Main observation and conclusion The first example of Rh-catalyzed kinetic resolution of 1,3-disubstituted allene-1,3-dienes involving intramolecular[4+2]-cycloaddition has been developed.Followed by C=C isomerization,...Main observation and conclusion The first example of Rh-catalyzed kinetic resolution of 1,3-disubstituted allene-1,3-dienes involving intramolecular[4+2]-cycloaddition has been developed.Followed by C=C isomerization,the reaction finally afforded aza-[4.3.0]bicyclic compounds with a very high en-antio-and E-selectivity.The mechanism has been unveiled by careful control experiments.The synthetic potentials of highly enanti-oenriched bicyclic products have also been demonstrated.展开更多
基金the National Natural Science Founda-tion of China(Grant No.21690063 for S.Ma and Grant No.21801041 for H.Qian)is greatly appreciated.We thank Mr.Feng Jiang in this group for reproducing the results of(3aS,7aS,E)-3h,(3aS,7aS,E)-3I,and(3aR,7aR,E)-3n presented in this study.
文摘Main observation and conclusion The first example of Rh-catalyzed kinetic resolution of 1,3-disubstituted allene-1,3-dienes involving intramolecular[4+2]-cycloaddition has been developed.Followed by C=C isomerization,the reaction finally afforded aza-[4.3.0]bicyclic compounds with a very high en-antio-and E-selectivity.The mechanism has been unveiled by careful control experiments.The synthetic potentials of highly enanti-oenriched bicyclic products have also been demonstrated.
