Breast cancer recognition is an important issue in elastography diagnostic imaging. Breast tumor biopsy has been for many years the reference procedure to assess histological definition for breast diseases. But biopsy...Breast cancer recognition is an important issue in elastography diagnostic imaging. Breast tumor biopsy has been for many years the reference procedure to assess histological definition for breast diseases. But biopsy measurement is an invasive method besides it takes larger time. So, fast and improved methods are needed. Using elastography technology, a digital image correlation technique can be used to calculate the displacement of breast tissue after it has suffered a compression force. This displacement is related to tissue stiffness, and breast cancer can be classified into benign or malignant according to that displacement. The value of compression force affects the displacement of tissue, and then affects the results of the breast cancer recognition. Finite element method was being used to simulate a model for the breast cancer as a phantom to be used in measurements and study of breast cancer diagnosis. The breast cancer using this phantom can be recognized within a short time. The proposed work succeeded in recognizing breast tumor phantom by an average correct recognition ratio CRR of about 94.25% on a simulation environment. The strain ratio SR for benign and malignant models is also computed. The result of the simulated breast tumor model is compared with real data of 10 lesion cases (6 benign and 4 malignant). The coefficient of variation CV between the simulated SR and the SR using real data reaches to about 5% for benign lesions and 4.78% for malignant lesions. The results of CRR and CV in this proposed work assure that the proposed breast cancer model using finite element modeling is a robust technique for breast tumor simulation where the behavior of real data of breast cancer can be predicted.展开更多
Objective: To determine the possible therapeutic gain of using three-dimensional conformal radiotherapy (3D-CRT) as a treatment option for portal vein tumor thrombus (PVTT) in patients with hepatocellular carcinoma (H...Objective: To determine the possible therapeutic gain of using three-dimensional conformal radiotherapy (3D-CRT) as a treatment option for portal vein tumor thrombus (PVTT) in patients with hepatocellular carcinoma (HCC) and to evaluate the tolerance and toxicity of using such treatment. Materials and methods: Sixty two patients were enrolled in this prospective study between June 2013 and August 2015. The clinical target volume (CTV) was the PVTT and the prescribed dose was 50 Gy/25 fractions. The median follow-up time was 7.4 months. Results: The thrombus crude response rate was 40.4% and the only significant prognostic factor for response was the thrombus size. Responders had significant better survival compared to non-responders with a median survival of 12.5 and 8 months respectively (P Conclusions: The results of this study suggest that radiotherapy should be considered as a safe treatment option for HCC patients with PVTT. It is effective not only for PVTT local control but also for survival, although prospective randomized trials are needed to confirm these results.展开更多
文摘Breast cancer recognition is an important issue in elastography diagnostic imaging. Breast tumor biopsy has been for many years the reference procedure to assess histological definition for breast diseases. But biopsy measurement is an invasive method besides it takes larger time. So, fast and improved methods are needed. Using elastography technology, a digital image correlation technique can be used to calculate the displacement of breast tissue after it has suffered a compression force. This displacement is related to tissue stiffness, and breast cancer can be classified into benign or malignant according to that displacement. The value of compression force affects the displacement of tissue, and then affects the results of the breast cancer recognition. Finite element method was being used to simulate a model for the breast cancer as a phantom to be used in measurements and study of breast cancer diagnosis. The breast cancer using this phantom can be recognized within a short time. The proposed work succeeded in recognizing breast tumor phantom by an average correct recognition ratio CRR of about 94.25% on a simulation environment. The strain ratio SR for benign and malignant models is also computed. The result of the simulated breast tumor model is compared with real data of 10 lesion cases (6 benign and 4 malignant). The coefficient of variation CV between the simulated SR and the SR using real data reaches to about 5% for benign lesions and 4.78% for malignant lesions. The results of CRR and CV in this proposed work assure that the proposed breast cancer model using finite element modeling is a robust technique for breast tumor simulation where the behavior of real data of breast cancer can be predicted.
文摘Objective: To determine the possible therapeutic gain of using three-dimensional conformal radiotherapy (3D-CRT) as a treatment option for portal vein tumor thrombus (PVTT) in patients with hepatocellular carcinoma (HCC) and to evaluate the tolerance and toxicity of using such treatment. Materials and methods: Sixty two patients were enrolled in this prospective study between June 2013 and August 2015. The clinical target volume (CTV) was the PVTT and the prescribed dose was 50 Gy/25 fractions. The median follow-up time was 7.4 months. Results: The thrombus crude response rate was 40.4% and the only significant prognostic factor for response was the thrombus size. Responders had significant better survival compared to non-responders with a median survival of 12.5 and 8 months respectively (P Conclusions: The results of this study suggest that radiotherapy should be considered as a safe treatment option for HCC patients with PVTT. It is effective not only for PVTT local control but also for survival, although prospective randomized trials are needed to confirm these results.
