Indolent B-cell lymphomas are a group of incurable cancers of the elderly that encompass various entities,such as chronic lymphocytic leukemia(CLL),follicular lymphoma(FL),and marginal zone lymphoma(MZL).All indolent ...Indolent B-cell lymphomas are a group of incurable cancers of the elderly that encompass various entities,such as chronic lymphocytic leukemia(CLL),follicular lymphoma(FL),and marginal zone lymphoma(MZL).All indolent lymphomas may evolve towards aggressive transformation with an increased proliferation index and decreased tumor doubling time.This transformation,which is called Richter’s syndrome in CLL,is associated with an aggressive clinical course and poor survival.At least in CLL,transformation of an indolent B-cell clone is molecularly different from that of de novo diffuse large B-cell lymphomas.1 Aging is known to be associated with immune decline,with increased inflammation,decreased immune surveillance and increased onset of malignancies among the consequences.2 Progression of indolent B-cell lymphomas is likely to be associated with escape from immune surveillance.展开更多
基金The group of J Feuillard is supported by grants from the Ligue Nationale contre le Cancer(Equipe Labellisee Ligue),the Institut National contre le Cancer(INCa),the Comité Orientation Recherche Cancer(CORC),the Limousin Region and the Haute Vienne and Correze comitees of the Ligue Nationale contre le Cancer and by the Lyons Club of CorrezeU Zimber-Strobl was supported by the German ResearchFoundation(SFB 1243,TP-A13).
文摘Indolent B-cell lymphomas are a group of incurable cancers of the elderly that encompass various entities,such as chronic lymphocytic leukemia(CLL),follicular lymphoma(FL),and marginal zone lymphoma(MZL).All indolent lymphomas may evolve towards aggressive transformation with an increased proliferation index and decreased tumor doubling time.This transformation,which is called Richter’s syndrome in CLL,is associated with an aggressive clinical course and poor survival.At least in CLL,transformation of an indolent B-cell clone is molecularly different from that of de novo diffuse large B-cell lymphomas.1 Aging is known to be associated with immune decline,with increased inflammation,decreased immune surveillance and increased onset of malignancies among the consequences.2 Progression of indolent B-cell lymphomas is likely to be associated with escape from immune surveillance.
