Tumor cells are characterized by metabolic reprogram-ming,a step that is necessary to support their high demand for energy and nutrients[1,2].Furthermore,once metastatic tumor cells are seeded,tumor microen-vironment ...Tumor cells are characterized by metabolic reprogram-ming,a step that is necessary to support their high demand for energy and nutrients[1,2].Furthermore,once metastatic tumor cells are seeded,tumor microen-vironment remodeling is immediately initiated,leading to the formation of more suitable conditions for growth.Tumor cells secrete several types of growth factors,cytokines,and chemokines to induce angiogenesis and tumor-associated immune cell recruitment,all of which can promote proliferation and metastasis,as well as trig-ger immune tolerance and drug resistance[3].Exploring the synergistic effect between metabolic reprogramming and microenvironment remodeling will likely facili-tate the discovery of novel biomarkers and therapeutic targets.展开更多
文摘Tumor cells are characterized by metabolic reprogram-ming,a step that is necessary to support their high demand for energy and nutrients[1,2].Furthermore,once metastatic tumor cells are seeded,tumor microen-vironment remodeling is immediately initiated,leading to the formation of more suitable conditions for growth.Tumor cells secrete several types of growth factors,cytokines,and chemokines to induce angiogenesis and tumor-associated immune cell recruitment,all of which can promote proliferation and metastasis,as well as trig-ger immune tolerance and drug resistance[3].Exploring the synergistic effect between metabolic reprogramming and microenvironment remodeling will likely facili-tate the discovery of novel biomarkers and therapeutic targets.
