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Mapping global research trends: Nutrition associations with nonalcoholic fatty liver disease - a Scopus bibliometric analysis 被引量:1
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作者 Muna Shakhshir Sa'ed H Zyoud 《World Journal of Gastroenterology》 SCIE CAS 2024年第24期3106-3119,共14页
BACKGROUND Several bibliometric analyses have been carried out to identify research hotspots and trends in nonalcoholic fatty liver disease(NAFLD)research.Nonetheless,there are still significant knowledge gaps that mu... BACKGROUND Several bibliometric analyses have been carried out to identify research hotspots and trends in nonalcoholic fatty liver disease(NAFLD)research.Nonetheless,there are still significant knowledge gaps that must be filled to advance our understanding of and ability to treat NAFLD.AIM To evaluate,through bibliometric and visual analysis,the current status of related research,related research frontiers,and the developmental trends in the field of diet and NAFLD.METHODS We retrieved publications about diet and NAFLD published between 1987 and 2022 from Scopus.Next,we used VOSviewer 1.6.20 to perform bibliometric analysis and visualization.RESULTS We found a total of 1905 studies,including 1637(85.93%)original articles and 195(10.24%)reviews,focused on the examination of NAFLD and its correlation with diet that were published between 1987 and 2022.Among the remaining five types of documents,38 were letters,notes,editorials,meeting minutes,or brief surveys,representing 1.99%of the total documents.The countries with the most publications on this topic were China(n=539;28.29%),followed by the United States(n=379;19.90%),Japan(n=133;6.98%),and South Korea(n=127;6.6%).According to the citation analysis,the retrieved papers were cited an average of 32.3 times and had an h-index of 106,with 61014 total citations.The two main clusters on the map included those related to:(1)Inflammation and oxidative stress;and(2)Dietary interventions for NAFLD.CONCLUSION This was the first study to use data taken from Scopus to visualize network mapping in a novel bibliometric analysis of studies focused on diet and NAFLD.After 2017,the two domains that received the most attention were“dietary interventions for NAFL”’and“‘inflammation and oxidative stress implicated in NAFLD and its correlation with diet.”We believe that this study provides important information for academics,dietitians,and doctors,and that additional research on dietary interventions and NAFLD is warranted. 展开更多
关键词 DIETARY NUTRITION BIBLIOMETRIC Nonalcoholic fatty liver SCOPUS VOSviewer
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Climate change drives flooding risk increases in the Yellow River Basin 被引量:1
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作者 Hengxing Lan Zheng Zhao +9 位作者 Langping Li Junhua Li Bojie Fu Naiman Tian Ruixun Lai Sha Zhou Yanbo Zhu Fanyu Zhang Jianbing Peng John J.Clague 《Geography and Sustainability》 CSCD 2024年第2期193-199,共7页
The Yellow River Basin(YRB)has experienced severe floods and continuous riverbed elevation throughout history.Global climate change has been suggested to be driving a worldwide increase in flooding risk.However,owing ... The Yellow River Basin(YRB)has experienced severe floods and continuous riverbed elevation throughout history.Global climate change has been suggested to be driving a worldwide increase in flooding risk.However,owing to insufficient evidence,the quantitative correlation between flooding and climate change remains illdefined.We present a long time series of maximum flood discharge in the YRB dating back to 1843 compiled from historical documents and instrument measurements.Variations in yearly maximum flood discharge show distinct periods:a dramatic decreasing period from 1843 to 1950,and an oscillating gentle decreasing from 1950 to 2021,with the latter period also showing increasing more extreme floods.A Mann-Kendall test analysis suggests that the latter period can be further split into two distinct sub-periods:an oscillating gentle decreasing period from 1950 to 2000,and a clear recent increasing period from 2000 to 2021.We further predict that climate change will cause an ongoing remarkable increase in future flooding risk and an∼44.4 billion US dollars loss of floods in the YRB in 2100. 展开更多
关键词 Flooding risk Risk management Climate change Flood discharge Extreme precipitation
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TP-PROFILE: Monitoring the Thermodynamic Structure of the Troposphere over the Third Pole
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作者 Xuelong CHEN Yajing LIU +6 位作者 Yaoming MA Weiqiang MA Xiangde XU Xinghong CHENG Luhan LI Xin XU Binbin WANG 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2024年第6期1264-1277,共14页
Ground-based microwave radiometers(MWRs)operating in the K-and V-bands(20–60 GHz)can help us obtain temperature and humidity profiles in the troposphere.Aside from some soundings from local meteorological observatori... Ground-based microwave radiometers(MWRs)operating in the K-and V-bands(20–60 GHz)can help us obtain temperature and humidity profiles in the troposphere.Aside from some soundings from local meteorological observatories,the tropospheric atmosphere over the Tibetan Plateau(TP)has never been continuously observed.As part of the Chinese Second Tibetan Plateau Scientific Expedition and Research Program(STEP),the Tibetan Plateau Atmospheric Profile(TPPROFILE)project aims to construct a comprehensive MWR troposphere observation network to study the synoptic processes and environmental changes on the TP.This initiative has collected three years of data from the MWR network.This paper introduces the data information,the data quality,and data downloading.Some applications of the data obtained from these MWRs were also demonstrated.Our comparisons of MWR against the nearest radiosonde observation demonstrate that the TP-PROFILE MWR system is adequate for monitoring the thermal and moisture variability of the troposphere over the TP.The continuous temperature and moisture profiles derived from the MWR data provide a unique perspective on the evolution of the thermodynamic structure associated with the heating of the TP.The TP-PROFILE project reveals that the low-temporal resolution instruments are prone to large uncertainties in their vapor estimation in the mountain valleys on the TP. 展开更多
关键词 microwave radiometer thermodynamic structure vertical profile Tibetan Plateau
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In vivo and in vitro study of resorbable magnesium wires for medical implants:Mg purity,surface quality,Zn alloying and polymer coating
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作者 K.Tesar J.Luňácková +12 位作者 M.Jex M.Žaloudková R.Vrbová M.Bartoš P.Klein L.Vištejnová J.Dušková E.Filová Z.Sucharda M.Steinerová S.Habr K.Balík A.Singh 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2024年第6期2472-2488,共17页
Magnesium is an excellent material in terms of biocompatibility and its corrosion products can serve as an active source for new bone formation.However,localized corrosion and H_(2)generation limit the potential of Mg... Magnesium is an excellent material in terms of biocompatibility and its corrosion products can serve as an active source for new bone formation.However,localized corrosion and H_(2)generation limit the potential of Mg-based implants.Utilizing low-alloyed Mg-Zn wires can strongly reduce problems with large H_(2)bubbles and improve the mechanical properties considerably while maintaining excellent long-term biocompatibility.Acidic pickling and a polymer coating can be effectively used to lower the rate of in vivo degradation.In this work,microstructural,mechanical,and in vitro characterization of 250μm and 300μm extruded wires made from ultra-pure Mg,commercially pure Mg,Mg-0.15Zn,Mg-0.4Zn and Mg-1Zn was performed.Additionally,Mg-0.4Zn wires together with a variant coated with a copolymer of L-lactide andε-caprolactone were tested in vivo on artificially damaged Wistar rat femurs.Based on the observed Mg-induced osteogenesis,polymer-coated Mg wires with a small addition of Zn are a perspective material for bone-support applications,such as cerclage and fixation wires. 展开更多
关键词 MAGNESIUM Resorbable Mg wire Mg-Zn implant degradation Biocompatibility study Zn grain boundary segregation
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Annual cost of illness of stomach and esophageal cancer patientsin urban and rural areas in China: A multi-center study 被引量:23
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作者 Zhixun Yang Hongmei Zeng +19 位作者 Ruyi Xia Qian Liu Kexin Sun Rongshou Zheng Siwei Zhang Changfa Xia He Li Shuzheng Liu Zhiyi Zhang Yuqin Liu Guizhou Guo Guohui Song Yigong Zhu Xianghong Wu Bingbing Song Xianzhen Liao Yanfang Chen Wenqiang Wei Guihua Zhuang Wanqing Chen 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2018年第4期439-448,共10页
Objective: Stomach and esophageal cancer are imposing huge threats to the health of Chinese people whereasthere were few studies on the financial burden of the two cancers.Methods: Costs per hospitalization of all p... Objective: Stomach and esophageal cancer are imposing huge threats to the health of Chinese people whereasthere were few studies on the financial burden of the two cancers.Methods: Costs per hospitalization of all patients with stomach or esophageal cancer discharged betweenSeptember 2015 and August 2016 in seven cities/counties in China were collected, together with their demographicinformation and clinical details. Former patients in the same hospitals were sampled to collect information onannual direct non-medical cost, indirect costs and annual number of hospitalization. Annual direct medical cost wasobtained by multiplying cost per hospitalization by annual number of hospitalization. Annual cost of illness (ACI)was obtained by adding the average value of annual direct medical cost, direct non-medical cost and indirect cost,stratified by sex, age, clinical stage, therapy and pathologic type in urban and rural areas. Costs per hospitalizationwere itemized into eight parts to calculate the proportion of each part. All costs were converted to 2016 US dollars(1 USD:6.6423 RMB).Results: Totally 19,986 cases were included, predominately male. Mean ages of stomach cancer and urbanpatients were lower than that of esophageal cancer and rural patients. ACI of stomach and esophageal cancerpatients were $10,449 and $13,029 in urban areas, and $2,927 and $3,504 in rural areas, respectively. Greater ACIwas associated with male, non-elderly patients as well as those who were in stage I and underwent surgeries.Western medicine fee took the largest proportion of cost per hospitalization.Conclusions: The ACI of stomach and esophageal cancer was tremendous and varied substantially among thepopulation in China. Preferential policies of medical insurance should be designed to tackle with this burden andfurther reduce the health care inequalities. 展开更多
关键词 Cost of illness stomach neoplasms esophageal neoplasms China
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Insulin like growth factor-1 increases fatty liver preservation in IGL-1 solution 被引量:7
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作者 Mohamed Amine Zaouali Susagna Padrissa-Altés +5 位作者 Ismail Ben Mosbah Hassen Ben Abdennebi Olivier Boillot Antoni Rimola Dalila Saidane-Mosbahi Joan Roselló-Catafau 《World Journal of Gastroenterology》 SCIE CAS CSCD 2010年第45期5693-5700,共8页
AIM: To investigate the benefits of insulin like growth factor-1 (IGF-1) supplementation to serum-free institut georges lopez-1 (IGL-1) solution to protect fatty liver against cold ischemia reperfusion injury. METHO... AIM: To investigate the benefits of insulin like growth factor-1 (IGF-1) supplementation to serum-free institut georges lopez-1 (IGL-1) solution to protect fatty liver against cold ischemia reperfusion injury. METHODS: Steatotic livers were preserved for 24 h in IGL-1  solution supplemented with or without IGF-1 and then perfused "ex vivo " for 2 h at 37℃. We examined the effects of IGF-1 on hepatic damage and function (transaminases, percentage of sulfobromophthalein clearance in bile and vascular resistance). We also studied other factors associated with the poor tolerance of fatty livers to cold ischemia reperfusion injury such as mitochondrial damage, oxidative stress, nitric oxide, tumor necrosis factor-α (TNF-α) and mitogen-activated protein kinases.RESULTS: Steatotic livers preserved in IGL-1 solutionsupplemented with IGF-1 showed lower transaminase levels, increased bile clearance and a reduction in vascular resistance when compared to those preserved in IGL-1solution alone. These benefits are mediated by activation of AKT and constitutive endothelial nitric oxide synthase (eNOS), as well as the inhibition of inflammatory cytokines such as TNF-α. Mitochondrial damage and oxidative stress were also prevented.CONCLUSION: IGL-1  enrichment with IGF-1 increasedfatty liver graft preservation through AKT and eNOS activation, and prevented TNF-α release during normothermic reperfusion. 展开更多
关键词 AKT Institut georges lopez-1 SOLUTION Insulin like growth factor-1 Ischemia REPERFUSION injury NITRIC oxide Oxidative stress Steatotic GRAFT PRESERVATION
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Association between Selenium in Soil and Diabetes in Chinese Residents Aged 35–74 Years:Results from the 2010 National Survey of Chronic Diseases and Behavioral Risk Factors Surveillance 被引量:4
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作者 WANG Qi Qi YU Shi Cheng +8 位作者 XU Cheng Dong LIU Jian Jun LI Yuan Qiu ZHANG Man Hui LONG Xiao Juan LIU Yun Ning BI Yu Fang ZHAO Wen Hua YAO Hong Yan 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2020年第4期260-268,共9页
Objective To explore the association between soil selenium levels and the risk of diabetes in Chinese adults aged 35–74 years.Methods Data for this study were derived from the China Chronic Diseases and Behavioral Ri... Objective To explore the association between soil selenium levels and the risk of diabetes in Chinese adults aged 35–74 years.Methods Data for this study were derived from the China Chronic Diseases and Behavioral Risk Factors Surveillance 2010 survey.Selenium concentrations in soil were obtained from the Atlas of Soil Environmental Background Values in China.A two-level binary logistic regression model was used to determine the association between soil selenium concentrations and the risk of diabetes,with participants nested within districts/counties.Results A total of 69,332 participants aged 35–74 years,from 158 districts/counties were included in the analysis.Concentrations of selenium in soil varied greatly across the 158 districts/counties,with a median concentration of 0.219 mg/kg(IQR:0.185–0.248).The results showed that both Quartile 1(0.119–0.185 mg/kg)and Quartile 4(0.249–0.344 mg/kg)groups were positively associated with diabetes compared to a soil selenium concentration of 0.186–0.219 mg/kg(Quartile 2),crude odds ratios(ORs)(95%CI)were 1.227(1.003–1.502)and 1.280(1.048–1.563).The P values were 0.045 and 0.013,for Quartile 1 and Quartile 4 groups,respectively.After adjusting for all confounding factors of interest,the Quartile 1 group became non-significant,and the Quartile 4 group had an adjusted OR(95%CI)of 1.203(1.018–1.421)relative to the reference group(Quartile 2),the P values was 0.030.No significant results were seen for the Quartile 3 group(0.220–0.248 mg/kg)compared to the reference group.Conclusion Excessive selenium concentrations in soil could increase the risk of diabetes among Chinese adults aged 35–74 years. 展开更多
关键词 SELENIUM DIABETES Odds ratio Behavioral risk factors Survey
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Analytical study of care quality and moral distress in clinical situations and patient care 被引量:4
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作者 Masoumeh Hasanlo Arezo Azarm +3 位作者 Parvaneh Asadi Kourosh Amini Hossein Ebrahimi Mohammad Asghari Jafarabadi 《Frontiers of Nursing》 CAS 2019年第4期327-334,共8页
Objective: Nursing profession conventionally meets a high standard of ethical behavior and action. One of the ethical challenges in nursing profession is moral distress. Nurses frequently expose to this phenomenon whi... Objective: Nursing profession conventionally meets a high standard of ethical behavior and action. One of the ethical challenges in nursing profession is moral distress. Nurses frequently expose to this phenomenon which leads to different consequences such as being bored by delivering patient care that decline care quality and make it challenging to achieve health purposes. This study was conducted to investigate the association between the aspects of moral distress and care quality.Methods: In this descriptive–analytical study, 545 nurses of intensive and cardiac care units and dialysis and psychiatric wards were recruited by census sampling. Three questionnaires, Sociodemographics, Moral Distress Scale, and Quality Patient Care Scale, were distributed among the participants and collected within 9 months. Data analysis was conducted by descriptive statistics, analysis of variance, and the least significant difference in SPSS 13.Results: Investigating moral distress domains(ignoring patient, decision-making power, and professional competence) and care quality domains(psychosocial, physical, and communicational) demonstrated that in being exposed to moral distress, ignoring patient had no effect on psychosocial domain(P=0.056), but decision-making and professional competence of moral distress had positive effect on psychosocial, physical(bodily), and communication domains of care quality.Conclusions: Because moral distress domains are effective on patient care quality, it is recommended to enhance the knowledge of nurses, especially beginners, about moral distress, increase their strength alongside standardizing nursing services in decisionmaking domains, improve the professional competence, and pay attention to patients. 展开更多
关键词 quality of healthcare moral distress clinical situations NURSE PATIENTS
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Age-associated changes in amyloid-β and formaldehyde concentrations in cerebrospinal fluid of rhesus monkeys 被引量:4
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作者 Zhen-Hui Li Xia-Ping He +2 位作者 Hao Li Rong-Qiao He Xin-Tian Hu 《Zoological Research》 SCIE CAS CSCD 2020年第4期444-448,共5页
DEAR EDITOR,Rhesus monkeys(Macaca mulatta)are valuable experimental animals for studies on neurodegenerative diseases due to their evolutionarily close relationship to humans(Zhang et al.,2014).Rhesus monkeys also dis... DEAR EDITOR,Rhesus monkeys(Macaca mulatta)are valuable experimental animals for studies on neurodegenerative diseases due to their evolutionarily close relationship to humans(Zhang et al.,2014).Rhesus monkeys also display similar hallmarks of aging and neurodegeneration as humans,including formation of senile plaques in the brain(Beckman et al.,2019;Paspalas et al.,2018). 展开更多
关键词 al. SENILE AMYLOID
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X-ray phase-sensitive microscope imaging with a grating interferometer:Theory and simulation
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作者 Jiecheng Yang Peiping Zhu +2 位作者 Dong Liang Hairong Zheng Yongshuai Ge 《Chinese Physics B》 SCIE EI CAS CSCD 2022年第9期652-657,共6页
A general theoretical framework is presented to explain the formation of the phase signal in an x-ray microscope integrated with a grating interferometer,which simultaneously enables the high spatial resolution imagin... A general theoretical framework is presented to explain the formation of the phase signal in an x-ray microscope integrated with a grating interferometer,which simultaneously enables the high spatial resolution imaging and the improved image contrast.By using this theory,several key parameters of phase contrast imaging can be predicted,for instance,the fringe visibility and period,and the conversion condition from the differential phase imaging(DPI)to the phase difference imaging(PDI).Additionally,numerical simulations are performed with certain x-ray optical components and imaging geometry.Comparison with the available experimental measurement[Appl.Phys.Lett.113063105(2018)]demonstrates the accuracy of this developed quantitative analysis method of x-ray phase-sensitive microscope imaging. 展开更多
关键词 x-ray phase contrast imaging x-ray microscope grating interferometer
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Evaluation of HPV Molecular Tests in Primary Screening for Cervical Cancer in Brazil
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作者 José E.Levi Adhemar Longatto-Filho +9 位作者 José Eluf-Neto Célia L.Rodrigues Cristina M.Oliveira Adriana C.Carloni Adriana T.Lorenzi Maricy Tacla José H.Fregnani Alexandre M.Ab’Saber Cristovam Scapulatempo Luisa LVilla 《Open Journal of Obstetrics and Gynecology》 2014年第8期470-478,共9页
Background: Incorporation of HPV tests into cervical cancer screening programs may be advantageous over conventional cytology, especially in developing nations, where the largest burden of cervical cancer is observed.... Background: Incorporation of HPV tests into cervical cancer screening programs may be advantageous over conventional cytology, especially in developing nations, where the largest burden of cervical cancer is observed. Objectives: To conduct an evaluation of commercially available molecular HPV tests in Brazilian women. Study design: Two groups were recruited: group A was composed of 511 women referred to the clinics because of a previous abnormal Pap test while group B consisted of 2464 subjects under routine screening. Cervical samples were collected using SurePath liquid cytology (LBC) device, and split into aliquots which were submitted to molecular testing by Hybrid Capture and cobas HPV. Colposcopy and biopsies were made according to the standard guidelines, directed by cytological diagnosis. Results: Prevalence of HSIL was 5.97% and 0.7% in Group A and B respectively. High-Risk HPV DNA was found in about 9% of group B women, while in group A this frequency was 24%. Having CIN3+ as the study end-point, the negative predictive values for molecular methods were above 99.8%. All “in-situ” and invasive cervical carcinomas were detected by both HPV nucleic acid assays. Conclusion: Use of HPV DNA testing was feasible and highly sensitive in cancer screening settings of Brazil. 展开更多
关键词 High-Risk HPV Test HPV-DNA Cervical Cancer Screening
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In-situ growth of MIL-53(Fe)on charcoal sponge as a highly efficient and recyclable photocatalyst for removal of Cr(Ⅵ)
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作者 Zhuo-Fan Yu Ye Yang +5 位作者 Hai-Feng Zhuang Sheng-Dao Shan Mihail-Simion Beldean-Galea Qing-Quan Xue Xiao-Feng Shen Shi-Jie Li 《Rare Metals》 SCIE EI CAS CSCD 2024年第9期4344-4355,共12页
The application of metalDorganic frameworks(MOFs)is hindered by several crucial factors,including low photocatalytic efficiency,poor stability and challenges in recycling.In this study,MIL-53(Fe)was grown in situ on a... The application of metalDorganic frameworks(MOFs)is hindered by several crucial factors,including low photocatalytic efficiency,poor stability and challenges in recycling.In this study,MIL-53(Fe)was grown in situ on a charcoal sponge(CS)with a large surface area,excellent mechanical properties,and high photocatalytic efficiency using a solvothermal method,thus addressing the above-mentioned shortcomings of MOF materials.Notably,CS/MIL-53(Fe)has an amazing light-harvesting capacity in the visible range,leading to a significant improvement in the utilization of light.The results of the experiments indicate that CS/MIL-53(Fe)displays a higher photocatalytic activity(87%Cr(Ⅵ))when exposed to visible light than CS(58%)or MIL-53(Fe)(27%),attributing to the increased separation of photogenerated carriers.e-is the main reactive radical and dominates the photocatalytic reduction process,rooting from that e-can reduce Cr(Ⅵ)to low-toxicity Cr(Ⅲ).This study presents a novel method for constructing photocatalysts with large surface areas,superior mechanical characteristics,and enhanced photocatalytic performance.Additionally,it achieves the resource utilization of agricultural and forestry waste. 展开更多
关键词 Cr(Ⅵ) Charcoal sponge MIL-53(Fe) PHOTOCATALYSIS Light absorption
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The innovative safe herbicide dienediamine saves paraquat
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作者 Jin-Qiu Xia Ping Xu Cheng-Bin Xiang 《Molecular Plant》 SCIE CSCD 2024年第1期11-12,共2页
Throughout the history of agriculture,the challenge of weed management has endured,necessitating significant investments to facilitate ideal crop growth and maximize yields.Strategies for weed control mainly involve m... Throughout the history of agriculture,the challenge of weed management has endured,necessitating significant investments to facilitate ideal crop growth and maximize yields.Strategies for weed control mainly involve manual and chemical methodologies.While manual weeding persists in certain regions,chemical herbicides notably represent the primary approach. 展开更多
关键词 approach. MANUAL CHEMICAL
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Bi-layered coded metasurface for multi-functional hologram with broadband transmission and efficient reflection
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作者 朱磊 李绪胜 +4 位作者 董亮 谢文静 尚关玉 Shah Nawaz Burokur 丁旭旻 《Chinese Optics Letters》 SCIE EI CAS CSCD 2024年第5期8-16,共9页
A multi-functional full-space metasurface based on frequency and polarization multiplexing is proposed.The metasurface unit consists of metallic patterns printed on the two faces of a single-layered dielectric substra... A multi-functional full-space metasurface based on frequency and polarization multiplexing is proposed.The metasurface unit consists of metallic patterns printed on the two faces of a single-layered dielectric substrate.The unit cell can control electromagnetic wavefronts to achieve a broadband transmission with amplitudes greater than 0.4 from 4.4 to 10.4 GHz.Meanwhile,at 11.7 GHz and 15.4 GHz,four high-efficiency reflection channels with a reflection amplitude greater than 0.8 are also realized.When illuminated by linearly polarized waves,five different functions can be realized at five different frequencies,which are demonstrated by theoretical calculations,full-wave simulations,and experimental measurements. 展开更多
关键词 multi-functional metasurface broadband transmission efficient reflection full space
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Unimolecular Self-Assembled Hemicyanine-Oleic Acid Conjugate Acts as a Novel Succinate Dehydrogenase Inhibitor to Amplify Photodynamic Therapy and Eliminate Cancer Stem Cells
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作者 Qiang Wang Tian Yang +7 位作者 Shiyou Li Chen Xu Chong Wang Yuxuan Xiong Xing Wang Jiangling Wan Xiangliang Yang Zifu Li 《Research》 SCIE EI CSCD 2024年第2期449-461,共13页
Photodynamic therapy with reactive oxygen species production is a prospective treatment to combat cancer stem cells(CSCs).However,the innate drawbacks,including short lifetime and diffusion distance of reactive oxygen... Photodynamic therapy with reactive oxygen species production is a prospective treatment to combat cancer stem cells(CSCs).However,the innate drawbacks,including short lifetime and diffusion distance of reactive oxygen species and hypoxia within solid tumors,have become bottlenecks for clinical applications of photodynamic therapy.Here,we develop a mitochondria-targeting hemicyanine-oleic acid conjugate(CyOA),which can self-assemble into supramolecular nanoparticles(NPs)without any exogenous excipients.CyOA is also shown for targeting the mitochondrial complex II protein succinate dehydrogenase to inhibit oxidative phosphorylation and reverse tumor hypoxia,resulting in 50.4-fold higher phototoxicity against breast cancer stem cells(BCSCs)compared to SO_(3)-CyOA NPs that cannot target to mitochondria.In 4T1 and BCSC tumor models,CyOA NPs achieve higher tumor inhibition and less lung metastasis nodules compared to the clinically used photosensitizer Hiporfin.This study develops a self-assembled small molecule that can serve as both oxidative phosphorylation inhibitor and photosensitizer for eradication of CSCs and treatment of solid tumors. 展开更多
关键词 cyanine OXIDATIVE treatment
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“互联网+”下众包供应链运作模式分析——以海尔和苏宁为案例 被引量:12
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作者 黎继子 刘春玲 张念 《科技进步与对策》 CSSCI 北大核心 2016年第21期24-31,共8页
在"互联网+"背景下,众包供应链(Crowdsourcing Supply Chain,CSC)作为一种新型供应链正成为研究热点。采用案例研究方法,以海尔和苏宁的发展轨迹为样本,分析企业众包供应链的发展模式和发展路径。研究表明,众包供应链有两种类... 在"互联网+"背景下,众包供应链(Crowdsourcing Supply Chain,CSC)作为一种新型供应链正成为研究热点。采用案例研究方法,以海尔和苏宁的发展轨迹为样本,分析企业众包供应链的发展模式和发展路径。研究表明,众包供应链有两种类型:精益型(Lean)众包供应链和敏捷型(Agile)众包供应链。同时,企业在决策流程中存在战略层面、策略层面和运作层面,以确定基于制造商主导、零售商主导、第三方主导的众包供应链模式,以及合作众包和竞争众包的情形。在此基础上,归纳了众包供应链运作的具体路径流程,为众包供应链的实施提供了完整解决方案。 展开更多
关键词 众包供应链 众包 运作模式 运作流程 案例研究
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水下爆炸条件下近药包表面能量测试技术研究 被引量:2
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作者 潘建强 盛振新 +2 位作者 毛海斌 刘建湖 张显丕 《中国测试》 CAS 北大核心 2016年第10期1-8,共8页
为测量水下爆炸条件下近药包表面的能量,提出基于预制飞片圆筒的水下爆炸条件下近药包表面能量测试技术。首先,采用AUTODYN软件,对水下爆炸条件下自由场和作用在飞片上的能流密度进行数值计算,通过对比两者随爆距的变化规律,对预制飞片... 为测量水下爆炸条件下近药包表面的能量,提出基于预制飞片圆筒的水下爆炸条件下近药包表面能量测试技术。首先,采用AUTODYN软件,对水下爆炸条件下自由场和作用在飞片上的能流密度进行数值计算,通过对比两者随爆距的变化规律,对预制飞片圆筒间接获取近药包表面能量的可行性进行论证。然后,采用激光位移传感器和探针测量爆炸后的飞片速度,进而将飞片的动能除以面积计算得到作用在飞片上的能流密度。将能流密度的测试值与计算值进行对比,两者基本一致,表明采用预制飞片圆筒来测量水下爆炸条件下近药包表面的能量是可行的,同时验证飞片速度测量系统的有效性,为近药包表面载荷特性的理论研究和试验测试提供技术基础。 展开更多
关键词 预制飞片圆筒 水下爆炸 近药包表面能量 测试技术
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雾天环境下高速公路可变限速控制方法研究 被引量:12
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作者 张珊 张存保 李薇 《交通信息与安全》 CSCD 北大核心 2018年第2期47-53,共7页
针对雾天环境下高速公路能见度下降导致交通安全和效率降低的问题,提出了一套雾天环境下高速公路的可变限速(VSL)控制方法,包括系统布置、工作流程和可变限速控制策略等,可以根据检测到的实时道路能见度和交通流数据,考虑最大安全车速... 针对雾天环境下高速公路能见度下降导致交通安全和效率降低的问题,提出了一套雾天环境下高速公路的可变限速(VSL)控制方法,包括系统布置、工作流程和可变限速控制策略等,可以根据检测到的实时道路能见度和交通流数据,考虑最大安全车速、交通流运行状态和驾驶员遵从度等因素的条件下,综合确定目标路段的限速值。利用G4高速公路实测数据,在Vissim软件中进行了2组对比仿真实验,结果表明,与无可变限速控制相比,实施可变限速控制的1组,最低车速在平流雾(团雾)环境下提高了27.24%(28.54%),同一控制周期下相邻路段的最大车速差减少了26.42%(41.91%)。提出的可变限速控制方法在雾天环境下能更有效地保障高速公路行车的安全和效率。 展开更多
关键词 交通控制 高速公路 可变限速控制 控制策略 雾天环境
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钢筋砼支撑梁爆破拆除新技术及应用 被引量:2
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作者 何理 钟冬望 +3 位作者 马建军 柯松林 宋琨 操鹏 《防灾减灾工程学报》 CSCD 北大核心 2020年第2期189-195,共7页
复杂环境下深基坑钢筋混凝土支撑梁的安全、高效拆除是城市建设过程中极为关键的环节。基于箍筋对支撑梁侧向约束作用机制的理论分析,揭示解除箍筋侧向约束效应前后梁内砼单元应力状态的演变规律及对支撑梁爆破效果的影响,并研发新的支... 复杂环境下深基坑钢筋混凝土支撑梁的安全、高效拆除是城市建设过程中极为关键的环节。基于箍筋对支撑梁侧向约束作用机制的理论分析,揭示解除箍筋侧向约束效应前后梁内砼单元应力状态的演变规律及对支撑梁爆破效果的影响,并研发新的支撑梁线性切割预处理方法、布孔方法及其毫秒延时起爆网路,形成较为系统的支撑梁爆破拆除技术。工程应用结果表明,支撑梁线性切割预处理方法可显著增强拆除效果;多向协同布孔法可改善爆炸能量耦合状态,减小爆破飞石危害;基于爆破网路连接单元的毫秒延时起爆网路可有效控制振动强度,提高网路可靠性。 展开更多
关键词 支撑梁 爆破拆除 起爆网路 爆破振动 爆破飞石
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Tocilizumab in patients with moderate or severe COVID-19: a randomized, controlled, open-label, multicenter trial 被引量:2
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作者 Dongsheng Wang Binqing Fu +25 位作者 Zhen Peng Dongliang Yang Mingfeng Han Min Li Yun Yang Tianjun Yang Liangye Sun Wei Li Wei Shi Xin Yao Yan Ma Fei Xu Xiaojing Wang Jun Chen Daqing Xia Yubei Sun Lin Dong Jumei Wang Xiaoyu Zhu Min Zhang Yonggang Zhou Aijun Pan Xiaowen Hu Xiaodong Mei Haiming Wei Xiaoling Xu 《Frontiers of Medicine》 SCIE CSCD 2021年第3期486-494,共9页
Tocilizumab has been reported to attenuate the“cytokine storm”in COVID-19 patients.We attempted to verify the effectiveness and safety of tocilizumab therapy in COVID-19 and identify patients most likely to benefit ... Tocilizumab has been reported to attenuate the“cytokine storm”in COVID-19 patients.We attempted to verify the effectiveness and safety of tocilizumab therapy in COVID-19 and identify patients most likely to benefit from this treatment.We conducted a randomized,controlled,open-label multicenter trial among COVID-19 patients.The patients were randomly assigned in a 1:1 ratio to receive either tocilizumab in addition to standard care or standard care alone.The cure rate,changes of oxygen saturation and interference,and inflammation biomarkers were observed.Thirty-three patients were randomized to the tocilizumab group,and 32 patients to the control group.The cure rate in the tocilizumab group was higher than that in the control group,but the difference was not statistically significant(94.12%vs.87.10%,rate difference 95%CI−7.19%–21.23%,P=0.4133).The improvement in hypoxia for the tocilizumab group was higher from day 4 onward and statistically significant from day 12(P=0.0359).In moderate disease patients with bilateral pulmonary lesions,the hypoxia ameliorated earlier after tocilizumab treatment,and less patients(1/12,8.33%)needed an increase of inhaled oxygen concentration compared with the controls(4/6,66.67%;rate difference 95%CI−99.17%to−17.50%,P=0.0217).No severe adverse events occurred.More mild temporary adverse events were recorded in tocilizumab recipients(20/34,58.82%)than the controls(4/31,12.90%).Tocilizumab can improve hypoxia without unacceptable side effect profile and significant influences on the time virus load becomes negative.For patients with bilateral pulmonary lesions and elevated IL-6 levels,tocilizumab could be recommended to improve outcome. 展开更多
关键词 TOCILIZUMAB coronavirus disease 2019(COVID-19) cytokine storm
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