In order to discover the novel anti-tumor agents, a series of 2-[（pyridin-2-yl）methylthio]-1 H-benzimidazole derivatives were designed and synthesized, and the structures were characterized by IR, MS, and proton NMR...In order to discover the novel anti-tumor agents, a series of 2-[（pyridin-2-yl）methylthio]-1 H-benzimidazole derivatives were designed and synthesized, and the structures were characterized by IR, MS, and proton NMR. 2-[（3,4-Dimethoxypyridin-2-yl）methylthio]-1 Hbenzimidazole was investigated with X-ray crystallography, and the molecule is in orthorhombic system, space group P212121, with a = 9.1828（16）, b = 11.625（2）, c = 13.463（2） ？, Z = 4, R = 0.0231 and wR = 0.0596. The antitumor activities of target compounds were evaluated against human liver cancer cell line HepG2, and human liver normal cell line HL7702 using MTT assay. The target compounds have demonstrated weak or moderate anti-tumor activity against HepG2, while all the target compounds exhibit no cytotoxic effects on HL7702.展开更多
A novel sesquiterpenoid was isolated from the whole plant of Glechoma longituba. Its structure was elucidated as 1, 8-epoxy-7（11）-germacren-5-one-12, 8-olide 1 on the basis of spectral evidences.
The host-guest interaction between cucurbit[8]uril（Q[8]） and chrysin（CHR） has been studied by means of 1H NMR, mass spectrometry（MS）, differential thermal analysis（DTA）, and UV-Vis spectrophotometry. The resul...The host-guest interaction between cucurbit[8]uril（Q[8]） and chrysin（CHR） has been studied by means of 1H NMR, mass spectrometry（MS）, differential thermal analysis（DTA）, and UV-Vis spectrophotometry. The results show that CHR forms a 1：1 inclusion complex with Q[8], with a binding constant of CHR with Q[8] by UV absorp- tion being 5.4 × 106. Phase solubility experiments show a 5.13-fold increase in the solubility of CHR through interac- tion with Q[8] {c（Q[8]）=10-4 real/L}. A study of the evolution of UV absorption spectra with time shows that Q[8] significantly increases the stability of CHR. The antioxidant activity of CHR-Q[8] has been tested by the ABTS me- thod. The CHR-Q[8] inclusion complex shows a better scavenging effect towards the ABTS radical than CHR, with respective IC50 values of 1.05 ×10-6 and 3.07× 10-6 mol/L. In vitro release studies have shown that CHR-Q[8] has a sustained release effcct.展开更多
基金supported by the National Natural Science Foundation of China(No.21342006)the Program for Innovative Research Team of the Ministry of Education of China(No.IRT_14R36)
文摘In order to discover the novel anti-tumor agents, a series of 2-[（pyridin-2-yl）methylthio]-1 H-benzimidazole derivatives were designed and synthesized, and the structures were characterized by IR, MS, and proton NMR. 2-[（3,4-Dimethoxypyridin-2-yl）methylthio]-1 Hbenzimidazole was investigated with X-ray crystallography, and the molecule is in orthorhombic system, space group P212121, with a = 9.1828（16）, b = 11.625（2）, c = 13.463（2） ？, Z = 4, R = 0.0231 and wR = 0.0596. The antitumor activities of target compounds were evaluated against human liver cancer cell line HepG2, and human liver normal cell line HL7702 using MTT assay. The target compounds have demonstrated weak or moderate anti-tumor activity against HepG2, while all the target compounds exhibit no cytotoxic effects on HL7702.
基金the National Natural Science Foundation of China [No. 30460150] the Previous Special Research Program of Significant Foundation Research 2004CCA03800.
文摘A novel sesquiterpenoid was isolated from the whole plant of Glechoma longituba. Its structure was elucidated as 1, 8-epoxy-7（11）-germacren-5-one-12, 8-olide 1 on the basis of spectral evidences.
基金Supported by the National Natural Science Foundation of China（No.21272045）.
文摘The host-guest interaction between cucurbit[8]uril（Q[8]） and chrysin（CHR） has been studied by means of 1H NMR, mass spectrometry（MS）, differential thermal analysis（DTA）, and UV-Vis spectrophotometry. The results show that CHR forms a 1：1 inclusion complex with Q[8], with a binding constant of CHR with Q[8] by UV absorp- tion being 5.4 × 106. Phase solubility experiments show a 5.13-fold increase in the solubility of CHR through interac- tion with Q[8] {c（Q[8]）=10-4 real/L}. A study of the evolution of UV absorption spectra with time shows that Q[8] significantly increases the stability of CHR. The antioxidant activity of CHR-Q[8] has been tested by the ABTS me- thod. The CHR-Q[8] inclusion complex shows a better scavenging effect towards the ABTS radical than CHR, with respective IC50 values of 1.05 ×10-6 and 3.07× 10-6 mol/L. In vitro release studies have shown that CHR-Q[8] has a sustained release effcct.
