The coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)may have a ripple effect that puts men at a risk of infertility.This article reviews the possible lin...The coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)may have a ripple effect that puts men at a risk of infertility.This article reviews the possible link between SARS-CoV-2 infection and male reproduction following speculations that the single-stranded RNA viruses could directly invade the testes.SARS-CoV-2 enters the human lung cells via angiotensin converting enzyme 2(ACE2).ACEs,its products,angiotensin-(1-7),and its receptor,MAS receptor,are expressed in the testes.Although the binding of SAR-CoV-2 to ACE2 could lead to excess angiotensinⅡwith possible enhanced inflammation,angiotensinⅡcould also promote sperm motility.In addition,the pathophysiology of SAR-CoV-2,especially in relation to male fertility,is yet to be fully understood;the suppression of androgen observed in COVID-19 infected men calls for the need for andrological assessment in infected male.展开更多
Exposure to mercuric chloride(HgCl2;5 mg kg–1 body weight;i.p.)induced oxidative stress in mice and substantially increased lipid peroxidation(LPO)and oxidized glutathione(GSSG)levels,decreased the level of reduced g...Exposure to mercuric chloride(HgCl2;5 mg kg–1 body weight;i.p.)induced oxidative stress in mice and substantially increased lipid peroxidation(LPO)and oxidized glutathione(GSSG)levels,decreased the level of reduced glu-tathione(GSH)and various antioxidant enzymes in liver and also increased the activities of liver marker enzymes in serum.Therapy with propolis extract,a resinous wax-like beehive product(200 mg kg–1 orally,after mercury administration),for 3 days inhibited LPO and the formation of GSSG and increased the level of GSH in the liver.Release of serum transaminases,alkaline phosphatase,lactate dehydrogenase and-glutamyl transpeptidase were significantly restored after propolis treatment.The activities of antioxidant enzymes,that is,superoxide dismutase,catalase,glutathione-S-transferase and glucose-6-phosphate dehydrogenase,were also concomitantly restored towards normal levels after propolis administration.These observations clearly demonstrate that propolis treatment augments antioxidant defense against mercury-induced toxicity and provide evidence that propolis has therapeutic potential as a hepatoprotective agent.展开更多
文摘The coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)may have a ripple effect that puts men at a risk of infertility.This article reviews the possible link between SARS-CoV-2 infection and male reproduction following speculations that the single-stranded RNA viruses could directly invade the testes.SARS-CoV-2 enters the human lung cells via angiotensin converting enzyme 2(ACE2).ACEs,its products,angiotensin-(1-7),and its receptor,MAS receptor,are expressed in the testes.Although the binding of SAR-CoV-2 to ACE2 could lead to excess angiotensinⅡwith possible enhanced inflammation,angiotensinⅡcould also promote sperm motility.In addition,the pathophysiology of SAR-CoV-2,especially in relation to male fertility,is yet to be fully understood;the suppression of androgen observed in COVID-19 infected men calls for the need for andrological assessment in infected male.
基金The authors wish to thank the Indian Council of Medical Research,New Delhi,India(45/15/2002/PHA/BMS)for financial assistance.
文摘Exposure to mercuric chloride(HgCl2;5 mg kg–1 body weight;i.p.)induced oxidative stress in mice and substantially increased lipid peroxidation(LPO)and oxidized glutathione(GSSG)levels,decreased the level of reduced glu-tathione(GSH)and various antioxidant enzymes in liver and also increased the activities of liver marker enzymes in serum.Therapy with propolis extract,a resinous wax-like beehive product(200 mg kg–1 orally,after mercury administration),for 3 days inhibited LPO and the formation of GSSG and increased the level of GSH in the liver.Release of serum transaminases,alkaline phosphatase,lactate dehydrogenase and-glutamyl transpeptidase were significantly restored after propolis treatment.The activities of antioxidant enzymes,that is,superoxide dismutase,catalase,glutathione-S-transferase and glucose-6-phosphate dehydrogenase,were also concomitantly restored towards normal levels after propolis administration.These observations clearly demonstrate that propolis treatment augments antioxidant defense against mercury-induced toxicity and provide evidence that propolis has therapeutic potential as a hepatoprotective agent.
