Objective: To explore the changes and clinical significance of biochemical indexes, antioxidant enzymes and related factors in patients with Parkinson. Methods: 50 patients with Parkinson's disease who were treate...Objective: To explore the changes and clinical significance of biochemical indexes, antioxidant enzymes and related factors in patients with Parkinson. Methods: 50 patients with Parkinson's disease who were treated in our hospital from March 2016 to March 2017 were selected as observation group. 50 healthy volunteers who were received physical examination in this hospital during the same period were selected as control group. The levels of bilirubin, blood uric acid, superoxide dismutase, glutathione peroxidase, catalase, TNF-α, tumor necrosis factor-α receptor-1, tumor necrosis factor-α receptor-2, monocyte chemoattractant protein-1 and macrophage inflammatory protein -1 of the patients in the two group were compared. Results: The level of serum bilirubin, uric acid, SOD, GSH-PX and CAT of patients in the observation group were (5.65±0.61) μmoL/L, (262.96±26.38) μmoL/L, (92.65±9.35) U/mL, (18.96±2.03) U/mL and (56.94±16.23) U/mL. The above indexes of patients in the observation group were significantly lower than those of patients in the control group (P<0.05). The serum level of TNF-α, sTNFR1, MCP-1 and MIP-1 of patients in the observation group were (19.65±2.07) pg/mL, (798.96±80.20) pg/mL, (43.65±4.27) ng/L and (23.96±2.41) ng/L. The above indexes of patients in the observation group were significantly higher than those of patients in the control group (P<0.05). Conclusion: Bilirubin, uric acid, antioxidant enzymes and inflammatory factors are all related to the progression of Parkinson's disease and can be used as auxiliary index in the diagnosis and treatment of Parkinson's disease.展开更多
文摘Objective: To explore the changes and clinical significance of biochemical indexes, antioxidant enzymes and related factors in patients with Parkinson. Methods: 50 patients with Parkinson's disease who were treated in our hospital from March 2016 to March 2017 were selected as observation group. 50 healthy volunteers who were received physical examination in this hospital during the same period were selected as control group. The levels of bilirubin, blood uric acid, superoxide dismutase, glutathione peroxidase, catalase, TNF-α, tumor necrosis factor-α receptor-1, tumor necrosis factor-α receptor-2, monocyte chemoattractant protein-1 and macrophage inflammatory protein -1 of the patients in the two group were compared. Results: The level of serum bilirubin, uric acid, SOD, GSH-PX and CAT of patients in the observation group were (5.65±0.61) μmoL/L, (262.96±26.38) μmoL/L, (92.65±9.35) U/mL, (18.96±2.03) U/mL and (56.94±16.23) U/mL. The above indexes of patients in the observation group were significantly lower than those of patients in the control group (P<0.05). The serum level of TNF-α, sTNFR1, MCP-1 and MIP-1 of patients in the observation group were (19.65±2.07) pg/mL, (798.96±80.20) pg/mL, (43.65±4.27) ng/L and (23.96±2.41) ng/L. The above indexes of patients in the observation group were significantly higher than those of patients in the control group (P<0.05). Conclusion: Bilirubin, uric acid, antioxidant enzymes and inflammatory factors are all related to the progression of Parkinson's disease and can be used as auxiliary index in the diagnosis and treatment of Parkinson's disease.
