The Clauser-Horne-Shimony-Holt(CHSH)game provides a captivating illustration of the advantages of quantum strategies over classical ones.In a recent study,a variant of the CHSH game leveraging a single qubit system,re...The Clauser-Horne-Shimony-Holt(CHSH)game provides a captivating illustration of the advantages of quantum strategies over classical ones.In a recent study,a variant of the CHSH game leveraging a single qubit system,referred to as the CHSH^(*)game,has been identified.We demonstrate that this mapping relationship between these two games remains effective even for a non-unitary gate.Here we delve into the breach of Tsirelson’s bound in a non-Hermitian system,predicting changes in the upper and lower bounds of the player’s winning probability when employing quantum strategies in a single dissipative qubit system.We experimentally explore the impact of the CHSH^(*)game on the player’s winning probability in a single trapped-ion dissipative system,demonstrating a violation of Tsirelson’s bound under the influence of parity-time(PT)symmetry.These results contribute to a deeper understanding of the influence of non-Hermitian systems on quantum games and the behavior of quantum systems under PT symmetry,which is crucial for designing more robust and efficient quantum protocols.展开更多
Micro-mass sensors have attracted increasing attention in the field of biomolecular and chemical detec- tion. It has been found that the size, shape, and geometry of the structure may affect the performance of the sen...Micro-mass sensors have attracted increasing attention in the field of biomolecular and chemical detec- tion. It has been found that the size, shape, and geometry of the structure may affect the performance of the sensor. As a result, a topology optimization methodology is proposed in this paper for the design of micro-mass sensors. A phase- field function controlled by nodal variables and finite element shape functions is used to describe the configuration of a sen- sor in the constructed optimization problem. The design goal is to maximize the mass detection sensitivity. On the basis of these formulations, an optimization algorithm is constructed using the finite element method and the method of moving asymptotes. Numerical examples are presented to demon- strate the validity of the proposed problem formulation. The results suggest that the performance of the micro-mass sensor can be improved by using the proposed approach.展开更多
Poor visibility in bad weather, such as haze and fog, is a major problem for many applications of computer vision. Thus, haze removal is highly required for receiving high performance of the vision algorithm. In this ...Poor visibility in bad weather, such as haze and fog, is a major problem for many applications of computer vision. Thus, haze removal is highly required for receiving high performance of the vision algorithm. In this paper, we propose a new fast dehazing method for real-time image and video processing. The transmission map estimated by an improved guided filtering scheme is smooth and respect with depth information of the underlying image. Results demonstrate that the proposed method achieves good dehazeing effect as well as real-time performance. The proposed algorithm, due to its speed and ability to improve visibility, may be used with advantages as pre-processing in many systems ranging from surveillance, intelligent vehicles, to remote sensing.展开更多
Point-of-care testing(POCT)technology is highly desirable for clinical diagnosis,healthcare monitoring,food safety inspection,and environment surveillance,because it enables rapid detection anywhere,anytime,and by any...Point-of-care testing(POCT)technology is highly desirable for clinical diagnosis,healthcare monitoring,food safety inspection,and environment surveillance,because it enables rapid detection anywhere,anytime,and by anyone.Electrochemiluminescence(ECL)has been widely used in chemo-/bio analysis due to its advantages such as high sensitivity,simplicity,rapidity and easy to control,and is now attracting increasing attention for POCT applications.However,to realize the accurate on-site quantitation,it is still challenging to develop portable devices which can precisely collect,analyze,transmit and display the ECL signals.This review will focus on how to develop a portable ECL device by summarizing recent examples and analyzing their key components part by part.Then the possible solutions to the existing challenges in the development and applications of portable ECL devices are summarized and discussed in detail,followed by offering future perspectives.We attempted to provide an appealing viewpoint to inspire interested researchers to comprehend and explore portable ECL sensing systems for practical applications and even commercialization.展开更多
Non-Hermitian systems satisfying parity-time(PT)symmetry have aroused considerable interest owing to their exotic features.Anti-PT symmetry is an important counterpart of the symmetry,and has been studied in various c...Non-Hermitian systems satisfying parity-time(PT)symmetry have aroused considerable interest owing to their exotic features.Anti-PT symmetry is an important counterpart of the symmetry,and has been studied in various classical systems.Although a Hamiltonian with anti-PT symmetry only differs from its PT-symmetric counterpart in a global phase,the information and energy exchange between systems and environment are different under them.It is also suggested theoretically that anti-PT symmetry is a useful concept in the context of quantum information storage with qubits coupled to a bosonic bath.So far,the observation of anti-PT symmetry in individual quantum systems remains elusive.Here,we implement an anti-PT-symmetric Hamiltonian of a single qubit in a single trapped ion by a designed microwave and optical control-pulse sequence.We characterize the anti-PT phase transition by mapping out the eigenvalues at different ratios between coupling strengths and dissipation rates.The full information of the quantum state is also obtained by quantum state tomography.Our work allows quantum simulation of genuine open-system feature of an anti-PT-symmetric system,which paves the way for utilizing non-Hermitian properties for quantum information processing.展开更多
Background The main therapeutic treatments for hepatic artery complications after orthotopic liver transplantation (OLT) include thrombolysis, percutaneous transluminal angioplasty, stent placement, and liver retran...Background The main therapeutic treatments for hepatic artery complications after orthotopic liver transplantation (OLT) include thrombolysis, percutaneous transluminal angioplasty, stent placement, and liver retransplantation. The prognosis of hepatic artery complications after OLT is not only related to the type, extent, and timing but also closely associated with the selection and timing of the therapeutic methods. However, there is no consensus of opinion regarding the treatment of these complications. The aim of this study was to determine optimal treatment for hepatic artery complications after OLT. Methods The clinical data of 25 patients diagnosed with hepatic artery thrombosis (HAT) and hepatic artery stenosis (HAS) between October 2003 and March 2007 were retrospectively reviewed. Treatments included liver retransplantation and interventions which contain thrombolysis, percutaneous transluminal angioplasty and stent placement. Results Among five patients with HAT, 3 were treated with thrombolysis. One recovered, one died after thrombolysis and another one died of multi-organ failure after retransplantation because of recurrent HAT. The remaining 2 patients underwent successful retransplantation and have survived after that. Among 12 patients presented with HAS within 1 month postoperatively, 2 patients underwent retransplantation due to irreversible liver failure and another 10 patients were treated with interventions. The liver function failed to improve in 3 patients and retransplantations were performed in 4 patients after stent placement because of ischemic cholangitis. Among 6 patients undergoing liver retransplantations, two died of intracranial hemorrhage and infection respectively. Eight patients presented with HAS after 1 month postoperatively, 5 patients were treated with interventional management and recovered after stent placement. Among another 3 patients presented with HAS, 2 patients’ liver function was stable and one patient received late liver retransplantation due to ischemic bile duct lesion. Conclusions Individualized therapeutic regimens should be adopted in treating hepatic artery complications after OLT, according to postoperative periods, types and whether ischemic bile duct lesion exists or not. Liver retransplantation is the best treatment for patients with hepatic artery thrombosis. Interventional treatments of late HAS without irreversible liver failure or bile duct ischemia are appropriate, whereas retransplantation is recommended for early HAS.展开更多
Background Orthotopic liver retransplantation (re-OLT) is the only effective therapy for irreversible failure of a liver graft. Early and late graft failure gives way to two different clinical conditions that should...Background Orthotopic liver retransplantation (re-OLT) is the only effective therapy for irreversible failure of a liver graft. Early and late graft failure gives way to two different clinical conditions that should be discussed separately. This study was designed to compare early and late re-OLT for patients with poor graft function after primary transplantation at our center and sum up our clinical experience in re-OLT. Methods The clinical data of 31 re-OLTs at our center from January 2004 to February 2007 were analyzed retrospectively, consisting of the first group with 14 cases of early re-OLT and the second group with 17 cases of late re-OLT.Results Biliary tract complications were the main indications for early re-OLT (57.1%) and late re-OLT (52.9%). Other common indications were vascular complications in early re-OLT and recurrence of primary diseases in late re-OLT. No significant differences were found between the groups with regard to the volume of bleeding during operation, cold ischemia time, operative duration, and perioperative mortality; except for the model of end-stage liver disease (MELD) score. Outcome was fatal for 7 patients in early re-OLT and 9 patients in late re-OLT. Two deaths were due to multiple organ failure with 3 deaths due to severe sepsis-related disease in early re-OLT, and 4 deaths were due to severe sepsis-related disease with 3 deaths due to recurrence of hepatocellular carcinoma (HCC) in late re-OLT. One and 2-year actuarial survival rates after re-OLT were 55.2% and 36.9%, respectively, for patients in early re-OLT, and 65.1% and 52% respectively, for patients in late re-OLT. No significant differences were found regarding survival rates between the two groups. Conclusions Similar clinical results can be achieved in early and late re-OLT. Proper indications and optimal operation timing, adequate preoperative preparation, experienced surgical procedures, and effective perioperative anti-infection strategy contribute to the improvement of overall survival rates of patients after re-OLT.展开更多
Background The most frequently used therapy for post-transplantation recurrence of hepatitis B virus (HBV) infection is lamivudine, but this drug is associated with a high resistance rate due to YMDD mutant. In prel...Background The most frequently used therapy for post-transplantation recurrence of hepatitis B virus (HBV) infection is lamivudine, but this drug is associated with a high resistance rate due to YMDD mutant. In preliminary reports, adefovir dipivoxil (ADV) has been shown to have activity against lamivudine-resistant strains of HBV. However, clinical experience in treatment of HBV infection after liver transplantation (LT) is still not entirely clear. This study was aimed to evaluate the prophylactic efficacy of ADV plus hepatitis B immunoglobulin (HBIG) in patients with YMDD mutant before LT. Methods From March 2004 to March 2006, 16 patients with chronic hepatitis B had lamivudine-resistant YMDD mutants detected prior to liver transplantation and received treatment with ADV plus additional intramuscular HBIG after LT as prophylaxis against graft reinfection. Tests for liver function, serum HBsAg, anti-HBs (HBIG), HBeAg, anti-HBc, anti-HBe, HBV-DNA, and creatinine were assessed pre- or post-liver transplantation. Results The median follow-up of these patients post-liver transplantation was 19.4 months. Fifteen patients survived and one patient died of recurrence of hepatocellular carcinoma (HCC). There was significant difference (10.98% vs. 2.26%, P〈0.05) in YMDD mutant rate between the patients with HBV-DNA over 106 copies/ml and those with HBV-DNA less than 106 copies/mi. Fifteen patients (93.8%) had undetectable HBV-DNA at 4 weeks and 1 (6.3%) at 6 months after LT. No hepatitis B recurrence was detected by persistent testing of HBsAg, HBeAg, and HBV-DNA and no increase of serum creatinine level associated with ADV was observed in any of the patients. Conclusion ADV combined with intramuscular HBIG can effectively prevent patients with pre-transplantation YMDD mutant from HBV recurrence after LT.展开更多
Recently,tissue engineering has developed into a powerful tool for repairing and reconstructing damaged tissues and organs.Tissue engineering scaffolds play a vital role in tissue engineering,as they not only provide ...Recently,tissue engineering has developed into a powerful tool for repairing and reconstructing damaged tissues and organs.Tissue engineering scaffolds play a vital role in tissue engineering,as they not only provide structural support for targeted cells but also serve as templates that guide tissue regeneration and control the tissue structure.Over the past few years,owing to unique physicochemical properties and excellent biocompatibility,various types of two-dimensional(2D)nanomaterials have been developed as candidates for the construction of tissue engineering scaffolds,enabling remarkable achievements in bone repair,wound healing,neural regeneration,and cardiac tissue engineering.These efforts have significantly advanced the development of tissue engineering.In this review,we summarize the latest advancements in the application of 2D nanomaterials in tissue engineering.First,each typical 2D nanomaterial is introduced briefly,followed by a detailed description of its applications in tissue engineering.Finally,the existing challenges and prospects for the future of the application of 2D nanomaterials in tissue engineering are discussed.展开更多
Baicalin,extracted from traditional Chinese medicine Scutellaria baicalensis Georg,possesses multiple pharmacological activities and has great potential for chronic skin wound repair.However,the poor solubility and la...Baicalin,extracted from traditional Chinese medicine Scutellaria baicalensis Georg,possesses multiple pharmacological activities and has great potential for chronic skin wound repair.However,the poor solubility and lack of suitable vehicles greatly limit its further application.Herein,we proposed a convenient and robust strategy,employing PBS solution as solvent,to enhance the solubility of baicalin.Furthermore,we constructed injectable baicalin/F127 hydrogels to study their application in skin wound treatment.The composition and temperature sensitivity of baicalin/Pluronic®F-127 hydrogels were confirmed by FTIR and rheological testing,respectively.In vitro release measurement indicated that the first order model was best fitted with the release profile of baicalin from hydrogel matrix.Besides,MTT assay,AO/EO staining assay as well as hemolytic activity test revealed the excellent cytocompatibility of baicalin/F127 hydrogels.Antioxidant activity assay demonstrated the cytoprotective activity of baicalin/F127 hydrogels against reactive oxygen species(ROS).Furthermore,the in vivo experiments exhibited the ability of baicalin/F127 hydrogel to accelerate wound healing.In conclusion,this novel injectable baicalin/F127 hydrogel should have bright application for chronic wound treatment.展开更多
Although intelligent hydrogels have shown bright potential application in biomedical fields,they were prepared by conventional methods and still face many serious challenges,such as uncontrollable stimulus-response an...Although intelligent hydrogels have shown bright potential application in biomedical fields,they were prepared by conventional methods and still face many serious challenges,such as uncontrollable stimulus-response and low response sensitivity.Recently,RAFT polymerization provides a versatile strategy for the fabrication of intelligent hydrogels with improved stimulus-response properties,owing to the ability to efficiently construct hydrogel precursors with well-defined structure,such as block copolymer,graft copolymer,star copolymer.In this review,we summarized the recent progress on intelligent hydrogels based on RAFT polymerization with emphasis on their fabrication strategies and applications for controlled drug delivery.展开更多
Modern computer graphics applications usually require high resolution object models for realistic rendering. However, it is expensive and difficult to deform such models in real time. In order to reduce the computatio...Modern computer graphics applications usually require high resolution object models for realistic rendering. However, it is expensive and difficult to deform such models in real time. In order to reduce the computational cost during deformations, a dense model is often manipulated through a simplified structure, called cage, which envelops the model. However, cages are usually built interactively by users, which is tedious and time-consuming. In this paper, we introduce a novel method that can build cages automatically for both 2D polygons and 3D triangular meshes. The method consists of two steps: 1) simplifying the input model with quadric error metrics and quadratic programming to build a coarse cage; 2) removing the self-intersections of the coarse cage with Delaunay partitions. With this new method, a user can build a cage to envelop an input model either entirely or partially with the approximate vertex number the user specifies. Experimental results show that, compared to other cage building methods with the same number of vertex, cages built by our method are more similar to the input models. Thus, the dense models can be manipulated with higher accuracy through our cages.展开更多
The well-known CCSDS(consultative committee for space data systems) LDPC(low density parity check) code for near-earth applications is discussed and used for a case study of Mc Eliece system. First, a data error is pi...The well-known CCSDS(consultative committee for space data systems) LDPC(low density parity check) code for near-earth applications is discussed and used for a case study of Mc Eliece system. First, a data error is picked out with the CCSDS LDPC code. The problem with its generator matrix is illustrated and overcome by a shortened code with some middle code bits deleted. In correspondence, its parity check matrix is also revised with the new quasi-cyclic(QC)-LDPC code. Second, a fast decoding scheme for general QC-LDPC codes is proposed based on flipping bits and fetching words. Besides, a lightweight CCSDS LDPC code based Mc Eliece system can be set up with such codes. The repaired CCSDS LDPC code is supposed to be still useful for communications and storages, and the normalized decoding algorithm is also efficient for general QC-LDPC codes.展开更多
Improving the transfer hydrogenation of N-heteroarenes is of key importance for various industrial pro-cesses and remains a challenge so far.We reported here a microcapsule-pyrolysis strategy to quasi-continuous synth...Improving the transfer hydrogenation of N-heteroarenes is of key importance for various industrial pro-cesses and remains a challenge so far.We reported here a microcapsule-pyrolysis strategy to quasi-continuous synthesis S,N co-doped carbon supported Co single atom catalysts(Co/SNC),which was used for transfer hydrogenation of quinoline with formic acid as the hydrogen donor.Given the unique ge-ometric and electronic properties of the Co single atoms,the excellent catalytic activity,selectivity and stability were observed.Benefiting from the quasi-continuous synthesis method,the as-obtained cata-lysts provide a reference for the large-scale preparation of single atom catalysts without amplification ef-fect.Highly catalytic performances and quasi-continuous preparation process,demonstrating a new and promising approach to rational design of atomically dispersed catalysts with maximum atomic efficiency in industrial.展开更多
As a daily food for billions of people for thousands of years,whole grain is rich in phenolic compounds and may have huge potentials to provide natural antioxidants.Herein,owing to the significant biomedical potential...As a daily food for billions of people for thousands of years,whole grain is rich in phenolic compounds and may have huge potentials to provide natural antioxidants.Herein,owing to the significant biomedical potential,the effect of whole wheat flour solution as antioxidant wound coating for enhanced wound healing has been studied.The results show that the low concentration of whole wheat flour solutions have good biocompatibility and can scavenge radical and intracellular ROS in vitro,accelerating tissue remodeling in vivo to promote wound healing.This kind of whole wheat flour solution has great potential application for cutaneous wound repair.展开更多
Co-analyzing a set of 3D shapes is a challenging task considering a large geometrical variability of the shapes. To address this challenge, this paper proposes a new automatic 3D shape co-segmentation algorithm by usi...Co-analyzing a set of 3D shapes is a challenging task considering a large geometrical variability of the shapes. To address this challenge, this paper proposes a new automatic 3D shape co-segmentation algorithm by using spectral graph method. Our method firstly represents input shapes as a set of weighted graphs and extracts multiple geometric features to measure the similarities of faces in each individual shape. Secondly all graphs are embedded into the spectral domain to find meaningful correspondences across the set, After that we build a joint weighted matrix for the graph set and then apply normalized cut criterion to find optimal co-segmentation of the input shapes. Finally we evaluate our approach on different categories of 3D shapes, and the experimental results demonstrate that our method can accurately co-segment a wide variety of shapes, which may have different poses and significant topology changes.展开更多
Biomimetic scaffolds present the promising potential for bone regeneration.As a natural gel-like traditional food,tofu with porous architecture and proved biological safety indicated a good potential to be a natural s...Biomimetic scaffolds present the promising potential for bone regeneration.As a natural gel-like traditional food,tofu with porous architecture and proved biological safety indicated a good potential to be a natural scaffold and easy to be improved by surface modification.Hereon,we fabricated the tofubased scaffolds and systematically explored the potential for bone tissue engineering.In addition,the collagen has been introduced by simple coating to further enha nce the surface compatibility of the tofubased scaffold in bone regeneration.The results showed that the tofu-based scaffolds possessed good porous structure and cytocompatibility.Notably,the tofu-based scaffolds could improve the expression of osteogenesis-related genes and proteins,leading to better bone regeneration after 2 months of implantation.All the results indicated that to fu would become an outstanding sustainable natural porous scaffold for bone regeneration with excellent bioactivities.展开更多
Skeletal muscle differentiation is a highly coordinated process that involves many cellular signaling pathways and microRNAs(miRNAs).A group of muscle-specific miRNAs has been reported to promote myogenesis by suppres...Skeletal muscle differentiation is a highly coordinated process that involves many cellular signaling pathways and microRNAs(miRNAs).A group of muscle-specific miRNAs has been reported to promote myogenesis by suppressing key signaling pathways for cell growth.However,the functional role and regulatory mechanism of most non-muscle-specific miRNAs with stage-specific changes during differentiation are largely unclear.Here,we describe the functional characterization of miR-101a/b,a pair of non-muscle-specific miRNAs that show the largest change among a group of transiently upregulated miRNAs during myogenesis in C2C12 cells.The overexpression of miR-101a/b inhibits myoblast differentiation by suppressing the p38/MAPK,Interferon Gamma,and Wnt pathways and enhancing the C/EBP pathway.Mef2a,a key protein in the p38/MAPK pathway,was identified as a direct target of miR-101a/b.Interestingly,we found that the long non-coding RNA(lncRNA)Malat1,which promotes muscle differentiation,interacts with miR-101a/b,and this interaction competes with Mef2a mRNA to relieve the inhibition of the p38/MAPK pathway during myogenesis.These results uncovered a“braking”role in differentiation of transiently upregulated miRNAs and provided new insights into the competing endogenous RNA(ceRNA)regulatory mechanism in myoblast differentiation and myogenesis.展开更多
Coronavirus disease 2019(COVID-19)is an infectious disease caused by a newly discovered coronavirus and has rapidly spread to most of the world and resulted in a global pandemic.However,there is a paucity of informati...Coronavirus disease 2019(COVID-19)is an infectious disease caused by a newly discovered coronavirus and has rapidly spread to most of the world and resulted in a global pandemic.However,there is a paucity of information available to characterize the immunodeficient population in the COVID-19 pandemic,especially information that focuses on patients after renal transplantation as the typical representative of this population.展开更多
基金supported by the National Key Research and Development Program of China(Grant No.2022YFC2204402)the Key-Area Research and Development Program of Guangdong Province(Grant No.2019B030330001)+7 种基金the Guangdong Science and Technology Project(Grant No.20220505020011)the Fundamental Research Funds for the Central Universities,Sun Yat-sen University(Grant No.2021qntd28)the Fundamental Research Funds for the Central Universities,Sun Yat-sen University(Grant No.2023lgbj020)SYSU Key Project of Advanced ResearchShenzhen Science and Technology Program(Grant No.JCYJ20220818102003006)the Shenzhen Science and Technology Program(Grant No.2021Szvup172)the supports from China Postdoctoral Science Foundation(Grant No.2021M703768)the supports from Guangdong Province Youth Talent Program(Grant No.2017GC010656)。
文摘The Clauser-Horne-Shimony-Holt(CHSH)game provides a captivating illustration of the advantages of quantum strategies over classical ones.In a recent study,a variant of the CHSH game leveraging a single qubit system,referred to as the CHSH^(*)game,has been identified.We demonstrate that this mapping relationship between these two games remains effective even for a non-unitary gate.Here we delve into the breach of Tsirelson’s bound in a non-Hermitian system,predicting changes in the upper and lower bounds of the player’s winning probability when employing quantum strategies in a single dissipative qubit system.We experimentally explore the impact of the CHSH^(*)game on the player’s winning probability in a single trapped-ion dissipative system,demonstrating a violation of Tsirelson’s bound under the influence of parity-time(PT)symmetry.These results contribute to a deeper understanding of the influence of non-Hermitian systems on quantum games and the behavior of quantum systems under PT symmetry,which is crucial for designing more robust and efficient quantum protocols.
基金supported by the National Natural Science Foundation of China(Grants 11202246 and 11002031)the China Postdoctoral Science Foundation funded project(Grant2012M511863)
文摘Micro-mass sensors have attracted increasing attention in the field of biomolecular and chemical detec- tion. It has been found that the size, shape, and geometry of the structure may affect the performance of the sensor. As a result, a topology optimization methodology is proposed in this paper for the design of micro-mass sensors. A phase- field function controlled by nodal variables and finite element shape functions is used to describe the configuration of a sen- sor in the constructed optimization problem. The design goal is to maximize the mass detection sensitivity. On the basis of these formulations, an optimization algorithm is constructed using the finite element method and the method of moving asymptotes. Numerical examples are presented to demon- strate the validity of the proposed problem formulation. The results suggest that the performance of the micro-mass sensor can be improved by using the proposed approach.
文摘Poor visibility in bad weather, such as haze and fog, is a major problem for many applications of computer vision. Thus, haze removal is highly required for receiving high performance of the vision algorithm. In this paper, we propose a new fast dehazing method for real-time image and video processing. The transmission map estimated by an improved guided filtering scheme is smooth and respect with depth information of the underlying image. Results demonstrate that the proposed method achieves good dehazeing effect as well as real-time performance. The proposed algorithm, due to its speed and ability to improve visibility, may be used with advantages as pre-processing in many systems ranging from surveillance, intelligent vehicles, to remote sensing.
基金The financial support from the National Key Research and Development Program of China(No.2022YFE0201800)Shenzhen Science and Technology Innovation Commission(Nos.GJHZ20210705142200001 and JCYJ20210324140004013)Guangdong Natural Science Foundation(Nos.2021A1515220020 and 2020B1212060077)is gratefully acknowledged。
文摘Point-of-care testing(POCT)technology is highly desirable for clinical diagnosis,healthcare monitoring,food safety inspection,and environment surveillance,because it enables rapid detection anywhere,anytime,and by anyone.Electrochemiluminescence(ECL)has been widely used in chemo-/bio analysis due to its advantages such as high sensitivity,simplicity,rapidity and easy to control,and is now attracting increasing attention for POCT applications.However,to realize the accurate on-site quantitation,it is still challenging to develop portable devices which can precisely collect,analyze,transmit and display the ECL signals.This review will focus on how to develop a portable ECL device by summarizing recent examples and analyzing their key components part by part.Then the possible solutions to the existing challenges in the development and applications of portable ECL devices are summarized and discussed in detail,followed by offering future perspectives.We attempted to provide an appealing viewpoint to inspire interested researchers to comprehend and explore portable ECL sensing systems for practical applications and even commercialization.
基金the Key-Area Research and Development Program of Guangdong Province(2019B030330001)the National Natural Science Foundation of China(11774436,11974434 and 12074439)+3 种基金the fundamental research funds for the Central Universities(Sun Yat-sen University,2021qntd28)Le Luo receives support from Guangdong Province Youth Talent Program(2017GC010656)Sun Yat-Sen University Core Technology Development Fund.Yang Liu receives support from Natural Science Foundation of Guangdong Province(2020A1515011159)Ji Bian receives support from China Postdoctoral Science Foundation(2021M703768).
文摘Non-Hermitian systems satisfying parity-time(PT)symmetry have aroused considerable interest owing to their exotic features.Anti-PT symmetry is an important counterpart of the symmetry,and has been studied in various classical systems.Although a Hamiltonian with anti-PT symmetry only differs from its PT-symmetric counterpart in a global phase,the information and energy exchange between systems and environment are different under them.It is also suggested theoretically that anti-PT symmetry is a useful concept in the context of quantum information storage with qubits coupled to a bosonic bath.So far,the observation of anti-PT symmetry in individual quantum systems remains elusive.Here,we implement an anti-PT-symmetric Hamiltonian of a single qubit in a single trapped ion by a designed microwave and optical control-pulse sequence.We characterize the anti-PT phase transition by mapping out the eigenvalues at different ratios between coupling strengths and dissipation rates.The full information of the quantum state is also obtained by quantum state tomography.Our work allows quantum simulation of genuine open-system feature of an anti-PT-symmetric system,which paves the way for utilizing non-Hermitian properties for quantum information processing.
基金This study was supported by grants from the Major State Basic Research Development Program (973 Program) of China (No. 2003CB515500), the National Natural Science Foundation of China (No. 30571769 and No. 30772044), Sci-tech Research Development Program of Guangdong Province (No. 2007A032000001 and No. 2007B060401033), and the Teamwork Projects Funded by Guangdong Natural Science Foundation (No. 05200177).
文摘Background The main therapeutic treatments for hepatic artery complications after orthotopic liver transplantation (OLT) include thrombolysis, percutaneous transluminal angioplasty, stent placement, and liver retransplantation. The prognosis of hepatic artery complications after OLT is not only related to the type, extent, and timing but also closely associated with the selection and timing of the therapeutic methods. However, there is no consensus of opinion regarding the treatment of these complications. The aim of this study was to determine optimal treatment for hepatic artery complications after OLT. Methods The clinical data of 25 patients diagnosed with hepatic artery thrombosis (HAT) and hepatic artery stenosis (HAS) between October 2003 and March 2007 were retrospectively reviewed. Treatments included liver retransplantation and interventions which contain thrombolysis, percutaneous transluminal angioplasty and stent placement. Results Among five patients with HAT, 3 were treated with thrombolysis. One recovered, one died after thrombolysis and another one died of multi-organ failure after retransplantation because of recurrent HAT. The remaining 2 patients underwent successful retransplantation and have survived after that. Among 12 patients presented with HAS within 1 month postoperatively, 2 patients underwent retransplantation due to irreversible liver failure and another 10 patients were treated with interventions. The liver function failed to improve in 3 patients and retransplantations were performed in 4 patients after stent placement because of ischemic cholangitis. Among 6 patients undergoing liver retransplantations, two died of intracranial hemorrhage and infection respectively. Eight patients presented with HAS after 1 month postoperatively, 5 patients were treated with interventional management and recovered after stent placement. Among another 3 patients presented with HAS, 2 patients’ liver function was stable and one patient received late liver retransplantation due to ischemic bile duct lesion. Conclusions Individualized therapeutic regimens should be adopted in treating hepatic artery complications after OLT, according to postoperative periods, types and whether ischemic bile duct lesion exists or not. Liver retransplantation is the best treatment for patients with hepatic artery thrombosis. Interventional treatments of late HAS without irreversible liver failure or bile duct ischemia are appropriate, whereas retransplantation is recommended for early HAS.
基金The project was supported by grants from the Major State Basic Research Development Program (973 Program) of China (No. 2003CB515507), the Guangdong Provincial Natural Science Foundation of China (No. 04105344), and the Guangdong Provincial Science Technology Project (No. 2005B30501005).
文摘Background Orthotopic liver retransplantation (re-OLT) is the only effective therapy for irreversible failure of a liver graft. Early and late graft failure gives way to two different clinical conditions that should be discussed separately. This study was designed to compare early and late re-OLT for patients with poor graft function after primary transplantation at our center and sum up our clinical experience in re-OLT. Methods The clinical data of 31 re-OLTs at our center from January 2004 to February 2007 were analyzed retrospectively, consisting of the first group with 14 cases of early re-OLT and the second group with 17 cases of late re-OLT.Results Biliary tract complications were the main indications for early re-OLT (57.1%) and late re-OLT (52.9%). Other common indications were vascular complications in early re-OLT and recurrence of primary diseases in late re-OLT. No significant differences were found between the groups with regard to the volume of bleeding during operation, cold ischemia time, operative duration, and perioperative mortality; except for the model of end-stage liver disease (MELD) score. Outcome was fatal for 7 patients in early re-OLT and 9 patients in late re-OLT. Two deaths were due to multiple organ failure with 3 deaths due to severe sepsis-related disease in early re-OLT, and 4 deaths were due to severe sepsis-related disease with 3 deaths due to recurrence of hepatocellular carcinoma (HCC) in late re-OLT. One and 2-year actuarial survival rates after re-OLT were 55.2% and 36.9%, respectively, for patients in early re-OLT, and 65.1% and 52% respectively, for patients in late re-OLT. No significant differences were found regarding survival rates between the two groups. Conclusions Similar clinical results can be achieved in early and late re-OLT. Proper indications and optimal operation timing, adequate preoperative preparation, experienced surgical procedures, and effective perioperative anti-infection strategy contribute to the improvement of overall survival rates of patients after re-OLT.
基金This study was supported by the grants from the Major State Basic Research Development Program (973 Program) of China (No.2003CB515500)the National Natural Science Foundation of China (No. 30571769)+1 种基金Sci-tech Research Development Program of Guangdong Province (No. 2004B35001003)the Teamwork Projects Funded by Guangdong Natural Science Foundation (No.05200177)
文摘Background The most frequently used therapy for post-transplantation recurrence of hepatitis B virus (HBV) infection is lamivudine, but this drug is associated with a high resistance rate due to YMDD mutant. In preliminary reports, adefovir dipivoxil (ADV) has been shown to have activity against lamivudine-resistant strains of HBV. However, clinical experience in treatment of HBV infection after liver transplantation (LT) is still not entirely clear. This study was aimed to evaluate the prophylactic efficacy of ADV plus hepatitis B immunoglobulin (HBIG) in patients with YMDD mutant before LT. Methods From March 2004 to March 2006, 16 patients with chronic hepatitis B had lamivudine-resistant YMDD mutants detected prior to liver transplantation and received treatment with ADV plus additional intramuscular HBIG after LT as prophylaxis against graft reinfection. Tests for liver function, serum HBsAg, anti-HBs (HBIG), HBeAg, anti-HBc, anti-HBe, HBV-DNA, and creatinine were assessed pre- or post-liver transplantation. Results The median follow-up of these patients post-liver transplantation was 19.4 months. Fifteen patients survived and one patient died of recurrence of hepatocellular carcinoma (HCC). There was significant difference (10.98% vs. 2.26%, P〈0.05) in YMDD mutant rate between the patients with HBV-DNA over 106 copies/ml and those with HBV-DNA less than 106 copies/mi. Fifteen patients (93.8%) had undetectable HBV-DNA at 4 weeks and 1 (6.3%) at 6 months after LT. No hepatitis B recurrence was detected by persistent testing of HBsAg, HBeAg, and HBV-DNA and no increase of serum creatinine level associated with ADV was observed in any of the patients. Conclusion ADV combined with intramuscular HBIG can effectively prevent patients with pre-transplantation YMDD mutant from HBV recurrence after LT.
基金This work was supported by the National Science and Technology Major Project of the Ministry of Science and Technology of China(No.2018ZX10301402)General Program of National Natural Science Foundation of China(No.51973243)+3 种基金Guangdong Innovative and Entrepreneurial Research Team Program(No.2016ZT06S029)General Program of Guangdong Natural Science Foundation(No.2020A1515010983)Science and Technology Planning Project of Shenzhen(Nos.JCYJ20170307141438157 and JCYJ20190807155801657)the Fundamental Research Funds for the Central Universities(No.191gzd35).
文摘Recently,tissue engineering has developed into a powerful tool for repairing and reconstructing damaged tissues and organs.Tissue engineering scaffolds play a vital role in tissue engineering,as they not only provide structural support for targeted cells but also serve as templates that guide tissue regeneration and control the tissue structure.Over the past few years,owing to unique physicochemical properties and excellent biocompatibility,various types of two-dimensional(2D)nanomaterials have been developed as candidates for the construction of tissue engineering scaffolds,enabling remarkable achievements in bone repair,wound healing,neural regeneration,and cardiac tissue engineering.These efforts have significantly advanced the development of tissue engineering.In this review,we summarize the latest advancements in the application of 2D nanomaterials in tissue engineering.First,each typical 2D nanomaterial is introduced briefly,followed by a detailed description of its applications in tissue engineering.Finally,the existing challenges and prospects for the future of the application of 2D nanomaterials in tissue engineering are discussed.
基金the National Science and Technology Major Project of the Ministry of Science and Technology of China(No.2018ZX10301402)International Cooperation and Exchange of the National Natural Science Foundation of China(No.51820105004)+3 种基金Science and Technology Program of Guangzhou(No.201707010094)Guangdong Innovative and Entrepreneurial Research Team Program(Nos.2013S086 and 2016ZT06S029)Science and Technology Planning Project of Shenzhen(Nos.JCYJ20170307141438157 and JCYJ20180307163534533)Fundamental Research Funds for the Central Universities(No.191gpy209)。
文摘Baicalin,extracted from traditional Chinese medicine Scutellaria baicalensis Georg,possesses multiple pharmacological activities and has great potential for chronic skin wound repair.However,the poor solubility and lack of suitable vehicles greatly limit its further application.Herein,we proposed a convenient and robust strategy,employing PBS solution as solvent,to enhance the solubility of baicalin.Furthermore,we constructed injectable baicalin/F127 hydrogels to study their application in skin wound treatment.The composition and temperature sensitivity of baicalin/Pluronic®F-127 hydrogels were confirmed by FTIR and rheological testing,respectively.In vitro release measurement indicated that the first order model was best fitted with the release profile of baicalin from hydrogel matrix.Besides,MTT assay,AO/EO staining assay as well as hemolytic activity test revealed the excellent cytocompatibility of baicalin/F127 hydrogels.Antioxidant activity assay demonstrated the cytoprotective activity of baicalin/F127 hydrogels against reactive oxygen species(ROS).Furthermore,the in vivo experiments exhibited the ability of baicalin/F127 hydrogel to accelerate wound healing.In conclusion,this novel injectable baicalin/F127 hydrogel should have bright application for chronic wound treatment.
基金supported by National Science and Technology Major Project of the Ministry of Science and Technology of China (No. 2018ZX10301402)International Cooperation and Exchange of the National Natural Science Foundation of China (No. 51820105004)+2 种基金the Science and Technology Program of Guangzhou (No. 201707010094)Guangdong Innovative and Entrepreneurial Research Team Program (Nos. 2013S086 and 2016ZT06S029)the Science and Technology Planning Project of Shenzhen (No. JCYJ20170307141438157)
文摘Although intelligent hydrogels have shown bright potential application in biomedical fields,they were prepared by conventional methods and still face many serious challenges,such as uncontrollable stimulus-response and low response sensitivity.Recently,RAFT polymerization provides a versatile strategy for the fabrication of intelligent hydrogels with improved stimulus-response properties,owing to the ability to efficiently construct hydrogel precursors with well-defined structure,such as block copolymer,graft copolymer,star copolymer.In this review,we summarized the recent progress on intelligent hydrogels based on RAFT polymerization with emphasis on their fabrication strategies and applications for controlled drug delivery.
基金Supported by the NSFC-Guangdong Joint Fund under Grant Nos. U0735001,U0835004,U0935004the National Basic Research 973 Program of China under Grant No. 2011CB302204
文摘Modern computer graphics applications usually require high resolution object models for realistic rendering. However, it is expensive and difficult to deform such models in real time. In order to reduce the computational cost during deformations, a dense model is often manipulated through a simplified structure, called cage, which envelops the model. However, cages are usually built interactively by users, which is tedious and time-consuming. In this paper, we introduce a novel method that can build cages automatically for both 2D polygons and 3D triangular meshes. The method consists of two steps: 1) simplifying the input model with quadric error metrics and quadratic programming to build a coarse cage; 2) removing the self-intersections of the coarse cage with Delaunay partitions. With this new method, a user can build a cage to envelop an input model either entirely or partially with the approximate vertex number the user specifies. Experimental results show that, compared to other cage building methods with the same number of vertex, cages built by our method are more similar to the input models. Thus, the dense models can be manipulated with higher accuracy through our cages.
基金Supported by the Guangzhou Innovation Leading Team Program (201909010008)。
文摘The well-known CCSDS(consultative committee for space data systems) LDPC(low density parity check) code for near-earth applications is discussed and used for a case study of Mc Eliece system. First, a data error is picked out with the CCSDS LDPC code. The problem with its generator matrix is illustrated and overcome by a shortened code with some middle code bits deleted. In correspondence, its parity check matrix is also revised with the new quasi-cyclic(QC)-LDPC code. Second, a fast decoding scheme for general QC-LDPC codes is proposed based on flipping bits and fetching words. Besides, a lightweight CCSDS LDPC code based Mc Eliece system can be set up with such codes. The repaired CCSDS LDPC code is supposed to be still useful for communications and storages, and the normalized decoding algorithm is also efficient for general QC-LDPC codes.
基金financial support from the National Natural Science Foundation of China(Nos.22078371,21938001,21961160741)Guangdong Provincial Key R&D Programme(No.2019B110206002)+4 种基金Special fund for Local Science and Technology Development by the Central Government,Local Innovative and Research Teams Project of Guangdong Pearl River Talents Pro-gram(No.2017BT01C102)the NSF of Guang-dong Province(No.2020A1515011141)the National key Research and Development Program Nanotechnology Specific Project(No.2020YFA0210900)the Science and Technology Key Project of Guangdong Province,China(No.2020B010188002)The Project Supported by Guangdong Natural Science Foundation(No.2021A1515010163).
文摘Improving the transfer hydrogenation of N-heteroarenes is of key importance for various industrial pro-cesses and remains a challenge so far.We reported here a microcapsule-pyrolysis strategy to quasi-continuous synthesis S,N co-doped carbon supported Co single atom catalysts(Co/SNC),which was used for transfer hydrogenation of quinoline with formic acid as the hydrogen donor.Given the unique ge-ometric and electronic properties of the Co single atoms,the excellent catalytic activity,selectivity and stability were observed.Benefiting from the quasi-continuous synthesis method,the as-obtained cata-lysts provide a reference for the large-scale preparation of single atom catalysts without amplification ef-fect.Highly catalytic performances and quasi-continuous preparation process,demonstrating a new and promising approach to rational design of atomically dispersed catalysts with maximum atomic efficiency in industrial.
基金financial support from National Science and Technology Major Project of the Ministry of Science and Technology of China(No.2018ZX10301402)International Cooperation and Exchange of the National Natural Science Foundation of China(No.51820105004)+2 种基金Guangdong Innovative and Entrepreneurial Research Team Program(Nos.2013S086 and 2016ZT06S029)Science and Technology Program of Guangzhou(No.201707010094),Science and Technology Planning Project of Shenzhen(No.JCYJ20170307141438157)the Fundamental Research Funds for the Central Universities(No.18lgpy58)。
文摘As a daily food for billions of people for thousands of years,whole grain is rich in phenolic compounds and may have huge potentials to provide natural antioxidants.Herein,owing to the significant biomedical potential,the effect of whole wheat flour solution as antioxidant wound coating for enhanced wound healing has been studied.The results show that the low concentration of whole wheat flour solutions have good biocompatibility and can scavenge radical and intracellular ROS in vitro,accelerating tissue remodeling in vivo to promote wound healing.This kind of whole wheat flour solution has great potential application for cutaneous wound repair.
基金supported by the National Basic Research 973 Program of China under Grant No. 2013CB329505the National Natural Science Foundation of China Guangdong Joint Fund under Grant Nos. U1135005, U1201252the National Natural Science Foundation of China under Grant Nos. 61103162, 61232011
文摘Co-analyzing a set of 3D shapes is a challenging task considering a large geometrical variability of the shapes. To address this challenge, this paper proposes a new automatic 3D shape co-segmentation algorithm by using spectral graph method. Our method firstly represents input shapes as a set of weighted graphs and extracts multiple geometric features to measure the similarities of faces in each individual shape. Secondly all graphs are embedded into the spectral domain to find meaningful correspondences across the set, After that we build a joint weighted matrix for the graph set and then apply normalized cut criterion to find optimal co-segmentation of the input shapes. Finally we evaluate our approach on different categories of 3D shapes, and the experimental results demonstrate that our method can accurately co-segment a wide variety of shapes, which may have different poses and significant topology changes.
基金the National Natural Science Foundation of China(No.51503129)Guangdong Innovative and Entrepreneurial Research Team Program(No.2016ZT06S029)+1 种基金the funding from the Science and Technology Program of Guangzhou(No.201707010094)Science and Technology Planning Project of Shenzhen(No.JCYJ20180307163534533)。
文摘Biomimetic scaffolds present the promising potential for bone regeneration.As a natural gel-like traditional food,tofu with porous architecture and proved biological safety indicated a good potential to be a natural scaffold and easy to be improved by surface modification.Hereon,we fabricated the tofubased scaffolds and systematically explored the potential for bone tissue engineering.In addition,the collagen has been introduced by simple coating to further enha nce the surface compatibility of the tofubased scaffold in bone regeneration.The results showed that the tofu-based scaffolds possessed good porous structure and cytocompatibility.Notably,the tofu-based scaffolds could improve the expression of osteogenesis-related genes and proteins,leading to better bone regeneration after 2 months of implantation.All the results indicated that to fu would become an outstanding sustainable natural porous scaffold for bone regeneration with excellent bioactivities.
基金supported by the National Natural Science Foundation of China(31970604,31701116,31770879,31771459,31900903,81870449,81974436)the Major Research Plan of the National Natural Science Foundation of China(91940000)+1 种基金the Fundamental Research Funds for the Central Universities(20lgpy112)Science and Technology New Star in ZhuJiang Guangzhou City(201806010151).
文摘Skeletal muscle differentiation is a highly coordinated process that involves many cellular signaling pathways and microRNAs(miRNAs).A group of muscle-specific miRNAs has been reported to promote myogenesis by suppressing key signaling pathways for cell growth.However,the functional role and regulatory mechanism of most non-muscle-specific miRNAs with stage-specific changes during differentiation are largely unclear.Here,we describe the functional characterization of miR-101a/b,a pair of non-muscle-specific miRNAs that show the largest change among a group of transiently upregulated miRNAs during myogenesis in C2C12 cells.The overexpression of miR-101a/b inhibits myoblast differentiation by suppressing the p38/MAPK,Interferon Gamma,and Wnt pathways and enhancing the C/EBP pathway.Mef2a,a key protein in the p38/MAPK pathway,was identified as a direct target of miR-101a/b.Interestingly,we found that the long non-coding RNA(lncRNA)Malat1,which promotes muscle differentiation,interacts with miR-101a/b,and this interaction competes with Mef2a mRNA to relieve the inhibition of the p38/MAPK pathway during myogenesis.These results uncovered a“braking”role in differentiation of transiently upregulated miRNAs and provided new insights into the competing endogenous RNA(ceRNA)regulatory mechanism in myoblast differentiation and myogenesis.
基金This work is funded by a Key Project of Health and Family Planning Commission of Hubei Province of China(No.WJ2019Z007)the National Key Research&Development Program of China(2018YFA0108804)+3 种基金the National Natural Science Foundation of China(Nos.81970650 and 81770753)the Youth Program of National Natural Science Foundation of China(No.81800661)the Fundamental Research Funds for the Central Universities(No.20ykpy34)the China Postdoctoral Science Foundation Funded Project(No.2020M683083).
文摘Coronavirus disease 2019(COVID-19)is an infectious disease caused by a newly discovered coronavirus and has rapidly spread to most of the world and resulted in a global pandemic.However,there is a paucity of information available to characterize the immunodeficient population in the COVID-19 pandemic,especially information that focuses on patients after renal transplantation as the typical representative of this population.