A Comprehensive Review of Exosomes with Therapeutic Potential in Cancer and Coeliac Disease

The aim of this review was to evaluate the therapeutic potential of exosomes, extracellular vesicles secreted by cells. They have emerged as potential therapeutic transporters for several diseases. This review provides an overview of exosomes’ therapeutic potential in cancer therapy and autoimmune conditions such as Coeliac Disease. The therapeutic effect is that the phospholipid-binding protein ANXA1 improves its anti-inflammatory properties. The review also analyzes the intricate processes of exosome production and composition ability to transport biomolecules such as proteins, microRNAs, and lipids, which promote intercellular communication and alter recipient cell behavior. Exosomes, linked to neurological disorders, cardiovascular disease, and cancer, present the means of targeted drug administration due to their innate specificity. Through genetic engineering and chemical modifications, exosomes can be tailored for specific purposes, demonstrating their versatility in targeted therapy. With ongoing research uncovering their therapeutic potential, exosomes present a promising frontier in novel medical treatments across various health conditions.

Modeling and Validation of Base Pressure for Aerodynamic Vehicles Based on Machine Learning Models

The application of abruptly enlarged flows to adjust the drag of aerodynamic vehicles using machine learning models has not been investigated previously.The process variables(Mach number(M),nozzle pressure ratio(η),area ratio(α),and length to diameter ratio(γ))were numerically explored to address several aspects of this process,namely base pressure(β)and base pressure with cavity(βcav).In this work,the optimal base pressure is determined using the PCA-BAS-ENN based algorithm to modify the base pressure presetting accuracy,thereby regulating the base drag required for smooth flow of aerodynamic vehicles.Based on the identical dataset,the GA-BP and PSO-BP algorithms are also compared to thePCA-BAS-ENNalgorithm.The data for training and testing the algorithmswas derived using the regression equation developed using the Box-Behnken Design(BBD).The results show that the PCA-BAS-ENN model delivered highly accurate predictions when compared to the other two models.As a result,the advantages of these results are two-fold,providing:(i)a detailed examination of the efficiency of different neural network algorithms in dealing with a genuine aerodynamic problem,and(ii)helpful insights for regulating process variables to improve technological,operational,and financial factors,simultaneously.

Millard-Gubler Syndrome in a Patient with Pontine Infarction: A Case Report

Millard-Gubler Syndrome is a rare neurological condition caused by damage to the sixth and seventh cranial nerves, as well as the corticospinal tract in the brainstem. It is characterized by the presence of ipsilateral facial paralysis and contralateral hemiplegia. We report a 55-year-old male patient who presented with sudden onset of left-sided weakness. Imaging revealed a pontine infarct. The patient therefore, was diagnosed with Millard-Gubler Syndrome also known as Ventral Pontine Syndrome based on his symptoms and imaging findings. He was treated with Aspirin and Atorvastatin and was referred to neurology for further consultation and to physiotherapy for his weakness. This case report highlights the importance of prompt recognition and diagnosis of Millard-Gubler Syndrome in patients with pontine infarction. Early identification especially with the use of high-resolution MRI can facilitate appropriate management and treatment, ultimately improving patient outcomes.

Framework for a Computer-Aided Treatment Prediction (CATP) System for Breast Cancer

This study offers a framework for a breast cancer computer-aided treat-ment prediction(CATP)system.The rising death rate among women due to breast cancer is a worldwide health concern that can only be addressed by early diagno-sis and frequent screening.Mammography has been the most utilized breast ima-ging technique to date.Radiologists have begun to use computer-aided detection and diagnosis(CAD)systems to improve the accuracy of breast cancer diagnosis by minimizing human errors.Despite the progress of artificial intelligence(AI)in the medical field,this study indicates that systems that can anticipate a treatment plan once a patient has been diagnosed with cancer are few and not widely used.Having such a system will assist clinicians in determining the optimal treatment plan and avoid exposing a patient to unnecessary hazardous treatment that wastes a significant amount of money.To develop the prediction model,data from 336,525 patients from the SEER dataset were split into training(80%),and testing(20%)sets.Decision Trees,Random Forest,XGBoost,and CatBoost are utilized with feature importance to build the treatment prediction model.The best overall Area Under the Curve(AUC)achieved was 0.91 using Random Forest on the SEER dataset.

Interleukin-33 exerts pleiotropic immunoregulatory effects in response to Plasmodium berghei ANKA(PbA)infection in mice

Objective:To determine the involvement and the modulatory effects of IL-33 during Plasmodium berghei ANKA(PbA)infection.Methods:PbA infection in male ICR mice was utilized as a model of malaria.Systemically circulating IL-33 levels were determined in blood plasma by enzyme-linked immunosorbent assay(ELISA).After 24 hours post-inoculation of PbA,recombinant IL-33 and ST2,and antibodies against IL-33 and IgG treatments were administered daily for 3 days.Tissue expression and localization of IL-33 were assessed in organs generally affected by malaria via immunohistochemistry.Moreover,histopathological examination was performed to assess the effects of the treatments.Results:The levels of systemic IL-33 were elevated at the critical phase of PbA infection.Likewise,immunohistochemical analysis revealed a significant upregulation of IL-33 expression at the critical phase in the brain,lungs,and spleen of PbA-infected mice as compared to healthy controls.Treatment with IL-33 protected against experimental cerebral malaria development and reduced pathological features in the brain and lungs of the PbA-infected mice.Conclusions:A potential critical role and involvement of IL-33 in PbA infection may hint at the resolution of immunopathological sequelae associated with malaria.

局部桩筏基础的设计与施工

以加拿大多伦多市某工程为例,介绍了在复杂地质条件下采用局部桩筏基础(PPRF)的设计及施工问题;探讨了设计PPRF的决定性因素;在保持PPRF设计的完整性前提下,提出了单位沉降量的准则,并用于筏板和桩的设计;计算了PPRF的滑移及转动;最后,采用有效方法对该工程采用的局部桩筏基础进行了计算分析。结果表明,PPRF的设计主要取决于侧向土压力、分布不均的建筑荷载以及地基土的非均匀承载力,工程桩应主要布置在沉降较大的区域,即位于筏板基础承受高压力而土体承载力较低的西北部。探讨局部桩筏基础的设计与施工为该类型工程的基础设计提供了一个新的解决途径。

New Insight in the Assessment of Left Ventricular Function in Paradoxical Low Flow Aortic Stenosis Patients with Normal Left Ventricular Ejection Fraction: A Mini-Review

Paradoxical valvular aortic stenosis (VAS) is a challenging area of clinical cardiology for the practitioners. It involves a small aortic valve area, low flow rate and mean pressure gradient although there is normal left ventricular ejection fraction. The aim of this study was to assess left ventricular (LV) dysfunction in a symptomatic severe aortic valve stenosis which is of crucial importance in identifying patients at risk of heart failure, postoperative complications and increased mortality. There are new insights which are involved in assessment of LV myocardial function including global longitudinal strain (GLS) by two-dimensional speckle tracking echocardiography (2D STE), myocardial performance index (MPI) and maximum rate of LV pressure rise (+dP/dt) during isovolumetric contraction time of the LV. This information can provide both diagnostic and prognostic information in addition to standard echocardiographic and clinical parameters. However, a profound understanding of the complex interaction between loading conditions, chamber geometry and contractility is necessary for the correct interpretation of myocardial deformation in order to draw appropriate conclusions in patients with aortic valve disease. This mini review is related to new and novel insights into the assessment of left ventricular function (LVF) in paradoxical low flow aortic stenosis patients with normal left ventricular ejection fraction (LVEF).

Magnetohydrodynamic flow and heat transfer impact on ZnO-SAE50 nanolubricant flow over an inclined rotating disk

The present article has been fine-tuned with the investigation of mixed convection Darcy-Forchheimer flow of ZnO-SAE50 oil nanolubricant over an inclined rotating disk under the influence of uniform applied magnetic field applied to various industries.The current study has been enriched with additional consideration of slip flow,thermal radiation,viscous dissipation,Joulian dissipation and internal heating.In view of augmentation of thermal conductivity of nanolubricant,a new micro-nano-convection model namely Patel model has been invoked.The specialty of this model involves the effects of specific surface area and nano-convection due to Brownian motion of nanoparticles,kinetic theory based micro-convection,liquid layering and particle concentration.Suitably transformed governing equations have been solved numerically by using Runge-Kutta-Fehlberg scheme.An analysis of the present study has shown that applied magnetic field,porosity of the medium,velocity slip and inertia coefficient account for the slowing down of radial as well as tangential flow of ZnO-SAE50 oil nanolubricant,thereby leading to an improvement in velocity and thermal boundary layers.

Establishment of inherent stability of pramipexole and development of validated stability indicating LC-UV and LC-MS method

Pramipexole belongs to a class of nonergot dopamine agonist recently approved for the treatment of early and advanced Parkinson＇s disease.A validated specific stability indicating reversed-phase liquid chromatographic method has been developed for the quantitative determination of pramipexole in bulk as well as in pharmaceutical dosage forms in the presence of degradation products.Forced degradation studies were performed by exposition of drug to hydrolytic（acidic and basic）,oxidative and photolytic stress conditions,as defined under ICH guideline Q1A（R2）.Significant degradation was observed under hydrolytic,oxidative and photolytic conditions and the degradation products formed were identified by LC-MS.

Effect of aqueous seed extract of Mucuna pruriens on arsenic-induced testicular toxicity in mice

Objective:To investigate the protective effects of Mucuna(M.)pruriens against arsenic-induced testicular impairment in albino mice.Methods:Thirty-six male albino mice were divided into six groups,with 6 mice in each group.Group 1 received drinking water as the normal control.Groups 2 to 6 received sodium arsenite(40 mg/L)in drinking water.Group 3 received sodium arsenite(40 mg/L)and 300 mg/kg body weight(b.w.)of N-acetylcysteine.Group 4 received sodium arsenite(40 mg/L)and 500 mg/kg b.w.of M.pruriens.Group 5 received sodium arsenite(40 mg/L)and 1000 mg/kg b.w.of M.pruriens.Group 6 received sodium arsenite(40 mg/L)and 2000 mg/kg b.w.of M.pruriens.N-acetylcysteine and M.pruriens were administered orally once a day.Animals were subjected to the above treatments for 45 days.Animals were sacrificed with overdose of ketamine 24 h following drug administration.The testis was used for biochemical estimations(lipid peroxidation and glutathione),and the epididymis was used to determine the sperm count and morphology.Results:Sodium arsenite significantly decreased(P<0.01)the sperm count and glutathione levels of the testis.It significantly increased(P<0.01)the abnormal architecture of the spermatozoa and lipid peroxidation levels.Treatment with M.pruriens significantly increased the sperm count and the glutathione levels[500 mg/kg b.w.and 1000 mg/kg b.w.(P<0.01)].A significant decrease in sperm abnormality and lipid peroxidation levels[500 mg/kg b.w.and 1000 mg/kg b.w.(P<0.01)]was also observed.Conclusions:The perturbed sperm parameters and antioxidant levels of the arsenic insulted testis are attenuated by 500 mg/kg b.w.and 1000 mg/kg b.w.M.pruriens.

Three-dimensional analysis of natural convection in nanofluid-filled parallelogrammic enclosure opened from top and heated with square heater

A numerical study based on the finite volume method has been performed to study the three-dimension natural convection in a parallelogrammic top side opened cavity filled nanofluid with partially heated square at the bottom side.Results are obtained for different governing parameters such as nanoparticle concentration (φ) from 0 to 0.05,inclination angle of the back and front walls (α) from 5° to 75°,Rayleigh number from 10^3 to 10^5,and length of heater changer from 0.1 to 1.The main finding from the obtained result showed that the inclination angle and nanoparticle volume fraction affect the flow structure and enhance the heat transfer.

Fine needle aspiration cytology in the diagnosis of cysticercosis cases

Objective:To document the value of Fine Needle Aspiration Cytology(FNAC) in the diagnosis of cysticercosis. Methods:Aspirates smears of 102 cases of cysticercosis from different sites like extremities,head,neck, forearm,arm,chest wall and abdominal wall were studied in the Department of Pathology,BPKIHS,Dharan, Nepal.Results:In 7 cases(9.73%) lingual cysticercosis was diagnosed.Involvement of breast was seen in 4 cases(5.56%) which is a rare presentation.On cytomorphological examination,parts of cysticercus cellulose were seen in(97.22%) cases.Conclusion:The characteristic cytomorphological features of parasitic tegument,parenchymatous portion,presence of giant cells and inflammatory cells in cytological smears help diagnose the cases of cysticercosis.FNAC provides safe and rapid tool for diagnosis of cysticercosis.In endemic areas,cysticercosis should be considered one of the differential diagnosis of the swellings.

The Current Status of Stem Cell Regeneration in Intra Oral Applications—A Systematic Review

Aim: 1) To review the literature of various applications of stem cell regeneration in dentistry from 2010 to 2016. 2) To review these studies and to summarize the current status of stem cell regeneration in intra oral applications. 3) To present the available successful data with regard to stem cell regeneration in dentistry and to highlight the future trends. Materials and Methods: Search Protocol: A systematic search was made in the PubMed database with the key words gingiva, papillary reconstruction, periodontal ligament, dental pulp, salivary gland, enamel re-mineralization, dentin, cementum, bone, whole tooth, cleft palate, regeneration and stem cells. All articles from 2010 to 2016, relevant to the topic were included. After the search a total of 1826 articles were obtained which were screened and categorized by three independent reviewers as review papers, in vitro, animal and human studies, pertaining to stem cell regeneration in intra oral applications. On the basis of the extracted data and outcome measures, conclusions were drawn. Results: Maximum number of animal studies has been done to regenerate periodontal tissues, bone, dentin and pulp tissues. Few human studies have been done till date. Although clinically, researchers have been able to regenerate periodontal-like tissue, bone and pulp-like tissue, they still haven’t been able to regenerate tissues that completely resemble tissues in their natural form. Conclusion: The future of stem cell therapy in dental applications looks promising. The predictability and efficacy of outcomes, as well as safety concerns of stem cell therapy is yet to be fully established. Ongoing research and development of newer scaffolds, understanding various signaling molecules and their cues, understanding gene expression and proteomics of stem cells are the future directions that will take us a step forward to achieving successful regeneration.

Identified Analytical Profile for Microelements, Trace Metals, Amino Acids and Screening of Anti-Diabetic Activity from Flower and Leaf Extracts of Moringa oleifera in Streptozotocin (STZ)-Induced Diabetic Rats

Background: Moringa oleifera plant is popularly known for its rich phytoconstituents and nutritional value and important medicinal values in both traditional and modern systems of medicine. We explored the present study for measurements of microelements, amino acid, phenolic content in hydro-al-coholic flower and leaf extracts of Moringa oleifera along with anti-diabetic activity in Streptozotocin (STZ)-induced diabetic male Wistar rats. Methodology: The micronutrients were determined by using atomic absorption spectrophotometer at 285 nm and 422 nm for Calcium (Ca), phosphorus (P), Iron (Fe), and Zinc (Zn), etc. The trace elements were also measured by spectrophotometer. The essential amino acid was determined by using Amino acid analyser. The total phenolic content in hydro-alcoholic extracts (flower and leaf) M. oleifera measured the absorbance at 760 nm by UV spectrophotometer. The screening of anti-diabetic activity HAFE and HALE of Moringa oleifera at two different dose of 100 and 200 mg/kg b.w. for 21 days were performed by determining the changes in biochemical parameters. Result and Discussion: The results revels that the presence of micronutrients, trace elements and amino acids in both flower and leaf of M. oleifera. The hydrolaocholic extracts of HAFE and HALE at 200 mg/kg b.w. showed significant antidiabetic activity compared with standard Glibenclamide. Whereas dose at 100 mg/kg b.w. showed moderate activity. Conclusion: In conclusion, the M. oleifera exhibits more effectiveness against STZ-induced diabetes. The HAFE and HALF extracts exhibited significant anti-diabetic property and active components may be isolated and clinical studies is required for further evaluation. Because of the rich source of phytoconstients, nutritional elements will be helpful in processed food products as dietary supplements especially for malnutrition in children in the current era.

Reasons for Charles de Gaulle Airport Collapse

In the early morning hours of May 23, 2004, passengers in Terminal 2E at the Charles de Gaulle Airport in Paris partially collapsed resulting in several fatalities. Structural failure was caused by multiple reasons, all contributing to failure. Similar structures have been successfully erected and built around the world. One famous and comparable structure is the Berlin Main Railway Station. After investigations, it becomes clear that Charles de Gaulle Airport lacks suitable and effective geometry, which is present in Berlin Railway Station.

A Prospective Study of Knowledge and Perception towards the Efficacy of Anti-Aging Cosmetics among Female Population of Ras Al Khaimah, UAE

Introduction: Cosmeceutical is a term used to describe cosmetics with antiaging effects these days. The aim of the current study was to determine the efficacy of different type of antiaging dermatological products based on consumer self-assessment and to identify those driving factors that influence women’s purchase of these products and to have an insight into their perception and knowledge about these products. Methods: A prospective study was conducted about the use of antiaging cosmetics, consumer satisfaction, skin concerns related with age, importance of younger looking skin and socioeconomic status. Results and Discussion: It was observed in the study that such products do work to improve skin conditions but the claim that wrinkles could be cured completely could not be determined. Participant reported discrepancies between ideal and real effect of antiaging cosmetics. Even if such cosmetic products are expensive people like to spend on these to fulfill the human dream of looking younger.

Antimicrobial Effect of Honey from the Arabian Gulf Region against Bacterial Isolates from Pus and Wound Swabs

Of the many beneficial effects attributed to honey, its antimicrobial properties have drawn considerable interest. Five types of natural honey originating from three countries but available in the local markets in UAE were randomly selected. The antibacterial activity of the honey types was tested against bacterial reference strains as well as 21 bacterial isolates obtained from pus and wound swabs from patients. All the five types of honey showed antibacterial activity, however, there were differences in the antibacterial efficacy of the different honey types. All the strains of Staphylococcus aureus (reference, clinical and methicillin-resistant) exhibited better susceptibilities contrast to the gram-negative isolates including Escherichia coli and Pseudomonas aeruginosa when tested against all different honey types. The findings from this study indicate that the antibacterial activity of locally available honey varies depending on their provenance. Further work is needed to identify factors which determine the antimicrobial efficacy of these different honey types. Their antibacterial activity can be explored for the treatment of wound infections in patients.

Effects of homogeneous-heterogeneous reactions and thermal radiation on magneto-hydrodynamic Cu-water nanofluid flow over an expanding flat plate with non-uniform heat source

This study presents the effect of non-uniform heat source on the magneto-hydrodynamic flow of nanofluid across an expanding plate with consideration of the homogeneous-heterogeneous reactions and thermal radiation effects.A nanofluid’s dynamic viscosity and effective thermal conductivity are specified with Corcione correlation.According to this correlation,the thermal conductivity is carried out by the Brownian motion.Similarity transformations reduce the governing equations concerned with energy,momentum,and concentration of nanofluid and then numerically solved.The influences of the effective parameters,e.g.,the internal heat source parameters,the volume fraction of nanofluid,the radiation parameter,the homogeneous reaction parameter,the magnetic parameter,the heterogeneous parameter and the Schmidt number are studied on the heat and flow transfer features.Further,regarding the effective parameters of the present work,the correlation for the Nusselt number has been developed.The outcomes illustrate that with the raising of the heterogeneous parameter and the homogeneous reaction parameter,the concentration profile diminishes.In addition,the outcomes point to a reverse relationship between the Nusselt number and the internal heat source parameters.

Health Risk of Maâmora’s Groundwater Pollution in Morocco

The problem of pollution affects the whole world groundwater. The purpose of our present study is to evaluate the impact of contamination from residues of industry and agriculture, and discharge of untreated domestic wastewaters on the physical, chemical, metal and bacteriological water quality of Maamora’s tablecloth (Sebou bassin, Kenitra, Morocco). The physicochemical parameters followed are: T ℃, pH, EC, NH4+, NO2-, NO3-, CI-, F-, HCO3-, CO32-, SiO2, SO42-,?Na+, Ca2+, Mg2+, K+, Pb2-, Cd2+, Fe2+, Cu2+, Zn2+, Ni2+, B3+, Dry Residue, Turbidity, Total Hardness (TH), Dissolved O2, Oxidisability, total and fecal coliforms, faecal streptococci and total and faecal germs of raw water from the boreholes. The physical, chemical, metal and bacteriological quality shows that the groundwater which is used as drinking water in the city of Kenitra and adjacent towns is generally good. However, high concentrations of nitrates (over 210.8 mg/L) and other metals (185 μg/l for lead;58.98 for nickel;187.3 μg/L for iron;2204 μg/L for zinc) in some wells are worrisome because of the serious health consequences.