In a recent publication published in Cell,Tamari et al.unraveled a previously unrecognized role of JAK1 signaling in vagal sensory neurons regulating the immune response to allergic lung inflammation.1 The authors sho...In a recent publication published in Cell,Tamari et al.unraveled a previously unrecognized role of JAK1 signaling in vagal sensory neurons regulating the immune response to allergic lung inflammation.1 The authors show that sensory neuromodulation could be an important therapeutic avenue for the treatment of lung inflammation.It is now well established that the number of patients suffering from allergic disorders,like those suffering from obesity and the metabolic syndrome,is rapidly increasing world-wide,accelerating the burden on individual health and healthcare systems.Thus,basic and clinical researchers urgently need to develop novel therapeutics and approaches to limit or prevent disease development or progression.展开更多
基金X.Y.received support from China Scholarship Council(No.201908370218).
文摘In a recent publication published in Cell,Tamari et al.unraveled a previously unrecognized role of JAK1 signaling in vagal sensory neurons regulating the immune response to allergic lung inflammation.1 The authors show that sensory neuromodulation could be an important therapeutic avenue for the treatment of lung inflammation.It is now well established that the number of patients suffering from allergic disorders,like those suffering from obesity and the metabolic syndrome,is rapidly increasing world-wide,accelerating the burden on individual health and healthcare systems.Thus,basic and clinical researchers urgently need to develop novel therapeutics and approaches to limit or prevent disease development or progression.
