Since the coronavirus disease 2019(COVID-19)began to spread,it remains pandemic worldwide.The European Medicines Agency’s human medicines committee and Food and Drug Administration have only granted a conditional mar...Since the coronavirus disease 2019(COVID-19)began to spread,it remains pandemic worldwide.The European Medicines Agency’s human medicines committee and Food and Drug Administration have only granted a conditional marketing authorization for remdesivir to treat COVID-19.It is essential to apply other valuable treatments.Convalescent plasma(CP),donated by persons who have recovered from COVID-19,is the cellular component of blood that contains specific antibodies.Therefore,to determine the feasibility of CP for COVID-19,the effectiveness and controversy are discussed in depth here.It is suggested that CP plays a certain role in the treatment of COVID-19.As a treatment,it may have its own indications and contraindications,which need to be further discussed.Meanwhile,it is critical to establish a standard procedure for treatment from CP collection,preservation,transport,to transfusion,and conduct some large sample randomized controlled trials to confirm the transfusion dosage,appropriate time,frequency,and actively prevent adverse outcomes that may occur.展开更多
基金This work was supported by the provincial and ministerial joint project of the State Key Laboratory for the Prevention and Treatment of High Morbidity in Central Asia(ProjectSKL-HIDCA2019-ZY4)Prevention and Treatment of Major Infectious Diseases such as AIDS and Hepatitis(Project SQ2018ZX100302).
文摘Since the coronavirus disease 2019(COVID-19)began to spread,it remains pandemic worldwide.The European Medicines Agency’s human medicines committee and Food and Drug Administration have only granted a conditional marketing authorization for remdesivir to treat COVID-19.It is essential to apply other valuable treatments.Convalescent plasma(CP),donated by persons who have recovered from COVID-19,is the cellular component of blood that contains specific antibodies.Therefore,to determine the feasibility of CP for COVID-19,the effectiveness and controversy are discussed in depth here.It is suggested that CP plays a certain role in the treatment of COVID-19.As a treatment,it may have its own indications and contraindications,which need to be further discussed.Meanwhile,it is critical to establish a standard procedure for treatment from CP collection,preservation,transport,to transfusion,and conduct some large sample randomized controlled trials to confirm the transfusion dosage,appropriate time,frequency,and actively prevent adverse outcomes that may occur.
