画书 指导性阅读
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Study of the hippocampus and the anterior cingulate gyrus by proton MR spectroscopy in patients with post-traumatic stress disorder 被引量:4
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作者 Min Guo Feng Chen +2 位作者 Jun-Cheng Guo Xiang-Ling Jiang Tao Liu 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2012年第2期162-164,共3页
Objective:To explore the characteristics of metabolic changes in patients with post-traumatic stress disorder through 1H-MRS in neuroanatomical circuit comparing with age-matches controls.Methods:Fifty patients with p... Objective:To explore the characteristics of metabolic changes in patients with post-traumatic stress disorder through 1H-MRS in neuroanatomical circuit comparing with age-matches controls.Methods:Fifty patients with post-traumatic stress disorder and SO gender-and agematched normal controls were involved.The neurochemical abnormalities including the levels of choline(Cho)/ creatine(Cr) and N-acetylaspartate(NAA)/Cr were measured respectively in hippocampus and the anterior cingulate gyrus with three-dimension 1H-proton specrroscopy(3D 1H-MRS).Results:The values of NAA/Cr ratios in hippocampus and the anterior cingulate gyrus were significant lower in patients with post-traumatic stress disorder(1.71±0.32,left l.58±0.29, right 1.55±0.31) than that in controls(2.24±0.41,left 1.98±0.27,right 2.02±0.36)(P【0.05).but the values of Cho/Cr in hippocampus(left 1.64±0.23,right 1.66±0.34) were no significant with that of controls(left 1.48±0.29,right 1.54±0.38).Values of Cho/Cr in cingulate gyrus were significant higher in post-traumatic stress disorder patients(I.88±0.44) than that in controls(1.37.±0.32) (P【0.05).Conclusions:The results indicate some special neurochemical and histological structure changes in post-traumatic stress disorder patients,which might occurre earlier in anterior cingulate gyrusthe than in hippocampus. 展开更多
关键词 LATE-LIFE DEPRESSION Magnetic resonance spectroscopy HIPPOCAMPUS ANTERIOR CINGULATE GYRUS
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强迫症患者、强迫型人格障碍患者和健康对照者之间的认知灵活性和计划能力比较(英文) 被引量:7
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作者 Negin PAAST Zohreh KHOSRAVI +2 位作者 Amir Hossein MEMARI Monir SHAYESTEHFAR Mohammad ARBABI 《上海精神医学》 CSCD 2016年第1期28-34,共7页
背景:强迫症患者(Obsessive Compulsive Disorder,OCD)与强迫型人格障碍患者(Obsessive Compulsive Personality Disorder,OCPD)的认知功能还没有得到充分的研究。目标:验证OCD和OCPD患者的认知灵活性和计划能力。方法:本研究在德黑兰... 背景:强迫症患者(Obsessive Compulsive Disorder,OCD)与强迫型人格障碍患者(Obsessive Compulsive Personality Disorder,OCPD)的认知功能还没有得到充分的研究。目标:验证OCD和OCPD患者的认知灵活性和计划能力。方法:本研究在德黑兰心理咨询门诊选定了25例OCD患者和20例OCPD患者,他们在既往两周都没有服药,并且从大学工作人员和当地社区居民中选定了25名健康对照者。对所有参与者均进行28项一般健康问卷(28-item version of the General Health Questionnaire,GHQ-28)、威斯康星卡片分类测验(Wisconsin Card Sorting Test,WCST)、和伦敦塔试验(Tower of London test,TOL))。本研究运用WCTS的两个测量指标(持续错误数和完成分类数)评估认知灵活性以及TOL的三个测量指标(12个试验总共的移动次数、总应答时和计划时间)评估计划能力。结果:2组患者的当前心理困扰程度显著高于对照组。在控制人口学因素和心理困扰水平后,OCD患者和OCPD患者在WCST测试中比对照组更容易出现持续性错误,而OCD患者(不包括OCPD患者)的完成分类数比对照组显著减少。OCD患者和OCDP患者都比对照组需要更多的移动次数来完成12项TOL任务,并且OCD患者比OCPD患者和对照组需要花更长的时间来完成任务。结论:与健康对照组相比,OCD和OCPD患者的认知灵活性和计划能力都有所受损,并且OCD和OCPD患者之间的认知功能测试也存在一些差异。我们需要对OCD和OCPD患者进行长期随访研究评估在强迫症状严重性加重与减轻时认知功能的改变,从而决定此类认知评估指标对于强迫症是否有诊断或临床关联性。 展开更多
关键词 强迫症 强迫型人格障碍 执行功能 神经心理学 伊朗
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Repetitive transcranial magnetic stimulation for hallucination in schizophrenia spectrum disorders A meta-analysis 被引量:8
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作者 Yingli Zhang Wei Liang +3 位作者 Shichang Yang Ping Dai Lijuan Shen Changhong Wang 《Neural Regeneration Research》 SCIE CAS CSCD 2013年第28期2666-2676,共11页
OBJECTIVE: This study assessed the efficacy and tolerability of repetitive transcranial magnetic stimulation for treatment of auditory hallucination of patients with schizophrenia spectrum disorders. DATA SOURCES: O... OBJECTIVE: This study assessed the efficacy and tolerability of repetitive transcranial magnetic stimulation for treatment of auditory hallucination of patients with schizophrenia spectrum disorders. DATA SOURCES: Online literature retrieval was conducted using PubMed, ISI Web of Science, EMBASE, Medline and Cochrane Central Register of Controlled Trials databases from January 1985 to May 2012. Key words were "transcranial magnetic stimulation", "TMS", "repetitive tran- scranial magnetic stimulation", and "hallucination". STUDY SELECTION: Selected studies were randomized controlled trials assessing therapeutic ef- ficacy of repetitive transcranial magnetic stimulation for hallucination in patients with schizophrenia spectrum disorders. Experimental intervention was low-frequency repetitive transcranial magnetic stimulation in left temporoparietal cortex for treatment of auditory hallucination in schizophrenia spectrum disorders. Control groups received sham stimulation. MAIN OUTCOME MEASURES: The primary outcome was total scores of Auditory Hallucinations Rating Scale, Auditory Hallucination Subscale of Psychotic Symptom Rating Scale, Positive and Negative Symptom Scale-Auditory Hallucination item, and Hallucination Change Scale. Secondary outcomes included response rate, global mental state, adverse effects and cognitive function. RESULTS: Seventeen studies addressing repetitive transcranial magnetic stimulation for treatment of schizophrenia spectrum disorders were screened, with controls receiving sham stimulation. All data were completely effective, involving 398 patients. Overall mean weighted effect size for repeti- tive transcranial magnetic stimulation versus sham stimulation was statistically significant (MD = -0.42, 95%C/: -0.64 to -0.20, P = 0.000 2). Patients receiving repetitive transcranial magnetic stimulation responded more frequently than sham stimulation (OR = 2.94, 95%C/: 1.39 to 6.24, P =0.005). No significant differences were found between active repetitive transcranial magnetic stimulation and sham stimulation for positive or negative symptoms. Compared with sham stimulation, active repeti- tive transcranial magnetic stimulation had equivocal outcome in cognitive function and commonly caused headache and facial muscle twitching. CONCLUSION: Repetitive transcranial magnetic stimulation is a safe and effective treatment for auditory hallucination in schizophrenia spectrum disorders, 展开更多
关键词 neural regeneration META-ANALYSIS transcranial magnetic stimulation auditory hallucination schizophre-nia schizophrenia spectrum disorders schizophreniform disorder temporoparietal cortex cognitive func-tion positive symptom grants-supported paper NEUROREGENERATION
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Antidepressants for bipolar disorder A meta-analysis of randomized, double-blind, controlled trials 被引量:3
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作者 Yingli Zhang Huan Yang +4 位作者 Shichang Yang Wei Liang Ping Dai Changhong Wang Yalin Zhang 《Neural Regeneration Research》 SCIE CAS CSCD 2013年第31期2962-2974,共13页
OBJECTIVE: To examine the efficacy and safety of short-term and long-term use of antidepres- sants in the treatment of bipolar disorder. DATA SOURCES: A literature search of randomized, double-blind, controlled tria... OBJECTIVE: To examine the efficacy and safety of short-term and long-term use of antidepres- sants in the treatment of bipolar disorder. DATA SOURCES: A literature search of randomized, double-blind, controlled trials published until December 2012 was performed using the PubMed, ISI Web of Science, Medline and Cochrane Central Register of Controlled Trials databases. The keywords "bipolar disorder, bipolar I disorder, bipolar II disorder, bipolar mania, bipolar depression, cyclothymia, mixed mania and depression, rapid cycling and bipolar disorder", AND "antidepressant agent, antidepressive agents second- generation, antidepressive agents tricyclic, monoamine oxidase inhibitor, noradrenaline uptake in- hibitor, serotonin uptake inhibitor, and tricyclic antidepressant agent" were used. The studies that were listed in the reference list of the published papers but were not retrieved in the above-mentioned databases were supplemented. STUDY SELECTION: Studies selected were double-blind randomized controlled trials assessing the efficacy and safety of antidepressants in patients with bipolar disorder. All participants were aged 18 years or older, and were diagnosed as having primary bipolar disorder. Antidepressants or antidepressants combined with mood stabilizers were used in experimental interventions. Placebos, mood stabilizers, antipsychotics and other antide pressants were used in the control interventions. Studies that were quasi-randomized studies, or used antidepressants in combination with antipsy- chotics in the experimental group were excluded. All analyses were conducted using Review Man- ager 5.1 provided by the Cochrane Collaboration. 展开更多
关键词 neural regeneration evidence-based medicine bipolar disorder bipolar depression ANTIDEPRESSANT response switching to mania SUICIDALITY META-ANALYSIS grants-supported paper NEUROREGENERATION
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Chinese emotional words in patients with major depressive disorder during a subliminal Stroop task An event-related potential study 被引量:1
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作者 Daxing Wu Shujing Xu Huifang Yin 《Neural Regeneration Research》 SCIE CAS CSCD 2010年第16期1274-1280,共7页
Patients with major depressive disorder (MDD) develop a negative cognitive bias, but how they respond to information in Chinese emotional words is unclear. Here we used a Stroop paradigm with subliminal Chinese emot... Patients with major depressive disorder (MDD) develop a negative cognitive bias, but how they respond to information in Chinese emotional words is unclear. Here we used a Stroop paradigm with subliminal Chinese emotional words to explore the event-related potential components of abnormal emotional processing Jn patients with MDD. The correct rate was similar in MDD and normal control groups, but MDD reaction time was longer than the normal controls, especially to the negative and neutral stimuli. In N270, repeated-measure analysis of variance demonstrated a significant main effect of the relation electrode and valence on peak amplitude and interactions between valence and electrode site. The peak amplitudes of the three kinds of words were different in the two groups (positive 〉 negative 〉 neutral). The topography of the difference waves indicated that the difference distributed in the frontal and left parietal-temporal sites across the scalp. In N400, there was a significant main effect of the relation electrode and valence on peak amplitude, and the latency showed a main effect of the electrode and an interaction between electrode and group. The amplitudes induced by type of words were significantly different from each other in both groups (positive 〉 negative 〉 neutral). The topography of the difference waves indicated that the effect of relation type was primarily at left and right frontal and central and left parietal-temporal regions. Both MDD patients and normal controls exhibited significant emotional Stroop effects during the processing of positive/negative Chinese emotional words. MDD patients showed interference in emotional stimuli in early cognitive processing that induced psychological resource intervention during late emotional information processing. 展开更多
关键词 Stroop test subliminal stimulations event-related potentials DEPRESSION Chinese emotional words
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Changes in sensorimotor regions of the cerebral cortex in congenital amusia:a case-control study 被引量:1
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作者 Jun-Jie Sun Xue-Qun Pan +4 位作者 Ru Yang Zhi-Shuai Jin Yi-Hui Li Jun Liu Da-Xing Wu 《Neural Regeneration Research》 SCIE CAS CSCD 2021年第3期531-536,共6页
Perceiving pitch is a central function of the human auditory system;congenital amusia is a disorder of pitch perception.The underlying neural mechanisms of congenital amusia have been actively discussed.However,little... Perceiving pitch is a central function of the human auditory system;congenital amusia is a disorder of pitch perception.The underlying neural mechanisms of congenital amusia have been actively discussed.However,little attention has been paid to the changes in the motor rain within congenital amusia.In this case-control study,17 participants with congenital amusia and 14 healthy controls underwent functional magnetic resonance imaging while resting with their eyes closed.A voxel-based degree centrality method was used to identify abnormal functional network centrality by comparing degree centrality values between the congenital amusia group and the healthy control group.We found decreased degree centrality values in the right primary sensorimotor areas in participants with congenital amusia relative to controls,indicating potentially decreased centrality of the corresponding brain regions in the auditory-sensory motor feedback network.We found a significant positive correlation between the degree centrality values and the Montreal Battery of Evaluation of Amusia scores.In conclusion,our study identified novel,hitherto undiscussed candidate brain regions that may partly contribute to or be modulated by congenital amusia.Our evidence supports the view that sensorimotor coupling plays an important role in memory and musical discrimination.The study was approved by the Ethics Committee of the Second Xiangya Hospital,Central South University,China(No.WDX20180101GZ01)on February 9,2019. 展开更多
关键词 congenital amusia degree centrality lifelong impairment local functional connectivity music discrimination primary motor area primary sensorimotor area primary sensory area resting-state functional magnetic resonance imaging voxel-based analysis
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Key psychosocial challenges in vascularized composite allotransplantation 被引量:3
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作者 Martin Kumnig Sheila G Jowsey-Gregoire 《World Journal of Transplantation》 2016年第1期91-102,共12页
Psychosocial factors are important elements in the assessment and follow-up care for vascularized composite allotransplantation(VCA) and require multidisciplinary evaluation protocols. This review will highlight diffe... Psychosocial factors are important elements in the assessment and follow-up care for vascularized composite allotransplantation(VCA) and require multidisciplinary evaluation protocols. This review will highlight differences between VCA with solid organ transplantation(SOT), provide information on the psychosocial selection of VCA candidates, ethical issues, psychological outcomes, and on the need for multicenter research. VCA is primarily a life-enhancing procedure to improve recipients' quality of life and psychological well-being and it represents a potential option to provide reproduction in case of penile or uterine transplantation. The risk benefit ratio is distinctly different than SOT with candidates desiring life enhancing outcomes including improved body image, return to occupations, restored touch, and for uterine transplant, pregnancy. The Chauvet Workgroup has been convened with membership from a number of transplant centers to address these issues and to call for multicenter research. A multicenter research network would share similar evaluation approaches so that meaningful research on psychosocial variables could inform the transplant community and patients about factors that increase risk of non-adherence and other adverse psychosocial and medical outcomes. 展开更多
关键词 Vascularized composite allotransplantation Psychological evaluation MOTIVATION Psychosocial outcomes Quality of life
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Primary and secondary school mental health teachers in professional identity of intervention programs 被引量:1
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作者 Hao Lei Cheng Guo Yanling Liu 《Health》 2012年第12期1299-1304,共6页
To explore the impact of teacher training on the professional identity of primary and secondary school mental health teachers, this study conducted a half-month professional development training program to 54 primary ... To explore the impact of teacher training on the professional identity of primary and secondary school mental health teachers, this study conducted a half-month professional development training program to 54 primary and secondary school mental health teachers, and performed measurement on the professional identity of the teachers in the experimental group and the control group with “Teachers’ Professional Identity Questionnaire”. The result shows that after the training there is a significant improvement in the professional identity of the teachers in the experimental group, and the teachers’ scores on the four dimensions of profession identity: the sense of role, the professional behavioral tendency, the occupational values, and the sense of belonging, all increased significantly. This indicates that the curriculum intervention for the primary and secondary school mental health teachers could effectively improve the teachers’ professional identity. 展开更多
关键词 Primary and Secondary School MENTAL Health TEACHERS PROFESSIONAL IDENTITY CURRICULUM INTERVENTION
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