Neuroregenerafion is a complex topic in neurosci- ence and includes 3 concepts： neurogenesis, neuro- plasticity, and neurorestoration. After injury of the nervous system, axons have the capacity for self-re- pair, re...Neuroregenerafion is a complex topic in neurosci- ence and includes 3 concepts： neurogenesis, neuro- plasticity, and neurorestoration. After injury of the nervous system, axons have the capacity for self-re- pair, regrowth or proliferation. The peripheral ner- vous system is more effective at restoring damaged axons than the central nervous system （CNS）. This is because formation of scar tissue in the CNS in- fluences neural regrowth or synthesis of growth-in- hibiting proteins, thereby preventing reconstruction of a neural circuit （Silver and Miller, 2004; Enciu et al., 2011）. Parkinson＇s disease （PD） and Alzheimer＇s disease （AD） are two most common degenerative diseases of the CNS among the elderly.展开更多
While much progress has been made in the field of hematopoietic stem cell transplantation （HSCT）, headway in the promotion of recovery following this procedure has been limited. Data regarding the potential of Chine...While much progress has been made in the field of hematopoietic stem cell transplantation （HSCT）, headway in the promotion of recovery following this procedure has been limited. Data regarding the potential of Chinese herbal medicine （CHM） for patients with hematologic disorders who received HSCT are gradually increasing; however, these data are mostly in Chinese. Therefore, we set out to summarize the existing data. We searched PubMed, the Cochrane Library and the China National Knowledge Infrastructure and retrieved 9 clinical studies related to this group of patients, in whom CHM was used as an intervention. Of the 9 papers, 6 were published by the same group of researchers. The focus of the reviewed studies was heterogeneous, and the objectives varied widely. With the exception of one randomized control trial, all of the studies were retrospective and observational; the median number of patients was 11.5, with the largest study containing 104 patients. CHM treatment was largely divided into two stages： （1） pre-HSCT, which was initiated as soon as conditioning chemotherapy was administered and aimed to counterbalance the adverse effects of these potent agents; （2） post-HSCT, which began immediately after transplantation and was intended to promote engraftment, control graft- versus-host disease and prolong survival. In addition, the 9 Chinese materia medica most commonly prescribed （appearing in four studies） were： Shengdihuang （Rehmannia glutinosa）, Baizhu （Atractylodes macrocephala）, Renshen （Panax ginseng）, Dangshen （ Codonopsis pilosula）, Maimendong （ Ophiopogon japonicus）, Danggui （Angelica sinensis）, Taizishen （Pseudostellaria heterophylla）, Huangqi （Astragalus membranaceus） and Ejiao （Equus asinus）.展开更多
文摘Neuroregenerafion is a complex topic in neurosci- ence and includes 3 concepts： neurogenesis, neuro- plasticity, and neurorestoration. After injury of the nervous system, axons have the capacity for self-re- pair, regrowth or proliferation. The peripheral ner- vous system is more effective at restoring damaged axons than the central nervous system （CNS）. This is because formation of scar tissue in the CNS in- fluences neural regrowth or synthesis of growth-in- hibiting proteins, thereby preventing reconstruction of a neural circuit （Silver and Miller, 2004; Enciu et al., 2011）. Parkinson＇s disease （PD） and Alzheimer＇s disease （AD） are two most common degenerative diseases of the CNS among the elderly.
基金supported by a grant from the China Medical University Hospital(DMR-105-005)
文摘While much progress has been made in the field of hematopoietic stem cell transplantation （HSCT）, headway in the promotion of recovery following this procedure has been limited. Data regarding the potential of Chinese herbal medicine （CHM） for patients with hematologic disorders who received HSCT are gradually increasing; however, these data are mostly in Chinese. Therefore, we set out to summarize the existing data. We searched PubMed, the Cochrane Library and the China National Knowledge Infrastructure and retrieved 9 clinical studies related to this group of patients, in whom CHM was used as an intervention. Of the 9 papers, 6 were published by the same group of researchers. The focus of the reviewed studies was heterogeneous, and the objectives varied widely. With the exception of one randomized control trial, all of the studies were retrospective and observational; the median number of patients was 11.5, with the largest study containing 104 patients. CHM treatment was largely divided into two stages： （1） pre-HSCT, which was initiated as soon as conditioning chemotherapy was administered and aimed to counterbalance the adverse effects of these potent agents; （2） post-HSCT, which began immediately after transplantation and was intended to promote engraftment, control graft- versus-host disease and prolong survival. In addition, the 9 Chinese materia medica most commonly prescribed （appearing in four studies） were： Shengdihuang （Rehmannia glutinosa）, Baizhu （Atractylodes macrocephala）, Renshen （Panax ginseng）, Dangshen （ Codonopsis pilosula）, Maimendong （ Ophiopogon japonicus）, Danggui （Angelica sinensis）, Taizishen （Pseudostellaria heterophylla）, Huangqi （Astragalus membranaceus） and Ejiao （Equus asinus）.
