It is hypothesized that liver impairment caused by coronavirus disease 2019(COVID-19)infection might play a central role in severe clinical presentations.Liver injury is closely associated with severe disease and,even...It is hypothesized that liver impairment caused by coronavirus disease 2019(COVID-19)infection might play a central role in severe clinical presentations.Liver injury is closely associated with severe disease and,even with antiviral drugs,have a poor prognosis in COVID-19 patients.In addition to the common hepatobiliary disorders caused by COVID-19,patients with pre-existing liver diseases demand special considerations during the current pandemic.Thus,it is vital that upon clinical presentation,patients with concurrent pre-existing liver disease associated with metabolic dysfunction and COVID-19 be managed properly to prevent liver failure.Careful monitoring and early detection of liver damage through biomarkers after hospitalization for COVID-19 is underscored in all cases,particularly in those with pre-existing metabolic liver injury.The purpose of this study was to determine most recent evidence regarding causality,potential risk factors,and challenges,therapeutic options,and management of COVID-19 infection in vulnerable patients with pre-existing liver injury.This review aims to highlight the current frontier of COVID-19 infection and liver injury and the direction of liver injury in these patients.展开更多
Cholangiocarcinoma(CCA)is a type of cancer with increasing prevalence around the world that originates from cholangiocytes,the epithelial cells of the bile duct.The tumor begins insidiously and is distinguished by hig...Cholangiocarcinoma(CCA)is a type of cancer with increasing prevalence around the world that originates from cholangiocytes,the epithelial cells of the bile duct.The tumor begins insidiously and is distinguished by high grade neoplasm,poor outcome,and high risk for recurrence.Liver transplantation has become broadly accepted as a treatment option for CCA.Liver transplantation is expected to play a crucial role as palliative and curative therapy for unresectable hilar CCA and intrahepatic CCA.The purpose of this study was to determine which cases with CCA should be subjected to liver transplantation instead of resection,although reported post-transplant recurrence rate averages approximately 20%.This review also aims to highlight the molecular current frontiers of CCA and directions of liver transplantation for CCA.展开更多
文摘It is hypothesized that liver impairment caused by coronavirus disease 2019(COVID-19)infection might play a central role in severe clinical presentations.Liver injury is closely associated with severe disease and,even with antiviral drugs,have a poor prognosis in COVID-19 patients.In addition to the common hepatobiliary disorders caused by COVID-19,patients with pre-existing liver diseases demand special considerations during the current pandemic.Thus,it is vital that upon clinical presentation,patients with concurrent pre-existing liver disease associated with metabolic dysfunction and COVID-19 be managed properly to prevent liver failure.Careful monitoring and early detection of liver damage through biomarkers after hospitalization for COVID-19 is underscored in all cases,particularly in those with pre-existing metabolic liver injury.The purpose of this study was to determine most recent evidence regarding causality,potential risk factors,and challenges,therapeutic options,and management of COVID-19 infection in vulnerable patients with pre-existing liver injury.This review aims to highlight the current frontier of COVID-19 infection and liver injury and the direction of liver injury in these patients.
文摘Cholangiocarcinoma(CCA)is a type of cancer with increasing prevalence around the world that originates from cholangiocytes,the epithelial cells of the bile duct.The tumor begins insidiously and is distinguished by high grade neoplasm,poor outcome,and high risk for recurrence.Liver transplantation has become broadly accepted as a treatment option for CCA.Liver transplantation is expected to play a crucial role as palliative and curative therapy for unresectable hilar CCA and intrahepatic CCA.The purpose of this study was to determine which cases with CCA should be subjected to liver transplantation instead of resection,although reported post-transplant recurrence rate averages approximately 20%.This review also aims to highlight the molecular current frontiers of CCA and directions of liver transplantation for CCA.
