Domestication of cranberry and blueberry began in the United States in the early 1800s and 1900s,respectively,and in part owing to their f lavors and health-promoting benefits are now cultivated and consumed worldwide...Domestication of cranberry and blueberry began in the United States in the early 1800s and 1900s,respectively,and in part owing to their f lavors and health-promoting benefits are now cultivated and consumed worldwide.The industry continues to face a wide variety of production challenges(e.g.disease pressures),as well as a demand for higher-yielding cultivars with improved fruit quality characteristics.Unfortunately,molecular tools to help guide breeding efforts for these species have been relatively limited compared with those for other high-value crops.Here,we describe the construction and analysis of the first pangenome for both blueberry and cranberry.Our analysis of these pangenomes revealed both crops exhibit great genetic diversity,including the presence-absence variation of 48.4%genes in highbush blueberry and 47.0%genes in cranberry.Auxiliary genes,those not shared by all cultivars,are significantly enriched with molecular functions associated with disease resistance and the biosynthesis of specialized metabolites,including compounds previously associated with improving fruit quality traits.The discovery of thousands of genes,not present in the previous reference genomes for blueberry and cranberry,will serve as the basis of future research and as potential targets for future breeding efforts.The pangenome,as a multiple-sequence alignment,as well as individual annotated genomes,are publicly available for analysis on the Genome Database for Vaccinium-a curated and integrated web-based relational database.Lastly,the core-gene predictions from the pangenomes will serve useful to develop a community genotyping platform to guide future molecular breeding efforts across the family.展开更多
Renal damage secondary to paracetamol intoxication is rare, estimated between 1% and 2% of intoxication cases. Its pathophysiology is still debated, the clinical involvement consisting in an acute tubular necrosis wit...Renal damage secondary to paracetamol intoxication is rare, estimated between 1% and 2% of intoxication cases. Its pathophysiology is still debated, the clinical involvement consisting in an acute tubular necrosis with a good prognosis if it is rapidly treated. Renal damage can sometimes occur without prior hepatic damage, and the onset of renal manifestations is generally between the 2nd and 7th day after taking paracetamol. If its management remains exclusively symptomatic, its late onset can sometimes lead to serious metabolic complications. It is therefore important to systematically monitor renal function following paracetamol drug intoxication. We report the case of a 60-year-old male subject hospitalized for the management of voluntary drug intoxication (VDI) with paracetamol complicated by acute hepatocellular failure and acute renal failure. His management required extrarenal purification (hemodialysis) and the evolution was favorable with recovery ad integrumof renal function. Conclusion: Although less known and of unelucidated physiopathology, nephrotoxicity secondary to voluntary drug intoxication with paracetamol is a reality and can lead in extreme cases to the use of extrarenal purification technique (hemodialysis).展开更多
Energy use is becoming more efficient due to technological innovations.We focused on the transportation sector in China to develop a national multisector computable general equilibrium(CGE)model for analyzing the rebo...Energy use is becoming more efficient due to technological innovations.We focused on the transportation sector in China to develop a national multisector computable general equilibrium(CGE)model for analyzing the rebound effect from an improvement of 10%in the energy efficiency.We compared the size of the energy rebound effect at both the macroeconomic and sectoral levels in different transportation modal subsectors,namely rail,road,water,and air travel.The findings showed that the magnitude of the rebound effect varies across the transportation modes.This is particularly true for the air transportation sector,which has an economy-wide rebound effect of 30.1%and an own-sector rebound effect of 74.6%because of a sharp increase in the export demand for air transport services.We also quantitatively evaluated the contribution of energy efficiency improvement in the transportation sector to China’s economic growth and carbon reductions and found a positive dividend effect on the economy as well as the environment.The modeling results suggest that improving overall transportation energy efficiency by 10%generates an economy-wide welfare gain of approximately 29 billion yuan,while 19 billion yuan are attributable to a more efficient road transportation subsector.Furthermore,to offset the effects of these mode-specific rebound effects,we simulated the effectiveness of different policies and solutions.These included economic instruments in the form of energy,environmental,and carbon taxes,household transport consumption structure adjustments,and energy structure adjustments.This study revealed that combining these sustainable development policies offers opportunities for economy-wide multisectoral improvements in energy savings,emissions reduction,and economic benefits.展开更多
基金supported by Michigan State University AgBioResearch,Michigan State University Institute for Cyber-Enabled Research,NIH 5T32GM110523-10,NSF NRT-HDR 1828149 USDANIFA HATCH MICL02742,USDA-NIFA AFRI 1015241,and USDANIFA SCRI award 2019-51181-30015supported in part by the National Science Foundation Research Traineeship Program(DGE-1828149)to M.J.
文摘Domestication of cranberry and blueberry began in the United States in the early 1800s and 1900s,respectively,and in part owing to their f lavors and health-promoting benefits are now cultivated and consumed worldwide.The industry continues to face a wide variety of production challenges(e.g.disease pressures),as well as a demand for higher-yielding cultivars with improved fruit quality characteristics.Unfortunately,molecular tools to help guide breeding efforts for these species have been relatively limited compared with those for other high-value crops.Here,we describe the construction and analysis of the first pangenome for both blueberry and cranberry.Our analysis of these pangenomes revealed both crops exhibit great genetic diversity,including the presence-absence variation of 48.4%genes in highbush blueberry and 47.0%genes in cranberry.Auxiliary genes,those not shared by all cultivars,are significantly enriched with molecular functions associated with disease resistance and the biosynthesis of specialized metabolites,including compounds previously associated with improving fruit quality traits.The discovery of thousands of genes,not present in the previous reference genomes for blueberry and cranberry,will serve as the basis of future research and as potential targets for future breeding efforts.The pangenome,as a multiple-sequence alignment,as well as individual annotated genomes,are publicly available for analysis on the Genome Database for Vaccinium-a curated and integrated web-based relational database.Lastly,the core-gene predictions from the pangenomes will serve useful to develop a community genotyping platform to guide future molecular breeding efforts across the family.
文摘Renal damage secondary to paracetamol intoxication is rare, estimated between 1% and 2% of intoxication cases. Its pathophysiology is still debated, the clinical involvement consisting in an acute tubular necrosis with a good prognosis if it is rapidly treated. Renal damage can sometimes occur without prior hepatic damage, and the onset of renal manifestations is generally between the 2nd and 7th day after taking paracetamol. If its management remains exclusively symptomatic, its late onset can sometimes lead to serious metabolic complications. It is therefore important to systematically monitor renal function following paracetamol drug intoxication. We report the case of a 60-year-old male subject hospitalized for the management of voluntary drug intoxication (VDI) with paracetamol complicated by acute hepatocellular failure and acute renal failure. His management required extrarenal purification (hemodialysis) and the evolution was favorable with recovery ad integrumof renal function. Conclusion: Although less known and of unelucidated physiopathology, nephrotoxicity secondary to voluntary drug intoxication with paracetamol is a reality and can lead in extreme cases to the use of extrarenal purification technique (hemodialysis).
基金supported by the National Key R&D Project of China(No.2018YFC0213600)National Natural Science Foundation of China(No.71834004,71431005,71673198,71273185 and 41571522)
文摘Energy use is becoming more efficient due to technological innovations.We focused on the transportation sector in China to develop a national multisector computable general equilibrium(CGE)model for analyzing the rebound effect from an improvement of 10%in the energy efficiency.We compared the size of the energy rebound effect at both the macroeconomic and sectoral levels in different transportation modal subsectors,namely rail,road,water,and air travel.The findings showed that the magnitude of the rebound effect varies across the transportation modes.This is particularly true for the air transportation sector,which has an economy-wide rebound effect of 30.1%and an own-sector rebound effect of 74.6%because of a sharp increase in the export demand for air transport services.We also quantitatively evaluated the contribution of energy efficiency improvement in the transportation sector to China’s economic growth and carbon reductions and found a positive dividend effect on the economy as well as the environment.The modeling results suggest that improving overall transportation energy efficiency by 10%generates an economy-wide welfare gain of approximately 29 billion yuan,while 19 billion yuan are attributable to a more efficient road transportation subsector.Furthermore,to offset the effects of these mode-specific rebound effects,we simulated the effectiveness of different policies and solutions.These included economic instruments in the form of energy,environmental,and carbon taxes,household transport consumption structure adjustments,and energy structure adjustments.This study revealed that combining these sustainable development policies offers opportunities for economy-wide multisectoral improvements in energy savings,emissions reduction,and economic benefits.
