Epigenetic mechanisms play an important part in the regulation of gene expression and these alterations may induce long-term changes in gene function and metabolism.They have received extensive attention in bridging t...Epigenetic mechanisms play an important part in the regulation of gene expression and these alterations may induce long-term changes in gene function and metabolism.They have received extensive attention in bridging the gap between environmental exposures and disease development via their influence on gene expression.DNA methylation is the earliest discovered epigenetic alteration.In this review,we try to examine the role of DNA methylation and histone modification in Age related macular degeneration(AMD)and Diabetic Retinopathy(DR),its vascular complications and recent progress.Given the complex nature of AMD and DR,it is crucial to improve therapeutics which will greatly enhance the quality of life and reduce the burden for millions of patients living with these potentially blinding conditions.展开更多
Ocular cells like,retinal pigment epithelium(RPE)is a highly specialized pigmented monolayer of post-mitotic cells,which is located in the posterior segment of the eye between neuro sensory retina and vascular choroid...Ocular cells like,retinal pigment epithelium(RPE)is a highly specialized pigmented monolayer of post-mitotic cells,which is located in the posterior segment of the eye between neuro sensory retina and vascular choroid.It functions as a selective barrier and nourishes retinal visual cells.As a result of high-level oxygen consumption of retinal cells,RPE cells are vulnerable to chronic oxidative stress and an increased level of reactive oxygen species(ROS)generated from mitochondria.These oxidative stress and ROS generation in retinal cells lead to RPE degeneration.Various sources including mtDNA damage could be an important factor of oxidative stress in RPE.Gene therapy and mitochondrial transfer studies are emerging fields in ocular disease research.For retinal degenerative diseases stem cell-based transplantation methods are developed from basic research to preclinical and clinical trials.Translational research contributions of gene and cell therapy would be a new strategy to prevent,treat and cure various ocular diseases.This review focuses on the effect of oxidative stress in ocular cell degeneration and recent translational researches on retinal degenerative diseases to cure blindness.展开更多
基金We thank Vision Research Foundation,Sankara Nethralaya,Chennai for supporting necessary facilities to carry out this review.
文摘Epigenetic mechanisms play an important part in the regulation of gene expression and these alterations may induce long-term changes in gene function and metabolism.They have received extensive attention in bridging the gap between environmental exposures and disease development via their influence on gene expression.DNA methylation is the earliest discovered epigenetic alteration.In this review,we try to examine the role of DNA methylation and histone modification in Age related macular degeneration(AMD)and Diabetic Retinopathy(DR),its vascular complications and recent progress.Given the complex nature of AMD and DR,it is crucial to improve therapeutics which will greatly enhance the quality of life and reduce the burden for millions of patients living with these potentially blinding conditions.
基金The authors would like to thank the Science and Engi・neering Research Board(ECR/2018/000718)Indian Council of Medical Research(File No.2018-2786/CMB/Adhoc-BMS)and Countil for Scie ntific and In dustrial Research((Ref No.:27(0353)/19/EMR-ll),Government of India,New Delhi for providing necessary funding to complete this review article successfully.
文摘Ocular cells like,retinal pigment epithelium(RPE)is a highly specialized pigmented monolayer of post-mitotic cells,which is located in the posterior segment of the eye between neuro sensory retina and vascular choroid.It functions as a selective barrier and nourishes retinal visual cells.As a result of high-level oxygen consumption of retinal cells,RPE cells are vulnerable to chronic oxidative stress and an increased level of reactive oxygen species(ROS)generated from mitochondria.These oxidative stress and ROS generation in retinal cells lead to RPE degeneration.Various sources including mtDNA damage could be an important factor of oxidative stress in RPE.Gene therapy and mitochondrial transfer studies are emerging fields in ocular disease research.For retinal degenerative diseases stem cell-based transplantation methods are developed from basic research to preclinical and clinical trials.Translational research contributions of gene and cell therapy would be a new strategy to prevent,treat and cure various ocular diseases.This review focuses on the effect of oxidative stress in ocular cell degeneration and recent translational researches on retinal degenerative diseases to cure blindness.
