To The Editor:Hemorrhagic rectocolitis is an autoimmune disease that affects the gastrointestinal tract.Treatment of the disease includes 5-aminosalicylic acid drugs such as mesalazine at first-line therapy,with a pos...To The Editor:Hemorrhagic rectocolitis is an autoimmune disease that affects the gastrointestinal tract.Treatment of the disease includes 5-aminosalicylic acid drugs such as mesalazine at first-line therapy,with a possible association of corticosteroids.In the case of severe inflammation,treatment with purine analogue(azathioprine),TNF-alpha inhibitor(infliximab,adalimumab),or integrin inhibitor(vedolizumab)may be initiated.展开更多
Rising rates of obesity has increased the global use of herbal supplements intended to control weight.However,taking these preparations without appropriate medical supervision could increase the risk of manifestation ...Rising rates of obesity has increased the global use of herbal supplements intended to control weight.However,taking these preparations without appropriate medical supervision could increase the risk of manifestation of side effects,especially at the hepatic level.In literature,different cases of acute liver injury consequent to the use of food supplements containing Garcinia cambogia and hydroxycitric acid are reported.This letter aims to review the most recent literature that analysed the herb-induced liver disease due to the use of hydroxycitric acid,from the first alert coming from the European Food and Drug Administration in 2009,to the last recent European food alerts from 2020 to 2021.It is noteworthy that in some cases it demonstrated the relationship between hydroxycitric acid and hepatotoxicity.Therefore,there is a need to draw more attention to the relationship between a safe use and a more awareness in the intake of these supplements,to preserve the safety of the consumers who increasingly purchase food supplements,products that have only nutritive properties and are never curative.展开更多
文摘To The Editor:Hemorrhagic rectocolitis is an autoimmune disease that affects the gastrointestinal tract.Treatment of the disease includes 5-aminosalicylic acid drugs such as mesalazine at first-line therapy,with a possible association of corticosteroids.In the case of severe inflammation,treatment with purine analogue(azathioprine),TNF-alpha inhibitor(infliximab,adalimumab),or integrin inhibitor(vedolizumab)may be initiated.
文摘Rising rates of obesity has increased the global use of herbal supplements intended to control weight.However,taking these preparations without appropriate medical supervision could increase the risk of manifestation of side effects,especially at the hepatic level.In literature,different cases of acute liver injury consequent to the use of food supplements containing Garcinia cambogia and hydroxycitric acid are reported.This letter aims to review the most recent literature that analysed the herb-induced liver disease due to the use of hydroxycitric acid,from the first alert coming from the European Food and Drug Administration in 2009,to the last recent European food alerts from 2020 to 2021.It is noteworthy that in some cases it demonstrated the relationship between hydroxycitric acid and hepatotoxicity.Therefore,there is a need to draw more attention to the relationship between a safe use and a more awareness in the intake of these supplements,to preserve the safety of the consumers who increasingly purchase food supplements,products that have only nutritive properties and are never curative.
