Among the four equally important major building blocks of life-that is,nucleic acids(DNA and RNA),proteins,lipids,and car-bohydrates(glycans)-the first two,DNA and RNA,follow the well-established principle of the“cen...Among the four equally important major building blocks of life-that is,nucleic acids(DNA and RNA),proteins,lipids,and car-bohydrates(glycans)-the first two,DNA and RNA,follow the well-established principle of the“central dogma”of transcription(DNA to RNA)and translation(RNA to protein).However,the latter two,glycans and lipids,are missing from biology’s central dogma.In fact,there may be an undiscovered law regarding communication between DNA,RNA,glycans,and lipids,and their roles in immunomodulation.Thus,it becomes necessary to ask:Does a paracentral dogma exist?Can glycans be the third life code-after the first and second life codes of nuclei acids and amino acids-for the materiality of the cell?展开更多
文摘Among the four equally important major building blocks of life-that is,nucleic acids(DNA and RNA),proteins,lipids,and car-bohydrates(glycans)-the first two,DNA and RNA,follow the well-established principle of the“central dogma”of transcription(DNA to RNA)and translation(RNA to protein).However,the latter two,glycans and lipids,are missing from biology’s central dogma.In fact,there may be an undiscovered law regarding communication between DNA,RNA,glycans,and lipids,and their roles in immunomodulation.Thus,it becomes necessary to ask:Does a paracentral dogma exist?Can glycans be the third life code-after the first and second life codes of nuclei acids and amino acids-for the materiality of the cell?
