PBS (Phosphate Buffed Saline), pH 7.4 extract of Guava leaves (<i>Psidium</i> <i>guajava</i> L.) inhibits the active MMP-2 like molecule both of plant origin as well as active MMP-2 of human (b...PBS (Phosphate Buffed Saline), pH 7.4 extract of Guava leaves (<i>Psidium</i> <i>guajava</i> L.) inhibits the active MMP-2 like molecule both of plant origin as well as active MMP-2 of human (breast cancer patients’ saliva) origin. The zymogram and ELISA were developed of different samples following standard methods. The isolation and identification of the new MMP-2 inhibitor(s) for its molecular characterization is under investigation.展开更多
Matrixmetalloproteinase-2 (MMP-2), also called gelatinase-A, is a 72 Kd protein present in chromosome 16 in human. It is a zinc binding protein, responsible for the degradation of Extra Cellular Matrix (ECM) in normal...Matrixmetalloproteinase-2 (MMP-2), also called gelatinase-A, is a 72 Kd protein present in chromosome 16 in human. It is a zinc binding protein, responsible for the degradation of Extra Cellular Matrix (ECM) in normal physiological as well as disease processes like arthritis and cancer. It has a specific role in the cancer development and angiogenesis. MMP-2 contributes to cell migration. MMPs are the key to normal development as well as in the pathology of cancer and other inflammatory diseases. The inhibitors of MMP-2 activity are very important in maintaining the normal activity of MMP-2 and have an important role in the management of cancer. Regulation of MMP-2 activity is done by inhibitors like, TIMPs. In this report, we are discussing about a possible inhibitor(s) present in the PBS extract of guava leaves, inhibiting the active MMP-2 present in the saliva of breast cancer patients.展开更多
文摘PBS (Phosphate Buffed Saline), pH 7.4 extract of Guava leaves (<i>Psidium</i> <i>guajava</i> L.) inhibits the active MMP-2 like molecule both of plant origin as well as active MMP-2 of human (breast cancer patients’ saliva) origin. The zymogram and ELISA were developed of different samples following standard methods. The isolation and identification of the new MMP-2 inhibitor(s) for its molecular characterization is under investigation.
文摘Matrixmetalloproteinase-2 (MMP-2), also called gelatinase-A, is a 72 Kd protein present in chromosome 16 in human. It is a zinc binding protein, responsible for the degradation of Extra Cellular Matrix (ECM) in normal physiological as well as disease processes like arthritis and cancer. It has a specific role in the cancer development and angiogenesis. MMP-2 contributes to cell migration. MMPs are the key to normal development as well as in the pathology of cancer and other inflammatory diseases. The inhibitors of MMP-2 activity are very important in maintaining the normal activity of MMP-2 and have an important role in the management of cancer. Regulation of MMP-2 activity is done by inhibitors like, TIMPs. In this report, we are discussing about a possible inhibitor(s) present in the PBS extract of guava leaves, inhibiting the active MMP-2 present in the saliva of breast cancer patients.
