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The role of microRNAs in B-cell development and function 被引量:1
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作者 Jingyi Li Ying Wan +2 位作者 Qing Ji Yongfei Fang Yuzhang Wu 《Cellular & Molecular Immunology》 SCIE CAS CSCD 2013年第2期107-112,共6页
MicroRNA (miRNA)-mediated gene silencing at the translational level has led to novel discoveries for numerous biological processes. Recently, there has been increasing evidence to indicate that miRNAs are involved i... MicroRNA (miRNA)-mediated gene silencing at the translational level has led to novel discoveries for numerous biological processes. Recently, there has been increasing evidence to indicate that miRNAs are involved in normal immune functions and inflammation. In this review, we focus on recent advances that have elucidated the role of miRNAs in B-cell development, differentiation, apoptosis and function. While the regulatory mechanisms of miRNAs in controlling and maintaining B-cell fate remain largely uncharacterized, further studies on miRNAs and their targets will increase our understanding of B-cell development and function. Such studies may be able to provide new therapeutic strategies for treating autoimmune diseases. 展开更多
关键词 MICRORNA B cell DEVELOPMENT FUNCTION
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