Purpose: To evaluate the influence of age, sex, race, refractive error and opt ic disc topography on the sensitivity and specificity of scanning laser polarime try (SLP) in the diagnosis of glaucoma. Methods: A total ...Purpose: To evaluate the influence of age, sex, race, refractive error and opt ic disc topography on the sensitivity and specificity of scanning laser polarime try (SLP) in the diagnosis of glaucoma. Methods: A total of 88 normal individual s and 95 glaucoma patients were included in this study. Glaucoma was defined on the basis of both optic nerve damage and visual field defects. Scanning laser po larimetry, optic disc topography, automated perimetry and refractometry were per formed in all subjects. The sensitivity and specificity of SLP were assessed app lying a previously calculated cut-off to a previously described linear discrimi nant function (LDF). Results: The sensitivity and specificity of SLP in the stud y population were 82%and 83%, respectively. Sensitivity and specificity were n ot affected by age, sex, race, average disc diameter or disc area. The sensitivi ty of SLP tended to be higher in myopes (93%) than in emmetropes (80%) and hyp eropes (71%) (P=0.08). Sensitivities were higher in individuals with cup areas >0.96 mm2(89%), rim areas ≤1.36 mm2 (92%), and cup area/disc area ratios >0.4 5 (89%) (P < 0.05). Stepwise logistic regression analysis indicated that the pr esence of a cup area > 0.96 mm2 and a rim area< 1.36 mm2 significantly increased the sensitivity of the LDF, whereas a cup area/disc area ratio ≤0.45 significa ntly increased the specificity of the LDF. Conclusion: The sensitivity and speci ficity of SLP may be influenced by refractive error and optic disc parameters th at are affected by glaucomatous damage (cup area, rim area and cup area/disc are a ratio). These parameters must be considered in studies evaluating the sensitiv ity and specificity of optic nerve/retinal nerve fibre layer imaging technologie s.展开更多
文摘Purpose: To evaluate the influence of age, sex, race, refractive error and opt ic disc topography on the sensitivity and specificity of scanning laser polarime try (SLP) in the diagnosis of glaucoma. Methods: A total of 88 normal individual s and 95 glaucoma patients were included in this study. Glaucoma was defined on the basis of both optic nerve damage and visual field defects. Scanning laser po larimetry, optic disc topography, automated perimetry and refractometry were per formed in all subjects. The sensitivity and specificity of SLP were assessed app lying a previously calculated cut-off to a previously described linear discrimi nant function (LDF). Results: The sensitivity and specificity of SLP in the stud y population were 82%and 83%, respectively. Sensitivity and specificity were n ot affected by age, sex, race, average disc diameter or disc area. The sensitivi ty of SLP tended to be higher in myopes (93%) than in emmetropes (80%) and hyp eropes (71%) (P=0.08). Sensitivities were higher in individuals with cup areas >0.96 mm2(89%), rim areas ≤1.36 mm2 (92%), and cup area/disc area ratios >0.4 5 (89%) (P < 0.05). Stepwise logistic regression analysis indicated that the pr esence of a cup area > 0.96 mm2 and a rim area< 1.36 mm2 significantly increased the sensitivity of the LDF, whereas a cup area/disc area ratio ≤0.45 significa ntly increased the specificity of the LDF. Conclusion: The sensitivity and speci ficity of SLP may be influenced by refractive error and optic disc parameters th at are affected by glaucomatous damage (cup area, rim area and cup area/disc are a ratio). These parameters must be considered in studies evaluating the sensitiv ity and specificity of optic nerve/retinal nerve fibre layer imaging technologie s.
