Research on Site Planning of Mobile Communication Network

In this paper,considering the cost of base station,coverage,call quality,and other practical factors,a multi-objective optimal site planning scheme is proposed.Firstly,based on practical needs,mathematical modeling methods were used to establish mathematical expressions for the three sub-objectives of cost objectives,coverage objectives,and quality objectives.Then,a multi-objective optimization model was established by combining threshold and traffic volume constraints.In order to reduce the time complexity of optimization,a non-dominated sorting genetic algorithm(NSGA)is used to solve the multi-objective optimization problem of site planning.Finally,a strategy for clustering and optimizing weak coverage areas was proposed.In order to avoid redundant neighborhood retrieval during cluster expansion,the Fast Density-Based Spatial Clustering of Applications with Noise(FDBSCAN)clustering method was adopted.With different sub-objectives as the main objectives,this paper obtained the distribution map of weak coverage areas before and after the establishment of new base stations,as well as relevant site planning maps,and provided three planning schemes for different main objectives.The simulation results show that the traffic coverage of the three station planning schemes is above 90%.The change in the main optimization objective will result in a significant difference between the cost of the three solutions and the coverage of weak coverage points.

Glial response in the midcingulate cortex in Huntington’s disease

Huntington’s disease(HD)is a genetic disease characterized by the progressive degeneration of the striatum and cortex.Patients can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psychiatric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive decline.The causal mutation underlying HD results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.

Neuroinflammation as a therapeutic target in Huntington's disease

In 1872, George Huntington presented his essay “On Chorea” to the Meigs and Mason Academy of Medicine and, in doing so, detailed a disease that would later bear his name. Huntington's disease(HD) is a genetic, neurodegenerative disease that manifests as the loss of motor control,cognitive impairment,and mood and psychiatric changes in paents.

Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs worldwide.Due to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more prevalent.Glaucoma primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

Calcium channels caught in peripheral glia’s tug-of-war on axon regeneration in Drosophila

Neural damage or degeneration is at the crux of many diseases,and treatment of these diseases will require the development of therapeutics to enhance and guide neural regeneration.Both intrinsic and extrinsic factors dictate a neuron’s ability to regenerate,and the combination of these factors results in the great regenerative capacity of the peripheral nervous system(PNS)and the poor regenerative capacity of the central nervous system(CNS)following injury.At the core of a neuron’s function is its ability to relay electrochemical signals,and a neuron’s excitability is a key factor in its ability to regenerate.Recent works have focused on the changes in neuronal electrophysiological properties,firing patterns,and ion flux after injury,which differentially activate signaling pathways at the core of regeneration.The role of glia in neuron regeneration has long been studied.

Exosomes originating from neural stem cells undergoing necroptosis participate in cellular communication by inducing TSC2 upregulation of recipient cells following spinal cord injury

We previously demonstrated that inhibiting neural stem cells necroptosis enhances functional recovery after spinal cord injury.While exosomes are recognized as playing a pivotal role in neural stem cells exocrine function,their precise function in spinal cord injury remains unclear.To investigate the role of exosomes generated following neural stem cells necroptosis after spinal cord injury,we conducted singlecell RNA sequencing and validated that neural stem cells originate from ependymal cells and undergo necroptosis in response to spinal cord injury.Subsequently,we established an in vitro necroptosis model using neural stem cells isolated from embryonic mice aged 16-17 days and extracted exosomes.The results showed that necroptosis did not significantly impact the fundamental characteristics or number of exosomes.Transcriptome sequencing of exosomes in necroptosis group identified 108 differentially expressed messenger RNAs,104 long non-coding RNAs,720 circular RNAs,and 14 microRNAs compared with the control group.Construction of a competing endogenous RNA network identified the following hub genes:tuberous sclerosis 2(Tsc2),solute carrier family 16 member 3(Slc16a3),and forkhead box protein P1(Foxp1).Notably,a significant elevation in TSC2 expression was observed in spinal cord tissues following spinal cord injury.TSC2-positive cells were localized around SRY-box transcription factor 2-positive cells within the injury zone.Furthermore,in vitro analysis revealed increased TSC2 expression in exosomal receptor cells compared with other cells.Further assessment of cellular communication following spinal cord injury showed that Tsc2 was involved in ependymal cellular communication at 1 and 3 days post-injury through the epidermal growth factor and midkine signaling pathways.In addition,Slc16a3 participated in cellular communication in ependymal cells at 7 days post-injury via the vascular endothelial growth factor and macrophage migration inhibitory factor signaling pathways.Collectively,these findings confirm that exosomes derived from neural stem cells undergoing necroptosis play an important role in cellular communication after spinal cord injury and induce TSC2 upregulation in recipient cells.

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

Recent advances and future directions in preclinical research of argininevasopressin(AVP) receptor blocker conivaptan in the context of stroke

Stroke is a major cause of mortality and permanent disability.The onset of stroke is followed by life-threatening pathophysiological responses including brain edema,elevation of intracranial pressure,disruption of blood-brain barrier（BBB）,brain infarct and permanent tissue damage.Brain edema develops due to accumulation of water in intracellular and extracellular compartments of the brain,

Research on Collaboration Decision Design of Complex C2 System

The design of collaboration decision of C2 system is one of the puzzles which dicision science studies in complex system. To solve the contravention between the theory of collaboration decision design and development requirement in distributed C2 system,three-stage design approach is proposed to research coherence and optimization by which decision-maker carries out decision regulations. First,getting information and decision process are described; decision indexes and regulation models of collaboration are established. And then,a test circumstance is designed and established for measuring various decision-maker’s capabilities of carrying out decision regulation by simulation and getting their load capability parameters. Finally,the obtained parameters from the experiment are disposed and substituted into the original models for proving the coherence of decision regulations. As a result,it is feasible for three-stage approach to design collaboration decision,and decision regulations can satisfy various decision-maker requirements.

Statistical Analysis and Research on the Authorized Patent of Donghua University

With retrieving the granted patents in 2002-2011 in Donghua University (DHU), the authorized invention patent distribution among colleges and subjects is introduced in this paper, based on the recorded patent database of the China State Intellectual Property Office. This paper can provide useful experiences in the discipline construction, benefiting the characteristics disciplines industry group and multidisciplinary infiltration and research cooperation. In addition, it encourages teachers and students to get more intellectual property rights for schools and improves the overall strength of the university.

Perspective and Research of the Criticism of American Serious Drama to Social Reality

The development of the American serious drama can adapt to the effective response of the social public to the social developmental psychology and social reality and present the criticism of the realistic society development status. The American serious drama makes analysis from the perspective of social development and criticizes the inequality in the realistic society based on pursuit of the equality of race,cultural inheritance and social value.The American serious drama can express the voice of the social public,conform to the cognitive psychology of the realistic society by the social public,highlight the specific development status in the American realistic society and express corresponding development viewpoints for the development direction.

Research on the mechanism of Chaihu Huangqin medicine based on integrated pharmacology to improve the clinical symptoms of COVID-19

Objective:Novel coronavirus(COVID-19)was used to improve the clinical symptoms of the new type coronavirus(LV),based on integrated pharmacology.Methods:TCMIP v2.0 was used to predict the key target and action pathway of Bupleurum baicalensis Georgi in improving the clinical symptoms of covid-19.The multi-dimensional network diagram of"drug pair active component key target action pathway"was drawn to explore its action mechanism from the molecular level.Results:Bupleurum and Scutellaria baicalensis could regulate IL signaling pathway and clec7a(a member of C-type lectin domain 7 family)/Inflammatory pathway,immune stress and other related signaling pathways can inhibit activated cytokines,alleviate excessive immune response,eliminate inflammation,and resist virus.In addition,the core targets of Bupleurum baicalensis baicalensis Georgi:nuclear factor kB(NFKB2,NFKB1),interleukin(IL-6,IL-1B),toll like receptor 4(TLR4),tumor necrosis factor(TNF)and so on are mostly induced by inflammation It is related to body damage.Bupleurum and scutellaria have the clinical effects of anti-inflammatory,antiviral,strengthening immunity,inhibiting pulmonary fibrosis and so on.Conclusion:Radix Bupleuri Scutellariae can be used to treat covid-19 by multi-channel,multi-target and multi ring.The results of this study provide a theoretical basis for Bupleurum Scutellaria to improve the use of COVID-19.

Research on Multi-Blockchain Electronic Archives Sharing Model

The purpose of introducing blockchain into electronic archives sharing and utilization is to break the information barrier between electronic archives sharing departments by relying on technologies such as smart contract and asymmetric encryption.Aiming at the problem of dynamic permission management in common access control methods,a new access control method based on smart contract under blockchain is proposed,which improves the intelligence level under blockchain technology.Firstly,the Internet attribute access control model based on smart contract is established.For the dynamic access of heterogeneous devices,the management contract,permission judgment contract and access control contract are designed;Secondly,the access object credit evaluation algorithm based on particle swarm optimization radial basis function(PSO-RBF)neural network is used to dynamically generate the access node credit threshold combined with the access policy,so as to realize the intelligent access right management method.Finally,combined with the abovemodels and algorithms,the workflow of electronic archives sharing and utilization model of multi blockchain is constructed.The experimental results show that the timeconsuming of the process increases linearly with the number of continuous access to electronic archives blocks,and the secure access control of sharing and utilization is feasible,secure and effective.

Research progress in the cell origin of basal cell carcinoma

Identification of the cell origin of human neoplasms remains a challenging but important task in cancer research.The outcomes in this area of study may allow us to design novel strategies for early cancer detection and targeted cancer therapeutics.Skin is a great organ to study cancer stem cells because stem cells in skin have been well investigated and approaches of genetic manipulation in specific cell compartments are available to mimic clinical skin cancer in a mouse model.Recently,by using different genetic engineered mouse models,several groups have tried to discover which cell type in skin was responsible for the initiation of basal cell carcinoma,the most common type of skin cancer.These studies raised more questions but also showed more ways for future investigation.

Language and Marginalization-a Research on Language Problems of Migrant Workers in Beijing

With migrant workers pouring out into cities together with their family,their problems become more and more prominent.By means of field study,the paper investigated the language problems and social problems of migrant workers,and confirmed the hypothesis that language problems cause migrant workers marginalized in the mainstream of the society.

The most cited articles on the topic of health behaviors in Google Trends research: a systematic review

Background: Over the past decade, the use of Web-based data in public health issues has been proven useful in assessing various aspects of human behavior. Google Trends is the most popular tool to gather such information and has been applied to several topics with the most focused subject related to health and medicine. However, the most cited articles and the popular medical subject headings (MESH terms) on health behaviors in Google Trends research remain unknown. The web-based behavior requires to monitor and analyze on-line data for examining actual human behavior to predict and even prevent health-related issues that constantly arise in daily life. Objective: This systematic review aimed at reporting and further presenting the most cited articles and the popular MESH terms on health behaviors in Google Trends (infodemiology) researches in health-related topics since 2009 to provide an overview of the topic burst for future research on the subject of health behavior. Methods: Following the Meta-Analyses guidelines for selecting studies, we searched for the term “Google Trends [Title]” in PubMed databases since 2009, applying specific criteria for types of journal articles. A total of 86 published papers were extracted, excluding those that did not fall inside the topics of health and medicine or the selected article types. We then further categorized the published papers according to MESH terms using social network analysis (SNA) and selected the most cited articles that related to the health behavior in Google Trends. Results: The most cited articles are those from the US in 2009 (PMID= 19845471 cited 88 times) and the UK in 2013 (PMID= 23619126 cited 74 times). The MESH term represented by Internet earns the highest impact factor (IF) and presents significantly different among term clusters (F (3,20)=15.79, p<0.001). The most number of citing journals is from PloS One. The most number of author affiliations is from the US. Conclusion: The monitoring of online queries can provide insight into human behavior, as the phenomenon is significantly and continuously growing at present and in the future for assessing behavioral changes in health topics.

Microbiological Assessment and Antimicrobials’ Use in an Infectious Diseases Department in Mali

The use of antimicrobials without microbiological proof is frequent and contributes to the emergence of resistance. The aim was to identify the organisms isolated during laboratory examinations and the type of antimicrobials consumed by patients hospitalized to Infectious Diseases’ Clinic. This is a cross-sectional and analytical study, carried out from January 1 to December 31, 2017 in the Infectious Diseases Department of Point “G” Teaching Hospital in Mali. All biological specimens from patients during the study period were analyzed. In total, 322 patients benefited from microbiological test, with a mean age of 40.9 ± 12.2 years (range 15 and 74 years) with a sex ratio of 0.93. Only 5.6% of patients were HIV negative. In all participants, a total of 658 microbiological specimen were taken, 224 (34.0%) identified at least one pathogen including bacteria in more than a half of the cases (58.5%). On the report of bacteriological analysis, the most frequently identified organisms were Mycobacterium tuberculosis (42.2%) mainly in sputum;Escherichia coli (24.2%) and Klebsiella pneumoniae (7.8%) commonly in urine and Gardnerella vaginalis (7.0%) exclusively in vaginal secretions. Candida albicans (5/8) and Cryptococcus neoformans (3/8) were the most common fungi while Plasmodium falciparum (96.4%) represented the parasite frequently found in blood. From a therapeutic standpoint, 1143 antimicrobials were prescribed to 322 admitted patients, i.e. 3.55 anti-infectives per patient. Antibiotics (excluding tuberculosis drugs), antiparasitics and antifungals represented respectively 46.2%;18.8% and 15.1% of anti-infectives. Antibiotic therapy was effective in 274 (85.1%) patients and among them, only 76 (27.7%) cases were based on microbiological evidence. Antibiotics are the most widely used antimicrobials in an infectious disease department. Empiric treatments are common but must be minimized by the search for microbiological evidence.

Obituary for Donald S.Coffey:Remembering a pioneer in the field of prostate cancer research.(1932-2017)

It is with the deepest sadness that we publish the following obituary for Donald S.Coffey,an Asian Journal of Urology(AJU)respected author.Dr.Coffey was invited to write a paper for the inaugural issue of AJU in 2014.Despite he was 82 years old,he accepted our invitation and contributed a thoughtful perspective article.

Research progress on the effect of oocyte smooth endoplasmic reticulum clusters on early embryo development and pregnancy outcome

With the clinical development and application of intracytoplasmic sperm injection(ICSI)technology in human assisted reproduction,the influence of oocyte quality on embryo development has been paid more and more attention.So far,there have been many reports on oocyte morphology affecting embryo development.It has been found in some works that the appearance of smooth endoplasmic reticulum clusters(SERC)in oocytes may affect the fertilization and embryo development of oocytes.However,with the increasing reports of SERC-containing oocytes obtained by in vitro fertilization and healthy offspring in recent years,there is still some controversy on whether to continue to use SERC-containing oocytes for the following assisted reproductive therapy in clinical practice.Based on this,this review aims to review the research progress of SERC in oocytes in recent years.

Complications of Peripartum Cardiomyopathy at the Departmental University Hospital Teaching of Borgou (Benin) in 2022: About 3 Cases

Introduction: Peripartum cardiomyopathy (PPCM) is a dilated cardiomyopathy occurring in the last month of pregnancy or the first five months postpartum without pre-existing cardiovascular pathology. It is a major cause of pregnancy-related heart failure with high morbidity and mortality. In severe forms (10% to 15% of cases), thrombo-embolic complications are the main cause. The initial hemodynamic evolution is totally unpredictable and sometimes extremely brutal and fatal. The objective of this work was to show the often pejorative evolution of PPCM in our country. Methods: We report in this work three serious clinical cases revealing the complications of this PPCM among patients admitted to the cardiology department of the CHUD-B/A in 2022 for heart failure. The data were collected according to the Declaration of Helsinki. Patients and Observations: The first case was a PPCM with severe left ventricular (LV) systolic dysfunction complicated by spontaneous left intraventricular contrast and right superficial sylvian ischemic stroke. The second case reports a global cardiac decompensation of a PPCM with severe LV systolic dysfunction complicated by an apical thrombus. The third case is that of a state of cardiogenic shock complicating a PPCM with severe LV systolic dysfunction. Among our 03 patients presenting these severe forms of PPCM, the evolution, in spite of the symptomatic and prognostic treatments of the heart failure, and even of the complications, was unfavourable with death in two of them. Conclusion: Complications of PPCM are frequent and fatal in Benin.